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We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (<jats:italic>n\u2009<\/jats:italic>=\u200932) or placebo group (<jats:italic>n<\/jats:italic>\u2009=\u200932) for 10\u00a0weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Magnesium supplementation significantly improved the components of quality of life including physical functioning (<jats:italic>p<\/jats:italic>\u2009=\u20090.011), role limitations due to physical health (<jats:italic>p<\/jats:italic>\u2009=\u20090.012), role limitations due to emotional problems (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), energy\/fatigue (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), emotional wellbeing (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), social functioning (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), general health (<jats:italic>p<\/jats:italic>\u2009=\u20090.013), and total quality of life (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This randomized clinical trial was registered at IRCT.ir on 2020\u201310-18 (Registration Code: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/irct.ir\/trial\/50264\">IRCT20130903014551N9<\/jats:ext-link>).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-022-00982-7","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T07:03:21Z","timestamp":1659423801000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial"],"prefix":"10.1186","volume":"20","author":[{"given":"Mahsima","family":"Jaripur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatav","family":"Ghasemi-Tehrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Gholizadeh-Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cain C. 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The reporting of this work is compliant with CONSORT guidelines. The lead author affirms that no important aspects of the study have been omitted and that any discrepancies from the study as planned. The Research Council and Ethical Committee of Isfahan University of Medical Sciences, Isfahan, Iran and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran approved this study (Code: IR.MUI.RESEARCH.REC.1399.406). This randomized clinical trial was registered at IRCT.ir on 2020\u201310-18 (Registration Code: IRCT20130903014551N9).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Transparency Declaration"}},{"value":"This study was ethically approved by The Research Council and Ethical Committee of Isfahan University of Medical Sciences, Isfahan, Iran, (Code: IR.MUI.RESEARCH.REC.1399.406), and was registered at IRCT.ir on 2020\u201310-18 (Registration Code: IRCT20130903014551N9). 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