{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:41:11Z","timestamp":1792593671098,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To explore the risk factors including the difference between mean gestational sac diameter and crown-rump length for missed abortion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Hospitalized patients with missed abortion and patients with continuing pregnancy to the second trimester from Chengdu Women's and Children's Central Hospital from June 2018 to June 2021 were retrospectively analyzed. The best cut-off value for age and difference between mean gestational sac diameter and crown-rump length (mGSD-CRL) were obtained by x-tile software. Univariate and multivariate logistic regression analysis were adopted to identify the possible risk factors for missed abortion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Age, gravidity, parity, history of cesarean section, history of recurrent abortion (\u2265\u20093 spontaneous abortions), history of ectopic pregnancy and overweight or obesity (BMI\u2009&gt;\u200924\u00a0kg\/m<jats:sup>2<\/jats:sup>) were related to missed abortion in univariate analysis. However, only age (\u2265\u200930 vs\u2009&lt;\u200930\u00a0years: OR\u2009=\u20091.683, 95%CI\u2009=\u20091.017\u20132.785, <jats:italic>P<\/jats:italic>\u2009=\u20090.043, power\u2009=\u200954.4%), BMI (&gt;\u200924 vs\u2009\u2264\u200924\u00a0kg\/m<jats:sup>2<\/jats:sup>: OR\u2009=\u20092.073, 95%CI\u2009=\u20091.056\u20134.068, <jats:italic>P<\/jats:italic>\u2009=\u20090.034, power\u2009=\u200981.3%) and mGSD-CRL (&gt;\u200920.0vs\u2009\u2264\u200911.7\u00a0mm: OR\u2009=\u20092.960, 95% CI\u2009=\u20091.397\u20136.273, <jats:italic>P<\/jats:italic>\u2009=\u20090.005, power\u2009=\u200998.9%; 11.7\u2009&lt;\u2009mGSD-CRL\u2009\u2264\u200920.0vs\u2009&gt;\u200920.0\u00a0mm: OR\u2009=\u20090.341, 95%CI\u2009=\u20090.172\u20130.676, <jats:italic>P<\/jats:italic>\u2009=\u20090.002, power\u2009=\u200984.8%) were identified as independent risk factors for missed abortion in multivariate analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients with age\u2009\u2265\u200930\u00a0years, BMI\u2009&gt;\u200924\u00a0kg\/m<jats:sup>2<\/jats:sup> or mGSD-CRL\u2009&gt;\u200920\u00a0mm had increasing risk for missed abortion, who should be more closely monitored and facilitated with necessary interventions at first trimester or even before conception to reduce the occurrence of missed abortion to have better clinical outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-022-00987-2","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T10:02:52Z","timestamp":1660039372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Risk factors for missed abortion: retrospective analysis of a single institution\u2019s experience"],"prefix":"10.1186","volume":"20","author":[{"given":"Wei-Zhen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ru","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"987_CR1","volume-title":"Williams Obstetrics","author":"FG Cunningham","year":"2018","unstructured":"Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. 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