{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:58:32Z","timestamp":1780567112824,"version":"3.54.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This study aims to study whether the change of endometrial thickness between the day of human chorionic gonadotrophin (HCG) administration and the day of embryo transfer (ET) has any effect on ectopic pregnancy (EP) rate following fresh in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) cycles.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study retrospectively analyzed 3134 patients who underwent fresh IVF\/ICSI ET, including 3022 intrauterine, 112 ectopic cycles. Multiple logistic regression analysis and stratified analysis were used to study the effect of endometrial compaction after HCG administration on EP in patients with non-thin endometrium after adjusting for confounding factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After adjusting for confounders, multiple logistic regression analysis found that the risk of EP in the compaction group was significantly lower than that in the non-compaction group (OR\u2009=\u20090.49; 95% CI: 0.31\u20130.78; <jats:italic>P<\/jats:italic>\u2009=\u20090.0023). The results of the stratified analysis demonstrated the EP rate in patients with an endometrial thickness\u2009\u2265\u20098\u00a0mm on the day of ET; the compaction group significantly reduced the incidence of EP (OR\u2009=\u20090.49; 95% CI: 0.31\u20130.79; <jats:italic>P<\/jats:italic>\u2009=\u20090.0036). In patients with an endometrial thickness\u2009\u2265\u20098\u00a0mm on the day of ET, the incidence of EP had no statistical significance in two group (OR\u2009=\u20091.02; 95% CI: 0.18\u20135.88; <jats:italic>P<\/jats:italic>\u2009=\u20099790).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion(s)<\/jats:title>\n                <jats:p>In patients with non-thin endometrium, endometrial thickness compaction from the day of HCG to the ET day reduced the risk of EP significantly.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-022-01020-2","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T04:03:31Z","timestamp":1666325011000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Endometrial compaction after human chorionic gonadotrophin administration reduces ectopic pregnancy rate following fresh embryo transfer in vitro fertilization\/intracytoplasmic sperm injection cycles in patients with non-thin endometrium: a retrospective cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Qiuyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"1020_CR1","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1097\/01.AOG.0000158860.26939.2d","volume":"105","author":"SK Van Den Eeden","year":"2005","unstructured":"Van Den Eeden SK, Shan J, Bruce C, Glasser M. Ectopic pregnancy rate and treatment utilization in a large managed care organization. Obstet Gynecol. 2005;105:1052\u20137. https:\/\/doi.org\/10.1097\/01.AOG.0000158860.26939.2d.","journal-title":"Obstet Gynecol"},{"key":"1020_CR2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/AOG.0b013e3181d0c328","volume":"115","author":"KW Hoover","year":"2010","unstructured":"Hoover KW, Tao G, Kent CK. Trends in the diagnosis and treatment of ectopic pregnancy in the United States. Obstet Gynecol. 2010;115:495\u2013502. https:\/\/doi.org\/10.1097\/AOG.0b013e3181d0c328.","journal-title":"Obstet Gynecol"},{"key":"1020_CR3","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1016\/j.fertnstert.2014.08.031","volume":"102","author":"DB Stulberg","year":"2014","unstructured":"Stulberg DB, Cain LR, Dahlquist I, Lauderdale DS. Ectopic pregnancy rates and racial disparities in the Medicaid population, 2004\u20132008. Fertil Steril. 2014;102:1671\u20136.","journal-title":"Fertil. Steril"},{"key":"1020_CR4","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.fertnstert.2016.05.019","volume":"106","author":"L Londra","year":"2016","unstructured":"Londra L, Moreau C, Strobino D, Bhasin A, Zhao Y. Is the type of gonadotropin-releasing hormone suppression protocolfor ovarian hyperstimulation associated with ectopic pregnancy in fresh autologous cycles for in vitro fertilization? Fertil Steril. 2016;106:666\u201372. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.05.019.","journal-title":"Fertil Steril"},{"key":"1020_CR5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/s0015-0282(98)00441-5","volume":"71","author":"A Strandell","year":"1999","unstructured":"Strandell A, Thorburn J, Hamberger L. Risk factors for ectopic pregnancy in assisted reproduction. Fertil Steril. 1999;71:282\u20136. https:\/\/doi.org\/10.1016\/s0015-0282(98)00441-5.","journal-title":"Fertil. Steril"},{"key":"1020_CR6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/01.AOG.0000196503.78126.62","volume":"107","author":"HB Clayton","year":"2006","unstructured":"Clayton HB, et al. Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol. 2006;107:595\u2013604. https:\/\/doi.org\/10.1097\/01.AOG.0000196503.78126.62.","journal-title":"Obstet. Gynecol"},{"key":"1020_CR7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/humrep\/dew194","volume":"31","author":"S Santos-Ribeiro","year":"2016","unstructured":"Santos-Ribeiro S, Tournaye H, Polyzos NP. Trends in ectopic pregnancy rates following assisted reproductive technologies in the UK: a 12-year ntionwide analysis including 160 000 pregnancies. Hum Reprod. 2016;31:393\u2013402.","journal-title":"Hum Reprod"},{"key":"1020_CR8","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/GCO.0b013e32833848fd","volume":"22","author":"HJ Chang","year":"2010","unstructured":"Chang HJ, Suh CS. Ectopic pregnancy after assisted reproductive technology: what are the risk factors? Curr Opin Obstet Gynecol. 2010;22:202\u20137.","journal-title":"Curr Opin Obstet Gynecol"},{"key":"1020_CR9","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1093\/humupd\/dmp057","volume":"16","author":"JL Shaw","year":"2010","unstructured":"Shaw JL, Dey SK, Critchley HO, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update. 2010;16:432\u201344.","journal-title":"Hum Reprod Update"},{"key":"1020_CR10","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.fertnstert.2015.08.029","volume":"104","author":"S Lin","year":"2015","unstructured":"Lin S, Li R, Zheng X, Chi H, Ren X, Yang R, et al. Influence of embryo culture medium on incidence of ectopic pregnancy in in vitro fertilization. Fertil Steril. 2015;104:1442\u20135.","journal-title":"Fertil Steril"},{"issue":"3","key":"1020_CR11","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.fertnstert.2014.11.023","volume":"103","author":"C Fang","year":"2015","unstructured":"Fang C, Huang R, Wei L-N, et al. Frozen-thawed day 5 blastocyst transfer is associated with a lower risk of ectopic pregnancy than day 3 transfer and fresh transfer. Fertil Steril. 2015;103(3):655\u201361. https:\/\/doi.org\/10.1016\/j.fertnstert.2014.11.023.","journal-title":"Fertil Steril"},{"issue":"4","key":"1020_CR12","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.fertnstert.2015.06.025","volume":"104","author":"KS Acharya","year":"2015","unstructured":"Acharya KS, Acharya CR, Meredith P, et al. Fertil Steril. 2015;104(4):873\u20138. https:\/\/doi.org\/10.1016\/j.fertnstert.2015.06.025.","journal-title":"Fertil Steril."},{"key":"1020_CR13","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/humrep\/dey281","volume":"33","author":"KE Liu","year":"2018","unstructured":"Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod. 2018;33:1883\u20138.","journal-title":"Hum Reprod"},{"issue":"1","key":"1020_CR14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.fertnstert.2019.09.003","volume":"113","author":"H Liu","year":"2020","unstructured":"Liu H, Zhang J, Wang B, et al. Effect of endometrial thickness on ectopic pregnancy in frozen embryo transfer cycles: an analysis including 17,244 pregnancy cycles. Fertil Steril. 2020;113(1):131\u20139. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.09.003.","journal-title":"Fertil Steril"},{"issue":"8","key":"1020_CR15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1093\/oxfordjournals.humrep.a136618","volume":"2","author":"F Puissant","year":"1987","unstructured":"Puissant F, Van M, Barlow P, et al. Embryo scoring as a prognostic tool in IVF treatment[J]. Hum Reprod. 1987;2(8):705\u20138. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a136618.","journal-title":"Hum Reprod"},{"issue":"6","key":"1020_CR16","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","volume":"73","author":"DK Gardner","year":"2000","unstructured":"Gardner DK, Lane M, Stevens J, et al. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer[J]. Fertil Steril. 2000;73(6):1155\u20138.","journal-title":"Fertil Steril"},{"issue":"3","key":"1020_CR17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.fertnstert.2019.05.001","volume":"112","author":"J Haas","year":"2019","unstructured":"Haas J, Smith R, Zilberberg E, et al. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers[J]. Fertil Steril. 2019;112(3):503\u20139.","journal-title":"Fertil Steril"},{"issue":"5","key":"1020_CR18","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.fertnstert.2019.12.030","volume":"113","author":"E Zilberberg","year":"2020","unstructured":"Zilberberg E, Smith R, Nayot D, et al. Endometrial compaction before frozen euploid embryo transfer improves ongoing pregnancy rates. Fertil Steril. 2020;113(5):990\u20135.","journal-title":"Fertil Steril"},{"issue":"1","key":"1020_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12958-019-0545-0","volume":"17","author":"Bu Z","year":"2019","unstructured":"Z Bu, Y Xinhong, S Lin, et al. The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. Reprod Biol Endocrinol. 2019;17(1):99.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"1020_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s12958-021-00841-x","volume":"19","author":"Ziqi J","year":"2021","unstructured":"J Ziqi, L Jingdi, Y EnTong, et al. Effect of endometrial thickness changes on clinical pregnancy rates after progesterone administration in a single frozen-thawed euploid blastocyst transfer cycle using natural cycles with luteal support for PGT-SR- and PGT-M-assisted reproduction: a retrospective cohort study. Reprod Biol Endocrinol. 2021;19(1):154. https:\/\/doi.org\/10.1186\/s12958-021-00841-x.","journal-title":"Reprod Biol Endocrinol"},{"issue":"11","key":"1020_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.546232","volume":"29","author":"J Ye","year":"2020","unstructured":"Ye J, Zhang J, Gao H, et al. Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles. Front Endocrinol (Lausanne). 2020;29(11): 546232. https:\/\/doi.org\/10.3389\/fendo.2020.546232.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"1020_CR22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10815-020-02043-7","volume":"38","author":"C Riestenberg","year":"2021","unstructured":"Riestenberg C, Quinn M, Akopians A, et al. Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles. J Assist Reprod Genet. 2021;38(2):407\u201312. https:\/\/doi.org\/10.1007\/s10815-020-02043-7.","journal-title":"J Assist Reprod Genet"},{"issue":"2","key":"1020_CR23","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00404-020-05763-4","volume":"303","author":"J Huang","year":"2021","unstructured":"Huang J, Lin J, Gao H, et al. Value of endometrial thickness change after human chorionic gonadotrophin administration in predicting pregnancy outcome following fresh transfer in vitro fertilization cycles. Arch Gynecol Obstet. 2021;303(2):565\u201372. https:\/\/doi.org\/10.1007\/s00404-020-05763-4.","journal-title":"Arch Gynecol Obstet"},{"issue":"8","key":"1020_CR24","doi-asserted-by":"publisher","first-page":"102072","DOI":"10.1016\/j.jogoh.2021.102072","volume":"50","author":"T Fang","year":"2021","unstructured":"Fang T, Chen M, Wenchang Yu, et al. The predictive value of endometrial thickness in 3117 fresh IVF\/ICSI cycles for ectopic pregnancy. J Gynecol Obstet Hum Reprod. 2021;50(8):102072. https:\/\/doi.org\/10.1016\/j.jogoh.2021.102072.","journal-title":"J Gynecol Obstet Hum Reprod"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-022-01020-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-022-01020-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-022-01020-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T04:05:18Z","timestamp":1666325118000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-022-01020-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1020"],"URL":"https:\/\/doi.org\/10.1186\/s12958-022-01020-2","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"15 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has been approved by the Ethics Committee of the first Hospital of Lanzhou University. Because this study is a retrospective study, and the identity information of the participate has been hidden when collecting the data, the consent to participate is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"151"}}