{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:45:53Z","timestamp":1780065953824,"version":"3.54.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Women with functional hypothalamic amenorrhea (FHA) reveal polycystic ovarian morphology (PCOM) in up to 50%. If stress sensitivity in women with polycystic ovary syndrome (PCOS) is the reason why PCOS women are prone to develop FHA, patients with FHA caused by stress should reveal PCOM more often.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a retrospective cohort study, 38 stress-associated and 38 excessive exercise-induced FHA women were included. The main outcome parameter was PCOM. In addition, the focus was on general patient characteristics as well as on prolactin, dehydroepiandrosterone-sulphate (DHEAS), and anti-Mullerian hormone (AMH).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>PCOM was found in 34\/76 patients (44.7%). The stress group showed a higher prevalence of PCOM than the excessive exercise group (57.9% versus 31.6%, <jats:italic>p\u2009=<\/jats:italic>\u20090.019) as well as higher prolactin levels (median 13.2ng\/mL versus 11.7ng\/mL, <jats:italic>p\u2009=<\/jats:italic>\u20090.008) and a trend towards higher DHEAS levels (<jats:italic>p\u2009=<\/jats:italic>\u20090.058).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In FHA women, the PCOM prevalence was significantly higher in the stress-group than in the excessive exercise-group. The well-known stress sensitivity in women with PCOS might explain why PCOS women are prone to develop FHA as well as the high PCOM prevalence in FHA women.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-023-01095-5","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T07:02:41Z","timestamp":1683788561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Stress and polycystic ovarian morphology in functional hypothalamic amenorrhea: a retrospective cohort study"],"prefix":"10.1186","volume":"21","author":[{"given":"Marlene","family":"Hager","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dewailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrig","family":"Marculescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ghobrial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Preston","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-5262","authenticated-orcid":false,"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"1095_CR1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/humrep\/deab024","volume":"36","author":"S Makoll\u00e9","year":"2021","unstructured":"Makoll\u00e9 S, Catteau-Jonard S, Robin G, Dewailly D. Revisiting the serum level of anti-M\u00fcllerian hormone in patients with functional hypothalamic anovulation. Hum Reprod. 2021;36:1043\u201351.","journal-title":"Hum Reprod"},{"key":"1095_CR2","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12958-022-00961-y","volume":"20","author":"M Hager","year":"2022","unstructured":"Hager M, Ott J, Marschalek J, Marschalek ML, Kinsky C, Marculescu R, Dewailly D. Basal and dynamic relationships between serum Anti-M\u00fcllerian hormone and gonadotropins in patients with functional hypothalamic amenorrhea, with or without polycystic ovarian morphology. Reprod Biol Endocrinol. 2022;20:98.","journal-title":"Reprod Biol Endocrinol"},{"key":"1095_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fertnstert.2022.09.029","volume":"118","author":"D Mayrhofer","year":"2022","unstructured":"Mayrhofer D, Dewailly D, Hager M, Marculescu R, Beitl K, Ott J. 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Due to the retrospective design, informed consent was not necessary, which is in accordance with the ethics committee of the Medical University of Vienna.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JO received remuneration for lecturing from Ferring GesmbH. All other authors report no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42"}}