{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:54:51Z","timestamp":1791082491786,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901480"],"award-info":[{"award-number":["81901480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ19H04009"],"award-info":[{"award-number":["LQ19H04009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Education Department of Zhejiang Province","award":["Y201942100"],"award-info":[{"award-number":["Y201942100"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During embryo implantation, blastocyst interacts with the receptivity endometrium and the endometrial epithelium secretes nurturing fluid to support embryonic development. Interferon-\u03bb (IFN-\u03bb) is a novel, non-redundant regulator that participates in the fetal\u2013maternal interaction; however, the precise molecular mechanism underlying its impact on uterine receptivity remains elusive. Here, microarray profiling revealed that 149 specific miRNAs were differentially expressed in the human endometrial cells following IFN-\u03bb treatment. In particular, miR-124-3p expression was significantly reduced after IFN-\u03bb treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). An in vivo mouse pregnancy model showed that miR-124-3p overexpression notably decreased embryo implantation rate and led to an aberrant epithelial phenotype. Furthermore, miR-124-3p negatively impacted the migration and proliferation of endometrial cells, and hindered embryonic developmental competence in terms of blastocyst formation and global DNA re-methylation. Downstream analysis showed that <jats:italic>LIF<\/jats:italic>, <jats:italic>MUC1<\/jats:italic> and <jats:italic>BCL2<\/jats:italic> are potential target genes for miR-124-3p, which was confirmed using western blotting and immunofluorescence assays. In conclusion, IFN-\u03bb-driven downregulation of miR-124-3p during embryo implantation modulates uterine receptivity. The dual functional role of miR-124-3p suggests a cross-talk model wherein, maternal endometrial miRNA acts as a transcriptomic modifier of the peri-implantation endometrium and embryo development.<\/jats:p>","DOI":"10.1186\/s12958-024-01187-w","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T07:02:32Z","timestamp":1706684552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["MiR-124-3p negatively impacts embryo implantation via suppressing uterine receptivity formation and embryo development"],"prefix":"10.1186","volume":"22","author":[{"given":"Kezhen","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanmin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biwei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"1187_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1530\/JME-19-0184","volume":"64","author":"R Akbar","year":"2020","unstructured":"Akbar R, Ullah K, Rahman TU, Cheng Y, Pang HY, Jin LY, Wang QJ, Huang HF, Sheng JZ. miR-183-5p regulates uterine receptivity and enhances embryo implantation. J Mol Endocrinol. 2020;64:43\u201352.","journal-title":"J Mol Endocrinol"},{"key":"1187_CR2","doi-asserted-by":"publisher","first-page":"10077","DOI":"10.1038\/s41598-017-10098-3","volume":"7","author":"S Altmae","year":"2017","unstructured":"Altmae S, Koel M, Vosa U, Adler P, Suhorutsenko M, Laisk-Podar T, Kukushkina V, Saare M, Velthut-Meikas A, Krjutskov K, Aghajanova L, Lalitkumar PG, Gemzell-Danielsson K, Giudice L, Simon C, Salumets A. Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Sci Rep. 2017;7:10077.","journal-title":"Sci Rep"},{"key":"1187_CR3","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1111\/jog.12442","volume":"40","author":"K Banno","year":"2014","unstructured":"Banno K, Yanokura M, Iida M, Masuda K, Aoki D. Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics. J Obstet Gynaecol Res. 2014;40:1957\u201367.","journal-title":"J Obstet Gynaecol Res"},{"key":"1187_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/jmcb\/mjv006","volume":"7","author":"B Chu","year":"2015","unstructured":"Chu B, Zhong L, Dou S, Wang J, Li J, Wang M, Shi Q, Mei Y, Wu M. miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor. J Mol Cell Biol. 2015;7:12\u201322.","journal-title":"J Mol Cell Biol"},{"key":"1187_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255\u201389.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1187_CR6","doi-asserted-by":"publisher","first-page":"e12858","DOI":"10.1111\/aji.12858","volume":"80","author":"C Di Pietro","year":"2018","unstructured":"Di Pietro C, Caruso S, Battaglia R, Iraci Sareri M, La Ferlita A, Strino F, Bonaventura G, Di Mauro M, Barcellona ML, Perciavalle V, Purrello M, Cianci A. MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by chronic endometritis, are new potential molecular markers of endometrial receptivity. Am J Reprod Immunol. 2018;80:e12858.","journal-title":"Am J Reprod Immunol"},{"key":"1187_CR7","first-page":"233","volume":"31","author":"MS Kupka","year":"2016","unstructured":"European IVF MC, European Society of Human R, Embryology, Kupka MS, D\u2019Hooghe T, Ferraretti AP, de Mouzon J, Erb K, Castilla JA, Calhaz-Jorge C, De Geyter C, Goossens V. Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE. Hum Reprod. 2016;31:233\u201348.","journal-title":"Hum Reprod"},{"key":"1187_CR8","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3390\/cancers13051137","volume":"13","author":"A Favier","year":"2021","unstructured":"Favier A, Rocher G, Larsen AK, Delangle R, Uzan C, Sabbah M, Castela M, Duval A, Mehats C, Canlorbe G. MicroRNA as epigenetic modifiers in endometrial cancer: a systematic review. Cancers (Basel). 2021;13:1137.","journal-title":"Cancers (Basel)"},{"key":"1187_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jri.2018.11.002","volume":"131","author":"M Ghaebi","year":"2019","unstructured":"Ghaebi M, Abdolmohammadi-Vahid S, Ahmadi M, Eghbal-Fard S, Dolati S, Nouri M, Talebi M, Hamdi K, Marofi F, Aghebati-Maleki L, Jadidi-Niaragh F, Dopour M, Yousefi M. T cell subsets in peripheral blood of women with recurrent implantation failure. J Reprod Immunol. 2019;131:21\u20139.","journal-title":"J Reprod Immunol"},{"key":"1187_CR10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15:509\u201324.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1187_CR11","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1262\/jrd.2021-115","volume":"68","author":"E Hayashi","year":"2022","unstructured":"Hayashi E, Wakayama S, Ito D, Hasegawa A, Mochida K, Ooga M, Ogura A, Wakayama T. Mouse in vivo-derived late 2-cell embryos have higher developmental competence after high osmolality vitrification and -80 degrees C preservation than IVF or ICSI embryos. J Reprod Dev. 2022;68:118\u201324.","journal-title":"J Reprod Dev"},{"key":"1187_CR12","first-page":"804","volume":"128","author":"YJ Kang","year":"2015","unstructured":"Kang YJ, Lees M, Matthews LC, Kimber SJ, Forbes K, Aplin JD. MiR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R. J Cell Sci. 2015;128:804\u201314.","journal-title":"J Cell Sci"},{"key":"1187_CR13","doi-asserted-by":"publisher","first-page":"160181","DOI":"10.1098\/rsob.160181","volume":"6","author":"KH Kim","year":"2016","unstructured":"Kim KH, Seo YM, Kim EY, Lee SY, Kwon J, Ko JJ, Lee KA. The miR-125 family is an important regulator of the expression and maintenance of maternal effect genes during preimplantational embryo development. Open Biol. 2016;6:160181.","journal-title":"Open Biol"},{"key":"1187_CR14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1600-0897.2004.00204.x","volume":"52","author":"Z Kondera-Anasz","year":"2004","unstructured":"Kondera-Anasz Z, Sikora J, Mielczarek-Palacz A. Leukemia inhibitory factor: an important regulator of endometrial function. Am J Reprod Immunol. 2004;52:97\u2013105.","journal-title":"Am J Reprod Immunol"},{"key":"1187_CR15","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1111\/j.1349-7006.2010.01650.x","volume":"101","author":"N Kosaka","year":"2010","unstructured":"Kosaka N, Iguchi H, Ochiya T. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 2010;101:2087\u201392.","journal-title":"Cancer Sci"},{"key":"1187_CR16","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1095\/biolreprod.109.081059","volume":"82","author":"S Kuokkanen","year":"2010","unstructured":"Kuokkanen S, Chen B, Ojalvo L, Benard L, Santoro N, Pollard JW. Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium. Biol Reprod. 2010;82:791\u2013801.","journal-title":"Biol Reprod"},{"key":"1187_CR17","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.fertnstert.2012.03.033","volume":"97","author":"N Laufer","year":"2012","unstructured":"Laufer N, Simon A. Recurrent implantation failure: current update and clinical approach to an ongoing challenge. Fertil Steril. 2012;97:1019\u201320.","journal-title":"Fertil Steril"},{"key":"1187_CR18","doi-asserted-by":"publisher","first-page":"152477","DOI":"10.1016\/j.prp.2019.152477","volume":"215","author":"J Li","year":"2019","unstructured":"Li J, Yanyan M, Mu L, Chen X, Zheng W. The expression of Bcl-2 in adenomyosis and its effect on proliferation, migration, and apoptosis of endometrial stromal cells. Pathol Res Pract. 2019;215:152477.","journal-title":"Pathol Res Pract"},{"key":"1187_CR19","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1093\/biolre\/ioz022","volume":"100","author":"L Li","year":"2019","unstructured":"Li L, Gou J, Yi T, Li Z. MicroRNA-30a-3p regulates epithelial-mesenchymal transition to affect embryo implantation by targeting Snai2dagger. Biol Reprod. 2019;100:1171\u20139.","journal-title":"Biol Reprod"},{"key":"1187_CR20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12958-017-0309-7","volume":"15","author":"J Liang","year":"2017","unstructured":"Liang J, Wang S, Wang Z. Role of microRNAs in embryo implantation. Reprod Biol Endocrinol. 2017;15:90.","journal-title":"Reprod Biol Endocrinol"},{"key":"1187_CR21","doi-asserted-by":"publisher","first-page":"e58502","DOI":"10.1371\/journal.pone.0058502","volume":"8","author":"YH Ng","year":"2013","unstructured":"Ng YH, Rome S, Jalabert A, Forterre A, Singh H, Hincks CL, Salamonsen LA. Endometrial exosomes\/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation. PLoS ONE. 2013;8:e58502.","journal-title":"PLoS ONE"},{"key":"1187_CR22","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3390\/ijms21061973","volume":"21","author":"MA Ochoa-Bernal","year":"2020","unstructured":"Ochoa-Bernal MA, Fazleabas AT. Physiologic events of embryo implantation and decidualization in human and non-human primates. Int J Mol Sci. 2020;21:1973.","journal-title":"Int J Mol Sci"},{"key":"1187_CR23","doi-asserted-by":"crossref","unstructured":"Omeljaniuk WJ, Laudanski P, Miltyk W. 2023. The role of miRNA molecules in the miscarriage process. Biol Reprod.","DOI":"10.1093\/biolre\/ioad047"},{"key":"1187_CR24","doi-asserted-by":"publisher","first-page":"102157","DOI":"10.1016\/j.jogoh.2021.102157","volume":"50","author":"MHR Raja","year":"2021","unstructured":"Raja MHR, Farooqui N, Zuberi N, Ashraf M, Azhar A, Baig R, Badar B, Rehman R. Endometriosis, infertility and MicroRNA\u2019s: a review. J Gynecol Obstet Hum Reprod. 2021;50:102157 ({von Grothusen, 2022 #2487}).","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"1187_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bbrc.2020.03.026","volume":"526","author":"C Romeo","year":"2020","unstructured":"Romeo C, Chen SH, Goulding E, Van Gorder L, Schwartz M, Walker M, Scott G, Scappini E, Ray M, Martin NP. AAV diffuses across zona pellucida for effortless gene delivery to fertilized eggs. Biochem Biophys Res Commun. 2020;526:85\u201390.","journal-title":"Biochem Biophys Res Commun"},{"key":"1187_CR26","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.fertnstert.2014.01.058","volume":"101","author":"EM Rosenbluth","year":"2014","unstructured":"Rosenbluth EM, Shelton DN, Wells LM, Sparks AE, Van Voorhis BJ. Human embryos secrete microRNAs into culture media\u2013a potential biomarker for implantation. Fertil Steril. 2014;101:1493\u2013500.","journal-title":"Fertil Steril"},{"key":"1187_CR27","doi-asserted-by":"publisher","first-page":"6210","DOI":"10.3390\/ijms23116210","volume":"23","author":"M Shekibi","year":"2022","unstructured":"Shekibi M, Heng S, Nie G. MicroRNAs in the regulation of endometrial receptivity for embryo implantation. Int J Mol Sci. 2022;23:6210.","journal-title":"Int J Mol Sci"},{"key":"1187_CR28","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1177\/1933719113488453","volume":"20","author":"LJ Shen","year":"2013","unstructured":"Shen LJ, He JL, Yang DH, Ding YB, Chen XM, Geng YQ, Liu SJ, Liu XQ, Wang YX. Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus. Reprod Sci. 2013;20:1518\u201328.","journal-title":"Reprod Sci"},{"key":"1187_CR29","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/ng.864","volume":"43","author":"SA Smallwood","year":"2011","unstructured":"Smallwood SA, Tomizawa S, Krueger F, Ruf N, Carli N, Segonds-Pichon A, Sato S, Hata K, Andrews SR, Kelsey G. Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet. 2011;43:811\u20134.","journal-title":"Nat Genet"},{"key":"1187_CR30","doi-asserted-by":"publisher","first-page":"7223","DOI":"10.1093\/nar\/gkr254","volume":"39","author":"A Turchinovich","year":"2011","unstructured":"Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011;39:7223\u201333.","journal-title":"Nucleic Acids Res"},{"key":"1187_CR31","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1007\/s10815-021-02316-9","volume":"38","author":"F Uysal","year":"2021","unstructured":"Uysal F, Cinar O, Can A. Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylation. J Assist Reprod Genet. 2021;38:3135\u201344.","journal-title":"J Assist Reprod Genet"},{"key":"1187_CR32","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1242\/dev.124289","volume":"142","author":"F Vilella","year":"2015","unstructured":"Vilella F, Moreno-Moya JM, Balaguer N, Grasso A, Herrero M, Martinez S, Marcilla A, Simon C. Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome. Development. 2015;142:3210\u201321.","journal-title":"Development"},{"key":"1187_CR33","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1093\/humrep\/deac019","volume":"37","author":"C von Grothusen","year":"2022","unstructured":"von Grothusen C, Frisendahl C, Modhukur V, Lalitkumar PG, Peters M, Faridani OR, Salumets A, Boggavarapu NR, Gemzell-Danielsson K. Uterine fluid microRNAs are dysregulated in women with recurrent implantation failure. Hum Reprod. 2022;37:734\u201346.","journal-title":"Hum Reprod"},{"key":"1187_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12958-018-0379-1","volume":"16","author":"F Wu","year":"2018","unstructured":"Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, Wang CC. Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation window. Reprod Biol Endocrinol. 2018;16:60.","journal-title":"Reprod Biol Endocrinol"},{"key":"1187_CR35","doi-asserted-by":"publisher","first-page":"22041","DOI":"10.1038\/srep22041","volume":"6","author":"Y Wu","year":"2016","unstructured":"Wu Y, Guo Z, Yao K, Miao Y, Liang S, Liu F, Wang Y, Zhang Y. The transcriptional Foundations of Sp110-mediated macrophage (RAW264.7) resistance to Mycobacterium tuberculosis H37Ra. Sci Rep. 2016;6:22041.","journal-title":"Sci Rep"},{"key":"1187_CR36","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.omtn.2017.04.010","volume":"7","author":"J Yang","year":"2017","unstructured":"Yang J, Zhang X, Chen X, Wang L, Yang G. Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia. Mol Ther Nucleic Acids. 2017;7:278\u201387.","journal-title":"Mol Ther Nucleic Acids"},{"key":"1187_CR37","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1177\/1933719118799199","volume":"26","author":"P Yang","year":"2019","unstructured":"Yang P, Wu Z, Ma C, Pan N, Wang Y, Yan L. Endometrial miR-543 is downregulated during the implantation window in women with endometriosis-related infertility. Reprod Sci. 2019;26:900\u20138.","journal-title":"Reprod Sci"},{"key":"1187_CR38","doi-asserted-by":"publisher","first-page":"e13718","DOI":"10.1111\/aji.13718","volume":"90","author":"K Yao","year":"2023","unstructured":"Yao K, Fang L, Sun Y. The transcriptional foundations of interferon-\u03bb-mediated endometrial cell to uterine receptivity. Am J Reprod Immunol. 2023;90:e13718.","journal-title":"Am J Reprod Immunol"},{"key":"1187_CR39","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1530\/REP-22-0463","volume":"165","author":"K Yao","year":"2023","unstructured":"Yao K, Sun Y, Ye X, Wu Y. Interferon-lambda contributes to endometrial receptivity. Reproduction. 2023;165:569\u201382.","journal-title":"Reproduction"},{"key":"1187_CR40","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12958-015-0019-y","volume":"13","author":"Q Zhang","year":"2015","unstructured":"Zhang Q, Zhang H, Jiang Y, Xue B, Diao Z, Ding L, Zhen X, Sun H, Yan G, Hu Y. MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Kruppel-like factor 12. Reprod Biol Endocrinol. 2015;13:23.","journal-title":"Reprod Biol Endocrinol"},{"key":"1187_CR41","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mam.2012.12.011","volume":"34","author":"S Zhang","year":"2013","unstructured":"Zhang S, Lin H, Kong S, Wang S, Wang H, Wang H, Armant DR. Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 2013;34:939\u201380.","journal-title":"Mol Aspects Med"},{"key":"1187_CR42","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41588-017-0003-x","volume":"50","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao ZA, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nat Genet. 2018;50:96\u2013105.","journal-title":"Nat Genet"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-024-01187-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-024-01187-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-024-01187-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T09:08:39Z","timestamp":1706692119000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-024-01187-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1187"],"URL":"https:\/\/doi.org\/10.1186\/s12958-024-01187-w","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]},"assertion":[{"value":"7 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animals were housed by the Guide for the Care and Use of Laboratory Animals and all procedures were approved by the Institution Animal Care and Use Committee of Zhejiang University. The manuscript is approved by all authors for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}