{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:27:11Z","timestamp":1789414031068,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Basic Research Project of the Yunnan Province-Outstanding Youth Foundation","award":["No. 202101AW070018"],"award-info":[{"award-number":["No. 202101AW070018"]}]},{"name":"the \u201c1000 Talent Plan\u201d of Yunnan Province","award":["No. RLQN20200001"],"award-info":[{"award-number":["No. RLQN20200001"]}]},{"name":"\"535 Talent Project of First Affiliated Hospital of Kunming Medical University\"","award":["No. 2023535D02"],"award-info":[{"award-number":["No. 2023535D02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concentrations within the reference range are associated with ovarian reserve in women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This cross-sectional study included 4933 infertile women with normal-range fT4 concentrations who received assisted reproductive technology treatment in our clinic. The data of women in different fT4 concentration tertiles (namely 12\u201315.33, 15.34\u201318.67, and 18.68\u201322 pmol\/L) were compared with ovarian reserve markers, namely the anti-M\u00fcllerian hormone (AMH) concentration, the antral follicle count (AFC), and the number of aspirated oocytes. The primary outcomes were the AMH concentration and the risk of DOR, diagnosed as an AMH concentration\u2009&lt;\u20091.1 ng\/mL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The average ages of women in the low-normal, middle-normal, and high-normal fT4 tertiles were 33.20 (standard deviation [SD]: 5.11), 32.33 (SD: 5.13), and 31.61 (SD: 5.10) years, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). AMH concentrations (adjusted mean: 3.32 [95% confidence interval {CI}: 3.16 to 3.50] vs. 3.51 [3.40 to 3.62] vs. 3.64 [3.50 to 3.80] ng\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.022) were significantly different between the fT4 concentration tertiles. The risk of DOR was significantly increased in the low-normal (adjusted odds ratio: 1.61 [95% CI: 1.01 to 2.58]) and middle-normal (1.47 [95% CI: 1.00 to 2.16]) tertiles compared with the high-normal tertile. Subgroup analysis showed that AMH concentrations were significantly different among the fT4 concentration tertiles in women aged\u2009&lt;\u200935 years (adjusted mean: 3.94 [95% CI: 3.70 to 4.20] vs. 4.25 [4.11 to 4.39] vs. 4.38 [4.18 to 4.58], <jats:italic>p<\/jats:italic>\u2009=\u20090.028), whereas this difference was not significant in women aged\u2009\u2265\u200935 years (<jats:italic>p<\/jats:italic>\u2009=\u20090.534). The general additive models using fT4 as a continuous variable indicated that a lower fT4 concentration within the normal range was significantly associated with a lower AMH concentration (<jats:italic>p<\/jats:italic>\u2009=\u20090.027), a lower AFC (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), a lower number of aspirated oocytes (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and a higher risk of DOR (<jats:italic>p<\/jats:italic>\u2009=\u20090.007).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Low-normal fT4 concentrations are associated with lower ovarian reserve in infertile women.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-024-01226-6","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T06:02:16Z","timestamp":1719036136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology"],"prefix":"10.1186","volume":"22","author":[{"given":"Qiaoling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-3253","authenticated-orcid":false,"given":"Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-4074","authenticated-orcid":false,"given":"Meng","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"1226_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)55974-3","author":"AN Wakim","year":"1993","unstructured":"Wakim AN, Polizotto SL, Buffo MJ, et al. 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All procedures performed in this studies were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The need for informed consent was waived due to the retrospective nature of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was waived due to the retrospective study design.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"72"}}