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Normal mitochondrial membrane potential with optimal mitochondrial performance is essential for sperm motility, capacitation, acrosome reaction, and DNA integrity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Defects in the sperm mitochondrial function can severely harm the fertility potential of males. The role of sperm mitochondria in fertilization and its final fate after fertilization is still controversial. Here, we review the current knowledge on human sperm mitochondria characteristics and their physiological and pathological conditions, paying special attention to improvements in assistant reproductive technology and available treatments to ameliorate male infertility.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although mitochondrial variants associated with male infertility have potential clinical use, research is limited. Further understanding is needed to determine how these characteristics lead to adverse pregnancy outcomes and affect male fertility potential.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-024-01252-4","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T07:02:04Z","timestamp":1721199724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["The impact of mitochondrial impairments on sperm function and male fertility: a systematic review"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7235-5440","authenticated-orcid":false,"given":"Minoo","family":"Vahedi Raad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-9037","authenticated-orcid":false,"given":"Amir Masoud","family":"Firouzabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-2511","authenticated-orcid":false,"given":"Maryam","family":"Tofighi Niaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-2982","authenticated-orcid":false,"given":"Ralf","family":"Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-4449","authenticated-orcid":false,"given":"Farzaneh","family":"Fesahat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"1252_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.anireprosci.2018.03.024","volume":"194","author":"CR Moraes","year":"2018","unstructured":"Moraes CR, Meyers S. 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