{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:16Z","timestamp":1791821116967,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Joint Fund project of Hubei Province","award":["2022CFD155"],"award-info":[{"award-number":["2022CFD155"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["N81701412"],"award-info":[{"award-number":["N81701412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2018CFB491"],"award-info":[{"award-number":["2018CFB491"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2021M158"],"award-info":[{"award-number":["WJ2021M158"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-024-01280-0","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:27:08Z","timestamp":1724412428000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of LH level on HCG trigger day on clinical outcomes in patients with diminished ovarian reserve undergoing GnRH-antagonist protocol"],"prefix":"10.1186","volume":"22","author":[{"given":"Qianjie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tailang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saijiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"1280_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10815-017-1058-4","volume":"351","author":"LM Pastore","year":"2018","unstructured":"Pastore LM, Christianson MS, Stelling J, et al. Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR. J Assist Reprod Genet. 2018;351:17\u201323.","journal-title":"J Assist Reprod Genet"},{"key":"1280_CR2","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.12688\/f1000research.10382.1","volume":"5","author":"P Humaidan","year":"2016","unstructured":"Humaidan P, Alviggi C, Fischer R, et al. The novel POSEIDON stratification of \u2018Low prognosis patients in assisted Reproductive Technology\u2019 and its proposed marker of successful outcome. F1000Res. 2016;5:2911.","journal-title":"F1000Res"},{"key":"1280_CR3","doi-asserted-by":"publisher","first-page":"e0207081","DOI":"10.1371\/journal.pone.0207081","volume":"1311","author":"MC Huang","year":"2018","unstructured":"Huang MC, Tzeng SL, Lee CI, et al. GnRH agonist long protocol versus GnRH antagonist protocol for various aged patients with diminished ovarian reserve: a retrospective study. PLoS ONE. 2018;1311:e0207081.","journal-title":"PLoS ONE"},{"key":"1280_CR4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3389\/fendo.2018.00767","volume":"9","author":"D Zhang","year":"2018","unstructured":"Zhang D, Xia L, Xu H, et al. Flexible low-dose GnRH antagonist protocol is effective in patients with sufficient Ovarian Reserve in IVF. Front Endocrinol (Lausanne). 2018;9:767.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1280_CR5","doi-asserted-by":"publisher","first-page":"640047","DOI":"10.3389\/fendo.2021.640047","volume":"12","author":"Y Luo","year":"2021","unstructured":"Luo Y, Liu S, Su H, et al. Low serum LH levels during ovarian stimulation with GnRH antagonist protocol decrease the live birth rate after fresh embryo transfers but have no impact in Freeze-all Cycles. Front Endocrinol (Lausanne). 2021;12:640047.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1280_CR6","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0015-0282(00)01745-3","volume":"753","author":"MA Esposito","year":"2001","unstructured":"Esposito MA, Barnhart KT, Coutifaris C, et al. Role of periovulatory luteinizing hormone concentrations during assisted reproductive technology cycles stimulated exclusively with recombinant follicle-stimulating hormone. Fertil Steril. 2001;753:519\u201324.","journal-title":"Fertil Steril"},{"key":"1280_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13048-023-01271-6","volume":"161","author":"H Jin","year":"2023","unstructured":"Jin H, Yang H, Zheng J, et al. Post-trigger luteinizing hormone concentration to positively predict oocyte yield in the antagonist protocol and its association with genetic variants of LHCGR. J Ovarian Res. 2023;161:189.","journal-title":"J Ovarian Res"},{"key":"1280_CR8","doi-asserted-by":"crossref","unstructured":"Shi Q, Jiang Y, Kong N et al. Serum LH level on the day of hCG administration as a predictor of the Reproductive outcomes in Ovulation induction cycle frozen-thawed embryo transfer. J Pers Med. 2022; 131.","DOI":"10.3390\/jpm13010052"},{"key":"1280_CR9","doi-asserted-by":"publisher","first-page":"1191827","DOI":"10.3389\/fendo.2023.1191827","volume":"14","author":"R Zhou","year":"2023","unstructured":"Zhou R, Dong M, Huang L, et al. Association between serum LH levels on hCG trigger day and live birth rate after fresh embryo transfer with GnRH antagonist regimen in different populations. Front Endocrinol (Lausanne). 2023;14:1191827.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1280_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13048-023-01110-8","volume":"161","author":"X Luo","year":"2023","unstructured":"Luo X, Deng B, Li L, et al. LH level on ovulation trigger day has a different impact on the outcomes of agonist and antagonist regimens during in vitro fertilization. J Ovarian Res. 2023;161:26.","journal-title":"J Ovarian Res"},{"key":"1280_CR11","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1007\/s43032-023-01196-x","volume":"308","author":"A Pal","year":"2023","unstructured":"Pal A, Mani T, Chinta P, et al. Effectiveness of GnRH agonist short protocol versus GnRH antagonist protocol in POSEIDON groups 3 and 4: a retrospective cohort study. Reprod Sci. 2023;308:2481\u20138.","journal-title":"Reprod Sci"},{"key":"1280_CR12","doi-asserted-by":"crossref","unstructured":"Wang J, Ding J, Qu B et al. Does serum LH level influence IVF outcomes in women with PCOS undergoing GnRH-antagonist stimulation: a novel indicator. J Clin Med. 2022;1116.","DOI":"10.3390\/jcm11164670"},{"key":"1280_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s12325-023-02702-y","volume":"411","author":"L Hu","year":"2024","unstructured":"Hu L, Bai L, Qin R, et al. Optimizing FSH concentration modulation in the short-acting GnRH-a long protocol for IVF\/ICSI: a retrospective study. Adv Ther. 2024;411:215\u201330.","journal-title":"Adv Ther"},{"key":"1280_CR14","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1093\/humrep\/deh827","volume":"206","author":"AJ Goverde","year":"2005","unstructured":"Goverde AJ, McDonnell J, Schats R, et al. Ovarian response to standard gonadotrophin stimulation for IVF is decreased not only in older but also in younger women in couples with idiopathic and male subfertility. Hum Reprod. 2005;206:1573\u20137.","journal-title":"Hum Reprod"},{"key":"1280_CR15","doi-asserted-by":"publisher","first-page":"1225121","DOI":"10.3389\/fendo.2023.1225121","volume":"14","author":"Y Chu","year":"2023","unstructured":"Chu Y, Wang L, Xie J, et al. Impact of growth hormone on IVF\/ICSI outcomes and endometrial receptivity of patients undergoing GnRH antagonist protocol with fresh embryo transfer: a pilot study. Front Endocrinol (Lausanne). 2023;14:1225121.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1280_CR16","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1093\/humrep\/deab065","volume":"366","author":"E Bosch","year":"2021","unstructured":"Bosch E, Alviggi C, Lispi M, et al. Reduced FSH and LH action: implications for medically assisted reproduction. Hum Reprod. 2021;366:1469\u201380.","journal-title":"Hum Reprod"},{"key":"1280_CR17","doi-asserted-by":"publisher","first-page":"8732","DOI":"10.1038\/s41598-020-65558-0","volume":"101","author":"M Jing","year":"2020","unstructured":"Jing M, Lin C, Zhu W, et al. Cost-effectiveness analysis of GnRH-agonist long-protocol and GnRH-antagonist protocol for in vitro fertilization. Sci Rep. 2020;101:8732.","journal-title":"Sci Rep"},{"key":"1280_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.rbmo.2014.05.007","volume":"293","author":"D Grow","year":"2014","unstructured":"Grow D, Kawwass JF, Kulkarni AD, et al. GnRH agonist and GnRH antagonist protocols: comparison of outcomes among good-prognosis patients using national surveillance data. Reprod Biomed Online. 2014;293:299\u2013304.","journal-title":"Reprod Biomed Online"},{"key":"1280_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1477-7827-10-26","volume":"10","author":"R Depalo","year":"2012","unstructured":"Depalo R, Jayakrishan K, Garruti G, et al. GnRH agonist versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF\/ET). Reprod Biol Endocrinol. 2012;10:26.","journal-title":"Reprod Biol Endocrinol"},{"key":"1280_CR20","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/S1472-6483(10)61059-0","volume":"145","author":"HG Al-Inany","year":"2007","unstructured":"Al-Inany HG, Abou-Setta AM, Aboulghar M. Gonadotrophin-releasing hormone antagonists for assisted conception: a cochrane review. Reprod Biomed Online. 2007;145:640\u20139.","journal-title":"Reprod Biomed Online"},{"key":"1280_CR21","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1186\/s12884-023-05916-8","volume":"231","author":"JS Zhou","year":"2023","unstructured":"Zhou JS, Chen JH, Tang FF, et al. The effect of luteinizing hormone changes in GnRH antagonist protocol on the outcome of controlled ovarian hyperstimulation and embryo transfer. BMC Pregnancy Childbirth. 2023;231:604.","journal-title":"BMC Pregnancy Childbirth"},{"key":"1280_CR22","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S1472-6483(10)60347-1","volume":"153","author":"R Palermo","year":"2007","unstructured":"Palermo R. Differential actions of FSH and LH during folliculogenesis. Reprod Biomed Online. 2007;153:326\u201337.","journal-title":"Reprod Biomed Online"},{"key":"1280_CR23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/0974-1208.82351","volume":"41","author":"P Kumar","year":"2011","unstructured":"Kumar P, Sait SF. Luteinizing hormone and its dilemma in ovulation induction. J Hum Reprod Sci. 2011;41:2\u20137.","journal-title":"J Hum Reprod Sci"},{"key":"1280_CR24","doi-asserted-by":"crossref","unstructured":"Chen L, Lai M, Huang X et al. Clinical efficacy of assisted reproductive technology combined with progesterone capsules in the treatment of infertility caused by diminished ovarian reserve and its influence on serum FSH, E(2), and LH levels of patients. J Healthc Eng. 2022; 2022:5319172.","DOI":"10.1155\/2022\/5319172"},{"key":"1280_CR25","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/S1472-6483(10)61991-8","volume":"124","author":"J Balasch","year":"2006","unstructured":"Balasch J, Fabregues F. LH in the follicular phase: neither too high nor too low. Reprod Biomed Online. 2006;124:406\u201315.","journal-title":"Reprod Biomed Online"},{"key":"1280_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5582\/ddt.2022.01110","volume":"172","author":"Y Xu","year":"2023","unstructured":"Xu Y, Chen J, Zhang Y, et al. Women undergoing in vitro fertilization\/intracytoplasmic sperm injection-embryo transfer (IVF\/ICSI-ET) might benefit from maintaining serum luteinizing hormone levels: a retrospective analysis. Drug Discov Ther. 2023;172:95\u2013103.","journal-title":"Drug Discov Ther"},{"key":"1280_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12958-022-00888-4","volume":"201","author":"W Zhang","year":"2022","unstructured":"Zhang W, Liu Z, Liu M, et al. Is it necessary to monitor the serum luteinizing hormone (LH) concentration on the human chorionic gonadotropin (HCG) day among young women during the follicular-phase long protocol? A retrospective cohort study. Reprod Biol Endocrinol. 2022;201:24.","journal-title":"Reprod Biol Endocrinol"},{"key":"1280_CR28","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/s41419-022-05054-7","volume":"137","author":"SR Park","year":"2022","unstructured":"Park SR, Kim SK, Kim SR, et al. Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells. Cell Death Dis. 2022;137:605.","journal-title":"Cell Death Dis"},{"key":"1280_CR29","doi-asserted-by":"publisher","first-page":"1085287","DOI":"10.3389\/fendo.2023.1085287","volume":"14","author":"J Xu","year":"2023","unstructured":"Xu J, Zhang C, Wang S, et al. Impact of progesterone concentration on human chorionic gonadotropin trigger day on clinical outcomes with one top-quality cleavage-stage embryo or blastocyst transfer in fresh in vitro fertilization cycles. Front Endocrinol (Lausanne). 2023;14:1085287.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1280_CR30","doi-asserted-by":"publisher","first-page":"722655","DOI":"10.3389\/fendo.2021.722655","volume":"12","author":"F Gao","year":"2021","unstructured":"Gao F, Wang Y, Wu D, et al. A premature rise of luteinizing hormone is Associated with a reduced cumulative live birth rate in patients >\/=37 years old undergoing GnRH antagonist in Vitro fertilization cycles. Front Endocrinol (Lausanne). 2021;12:722655.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1280_CR31","first-page":"171","volume":"332","author":"E Demirdag","year":"2022","unstructured":"Demirdag E, Guler I, Akdulum MFC, et al. The impact of serum LH levels on the day of hCG trigger on IVF outcomes in patients undergoing GnRH antagonist protocols. GAZI Med J. 2022;332:171\u20134.","journal-title":"GAZI Med J"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-024-01280-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-024-01280-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-024-01280-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:31:20Z","timestamp":1724412680000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-024-01280-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1280"],"URL":"https:\/\/doi.org\/10.1186\/s12958-024-01280-0","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval number: 2023\u00a0K-K192.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"107"}}