{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:27:48Z","timestamp":1790180868041,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-024-01289-5","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T05:01:51Z","timestamp":1727499711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Discussion on the evaluation of the therapeutic efficacy of uterine artery blood flow parameters and serum PLGF and sFlt-1 in patients with recurrent spontaneous abortion"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaolu","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"1289_CR1","first-page":"653","volume":"57","author":"Chinese Society of Obstetrics and Gynecology, Chinese Medical Association, Obstetrics Group, Expert Consensus Writing Group on the Diagnosis and Treatment of Recurrent Miscarriage","year":"2022","unstructured":"Chinese Society of Obstetrics and Gynecology, Chinese Medical Association, Obstetrics Group, Expert Consensus Writing Group on the Diagnosis and Treatment of Recurrent Miscarriage. Expert Consensus on the Diagnosis and Treatment of Recurrent Miscarriage (2022). Chin J Obstet Gynecol. 2022;57:653\u201367.","journal-title":"Chin J Obstet Gynecol."},{"key":"1289_CR2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/S0015-0282(16)58382-4","volume":"66","author":"S Daya","year":"1996","unstructured":"Daya S, Stephenson M. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril. 1996;66:24\u20139.","journal-title":"Fertil Steril."},{"key":"1289_CR3","doi-asserted-by":"publisher","first-page":"e41424","DOI":"10.1371\/journal.pone.0041424","volume":"7","author":"C Weimar","year":"2012","unstructured":"Weimar C, Kavelaars A, Brosens JJ, et al. Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS ONE. 2012;7:e41424.","journal-title":"PLoS ONE."},{"key":"1289_CR4","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","volume":"10","author":"F Yang","year":"2019","unstructured":"Yang F, Zheng Q, Jin L. Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface. Front Immunol. 2019;10:2317.","journal-title":"Front Immunol."},{"issue":"3","key":"1289_CR5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3109\/14767058.2014.916676","volume":"28","author":"ZS Ozkan","year":"2015","unstructured":"Ozkan ZS, Devec\u0131 D, S\u0131msek M, et al. What is the impact of SOCS3, IL-35 and IL17 in immune pathogenesis of recurrent pregnancy loss?[J]. J Mater Fetal Neonatal Med. 2015;28(3):324\u20138.","journal-title":"J Mater Fetal Neonatal Med."},{"key":"1289_CR6","unstructured":"Jianping Z, Qide Lin, Dajin L, et al. Diagnosis and treatment of recurrent abortion Progress. Modern Obstet Gynecol. 2006;15(7):481\u201392."},{"key":"1289_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43044-020-00097-7","volume":"72","author":"P Barwad","year":"2020","unstructured":"Barwad P, Prasad K, Vijay J, et al. Is there a transcatheter solution for a sick neonate with hypoplastic right heart syndrome?: Pulmonary valve perforation in a neonate withhypoplastic right ventricle with pulmonary atresia, restrictive VSD\u2014a case report[J]. Egypt Heart J. 2020;72:1\u20135.","journal-title":"Egypt Heart J."},{"key":"1289_CR8","doi-asserted-by":"publisher","first-page":"e2302","DOI":"10.1371\/journal.pone.0002302","volume":"3","author":"S Muttukrishna","year":"2008","unstructured":"Muttukrishna S, Suri S, Groome N, et al. Relationships between TGF\u03b2 proteins and oxygen concentrations inside the first trimester human gestational sac. Plos One. 2008;3:e2302.","journal-title":"Plos One."},{"key":"1289_CR9","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/j.1471-0528.1972.tb12922.x","volume":"79","author":"I Brosens","year":"1972","unstructured":"Brosens I, Renaer M. On the pathogenesis of placental infarcts in pre-eclampsia. BJOG. 1972;79:794\u20139.","journal-title":"BJOG."},{"key":"1289_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S1028-4559(09)60032-2","volume":"48","author":"GJ Burton","year":"2009","unstructured":"Burton GJ, Jones CJP. Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta. Taiwan J Obstet Gynecol. 2009;48:28\u201337.","journal-title":"Taiwan J Obstet Gynecol."},{"key":"1289_CR11","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.1210\/en.2004-0533","volume":"145","author":"N Takeshi","year":"2004","unstructured":"Takeshi N, Tomoyuki F, Maki K, et al. Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology. 2004;145:4838.","journal-title":"Endocrinology."},{"key":"1289_CR12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1053\/plac.2000.0560","volume":"21","author":"C Redman","year":"2000","unstructured":"Redman C, Sargent IL. Placental debris, oxidative stress and pre-eclampsia. Placenta. 2000;21:597\u2013602.","journal-title":"Placenta."},{"key":"1289_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/01.OGX.0000083700.80693.DA","volume":"58","author":"SE Maynard","year":"2003","unstructured":"Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. Obstet Gynecol Surv. 2003;58:649\u201358.","journal-title":"Obstet Gynecol Surv."},{"key":"1289_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ajog.2004.09.029","volume":"192","author":"P Bose","year":"2005","unstructured":"Bose P, Black S, Kadyrov M, et al. Heparin and aspirin attenuate placental apoptosis in vitro: Implications for early pregnancy failure. Am J Obstet Gynecol. 2005;192:23\u201330.","journal-title":"Am J Obstet Gynecol."},{"key":"1289_CR15","unstructured":"Minyan Y, Guanyou H, Shuyun Z, et al. Clinical effect of prepregnancy aspirin combined with low dose of low molecular weight heparin sodium during pregnancy on recurrent abortion caused by prethrombotic state.\u00a0Pract Clin Med J. 2018;22:115\u20136+9."},{"key":"1289_CR16","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/molehr\/gal026","volume":"12","author":"FA Hills","year":"2006","unstructured":"Hills FA, Abrahams VM, Francis J, et al. Heparin prevents programmed cell death in human trophoblast. Mol Hum Reprod. 2006;12:237\u201343.","journal-title":"Mol Hum Reprod."},{"key":"1289_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000216164","volume":"20","author":"HC Hemker","year":"1990","unstructured":"Hemker HC, B\u00e9guin S. Mode of action of unfractionated and low molecular weight heparins on the generation of thrombin in plasma. Pathophysiol Haemost Thromb. 1990;20:81\u201392.","journal-title":"Pathophysiol Haemost Thromb."},{"key":"1289_CR18","first-page":"258","volume":"101","author":"M Shaker","year":"2009","unstructured":"Shaker M, Lars P. Anti-cancer properties of low-molecular-weight heparin: preclinical evidence. Haemost Thromb. 2009;101:258\u201367.","journal-title":"Haemost Thromb."},{"issue":"Suppl 1","key":"1289_CR19","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000216929","volume":"23","author":"JA McIntyre","year":"1993","unstructured":"McIntyre JA, Taylor CG, Torry DS, Wagenknecht DR, Wilson J, Faulk WP. Heparin and pregnancy in women with a history of repeated miscarriages. Haemostasis. 1993;23(Suppl 1):202\u201311. https:\/\/doi.org\/10.1159\/000216929.","journal-title":"Haemostasis."},{"key":"1289_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.thromres.2015.11.026","volume":"137","author":"E Shomer","year":"2016","unstructured":"Shomer E, Katzenell S, Zipori Y, et al. Microvesicles of pregnant women receiving low molecular weight heparin improve trophoblast function[J]. Thromb Res. 2016;137:141\u20137.","journal-title":"Thromb Res."},{"key":"1289_CR21","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/aji.12348","volume":"73","author":"L Luley","year":"2015","unstructured":"Luley L, Schumacher A, Mulla MJ, et al. Low molecular weight heparin modulates maternal immune response in pregnant women and mice with thrombophilia. Am J Reprod Immunol. 2015;73:417\u201327.","journal-title":"Am J Reprod Immunol."},{"key":"1289_CR22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/14767050701830480","volume":"21","author":"R Romero","year":"2008","unstructured":"Romero R, Nien JK, Espinoza J, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Med\u00a0 2008;21:9\u201323.","journal-title":"J Matern Fetal Med\u00a0"},{"key":"1289_CR23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.clinbiochem.2010.02.010","volume":"43","author":"J Schiettecatte","year":"2010","unstructured":"Schiettecatte J, Russcher H, Anckaert E, et al. Multicenter evaluation of the first automated Elecsys sFlt-1 and PlGF assays in normal pregnancies and preeclampsia. Clin Biochem. 2010;43:768\u201370.","journal-title":"Clin Biochem"},{"key":"1289_CR24","first-page":"166","volume":"43","author":"G Hongmei","year":"2020","unstructured":"Hongmei G, Xiaowen C. Research progress on the effects of placental growth factor on pregnancy. Int J Biomed Eng. 2020;43:166\u201370.","journal-title":"Int J Biomed Eng"},{"key":"1289_CR25","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1182\/blood-2010-01-267252","volume":"115","author":"P Clark","year":"2010","unstructured":"Clark P, Walker ID, Langhorne P, et al. SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood. 2010;115:4162\u20137.","journal-title":"Blood"},{"key":"1289_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3892\/etm.2020.9489","volume":"21","author":"X Yu","year":"2021","unstructured":"Yu X. Aspirin and heparin in the treatment of recurrent spontaneous abortion associated with antiphospholipid antibody syndrome: a systematic review and meta-analysis. Exp Ther Med. 2021;21:57.","journal-title":"Exp Ther Med."},{"key":"1289_CR27","unstructured":"Jing S. Diagnostic and predictive value of SFLT-1, PlGF and sFlt-\/PlGF in hypertensive diseases during pregnancy. Peking Union Medical College, Tsinghua University Health Science Center. 2012."},{"issue":"566\u20138","key":"1289_CR28","first-page":"55","volume":"27","author":"L Xiaoning","year":"2019","unstructured":"Xiaoning L, Xiaohua P, Caixia S. Prognostic analysis of serum PLGF and PAPP-A detection combined with B-ultrasound in the first and second trimester of preeclampsia. Chin J Eugen Genet. 2019;27(566\u20138):55.","journal-title":"Chin J Eugen Genet"},{"key":"1289_CR29","first-page":"308","volume":"43","author":"H Xueyi","year":"2016","unstructured":"Xueyi H, Chenhong W. Prognostic value of sFlt-1, PlGF, 25-hydroxyvitamin D, D-dimer, vWF and P-selectin in peripheral blood for preeclampsia. Int J Obstet Gynecol. 2016;43:308\u201311.","journal-title":"Int J Obstet Gynecol"},{"key":"1289_CR30","first-page":"995","volume":"40","author":"P Fengjuan","year":"2019","unstructured":"Fengjuan P, Guie T, Caixia T. Changes of serum VEGF Flt-1 PLGF PAPP-A levels in pregnant women with preeclampsia and its diagnostic value. Anhui Med Sci. 2019;40:995\u20138.","journal-title":"Anhui Med Sci"},{"key":"1289_CR31","first-page":"135","volume":"76","author":"M Hasko","year":"2011","unstructured":"Hasko M, Biringer K, Biskupsk\u00e1 BK, et al. [Selected markers in early prediction of preeclampsia]. Ceska Gynekol. 2011;76:135\u20139.","journal-title":"Ceska Gynekol."},{"key":"1289_CR32","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3109\/10641950902968684","volume":"29","author":"SE Maynard","year":"2010","unstructured":"Maynard SE, Simas TAM, Bur L, et al. Soluble endoglin for the prediction of preeclampsia in a high risk cohort. Hypertens Pregnancy. 2010;29:330.","journal-title":"Hypertens Pregnancy"},{"key":"1289_CR33","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1080\/00016340802253759","volume":"87","author":"AD Vivo","year":"2011","unstructured":"Vivo AD, Baviera G, Giordano D, et al. Endoglin, PlGF and sFlt-1 as markers for predicting pre-eclampsia. Acta Obstet Gynecol Scand. 2011;87:837\u201342.","journal-title":"Acta Obstet Gynecol Scand."},{"issue":"4","key":"1289_CR34","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.119.13763","volume":"75","author":"H Stepan","year":"2020","unstructured":"Stepan H, Hund M, Andraczek T. Combining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia: The Angiogenic-Placental Syndrome. Hypertension. 2020;75(4):918\u201326.","journal-title":"Hypertension."},{"issue":"2","key":"1289_CR35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1161\/HYPERTENSIONAHA.120.15146","volume":"77","author":"LA Dr\u00f6ge","year":"2021","unstructured":"Dr\u00f6ge LA, Perschel FH, St\u00fctz N, et al. Prediction of Preeclampsia-Related Adverse Outcomes With the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)\/PlGF (Placental Growth Factor)-Ratio in the Clinical Routine: A Real-World Study. Hypertension. 2021;77(2):461\u201371.","journal-title":"Hypertension."},{"key":"1289_CR36","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/HYPERTENSIONAHA.119.12739","volume":"74","author":"AS Cerdeira","year":"2019","unstructured":"Cerdeira AS, O\u2019Sullivan J, Ohuma EO, et al. Randomized interventional study on prediction of preeclampsia\/eclampsia in women with suspected preeclampsia INSPIRE. Hypertension. 2019;74:983\u201390.","journal-title":"Hypertension."},{"key":"1289_CR37","first-page":"1423","volume":"42","author":"L Tingting","year":"2019","unstructured":"Tingting L, Juanni W, Xiaoling W, et al. Study on the diagnostic value of sequential uterine artery ultrasonography, photoelectric volume pulse wave combined with serological indexes in pregnancy hypertension and preeclampsia. J Xinjiang Med Univ. 2019;42:1423\u20139.","journal-title":"J Xinjiang Med Univ."},{"key":"1289_CR38","doi-asserted-by":"publisher","first-page":"e75759","DOI":"10.1371\/journal.pone.0075759","volume":"8","author":"L Pang","year":"2013","unstructured":"Pang L, Wei Z, et al. An increase in Vascular Endothelial Growth Factor (VEGF) and VEGF soluble receptor-1 (sFlt-1) are associated with early recurrent spontaneous abortion. Plos One. 2013;8:e75759.","journal-title":"Plos One."}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-024-01289-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-024-01289-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-024-01289-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T06:03:54Z","timestamp":1729836234000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-024-01289-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1289"],"URL":"https:\/\/doi.org\/10.1186\/s12958-024-01289-5","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,28]]},"assertion":[{"value":"17 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An article note was added.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the ethics committee of the first affiliated hospital of Soochow University.(Approval No. 121(2022)). All participants provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"119"}}