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The measured lipid parameters include LDL (low-density lipoprotein), HDL (high-density lipoprotein), TC (total cholesterol), and TG (triglycerides).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>119 (15.5%) of the 767 patients developed GDM. On average, women who developed GDM were older, had a higher BMI, LDL, TC, and TG, and lower HDL. After adjusting for confounders, LDL and HDL showed a significant association with GDM (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but TC and TG did not. Binary LDL\/HDL and TC\/HDL ratios showed the strongest association with GDM incidence (OR 1.957 [95%CI 1.258\u20133.044] and 1.942 [1.243\u20133.034] respectively). Subgroup analysis showed that an elevated LDL\/HDL ratio also increased GDM risk in subgroups with a typically lower prevalence of GDM, such as young women with a low BMI and low blood pressure. Both lipid ratios (LDL\/HDL and TC\/HD) show strong interactions with baseline age, fasting plasma glucose, and LH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this cohort of Chinese women undergoing ART, pre-pregnancy LDL\/HDL and TC\/HDL were associated with GDM the strongest from the lipid parameters and could be useful to estimate GDM risk even before ART treatments and pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial number<\/jats:title>\n                <jats:p>NCT03503006 registered on the 21st of March 2018 (on clinicaltrials.gov). <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT03503006?locStr=Changsha,%20Hunan,%20China&amp;country=China&amp;state=Hunan&amp;city=Changsha&amp;cond=ivf&amp;rank=2\">https:\/\/clinicaltrials.gov\/study\/NCT03503006?locStr=Changsha,%20Hunan,%20China&amp;country=China&amp;state=Hunan&amp;city=Changsha&amp;cond=ivf&amp;rank=2<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-024-01320-9","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T07:09:47Z","timestamp":1733382587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pre-pregnancy LDL\/HDL and total Cholesterol\/HDL ratios are strong predictors of gestational diabetes mellitus in women undergoing assisted reproductive technologies"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-2108","authenticated-orcid":false,"given":"Yvonne","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-5210","authenticated-orcid":false,"given":"Johann-Georg","family":"Hocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7858-067X","authenticated-orcid":false,"given":"Shujuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6984-834X","authenticated-orcid":false,"given":"Liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-0917","authenticated-orcid":false,"given":"Huijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-0854","authenticated-orcid":false,"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7474-0680","authenticated-orcid":false,"given":"Fei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-2918","authenticated-orcid":false,"given":"Bernhard K.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-2546","authenticated-orcid":false,"given":"Ge","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-0579","authenticated-orcid":false,"given":"Berthold","family":"Hocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"1320_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.atherosclerosis.2016.02.006","volume":"248","author":"L Pan","year":"2016","unstructured":"Pan L, Yang Z, Wu Y, Yin RX, Liao Y, Wang J, et al. 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