{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:39:58Z","timestamp":1790278798511,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As part of a conventional controlled ovarian hyperstimulation (COH) regimen, final follicular maturation is usually triggered by a single bolus dose of human chorionic gonadotropin (hCG). COH, which combines GnRH antagonist co-treatment with GnRH agonist(GnRHa) trigger, is often used in attempts to eliminate severe early ovarian hyperstimulation syndrome and to improve oocyte\/embryo yield and quality. Recently, the combination of GnRHa, with hCG trigger has also been implemented into clinical practice. Here, we analyze and discuss published studies on various ways of triggering final follicular maturation, seeking to elucidate the appropriateness of each approach for specific patient subgroups.<\/jats:p>","DOI":"10.1186\/s12958-024-01332-5","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T22:03:55Z","timestamp":1737583435000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Triggering final follicular maturation for IVF cycles"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0865-1196","authenticated-orcid":false,"given":"Raoul","family":"Orvieto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"1332_CR1","unstructured":"Fritz MA, Speroff L, editors. Regulation of the menstrual cycle. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011."},{"key":"1332_CR2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/humupd\/dmu009","volume":"20","author":"K Skorupskaite","year":"2014","unstructured":"Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20:485\u2013500.","journal-title":"Hum Reprod Update"},{"key":"1332_CR3","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/S0015-0282(03)00173-0","volume":"79","author":"M Ludwig","year":"2003","unstructured":"Ludwig M, Doody KJ, Doody KM. Use of recombinant human chorionic gonadotropin in ovulation induction. Fertil Steril. 2003;79:1051\u20139.","journal-title":"Fertil Steril"},{"key":"1332_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1757-2215-6-77","volume":"6","author":"R Orvieto","year":"2013","unstructured":"Orvieto R. Ovarian hyperstimulation syndrome \u2013 an optimal solution for an unresolved enigma. J Ovarian Res. 2013;6:77.","journal-title":"J Ovarian Res"},{"key":"1332_CR5","first-page":"1507","volume":"83","author":"The European Recombinant Human LH Study Group","year":"1998","unstructured":"The European Recombinant Human LH Study Group. Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH- and FSH-deficient anovulatory women: a dose-finding study. The European Recombinant Human LH Study Group. J Clin Endocrinol Metab. 1998;83:1507\u201314.","journal-title":"J Clin Endocrinol Metab"},{"key":"1332_CR6","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/humrep\/deh613","volume":"20","author":"R Orvieto","year":"2005","unstructured":"Orvieto R. Can we eliminate severe ovarian hyperstimulation syndrome? Hum Reprod. 2005;20:320\u20132.","journal-title":"Hum Reprod"},{"key":"1332_CR7","first-page":"CD008046","volume":"10","author":"MA Youssef","year":"2014","unstructured":"Youssef MA, Van der Veen F, Al-Inany HG, Mochtar MH, Griesinger G, Nagi Mohesen M, et al. Gonadotropin-releasing hormone agonist versus hCG for oocyte triggering in antagonist-assisted reproductive technology. Cochrane Database Syst Rev. 2014;10:CD008046.","journal-title":"Cochrane Database Syst Rev"},{"key":"1332_CR8","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s10815-016-0775-4","volume":"33","author":"R Orvieto","year":"2016","unstructured":"Orvieto R. Triggering final follicular maturation-hCG, GnRH-agonist or both, when and to whom? J Assist Reprod Genet. 2016;33:1415\u20136.","journal-title":"J Assist Reprod Genet"},{"key":"1332_CR9","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1172\/JCI75730","volume":"124","author":"CN Jayasena","year":"2014","unstructured":"Jayasena CN, Abbara A, Comninos AN, Nijher GM, Christopoulos G, Narayanaswamy S, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest. 2014;124:3667\u201377.","journal-title":"J Clin Invest"},{"key":"1332_CR10","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1210\/jc.2015-2332","volume":"100","author":"A Abbara","year":"2015","unstructured":"Abbara A, Jayasena CN, Christopoulos G, Narayanaswamy S, Izzi-Engbeaya C, Nijher GM, et al. Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy. J Clin Endocrinol Metab. 2015;100:3322\u201331.","journal-title":"J Clin Endocrinol Metab"},{"key":"1332_CR11","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1093\/humrep\/dex253","volume":"32","author":"A Abbara","year":"2017","unstructured":"Abbara A, Clarke S, Islam R, Prague JK, Comninos AN, Narayanaswamy S, et al. A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a phase 2 randomized controlled trial. Hum Reprod. 2017;32:1915\u201324.","journal-title":"Hum Reprod"},{"key":"1332_CR12","doi-asserted-by":"publisher","first-page":"e46682","DOI":"10.1371\/journal.pone.0046682","volume":"7","author":"L Casarini","year":"2012","unstructured":"Casarini L, Lispi M, Longobardi S, Milosa F, La Marca A, Tagliasacchi D, et al. LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling. PLoS ONE. 2012;7:e46682.","journal-title":"PLoS ONE"},{"key":"1332_CR13","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.fertnstert.2016.06.002","volume":"106","author":"J Haas","year":"2016","unstructured":"Haas J, Ophir L, Barzilay E, Machtinger R, Yung Y, Orvieto R, et al. Standard human chorionic gonadotropin versus double trigger for final oocyte maturation results in different granulosa cells gene expressions: a pilot study. Fertil Steril. 2016;106:653\u201359.","journal-title":"Fertil Steril"},{"key":"1332_CR14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12958-022-01017-x","volume":"20","author":"Y Yung","year":"2022","unstructured":"Yung Y, Aizer A, Tieb S, Maydan SA, Maman E, Haham LM, et al. The in-vitro effect of gonadotropins\u2019 type and combination on granulosa cells gene expressions. Reprod Biol Endocrinol. 2022;20:144.","journal-title":"Reprod Biol Endocrinol"},{"key":"1332_CR15","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.fertnstert.2013.07.1976","volume":"100","author":"MH Lin","year":"2013","unstructured":"Lin MH, Wu FS, Lee RK, Li SH, Lin SY, Hwu YM. Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles. Fertil Steril. 2013;100:1296\u2013302.","journal-title":"Fertil Steril"},{"key":"1332_CR16","first-page":"203","volume":"6","author":"W Decleer","year":"2014","unstructured":"Decleer W, Osmanagaoglu K, Seynhave B, Kolibianakis S, Tarlatzis B, Devroey P. Comparison of hCG triggering versus hCG in combination with a GnRH agonist: a prospective randomized controlled trial. 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Gyn Endocrinol. 2015;31:145\u20137.","journal-title":"Gyn Endocrinol"},{"key":"1332_CR21","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/humrep\/der092","volume":"26","author":"AP Ferraretti","year":"2011","unstructured":"Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, et al. ESHRE consensus on the definition of \u2018poor response\u2019 to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26:1616\u201324.","journal-title":"Hum Reprod"},{"key":"1332_CR22","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1093\/humrep\/17.3.634","volume":"17","author":"F Martinez","year":"2002","unstructured":"Martinez F, Barri PN, Coroleu B, Tur R, Sorsa-Leslie T, Harris WJ, et al. Women with poor response to IVF have lowered circulating gonadotrophin surge-attenuating factor (GnSAF) bioactivity during spontaneous and stimulated cycles. 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