{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:35:17Z","timestamp":1776436517890,"version":"3.51.2"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224BAB216025"],"award-info":[{"award-number":["20224BAB216025"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260315"],"award-info":[{"award-number":["82260315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Key Laboratory of Reproductive Health","award":["2024SSY06211"],"award-info":[{"award-number":["2024SSY06211"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-025-01355-6","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:55:28Z","timestamp":1740552928000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study"],"prefix":"10.1186","volume":"23","author":[{"given":"Jialyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leizhen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haisheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxia","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"von Versen-H\u00f6ynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingwu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"1","key":"1355_CR1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/ijerph18010284","volume":"18","author":"J Qi","year":"2021","unstructured":"Qi J, Zhou Y, Hua J, Zhang L, Bian J, Liu B, et al. The scRNA-seq expression profiling of the receptor ACE2 and the Cellular protease TMPRSS2 reveals human organs susceptible to SARS-CoV-2 infection. Int J Environ Res Public Health. 2021;18(1):284.","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"1355_CR2","doi-asserted-by":"publisher","first-page":"e0243959","DOI":"10.1371\/journal.pone.0243959","volume":"15","author":"J Goad","year":"2020","unstructured":"Goad J, Rudolph J, Rajkovic A. Female reproductive tract has low concentration of SARS-CoV2 receptors. PLoS ONE. 2020;15(12):e0243959.","journal-title":"PLoS ONE"},{"issue":"6","key":"1355_CR3","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1016\/j.ygeno.2021.08.012","volume":"113","author":"M Wu","year":"2021","unstructured":"Wu M, Ma L, Xue L, Zhu Q, Zhou S, Dai J, et al. Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: identification of cell types and trends with age. Genomics. 2021;113(6):3449\u201360.","journal-title":"Genomics"},{"issue":"21","key":"1355_CR4","doi-asserted-by":"publisher","first-page":"12836","DOI":"10.3390\/ijms232112836","volume":"23","author":"S Perrone","year":"2022","unstructured":"Perrone S, Cannavo L, Manti S, Rullo I, Buonocore G, Esposito SMR, et al. Pediatric Multisystem Syndrome Associated with SARS-CoV-2 (MIS-C): the interplay of oxidative stress and inflammation. Int J Mol Sci. 2022;23(21):12836.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1355_CR5","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.euf.2020.05.009","volume":"6","author":"M Yang","year":"2020","unstructured":"Yang M, Chen S, Huang B, Zhong JM, Su H, Chen YJ, et al. Pathological findings in the testes of COVID-19 patients: clinical implications. Eur Urol Focus. 2020;6(5):1124\u20139.","journal-title":"Eur Urol Focus"},{"issue":"12","key":"1355_CR6","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1007\/s40618-022-01801-x","volume":"45","author":"G Corona","year":"2022","unstructured":"Corona G, Vena W, Pizzocaro A, Pallotti F, Paoli D, Rastrelli G, et al. Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis. J Endocrinol Invest. 2022;45(12):2207\u201319.","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"1355_CR7","doi-asserted-by":"publisher","first-page":"166295","DOI":"10.1016\/j.bbadis.2021.166295","volume":"1868","author":"Y Herrero","year":"2022","unstructured":"Herrero Y, Pascuali N, Velazquez C, Oubina G, Hauk V, de Zuniga I, et al. SARS-CoV-2 infection negatively affects ovarian function in ART patients. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166295.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"5","key":"1355_CR8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1530\/REP-22-0243","volume":"164","author":"L Chico-Sordo","year":"2022","unstructured":"Chico-Sordo L, Polonio AM, Cordova-Oriz I, Medrano M, Herraiz S, Bronet F, et al. Telomeres and oocyte maturation rate are not reduced by COVID-19 except in severe cases. Reproduction. 2022;164(5):259\u201367.","journal-title":"Reproduction"},{"key":"1355_CR9","doi-asserted-by":"publisher","first-page":"635255","DOI":"10.3389\/fmed.2021.635255","volume":"8","author":"T Ding","year":"2021","unstructured":"Ding T, Wang T, Zhang J, Cui P, Chen Z, Zhou S, et al. Analysis of ovarian Injury Associated with COVID-19 Disease in Reproductive-aged women in Wuhan, China: an observational study. Front Med (Lausanne). 2021;8:635255.","journal-title":"Front Med (Lausanne)"},{"issue":"6","key":"1355_CR10","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.fertnstert.2022.09.013","volume":"118","author":"L de Miguel-Gomez","year":"2022","unstructured":"de Miguel-Gomez L, Sebastian-Leon P, Romeu M, Pellicer N, Faus A, Pellicer A, et al. Endometrial gene expression differences in women with coronavirus disease 2019. Fertil Steril. 2022;118(6):1159\u201369.","journal-title":"Fertil Steril"},{"key":"1355_CR11","doi-asserted-by":"publisher","first-page":"1233986","DOI":"10.3389\/fendo.2023.1233986","volume":"14","author":"Y Xue","year":"2023","unstructured":"Xue Y, Xiong Y, Cheng X, Li K. Impact of SARS-CoV-2 infection on clinical outcomes of in vitro fertilization treatments: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1233986.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"1355_CR12","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.fertnstert.2021.12.032","volume":"117","author":"L Boudry","year":"2022","unstructured":"Boudry L, Essahib W, Mateizel I, Van de Velde H, De Geyter D, Pierard D, et al. Undetectable viral RNA in follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive women. Fertil Steril. 2022;117(4):771\u201380.","journal-title":"Fertil Steril"},{"issue":"7","key":"1355_CR13","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s11427-023-2291-0","volume":"66","author":"X Chen","year":"2023","unstructured":"Chen X, Shi H, Li C, Zhong W, Cui L, Zhang W, et al. The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study. Sci China Life Sci. 2023;66(7):1697\u2013700.","journal-title":"Sci China Life Sci"},{"issue":"7","key":"1355_CR14","doi-asserted-by":"publisher","first-page":"e2323219","DOI":"10.1001\/jamanetworkopen.2023.23219","volume":"6","author":"F Tian","year":"2023","unstructured":"Tian F, Li S, Li N, Zhao H, Luo M, Zhang J, et al. Association of SARS-CoV-2 infection during controlled ovarian stimulation with oocyte- and embryo-related outcomes. JAMA Netw Open. 2023;6(7):e2323219.","journal-title":"JAMA Netw Open"},{"issue":"5","key":"1355_CR15","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.5114\/aoms.2019.85145","volume":"15","author":"LF Tian","year":"2019","unstructured":"Tian LF, Tan J, Zou Y, Su Q, Li Y, Xu DF, et al. Mild starting dosage ovarian stimulation combined with a modified prolonged GnRH-a protocol improved IVF\/ICSI outcomes in normal ovarian responders. Arch Med Sci. 2019;15(5):1294\u2013300.","journal-title":"Arch Med Sci"},{"issue":"8","key":"1355_CR16","doi-asserted-by":"publisher","first-page":"e104779","DOI":"10.1371\/journal.pone.0104779","volume":"9","author":"L Dai","year":"2014","unstructured":"Dai L, Deng C, Li Y, Zhu J, Mu Y, Deng Y, et al. Birth weight reference percentiles for Chinese. PLoS ONE. 2014;9(8):e104779.","journal-title":"PLoS ONE"},{"issue":"1","key":"1355_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/mrd.23658","volume":"90","author":"D Braga","year":"2023","unstructured":"Braga D, Setti AS, Iaconelli A Jr., Borges E Jr. Previous infection with SARS-CoV-2 impacts embryo morphokinetics but not clinical outcomes in a time-lapse imaging system. Mol Reprod Dev. 2023;90(1):53\u20138.","journal-title":"Mol Reprod Dev"},{"issue":"8","key":"1355_CR18","doi-asserted-by":"publisher","first-page":"200162","DOI":"10.1098\/rsob.200162","volume":"10","author":"BAT Weatherbee","year":"2020","unstructured":"Weatherbee BAT, Glover DM, Zernicka-Goetz M. Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester. Open Biol. 2020;10(8):200162.","journal-title":"Open Biol"},{"issue":"1","key":"1355_CR19","doi-asserted-by":"publisher","first-page":"15451","DOI":"10.1038\/s41598-022-18906-1","volume":"12","author":"M Montano","year":"2022","unstructured":"Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, et al. SARS-CoV-2 can infect human embryos. Sci Rep. 2022;12(1):15451.","journal-title":"Sci Rep"},{"key":"1355_CR20","doi-asserted-by":"crossref","unstructured":"Artini PG, Scarfo G, Marzi I, Fusi J, Obino ME, Franzoni F et al. Oxidative Stress-Related Signaling Pathways Predict Oocytes\u2019 Fertilization In Vitro and Embryo Quality. Int J Mol Sci. 2022;23(21).","DOI":"10.3390\/ijms232113442"},{"issue":"1","key":"1355_CR21","doi-asserted-by":"publisher","first-page":"21702","DOI":"10.1038\/s41598-022-25757-3","volume":"12","author":"S Albeitawi","year":"2022","unstructured":"Albeitawi S, Al-Alami ZM, Hamadneh J, Alqam H, Qublan H, Al Natsheh M. COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome. Sci Rep. 2022;12(1):21702.","journal-title":"Sci Rep"},{"issue":"18","key":"1355_CR22","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.3390\/jcm11185265","volume":"11","author":"Y Kabalkin","year":"2022","unstructured":"Kabalkin Y, Bentov Y, Gil M, Beharier O, Jaber S, Moav-Zafrir A, et al. Mild COVID-19 was not Associated with impaired IVF outcomes or early pregnancy loss in IVF patients. J Clin Med. 2022;11(18):5265.","journal-title":"J Clin Med"},{"issue":"1","key":"1355_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12958-022-00918-1","volume":"20","author":"M Wang","year":"2022","unstructured":"Wang M, Hu J, Huang B, Yang Q, Liu S, Li Z, et al. Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro fertilization\/intracytoplasmic sperm injection outcomes: a retrospective cohort study. Reprod Biol Endocrinol. 2022;20(1):46.","journal-title":"Reprod Biol Endocrinol"},{"issue":"5","key":"1355_CR24","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/humrep\/deac043","volume":"37","author":"M Youngster","year":"2022","unstructured":"Youngster M, Avraham S, Yaakov O, Landau Rabbi M, Gat I, Yerushalmi G, et al. IVF under COVID-19: treatment outcomes of fresh ART cycles. Hum Reprod. 2022;37(5):947\u201353.","journal-title":"Hum Reprod"},{"key":"1355_CR25","doi-asserted-by":"publisher","first-page":"1239903","DOI":"10.3389\/fendo.2023.1239903","volume":"14","author":"J Huang","year":"2023","unstructured":"Huang J, Liu Y, Xia L, Zhao Y, Tian L, Xu D, et al. Effect of prior female SARS-CoV-2 infection on IVF outcomes: a prospective cohort study. Front Endocrinol (Lausanne). 2023;14:1239903.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1355_CR26","first-page":"109","volume":"43","author":"Recommendations on the management of assisted reproductive technology","year":"2023","unstructured":"Recommendations on the management of assisted reproductive technology. Under the Class B infectious disease policy for COVID-19 (first edition) [In Chinese]. Chin J Reprod Contracep. 2023;43:109\u201311.","journal-title":"Chin J Reprod Contracep"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01355-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-025-01355-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01355-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:55:33Z","timestamp":1740552933000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-025-01355-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1355"],"URL":"https:\/\/doi.org\/10.1186\/s12958-025-01355-6","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"17 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Reproductive Medicine Ethics Committee of Jiangxi Maternal and Child Health Hospital (No. 2023-04), and conducted in accordance with the Declaration of Helsinki. All patients signed informed contents for participation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30"}}