{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:20:45Z","timestamp":1787170845148,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-025-01372-5","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T22:03:18Z","timestamp":1741384998000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnosis and management of infertility in patients with polycystic ovary syndrome (PCOS): guidelines from the Italian Society of Human Reproduction (SIRU) and the Italian\u00a0Centers for the Study and Conservation of Eggs and Sperm (CECOS\u00a0Italy)"],"prefix":"10.1186","volume":"23","author":[{"given":"Stefano","family":"Palomba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Seminara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Morgante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Papaleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Ragusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Allegra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Guglielmino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Somigliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SIRU-CECOS Working Group on Italian Guideline for Infertility in PCOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bartolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Carone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Costantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Liprino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Laganara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Marci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sosa Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Volpes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"key":"1372_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1210\/er.2015-1018","volume":"36","author":"DA Dumesic","year":"2015","unstructured":"Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. Endocr Rev. 2015;36:487\u2013525.","journal-title":"Endocr Rev"},{"key":"1372_CR2","first-page":"2421","volume":"36","author":"S Palomba","year":"2021","unstructured":"Palomba S. Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper Hum Reprod. 2021;36:2421\u20138.","journal-title":"An opinion paper Hum Reprod"},{"issue":"38","key":"1372_CR3","first-page":"1655","volume":"2023","author":"Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS network. recommendations from the","year":"2023","unstructured":"Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS network. recommendations from the. International Evidence-based Guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod. 2023;2023:1655\u201379.","journal-title":"Hum Reprod"},{"key":"1372_CR4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/humupd\/dmae003","volume":"30","author":"AH Balen","year":"2024","unstructured":"Balen AH, Tamblyn J, Skorupskaite K, Munro MG. FIGO Committee on Menstrual Disorders and Related Health Impacts and Reproductive Medicine, Endocrinology and Infertility. A comprehensive review of the new FIGO classification of ovulatory disorders. Hum Reprod Update. 2024;30:355\u201382.","journal-title":"Hum Reprod Update"},{"key":"1372_CR5","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/humupd\/dmaa051","volume":"27","author":"S Palomba","year":"2021","unstructured":"Palomba S, Piltonen TT, Giudice LC. Endometrial function in women with polycystic ovary syndrome: a comprehensive review. Hum Reprod Update. 2021;27:584\u2013618.","journal-title":"Hum Reprod Update"},{"key":"1372_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.tem.2016.11.008","volume":"28","author":"S Palomba","year":"2017","unstructured":"Palomba S, Daolio J, La Sala GB. Oocyte competence in women with polycystic ovary syndrome. Trends Endocrinol Metab. 2017;28:186\u201398.","journal-title":"Trends Endocrinol Metab"},{"key":"1372_CR7","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.fertnstert.2023.11.008","volume":"121","author":"KM Moss","year":"2024","unstructured":"Moss KM, Doust J, Copp T, Homer H, Mishra GD. Fertility treatment pathways and births for women with and without polycystic ovary syndrome-a retrospective population linked data study. Fertil Steril. 2024;121:314\u201322.","journal-title":"Fertil Steril"},{"key":"1372_CR8","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.fertnstert.2023.11.037","volume":"121","author":"S Palomba","year":"2024","unstructured":"Palomba S. The progression of intensity and complexity of treatment as a cornerstone of the management of polycystic ovary syndrome-related infertility. Fertil Steril. 2024;121:252\u20133.","journal-title":"Fertil Steril"},{"key":"1372_CR9","unstructured":"Coclite D, Napoletano A, Fauci AJ, Graziano G, Iannone P. Manuale metodologico per la produzione di linee guida di pratica clinica. 2017. Adjourned form available at: https:\/\/www.iss.it\/documents\/20126\/7949265\/Manuale+Metodologico+-+marzo+2023.pdf\/01f4bc8e-f3e6-66ec-bbe1-e80186908c6c?t=1679921943422."},{"key":"1372_CR10","doi-asserted-by":"crossref","unstructured":"Palomba S, Vigan\u00f2 P, Chamayou S, Donarelli Z, Costantini MP, Marci R, Piomboni P, Fino E, Montano L, Guglielmino A, Somigliana E; and the SIRU Working Group on Italian Guideline for Infertility. Diagnosis and management of infertility: NICE-adapted guidelines from the Italian Society of Human Reproduction. Reprod Biol Endocrinol 2024;22:9.","DOI":"10.1186\/s12958-023-01179-2"},{"key":"1372_CR11","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s40618-015-0274-y","volume":"38","author":"P Moghetti","year":"2015","unstructured":"Moghetti P, Carmina E, De Leo V, Lanzone A, Orio F, Pasquali R, Toscano V. How to manage the reproductive issues of PCOS: a integrated endocrinological and gynecological consensus statement of the Italian Society of Endocrinology. J Endocrinol Invest. 2015;38:1025\u201337.","journal-title":"J Endocrinol Invest"},{"key":"1372_CR12","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1080\/14656566.2024.2418985","volume":"25","author":"S Palomba","year":"2024","unstructured":"Palomba S, Molinaro M, Ingargiola A, Aversa A. Recent developments in drug treatment strategies for infertility in patients with polycystic ovary syndrome. Expert Opin Pharmacother. 2024;25:2191\u2013202.","journal-title":"Expert Opin Pharmacother"},{"key":"1372_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jclinepi.2016.09.009","volume":"81","author":"HJ Sch\u00fcnemann","year":"2017","unstructured":"Sch\u00fcnemann HJ, Wiercioch W, Brozek J, Etxeandia-Ikobaltzeta I, Mustafa RA, Manja V, Brignardello-Petersen R, Neumann I, Falavigna M, Alhazzani W, Santesso N, Zhang Y, Meerpohl JJ, Morgan RL, Rochwerg B, Darzi A, Rojas MX, Carrasco-Labra A, Adi Y, AlRayees Z, Riva J, Bollig C, Moore A, Yepes-Nu\u00f1ez JJ, Cuello C, Waziry R, Akl EA. GRADE Evidence to Decision (EtD) frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT. J Clin Epidemiol. 2017;81:101\u201310.","journal-title":"J Clin Epidemiol"},{"key":"1372_CR14","first-page":"217","volume":"102","author":"A Cartabellotta","year":"2011","unstructured":"Cartabellotta A. AGREE II: come valutare la qualit\u00e0 delle linee-guida [AGREE II: assessing the quality of practice guidelines]. Recenti Prog Med. 2011;102:217\u20139.","journal-title":"Recenti Prog Med"},{"key":"1372_CR15","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jclinepi.2011.10.008","volume":"65","author":"MC Brouwers","year":"2012","unstructured":"Brouwers MC, Kho ME, Browman GP, Burgers JS, Cluzeau F, Feder G, Fervers B, Graham I, Grimshaw J, Hanna SE. The global rating scale complements the AGREE II in advancing the quality of practice guidelines. J Clin Epidemiol. 2012;65:526\u201334.","journal-title":"J Clin Epidemiol"},{"key":"1372_CR16","doi-asserted-by":"publisher","first-page":"i1152","DOI":"10.1136\/bmj.i1152","volume":"352","author":"MC Brouwers","year":"2016","unstructured":"Brouwers MC, Kerkvliet K, Spithoff K. The AGREE Reporting Checklist: a tool to improve reporting of clinical practice guidelines. BMJ. 2016;352: i1152.","journal-title":"BMJ"},{"key":"1372_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jclinepi.2020.07.005","volume":"127","author":"TF Frandsen","year":"2020","unstructured":"Frandsen TF, Bruun Nielsen MF, Lindhardt CL, Eriksen MB. Using the full PICO model as a search tool for systematic reviews resulted in lower recall for some PICO elements. J Clin Epidemiol. 2020;127:69\u201375.","journal-title":"J Clin Epidemiol"},{"issue":"Suppl 3","key":"1372_CR18","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1016\/j.injury.2022.01.047","volume":"54","author":"E Guerra-Farfan","year":"2023","unstructured":"Guerra-Farfan E, Garcia-Sanchez Y, Jornet-Gibert M, Nu\u00f1ez JH, Balaguer-Castro M, Madden K. Clinical practice guidelines: The good, the bad, and the ugly. Injury. 2023;54(Suppl 3):S26\u20139.","journal-title":"Injury"},{"key":"1372_CR19","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1210\/jc.2005-0628","volume":"90","author":"R Azziz","year":"2005","unstructured":"Azziz R, Marin C, Hoq L, Badamgarav E, Song P. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab. 2005;90:4650\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"1372_CR20","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1093\/humrep\/dem426","volume":"23","author":"Thessaloniki ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2008","unstructured":"Thessaloniki ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod. 2008;23:462\u201377.","journal-title":"Hum Reprod"},{"key":"1372_CR21","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"BC Fauser","year":"2012","unstructured":"Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, Boivin J, Petraglia F, Wijeyeratne CN, Norman RJ, Dunaif A, Franks S, Wild RA, Dumesic D, Barnhart K. Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS consensus workshop group. Fertil Steril. 2012;97:28\u201338.","journal-title":"Fertil Steril"},{"key":"1372_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/EJE-14-0253","volume":"171","author":"G Conway","year":"2014","unstructured":"Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Franks S, Gambineri A, Kelestimur F, Macut D, Micic D, Pasquali R, Pfeifer M, Pignatelli D, Pugeat M, Yildiz BO, ESE PCOS Special Interest Group. The polycystic ovary syndrome: a position statement from the European society of endocrinology. Eur J Endocrinol. 2014;171:1\u201329.","journal-title":"Eur J Endocrinol."},{"key":"1372_CR23","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1210\/jc.2013-2350","volume":"98","author":"RS Legro","year":"2013","unstructured":"Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK. Endocrine Society Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98:4565\u201392.","journal-title":"J Clin Endocrinol Metab."},{"key":"1372_CR24","doi-asserted-by":"crossref","unstructured":"American college of obstetricians and gynecologists\u2019 committee on practice bulletins\u2014gynecology. ACOG practice bulletin No. 194: polycystic ovary syndrome. Obstet Gynecol. 2018;131:e157-e171.","DOI":"10.1097\/AOG.0000000000002656"},{"key":"1372_CR25","doi-asserted-by":"crossref","unstructured":"Costello MF, Misso ML, Balen A, Boyle J, Devoto L, Garad RM, Hart R, Johnson L, Jordan C, Legro RS, Norman RJ, Mocanu E, Qiao J, Rodgers RJ, Rombauts L, Tassone EC, Thangaratinam S, Vanky E, Teede HJ; International PCOS Network. Evidence summaries and recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome: assessment and treatment of infertility. Hum Reprod Open. 2019;2019:hoy021.","DOI":"10.1093\/hropen\/hoy021"},{"issue":"257","key":"1372_CR26","first-page":"e220232","volume":"28","author":"CT Tay","year":"2023","unstructured":"Tay CT, Garrad R, Mousa A, Bahri M, Joham A, Teede H. Polycystic ovary syndrome (PCOS): international collaboration to translate evidence and guide future research. J Endocrinol. 2023;28:e220232.","journal-title":"J Endocrinol"},{"key":"1372_CR27","doi-asserted-by":"publisher","first-page":"389","DOI":"10.5694\/mja2.52432","volume":"221","author":"HJ Teede","year":"2024","unstructured":"Teede HJ, Mousa A, Tay CT, Costello MF, Brennan L, Norman RJ, Pena AS, Boyle JA, Joham A, Berry L, Moran L. Summary of the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome: an Australian perspective. Med J Aust. 2024;221:389\u201395.","journal-title":"Med J Aust"},{"key":"1372_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/aogs.14725","volume":"103","author":"M Forslund","year":"2024","unstructured":"Forslund M, Melin J, Stener-Victorin E, Hirschberg AL, Teede H, Vanky E, Piltonen T. International evidence-based guideline on assessment and management of PCOS-A Nordic perspective. Acta Obstet Gynecol Scand. 2024;103:7\u201312.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"1372_CR29","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13048-024-01372-w","volume":"17","author":"S Palomba","year":"2024","unstructured":"Palomba S, Caserta D, Levi-Setti PE, Busnelli A. Efficacy and safety of follitropin delta for ovarian stimulation in vitro fertilization\/ intracytoplasmic sperm injection cycles: a systematic review with meta-analysis. J Ovarian Res. 2024;17:60.","journal-title":"J Ovarian Res"},{"key":"1372_CR30","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.fertnstert.2024.05.143","volume":"122","author":"SM Nelson","year":"2024","unstructured":"Nelson SM, Shaw M, Alrashid K, Anderson RA. Individualized dosing of follitropin delta affects live birth and safety in in vitro fertilization treatment: an individual participant data meta-analysis of randomized controlled trials. Fertil Steril. 2024;122:445\u201354.","journal-title":"Fertil Steril"},{"issue":"24","key":"1372_CR31","first-page":"02006","volume":"S0015\u20130282","author":"S Palomba","year":"2024","unstructured":"Palomba S, Caserta D. Follitropin delta: is further evidence needed? Fertil Steril. 2025;123:373.","journal-title":"Fertil Steril"},{"key":"1372_CR32","doi-asserted-by":"crossref","unstructured":"Bordewijk EM, Weiss NS, Nahuis MJ, Kwee J, Lambeek AF, van Unnik GA, Vrouenraets FPJ, Cohlen BJ, van de Laar-van Asseldonk TAM, Lambalk CB, Goddijn M, Hompes PG, van der Veen F, Mol BWJ, van Wely M; M-ovin study group. Gonadotrophins or clomiphene citrate in women with normogonadotropic anovulation and CC failure: does the endometrium matter? Hum Reprod. 2020;35:1319\u20131324.","DOI":"10.1093\/humrep\/deaa052"},{"key":"1372_CR33","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.fertnstert.2024.05.163","volume":"122","author":"K van der Ham","year":"2024","unstructured":"van der Ham K, Laven JSE, Tay CT, Mousa A, Teede H, Louwers YV. Anti-m\u00fcllerian hormone as a diagnostic biomarker for polycystic ovary syndrome and polycystic ovarian morphology: a systematic review and meta-analysis. Fertil Steril. 2024;122:727\u201339.","journal-title":"Fertil Steril"},{"key":"1372_CR34","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1093\/humrep\/dead147","volume":"38","author":"M Peign\u00e9","year":"2023","unstructured":"Peign\u00e9 M, Bernard V, Dijols L, Creux H, Robin G, Hock\u00e9 C, Grynberg M, Dewailly D, Sonigo C. Using serum anti-M\u00fcllerian hormone levels to predict the chance of live birth after spontaneous or assisted conception: a systematic review and meta-analysis. Hum Reprod. 2023;38:1789\u2013806.","journal-title":"Hum Reprod"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01372-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-025-01372-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01372-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T09:43:28Z","timestamp":1741427008000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-025-01372-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1372"],"URL":"https:\/\/doi.org\/10.1186\/s12958-025-01372-5","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,8]]},"assertion":[{"value":"6 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"37"}}