{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:39:02Z","timestamp":1792132742829,"version":"4.4.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National key R&D program of China","doi-asserted-by":"crossref","award":["2022YFC2704100"],"award-info":[{"award-number":["2022YFC2704100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-025-01375-2","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T06:56:51Z","timestamp":1742021811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study"],"prefix":"10.1186","volume":"23","author":[{"given":"Wenqing","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangmei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"issue":"3","key":"1375_CR1","doi-asserted-by":"publisher","first-page":"e2511","DOI":"10.1016\/j.ajog.2019.09.007","volume":"222","author":"NC Stentz","year":"2020","unstructured":"Stentz NC, et al. Infertility and mortality. Am J Obstet Gynecol. 2020;222(3):e2511\u201325110.","journal-title":"Am J Obstet Gynecol"},{"key":"1375_CR2","doi-asserted-by":"crossref","unstructured":"Wang YX et al. Association of infertility with premature mortality among US women: prospective cohort study. Lancet Reg Health Am, 2022. 7.","DOI":"10.1016\/j.lana.2021.100122"},{"key":"1375_CR3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.maturitas.2019.10.011","volume":"131","author":"S Jaillard","year":"2020","unstructured":"Jaillard S, et al. Analysis of NR5A1 in 142 patients with premature ovarian insufficiency, diminished ovarian reserve, or unexplained infertility. Maturitas. 2020;131:78\u201386.","journal-title":"Maturitas"},{"issue":"6","key":"1375_CR4","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.fertnstert.2020.09.134","volume":"114","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2020","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Electronic address, A.a.o. And M. Practice committee of the American society for reproductive, testing And interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2020;114(6):1151\u20137.","journal-title":"Fertil Steril"},{"issue":"3","key":"1375_CR5","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.fertnstert.2015.05.017","volume":"104","author":"K Devine","year":"2015","unstructured":"Devine K, et al. Diminished ovarian reserve in the united States assisted reproductive technology population: diagnostic trends among 181,536 cycles from the society for assisted reproductive technology clinic outcomes reporting system. Fertil Steril. 2015;104(3):612\u201319. e3.","journal-title":"Fertil Steril"},{"issue":"4","key":"1375_CR6","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1080\/13697137.2019.1574738","volume":"22","author":"S Golezar","year":"2019","unstructured":"Golezar S, et al. The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis. Climacteric. 2019;22(4):403\u201311.","journal-title":"Climacteric"},{"issue":"11","key":"1375_CR7","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.tem.2018.07.002","volume":"29","author":"X Jiao","year":"2018","unstructured":"Jiao X, et al. Molecular genetics of premature ovarian insufficiency. Trends Endocrinol Metab. 2018;29(11):795\u2013807.","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"1375_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10815-017-1058-4","volume":"35","author":"LM Pastore","year":"2018","unstructured":"Pastore LM, et al. Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR. J Assist Reprod Genet. 2018;35(1):17\u201323.","journal-title":"J Assist Reprod Genet"},{"issue":"10","key":"1375_CR9","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1210\/mend-5-10-1405","volume":"5","author":"TA Camp","year":"1991","unstructured":"Camp TA, Rahal JO, Mayo KE. Cellular localization and hormonal regulation of follicle-stimulating hormone and luteinizing hormone receptor messenger RNAs in the rat ovary. Mol Endocrinol. 1991;5(10):1405\u201317.","journal-title":"Mol Endocrinol"},{"issue":"1\u20132","key":"1375_CR10","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mce.2007.06.007","volume":"276","author":"D Piersma","year":"2007","unstructured":"Piersma D, et al. Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer. Mol Cell Endocrinol. 2007;276(1\u20132):63\u201370.","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"1375_CR11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/FPC.0b013e3282f4e98c","volume":"18","author":"M Simoni","year":"2008","unstructured":"Simoni M, et al. Polymorphisms of the luteinizing hormone\/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility. Pharmacogenet Genomics. 2008;18(3):193\u2013200.","journal-title":"Pharmacogenet Genomics"},{"issue":"3","key":"1375_CR12","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1093\/humrep\/dev342","volume":"31","author":"I Lindgren","year":"2016","unstructured":"Lindgren I, et al. Combined assessment of polymorphisms in the LHCGR and FSHR genes predict chance of pregnancy after in vitro fertilization. Hum Reprod. 2016;31(3):672\u201383.","journal-title":"Hum Reprod"},{"issue":"5","key":"1375_CR13","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/humupd\/dmy019","volume":"24","author":"C Alviggi","year":"2018","unstructured":"Alviggi C, et al. Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis. Hum Reprod Update. 2018;24(5):599\u2013614.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"1375_CR14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.fertnstert.2022.06.011","volume":"118","author":"P Pirtea","year":"2022","unstructured":"Pirtea P, et al. Gonadotropin receptor polymorphisms (FSHR N680S and LHCGR N312S) are not predictive of clinical outcome and live birth in assisted reproductive technology. Fertil Steril. 2022;118(3):494\u2013503.","journal-title":"Fertil Steril"},{"issue":"1","key":"1375_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10815-018-1318-y","volume":"36","author":"I Lindgren","year":"2019","unstructured":"Lindgren I, et al. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization. J Assist Reprod Genet. 2019;36(1):29\u201338.","journal-title":"J Assist Reprod Genet"},{"issue":"3","key":"1375_CR16","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.rbmo.2021.06.016","volume":"43","author":"C Guo","year":"2021","unstructured":"Guo C, et al. Associations of FSHR and LHCGR gene variants with ovarian reserve and clinical pregnancy rates. Reprod Biomed Online. 2021;43(3):561\u20139.","journal-title":"Reprod Biomed Online"},{"issue":"D1","key":"1375_CR17","doi-asserted-by":"publisher","first-page":"D971","DOI":"10.1093\/nar\/gkz829","volume":"48","author":"Y Gao","year":"2020","unstructured":"Gao Y, et al. PGG.Han: the Han Chinese genome database and analysis platform. Nucleic Acids Res. 2020;48(D1):D971\u20136.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1375_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s13059-019-1838-5","volume":"20","author":"C Zhang","year":"2019","unstructured":"Zhang C, et al. PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations. Genome Biol. 2019;20(1):215.","journal-title":"Genome Biol"},{"issue":"5","key":"1375_CR19","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.fertnstert.2022.07.017","volume":"118","author":"A Rodriguez-Fuentes","year":"2022","unstructured":"Rodriguez-Fuentes A, et al. Volume-based follicular output rate improves prediction of the number of mature oocytes: a prospective comparative study. Fertil Steril. 2022;118(5):885\u201392.","journal-title":"Fertil Steril"},{"key":"1375_CR20","doi-asserted-by":"publisher","first-page":"973544","DOI":"10.3389\/fendo.2022.973544","volume":"13","author":"P Li","year":"2022","unstructured":"Li P, Chen Z. Association of follicle-to-oocyte index and clinical pregnancy in IVF treatment: A retrospective study of 4,323 fresh embryo transfer cycles. Front Endocrinol (Lausanne). 2022;13:973544.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1375_CR21","doi-asserted-by":"crossref","unstructured":"Carosso AR et al. Women in advanced reproductive age: are the follicular output rate, the Follicle-Oocyte index and the ovarian sensitivity index predictors of live birth in an IVF. Cycle? J Clin Med, 2022. 11(3).","DOI":"10.3390\/jcm11030859"},{"issue":"2","key":"1375_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.pharmthera.2008.07.005","volume":"120","author":"YX Tao","year":"2008","unstructured":"Tao YX. Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics. Pharmacol Ther. 2008;120(2):129\u201348.","journal-title":"Pharmacol Ther"},{"issue":"3","key":"1375_CR23","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.tem.2009.11.003","volume":"21","author":"PM Conn","year":"2010","unstructured":"Conn PM, Ulloa-Aguirre A. Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Trends Endocrinol Metab. 2010;21(3):190\u20137.","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"1375_CR24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13048-019-0595-0","volume":"12","author":"M Zhao","year":"2019","unstructured":"Zhao M, et al. A novel EIF4ENIF1 mutation associated with a diminished ovarian reserve and premature ovarian insufficiency identified by whole-exome sequencing. J Ovarian Res. 2019;12(1):119.","journal-title":"J Ovarian Res"},{"key":"1375_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ejogrb.2018.01.025","volume":"222","author":"AR G","year":"2018","unstructured":"G AR, et al. Role of Lh polymorphisms and r-hLh supplementation in GnRh agonist treated ART cycles: A cross sectional study. Eur J Obstet Gynecol Reprod Biol. 2018;222:119\u201325.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"15","key":"1375_CR26","first-page":"4757","volume":"22","author":"QQ Yin","year":"2018","unstructured":"Yin QQ, et al. Rs13405728 is associated with slow ovarian response in assisted reproductive technology. Eur Rev Med Pharmacol Sci. 2018;22(15):4757\u201361.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1375_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1477-7827-11-71","volume":"11","author":"TJ O\u2019Brien","year":"2013","unstructured":"O\u2019Brien TJ, et al. Association between the luteinizing hormone\/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. Reprod Biol Endocrinol. 2013;11:71.","journal-title":"Reprod Biol Endocrinol"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01375-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-025-01375-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01375-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T06:56:58Z","timestamp":1742021818000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-025-01375-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,15]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1375"],"URL":"https:\/\/doi.org\/10.1186\/s12958-025-01375-2","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,15]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China (TJ-IRB20211016). All participants provided written informed consent and all methods were carried out in accordance with the approved guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}