{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:40:05Z","timestamp":1773700805197,"version":"3.50.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Science Centre in Krakow, Poland","award":["Grant PRELUDIUM 2019\/35\/N\/NZ9\/00663"],"award-info":[{"award-number":["Grant PRELUDIUM 2019\/35\/N\/NZ9\/00663"]}]},{"name":"Institute of Animal Reproduction and Food Research, Polish Academy of Sciences","award":["17\/FBW\/2023"],"award-info":[{"award-number":["17\/FBW\/2023"]}]},{"name":"statutory funding from the University of Life Sciences in Poznan , Poland","award":["No. 506-511-09-00"],"award-info":[{"award-number":["No. 506-511-09-00"]}]},{"name":"statutory funding from the University of Life Sciences in Poznan , Poland","award":["No. 506-511-09-00"],"award-info":[{"award-number":["No. 506-511-09-00"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-025-01412-0","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:35:44Z","timestamp":1748230544000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner"],"prefix":"10.1186","volume":"23","author":[{"given":"Emilia","family":"Grz\u0119da","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Gutkowska-Kawka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Matuszewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Kila\u0144czyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika M.","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Dylewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna H.","family":"Sliwowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"1412_CR1","doi-asserted-by":"crossref","unstructured":"Puzuka A, Alksere B, Gailite L, Erenpreiss J. Idiopathic infertility as a feature of genome instability. Life (Basel). 2021;11(7):628.","DOI":"10.3390\/life11070628"},{"issue":"1","key":"1412_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12978-023-01578-z","volume":"20","author":"SN Biggs","year":"2023","unstructured":"Biggs SN, Kennedy J, Lewis SL, Hearps S, O\u2019Bryan MK, McLachlan R, et al. Lifestyle and environmental risk factors for unexplained male infertility: study protocol for Australian Male Infertility Exposure (AMIE), a case-control study. Reprod Health. 2023;20(1):32.","journal-title":"Reprod Health"},{"issue":"1","key":"1412_CR3","doi-asserted-by":"publisher","first-page":"18546","DOI":"10.1038\/s41598-019-54799-3","volume":"9","author":"MD Gomez-Elias","year":"2019","unstructured":"Gomez-Elias MD, Rainero Caceres TS, Giaccagli MM, Guazzone VA, Dalton GN, De Siervi A, et al. Association between high-fat diet feeding and male fertility in high reproductive performance mice. Sci Rep. 2019;9(1):18546.","journal-title":"Sci Rep"},{"key":"1412_CR4","doi-asserted-by":"crossref","unstructured":"Patel VN, Ginsburg KB, Etnyre E, Shun F, Loeb A, Krawetz SA, et al. Practice patterns for the treatment of idiopathic infertility: is there a role for advanced semen testing?. AME Med J. 2019;4:4.","DOI":"10.21037\/amj.2019.01.01"},{"key":"1412_CR5","unstructured":"Jurkowska K, Kratz EM, Sawicka E, Piwowar A. The impact of metalloestrogens on the physiology of male reproductive health as a current problem of the XXI century. J Physiol Pharmacol. 2019;70(3)."},{"issue":"1","key":"1412_CR6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.metabol.2013.09.001","volume":"63","author":"N Wang","year":"2014","unstructured":"Wang N, Luo LL, Xu JJ, Xu MY, Zhang XM, Zhou XL, et al. Obesity accelerates ovarian follicle development and follicle loss in rats. Metabolism. 2014;63(1):94\u2013103.","journal-title":"Metabolism"},{"key":"1412_CR7","doi-asserted-by":"crossref","unstructured":"Dicken SJ, Batterham RL. The role of diet quality in mediating the association between ultra-processed food intake, obesity and health-related outcomes: a review of prospective cohort studies. Nutrients. 2021;14(1):23.","DOI":"10.3390\/nu14010023"},{"key":"1412_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.arr.2016.10.005","volume":"39","author":"MP Mattson","year":"2017","unstructured":"Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46\u201358.","journal-title":"Ageing Res Rev"},{"key":"1412_CR9","doi-asserted-by":"crossref","unstructured":"Suvorov A. Population numbers and reproductive health. Endocrinol. 2021;162(11).","DOI":"10.1210\/endocr\/bqab154"},{"issue":"8","key":"1412_CR10","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1210\/en.2017-00371","volume":"158","author":"NM Hohos","year":"2017","unstructured":"Hohos NM, Skaznik-Wikiel ME. High-Fat Diet and Female Fertility. Endocrinology. 2017;158(8):2407\u201319.","journal-title":"Endocrinology"},{"key":"1412_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.cca.2020.05.039","volume":"508","author":"T Wasilewski","year":"2020","unstructured":"Wasilewski T, Lukaszewicz-Zajac M, Wasilewska J, Mroczko B. Biochemistry of infertility. Clin Chim Acta. 2020;508:185\u201390.","journal-title":"Clin Chim Acta"},{"key":"1412_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111208","volume":"527","author":"VP Chakravarthi","year":"2021","unstructured":"Chakravarthi VP, Ghosh S, Housami SM, Wang H, Roby KF, Wolfe MW, et al. ERbeta regulated ovarian kisspeptin plays an important role in oocyte maturation. Mol Cell Endocrinol. 2021;527: 111208.","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"1412_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s10815-016-0672-x","volume":"33","author":"Z Merhi","year":"2016","unstructured":"Merhi Z, Thornton K, Bonney E, Cipolla MJ, Charron MJ, Buyuk E. Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1. J Assist Reprod Genet. 2016;33(4):535\u201343.","journal-title":"J Assist Reprod Genet"},{"key":"1412_CR14","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3389\/fendo.2017.00365","volume":"8","author":"KL Hu","year":"2017","unstructured":"Hu KL, Zhao H, Chang HM, Yu Y, Qiao J. Kisspeptin\/Kisspeptin Receptor System in the Ovary. Front Endocrinol (Lausanne). 2017;8:365.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1412_CR15","doi-asserted-by":"crossref","unstructured":"Sharma A, Thaventhiran T, Minhas S, Dhillo WS, Jayasena CN. Kisspeptin and testicular function-is it necessary?. Int J Mol Sci. 2020;21(8):2958.","DOI":"10.3390\/ijms21082958"},{"key":"1412_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fendo.2018.00145","volume":"9","author":"M Dudek","year":"2018","unstructured":"Dudek M, Ziarniak K, Sliwowska JH. Kisspeptin and Metabolism: The Brain and Beyond. Front Endocrinol (Lausanne). 2018;9:145.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"1412_CR17","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/humupd\/dmg024","volume":"9","author":"R Pasquali","year":"2003","unstructured":"Pasquali R, Pelusi C, Genghini S, Cacciari M, Gambineri A. Obesity and reproductive disorders in women. Hum Reprod Update. 2003;9(4):359\u201372.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"1412_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12958-018-0336-z","volume":"16","author":"E Silvestris","year":"2018","unstructured":"Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):22.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"1412_CR19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.fertnstert.2004.03.056","volume":"82","author":"TK Jensen","year":"2004","unstructured":"Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82(4):863\u201370.","journal-title":"Fertil Steril"},{"issue":"7","key":"1412_CR20","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1016\/j.fertnstert.2009.01.100","volume":"93","author":"JE Chavarro","year":"2010","unstructured":"Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010;93(7):2222\u201331.","journal-title":"Fertil Steril"},{"issue":"5","key":"1412_CR21","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/j.fertnstert.2010.11.044","volume":"95","author":"HW Bakos","year":"2011","unstructured":"Bakos HW, Henshaw RC, Mitchell M, Lane M. Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril. 2011;95(5):1700\u20134.","journal-title":"Fertil Steril"},{"issue":"5","key":"1412_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/cen.12591","volume":"82","author":"VJ Stokes","year":"2015","unstructured":"Stokes VJ, Anderson RA, George JT. How does obesity affect fertility in men - and what are the treatment options? Clin Endocrinol (Oxf). 2015;82(5):633\u20138.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"1412_CR23","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s10815-017-0915-5","volume":"34","author":"YJ Lin","year":"2017","unstructured":"Lin YJ, Tsai CC, Huang LT, Sheen JM, Tiao MM, Yu HR, et al. Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock. J Assist Reprod Genet. 2017;34(6):817\u201326.","journal-title":"J Assist Reprod Genet"},{"key":"1412_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.physbeh.2013.05.029","volume":"119","author":"SC Sagae","year":"2013","unstructured":"Sagae SC, Lubaczeuski C, Zacharias P, Bonfleur ML, Franci CR, Sanvitto GL. Prevention of metabolic disorders and reproductive performance deficits by the blockade of Angiotensin II AT1 receptor in female rats fed with cafeteria diet. Physiol Behav. 2013;119:1\u20138.","journal-title":"Physiol Behav"},{"issue":"5","key":"1412_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151558","volume":"122","author":"J Matuszewska","year":"2020","unstructured":"Matuszewska J, Ziarniak K, Dudek M, Kolodziejski P, Pruszynska-Oszmalek E, Sliwowska JH. Effects of short-term exposure to high-fat diet on histology of male and female gonads in rats. Acta Histochem. 2020;122(5): 151558.","journal-title":"Acta Histochem"},{"issue":"5","key":"1412_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2021.151751","volume":"123","author":"K Ziarniak","year":"2021","unstructured":"Ziarniak K, Dudek M, Matuszewska J, Bijoch L, Skrzypski M, Celichowski J, et al. Two weeks of moderate intensity locomotor training increased corticosterone concentrations but did not alter the number of adropin-immunoreactive cells in the hippocampus of diabetic type 2 and control rats. Acta Histochem. 2021;123(5): 151751.","journal-title":"Acta Histochem"},{"issue":"5","key":"1412_CR27","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.rbmo.2015.08.004","volume":"31","author":"MV Bazzano","year":"2015","unstructured":"Bazzano MV, Torelli C, Pustovrh MC, Paz DA, Elia EM. Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets. Reprod Biomed Online. 2015;31(5):655\u201367.","journal-title":"Reprod Biomed Online"},{"key":"1412_CR28","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3389\/fphys.2017.00807","volume":"8","author":"CA Ibanez","year":"2017","unstructured":"Ibanez CA, Erthal RP, Ogo FM, Peres MNC, Vieira HR, Conejo C, et al. A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise. Front Physiol. 2017;8:807.","journal-title":"Front Physiol"},{"issue":"2","key":"1412_CR29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/aja.aja_67_18","volume":"21","author":"FA de Oliveira","year":"2019","unstructured":"de Oliveira FA, Costa WS, Sampaio FJ, Gregorio BM. Resveratrol attenuates metabolic sperm and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates. Asian J Androl. 2019;21(2):201\u20137.","journal-title":"Asian J Androl."},{"key":"1412_CR30","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1477-7827-9-32","volume":"9","author":"CD Fernandez","year":"2011","unstructured":"Fernandez CD, Bellentani FF, Fernandes GS, Perobelli JE, Favareto AP, Nascimento AF, et al. Diet-induced obesity in rats leads to a decrease in sperm motility. Reprod Biol Endocrinol. 2011;9:32.","journal-title":"Reprod Biol Endocrinol"},{"key":"1412_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.785674","volume":"13","author":"E Grzeda","year":"2022","unstructured":"Grzeda E, Matuszewska J, Ziarniak K, Gertig-Kolasa A, Krzysko-Pieczka I, Skowronska B, et al. Animal Foetal Models of Obesity and Diabetes - From Laboratory to Clinical Settings. Front Endocrinol (Lausanne). 2022;13: 785674.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"1412_CR32","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1177\/1933719116683809","volume":"24","author":"RA Galarza","year":"2017","unstructured":"Galarza RA, Rhon Calderon EA, Cortez AE, Faletti AG. Maternal Overweight Disrupts the Sexual Maturation of the Offspring. Reprod Sci. 2017;24(9):1284\u201392.","journal-title":"Reprod Sci"},{"key":"1412_CR33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jnutbio.2019.05.014","volume":"71","author":"RA Galarza","year":"2019","unstructured":"Galarza RA, Rhon-Calderon EA, Bizzozero M, Meneghini MA, Cortez AE, Lux-Lantos VA, et al. Impact of maternal overweight on the sexual maturity of male offspring in rats. J Nutr Biochem. 2019;71:27\u201334.","journal-title":"J Nutr Biochem"},{"issue":"4","key":"1412_CR34","first-page":"353","volume":"156","author":"Z Kalem","year":"2018","unstructured":"Kalem Z, Kalem MN, Anado E, Bakirarar B, Yilmaz C, Elmas C, et al. Maternal nutrition and reproductive functions of female and male offspring. Reproduction. 2018;156(4):353\u201364.","journal-title":"Reproduction"},{"issue":"5","key":"1412_CR35","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1093\/biolre\/ioad101","volume":"109","author":"J Matuszewska","year":"2023","unstructured":"Matuszewska J, Nowacka-Woszuk J, Radziejewska A, Grzeda E, Pruszynska-Oszmalek E, Dylewski L, et al. Maternal cafeteria diet influences kisspeptin (Kiss1), kisspeptin receptor(Gpr54), and sirtuin (Sirt1) genes, hormonal and metabolic profiles, and reproductive functions in rat offspring in a sex-specific mannerdagger. Biol Reprod. 2023;109(5):654\u201368.","journal-title":"Biol Reprod"},{"issue":"1","key":"1412_CR36","doi-asserted-by":"publisher","first-page":"18573","DOI":"10.1038\/s41598-021-97487-x","volume":"11","author":"J Matuszewska","year":"2021","unstructured":"Matuszewska J, Zalewski T, Klimaszyk A, Ziarniak K, Jurga S, Chmurzynska A, et al. Mothers\u2019 cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring. Sci Rep. 2021;11(1):18573.","journal-title":"Sci Rep"},{"issue":"4","key":"1412_CR37","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1095\/biolreprod65.4.1170","volume":"65","author":"H Chiarini-Garcia","year":"2001","unstructured":"Chiarini-Garcia H, Russell LD. High-resolution light microscopic characterization of mouse spermatogonia. Biol Reprod. 2001;65(4):1170\u20138.","journal-title":"Biol Reprod"},{"issue":"631\u2013637","key":"1412_CR38","first-page":"719","volume":"10","author":"J Oksanen","year":"2007","unstructured":"Oksanen J, Kindt R, Legendre P, O\u2019Hara B, Stevens MHH, Oksanen MJ, et al. The vegan package Community ecology package. 2007;10(631\u2013637):719.","journal-title":"The vegan package Community ecology package"},{"key":"1412_CR39","first-page":"595","volume":"1","author":"MW Beck","year":"2017","unstructured":"Beck MW. ggord: Ordination Plots with ggplot2. R package version. 2017;1:595.","journal-title":"R package version"},{"key":"1412_CR40","unstructured":"Team RC. RA language and environment for statistical computing, R Foundation for Statistical. Computing. 2020."},{"issue":"1","key":"1412_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v067.i01","volume":"67","author":"D Bates","year":"2015","unstructured":"Bates D, M\u00e4chler M, Bolker B, Walker S. Fitting Linear Mixed-Effects Models Using lme4. J Stat Softw. 2015;67(1):1\u201348.","journal-title":"J Stat Softw"},{"issue":"1","key":"1412_CR42","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12958-022-00966-7","volume":"20","author":"Z Yao","year":"2022","unstructured":"Yao Z, Lin M, Lin T, Gong X, Qin P, Li H, et al. The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats. Reprod Biol Endocrinol. 2022;20(1):100.","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"1412_CR43","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1095\/biolreprod.114.121962","volume":"91","author":"V Reame","year":"2014","unstructured":"Reame V, Pytlowanciv EZ, Ribeiro DL, Pissolato TF, Taboga SR, Goes RM, et al. Obesogenic environment by excess of dietary fats in different phases of development reduces spermatic efficiency of wistar rats at adulthood: correlations with metabolic status. Biol Reprod. 2014;91(6):151.","journal-title":"Biol Reprod"},{"issue":"10","key":"1412_CR44","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13637","volume":"51","author":"E Zambrano","year":"2021","unstructured":"Zambrano E, Nathanielsz PW, Rodriguez-Gonzalez GL. Developmental programming and ageing of male reproductive function. Eur J Clin Invest. 2021;51(10): e13637.","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"1412_CR45","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/ijo.2014.209","volume":"39","author":"GL Rodriguez-Gonzalez","year":"2015","unstructured":"Rodriguez-Gonzalez GL, Vega CC, Boeck L, Vazquez M, Bautista CJ, Reyes-Castro LA, et al. Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. Int J Obes (Lond). 2015;39(4):549\u201356.","journal-title":"Int J Obes (Lond)"},{"issue":"1","key":"1412_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12986-020-00517-0","volume":"18","author":"J Feng","year":"2021","unstructured":"Feng J, Xu R, Li Y, Zhou Q, Song G, Deng Y, et al. The effect of high-fat diet and exercise on KISS-1\/GPR54 expression in testis of growing rats. Nutr Metab (Lond). 2021;18(1):1.","journal-title":"Nutr Metab (Lond)"},{"issue":"5","key":"1412_CR47","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/humupd\/dmi020","volume":"11","author":"MK Skinner","year":"2005","unstructured":"Skinner MK. Regulation of primordial follicle assembly and development. Hum Reprod Update. 2005;11(5):461\u201371.","journal-title":"Hum Reprod Update"},{"issue":"18","key":"1412_CR48","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1080\/15384101.2016.1207835","volume":"15","author":"A Figueiredo","year":"2016","unstructured":"Figueiredo A, Fran\u00e7a L, Hess R, Costa G. Sertoli cells are capable of proliferation into adulthood in the transition region between the seminiferous tubules and the rete testis in Wistar rats. Cell Cycle. 2016;15(18):2486\u201396.","journal-title":"Cell Cycle"},{"key":"1412_CR49","doi-asserted-by":"crossref","unstructured":"Hess RA, Renato de Franca L. Spermatogenesis and cycle of the seminiferous epithelium. Adv Exp Med Biol. 2008;636:1\u201315.","DOI":"10.1007\/978-0-387-09597-4_1"},{"issue":"1","key":"1412_CR50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5603\/FHC.2011.0010","volume":"49","author":"A Kolasa","year":"2011","unstructured":"Kolasa A, Marchlewicz M, Wenda-Rozewicka L, Wiszniewska B. DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions. Folia Histochem Cytobiol. 2011;49(1):62\u201371.","journal-title":"Folia Histochem Cytobiol"},{"issue":"6 Pt 2","key":"1412_CR51","doi-asserted-by":"publisher","first-page":"e621","DOI":"10.1111\/j.1365-2605.2011.01209.x","volume":"34","author":"SA Auharek","year":"2011","unstructured":"Auharek SA, Avelar GF, Lara NL, Sharpe RM, Franca LR. Sertoli cell numbers and spermatogenic efficiency are increased in inducible nitric oxide synthase mutant mice. Int J Androl. 2011;34(6 Pt 2):e621\u20139.","journal-title":"Int J Androl"},{"key":"1412_CR52","first-page":"197","volume-title":"Male Reproduction: A Multidisciplinary Overview","author":"LR Fran\u00e7a","year":"1998","unstructured":"Fran\u00e7a LR. Russell, L.D. The Testis of Domestic Animals. In: Regadera J, Martinez-Garcia F, editors. Male Reproduction: A Multidisciplinary Overview. Madrid: Churchill Livingstone; 1998. p. 197\u2013219."},{"issue":"1","key":"1412_CR53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12958-019-0457-z","volume":"17","author":"Z Zhou","year":"2019","unstructured":"Zhou Z, Lin Q, Xu X, Illahi GS, Dong C, Wu X. Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin\/GPR54 system. Reprod Biol Endocrinol. 2019;17(1):13.","journal-title":"Reprod Biol Endocrinol"},{"key":"1412_CR54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/1477-7827-12-127","volume":"12","author":"Q Zhou","year":"2014","unstructured":"Zhou Q, Chen H, Yang S, Li Y, Wang B, Chen Y, et al. High-fat diet decreases the expression of Kiss1 mRNA and kisspeptin in the ovary, and increases ovulatory dysfunction in postpubertal female rats. Reprod Biol Endocrinol. 2014;12:127.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"1412_CR55","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1530\/EJE-17-0207","volume":"177","author":"TK Kallak","year":"2017","unstructured":"Kallak TK, Hellgren C, Skalkidou A, Sandelin-Francke L, Ubhayasekhera K, Bergquist J, et al. Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain. Eur J Endocrinol. 2017;177(4):379\u201388.","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1412_CR56","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1530\/REP-13-0037","volume":"146","author":"CM Christante","year":"2013","unstructured":"Christante CM, Taboga SR, Pinto-Fochi ME, Goes RM. Maternal obesity disturbs the postnatal development of gonocytes in the rat without impairment of testis structure at prepubertal age. Reproduction. 2013;146(6):549\u201358.","journal-title":"Reproduction"},{"issue":"1","key":"1412_CR57","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1053\/beem.2002.0177","volume":"16","author":"LC Alonso","year":"2002","unstructured":"Alonso LC, Rosenfield RL. Oestrogens and puberty. Best Pract Res Clin Endocrinol Metab. 2002;16(1):13\u201330.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"19","key":"1412_CR58","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1242\/dev.127.19.4277","volume":"127","author":"S Dupont","year":"2000","unstructured":"Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M. Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 2000;127(19):4277\u201391.","journal-title":"Development"},{"issue":"2","key":"1412_CR59","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1210\/endo-95-2-513","volume":"95","author":"RE Steele","year":"1974","unstructured":"Steele RE, Weisz J. Changes in sensitivity of the estradiol-LH feedback system with puberty in the female rat. Endocrinology. 1974;95(2):513\u201320.","journal-title":"Endocrinology"},{"issue":"2","key":"1412_CR60","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1161\/01.HYP.0000111833.82664.0c","volume":"43","author":"FL Wynne","year":"2004","unstructured":"Wynne FL, Payne JA, Cain AE, Reckelhoff JF, Khalil RA. Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats. Hypertension. 2004;43(2):405\u201312.","journal-title":"Hypertension"},{"key":"1412_CR61","doi-asserted-by":"crossref","unstructured":"Fuentes N, Silveyra, P. Estrogen receptor signaling mechanisms2019. 135\u201370 p.","DOI":"10.1016\/bs.apcsb.2019.01.001"},{"issue":"6","key":"1412_CR62","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3892\/etm.2020.9264","volume":"20","author":"S Yan","year":"2020","unstructured":"Yan S, Wang F, Shi Q. The effect of maternal high-fat-diet mediated oxidative stress on ovarian function in mice offspring. Exp Ther Med. 2020;20(6):135.","journal-title":"Exp Ther Med"},{"key":"1412_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2023.107294","volume":"255","author":"W Wei","year":"2023","unstructured":"Wei W, Qin F, Gao J, Chang J, Pan X, Jiang X, et al. The effect of maternal consumption of high-fat diet on ovarian development in offspring. Anim Reprod Sci. 2023;255: 107294.","journal-title":"Anim Reprod Sci"},{"key":"1412_CR64","doi-asserted-by":"crossref","unstructured":"Cinzori ME, Strakovsky RS. Effects of Elevated Maternal Adiposity on Offspring Reproductive Health: A Perspective From Epidemiologic Studies. J Endocr Soc. 2022;7(1):bvac163.","DOI":"10.1210\/jendso\/bvac163"},{"issue":"10","key":"1412_CR65","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13603","volume":"24","author":"T Muhammad","year":"2023","unstructured":"Muhammad T, Wan Y, Lv Y, Li H, Naushad W, Chan WY, et al. Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks. Obes Rev. 2023;24(10): e13603.","journal-title":"Obes Rev"},{"issue":"1","key":"1412_CR66","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12894-018-0360-5","volume":"18","author":"YF Jia","year":"2018","unstructured":"Jia YF, Feng Q, Ge ZY, Guo Y, Zhou F, Zhang KS, et al. Obesity impairs male fertility through long-term effects on spermatogenesis. BMC Urol. 2018;18(1):42.","journal-title":"BMC Urol"},{"issue":"3","key":"1412_CR67","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.101776","volume":"18","author":"M Amiri","year":"2020","unstructured":"Amiri M, Ramezani TF. Potential Adverse Effects of Female and Male Obesity on Fertility: A Narrative Review. Int J Endocrinol Metab. 2020;18(3): e101776.","journal-title":"Int J Endocrinol Metab"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01412-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-025-01412-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01412-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:04:05Z","timestamp":1748235845000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-025-01412-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1412"],"URL":"https:\/\/doi.org\/10.1186\/s12958-025-01412-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5699990\/v1","asserted-by":"object"}]},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"23 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiment was approved by the Local Ethics Committee for Experiments on Animals at\u00a0Poznan University of Life Sciences, Poland (no. 55\/2018).This study was supported by the National Science Centre in Krakow, Poland (Grant PRELUDIUM 2019\/35\/N\/NZ9\/00663 to JM), statutory funding from the University of Life Sciences in Poznan (No. 506\u2013511-09\u201300 to JHS), and the Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (17\/FBW\/2023 to MMK).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}