{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:24:57Z","timestamp":1790803497189,"version":"4.1.0"},"reference-count":365,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Natural Science Foundation of Liaoning Province","award":["2024-BSLH-322"],"award-info":[{"award-number":["2024-BSLH-322"]}]},{"name":"Basic Research Projects for Higher Educational Institutions in Liaoning Province","award":["JYTMS20230094"],"award-info":[{"award-number":["JYTMS20230094"]}]},{"name":"The 345 Talent Project of Shengjing Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-025-01454-4","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:45:11Z","timestamp":1758739511000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Systemic impacts of diabetes on spermatogenesis and intervention strategies: multilayered mechanism analysis and cutting-edge therapeutic approaches"],"prefix":"10.1186","volume":"23","author":[{"given":"Jinyue","family":"Rong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"1454_CR1","doi-asserted-by":"publisher","first-page":"m997","DOI":"10.1136\/bmj.m997","volume":"369","author":"Y Li","year":"2020","unstructured":"Li Y, et al. Prevalence of diabetes recorded in Mainland China using 2018 diagnostic criteria from the American diabetes association: National cross sectional study. BMJ. 2020;369:m997.","journal-title":"BMJ"},{"issue":"8003","key":"1454_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-024-07019-6","volume":"627","author":"K Suzuki","year":"2024","unstructured":"Suzuki K, et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. 2024;627(8003):347\u201357.","journal-title":"Nature"},{"issue":"Suppl 1","key":"1454_CR3","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.2337\/dc20-S002","volume":"43","author":"A American Diabetes","year":"2020","unstructured":"American Diabetes A. 2. Classification and diagnosis of diabetes: standards of medical care in Diabetes-2020. Diabetes Care. 2020;43(Suppl 1):S14\u201331.","journal-title":"Diabetes Care"},{"issue":"1","key":"1454_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2337\/dc19-0880","volume":"43","author":"M Battaglia","year":"2020","unstructured":"Battaglia M, et al. Introducing the endotype concept to address the challenge of disease heterogeneity in type 1 diabetes. Diabetes Care. 2020;43(1):5\u201312.","journal-title":"Diabetes Care"},{"issue":"11","key":"1454_CR5","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00125-021-05542-z","volume":"64","author":"MC Riddle","year":"2021","unstructured":"Riddle MC, et al. Consensus report: definition and interpretation of remission in type 2 diabetes. Diabetologia. 2021;64(11):2359\u201366.","journal-title":"Diabetologia"},{"key":"1454_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev-med-050219-034524","volume":"72","author":"A Balasubramanyam","year":"2021","unstructured":"Balasubramanyam A. Defining and classifying new subgroups of diabetes. Annu Rev Med. 2021;72:63\u201374.","journal-title":"Annu Rev Med"},{"issue":"1","key":"1454_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s10020-023-00771-x","volume":"30","author":"R Huang","year":"2024","unstructured":"Huang R, et al. Diabetes-induced male infertility: potential mechanisms and treatment options. Mol Med. 2024;30(1):11.","journal-title":"Mol Med"},{"issue":"6","key":"1454_CR8","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1111\/andr.12097","volume":"3","author":"S La Vignera","year":"2015","unstructured":"La Vignera S, et al. Reproductive function in male patients with type 1 diabetes mellitus. Andrology. 2015;3(6):1082\u20137.","journal-title":"Andrology"},{"key":"1454_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fendo.2018.00268","volume":"9","author":"RA Condorelli","year":"2018","unstructured":"Condorelli RA, et al. Diabetes mellitus and infertility: different pathophysiological effects in type 1 and type 2 on sperm function. Front Endocrinol (Lausanne). 2018;9:268.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"1454_CR10","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/andr.13681","volume":"13","author":"A Delbarba","year":"2025","unstructured":"Delbarba A, et al. Type 1 diabetes mellitus and sperm quality: A case-control study. Andrology. 2025;13(2):208\u201316.","journal-title":"Andrology"},{"key":"1454_CR11","doi-asserted-by":"crossref","unstructured":"Biasi A, et al. Impact of type 1 diabetes on testicular microtubule dynamics, sperm physiology, and male reproductive health in rat. Int J Mol Sci. 2025;26(10):4579.","DOI":"10.3390\/ijms26104579"},{"key":"1454_CR12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/ITT.S499605","volume":"14","author":"A Berbudi","year":"2025","unstructured":"Berbudi A, Khairani S, Tjahjadi AI. Interplay between insulin resistance and immune dysregulation in type 2 diabetes mellitus: implications for therapeutic interventions. Immunotargets Ther. 2025;14:359\u201382.","journal-title":"Immunotargets Ther"},{"issue":"1","key":"1454_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12933-025-02734-4","volume":"24","author":"S Delalat","year":"2025","unstructured":"Delalat S, et al. Dysregulated inflammation, oxidative stress, and protein quality control in diabetic hfpef: unraveling mechanisms and therapeutic targets. Cardiovasc Diabetol. 2025;24(1):211.","journal-title":"Cardiovasc Diabetol"},{"key":"1454_CR14","doi-asserted-by":"publisher","first-page":"1520835","DOI":"10.3389\/fendo.2025.1520835","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Fu X, Li H. Mechanisms of oxidative stress-induced sperm dysfunction. Front Endocrinol (Lausanne). 2025;16:1520835.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR15","doi-asserted-by":"crossref","unstructured":"DeFronzo RA, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:15019.","DOI":"10.1038\/nrdp.2015.19"},{"issue":"2","key":"1454_CR16","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s12020-024-03729-z","volume":"85","author":"M Zaimi","year":"2024","unstructured":"Zaimi M, et al. Gonadal dysfunction in women with diabetes mellitus. Endocrine. 2024;85(2):461\u201372.","journal-title":"Endocrine"},{"key":"1454_CR17","first-page":"R1-17","volume":"191(6)","author":"C Miller","year":"2024","unstructured":"Miller C, et al. Mechanisms in endocrinology: hypogonadism and metabolic health in men-novel insights into pathophysiology. Eur J Endocrinol. 2024;191(6):R1\u201317.","journal-title":"Eur J Endocrinol"},{"key":"1454_CR18","doi-asserted-by":"publisher","first-page":"821113","DOI":"10.3389\/fendo.2022.821113","volume":"13","author":"C Pelusi","year":"2022","unstructured":"Pelusi C. The effects of the new therapeutic treatments for diabetes mellitus on the male reproductive axis. Front Endocrinol (Lausanne). 2022;13:821113.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR19","doi-asserted-by":"crossref","unstructured":"Russo V, Chen R, Armamento-Villareal R. Hypogonadism, Type-2 diabetes mellitus, and bone health: A narrative review. Front Endocrinol. 2021;11:607240.","DOI":"10.3389\/fendo.2020.607240"},{"key":"1454_CR20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3389\/fendo.2019.00345","volume":"10","author":"R Pivonello","year":"2019","unstructured":"Pivonello R, et al. Metabolic disorders and male hypogonadotropic hypogonadism. Front Endocrinol (Lausanne). 2019;10:345.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR21","doi-asserted-by":"publisher","first-page":"1035338","DOI":"10.3389\/fendo.2022.1035338","volume":"13","author":"M Dai","year":"2022","unstructured":"Dai M, et al. Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study. Front Endocrinol (Lausanne). 2022;13:1035338.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1454_CR22","doi-asserted-by":"publisher","first-page":"e000497","DOI":"10.1136\/bmjdrc-2017-000497","volume":"7","author":"KF Mwila","year":"2019","unstructured":"Mwila KF, Bwembya PA, Jacobs C. Experiences and challenges of adults living with type 2 diabetes mellitus presenting at the university teaching hospital in lusaka, Zambia. BMJ Open Diabetes Res Care. 2019;7(1):e000497.","journal-title":"BMJ Open Diabetes Res Care"},{"key":"1454_CR23","doi-asserted-by":"crossref","unstructured":"Gualtieri R, et al. Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development. Antioxid (Basel). 2021;10(7):1025.","DOI":"10.3390\/antiox10071025"},{"issue":"1","key":"1454_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13098-021-00728-2","volume":"13","author":"O Zhong","year":"2021","unstructured":"Zhong O, et al. Association of diabetes and obesity with sperm parameters and testosterone levels: a meta-analysis. Diabetol Metab Syndr. 2021;13(1):109.","journal-title":"Diabetol Metab Syndr"},{"issue":"1","key":"1454_CR25","first-page":"53","volume":"11","author":"E Mangoli","year":"2013","unstructured":"Mangoli E, et al. Effects of experimentally-induced diabetes on sperm parameters and chromatin quality in mice. Iran J Reprod Med. 2013;11(1):53\u201360.","journal-title":"Iran J Reprod Med"},{"issue":"1","key":"1454_CR26","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/andr.12567","volume":"7","author":"VU Nna","year":"2019","unstructured":"Nna VU, et al. Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of Metformin. Andrology. 2019;7(1):110\u201323.","journal-title":"Andrology"},{"issue":"1","key":"1454_CR27","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s10020-024-00868-x","volume":"30","author":"Y Xiao","year":"2024","unstructured":"Xiao Y, et al. BRD7 facilitates ferroptosis via modulating clusterin promoter hypermethylation and suppressing AMPK signaling in diabetes-induced testicular damage. Mol Med. 2024;30(1):100.","journal-title":"Mol Med"},{"key":"1454_CR28","doi-asserted-by":"publisher","first-page":"1399256","DOI":"10.3389\/fendo.2024.1399256","volume":"15","author":"M Venditti","year":"2024","unstructured":"Venditti M, et al. Type 1 diabetes impairs the activity of rat testicular somatic and germ cells through NRF2\/NLRP3 pathway-mediated oxidative stress. Front Endocrinol (Lausanne). 2024;15:1399256.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR29","doi-asserted-by":"crossref","unstructured":"Delbarba A, et al. Type 1 diabetes mellitus and sperm quality: A case-control study. Andrology. 2025;13(2):208\u201316.","DOI":"10.1111\/andr.13681"},{"issue":"1","key":"1454_CR30","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2174\/157339908783502398","volume":"4","author":"S Amaral","year":"2008","unstructured":"Amaral S, Oliveira PJ, Ramalho-Santos J. Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev. 2008;4(1):46\u201354.","journal-title":"Curr Diabetes Rev"},{"key":"1454_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jri.2017.08.007","volume":"123","author":"X Lu","year":"2017","unstructured":"Lu X, et al. Effect of diabetes mellitus on the quality and cytokine content of human semen. J Reprod Immunol. 2017;123:1\u20132.","journal-title":"J Reprod Immunol"},{"issue":"6","key":"1454_CR32","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1080\/14647273.2023.2251679","volume":"26","author":"A Braham","year":"2023","unstructured":"Braham A, et al. Nuclear sperm integrity and ICSI prognosis in Tunisian patients with MMAF syndrome (multiple morphological abnormalities of the sperm flagella). Hum Fertil (Camb). 2023;26(6):1429\u201338.","journal-title":"Hum Fertil (Camb)"},{"issue":"1","key":"1454_CR33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ajhg.2021.11.022","volume":"109","author":"C Tan","year":"2022","unstructured":"Tan C, et al. Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice. Am J Hum Genet. 2022;109(1):157\u201371.","journal-title":"Am J Hum Genet"},{"issue":"6","key":"1454_CR34","doi-asserted-by":"publisher","first-page":"101477","DOI":"10.1016\/j.beem.2020.101477","volume":"34","author":"L Rodrigo","year":"2020","unstructured":"Rodrigo L. Sperm genetic abnormalities and their contribution to embryo aneuploidy & miscarriage. Best Pract Res Clin Endocrinol Metab. 2020;34(6):101477.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"1454_CR35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/andr.13342","volume":"11","author":"F Lotti","year":"2023","unstructured":"Lotti F, Maggi M. Effects of diabetes mellitus on sperm quality and fertility outcomes: clinical evidence. Andrology. 2023;11(2):399\u2013416.","journal-title":"Andrology"},{"key":"1454_CR36","doi-asserted-by":"publisher","first-page":"101303","DOI":"10.1016\/j.mam.2024.101303","volume":"99","author":"A Graziani","year":"2024","unstructured":"Graziani A, et al. Diabetes and male fertility disorders. Mol Aspects Med. 2024;99:101303.","journal-title":"Mol Aspects Med"},{"key":"1454_CR37","doi-asserted-by":"publisher","first-page":"662903","DOI":"10.3389\/fcell.2021.662903","volume":"9","author":"JY Hwang","year":"2021","unstructured":"Hwang JY, et al. Genetic defects in DNAH2 underlie male infertility with multiple morphological abnormalities of the sperm flagella in humans and mice. Front Cell Dev Biol. 2021;9:662903.","journal-title":"Front Cell Dev Biol"},{"key":"1454_CR38","doi-asserted-by":"publisher","first-page":"7468019","DOI":"10.1155\/2018\/7468019","volume":"2018","author":"W Zha","year":"2018","unstructured":"Zha W, et al. Curcumin attenuates testicular injury in rats with streptozotocin-induced diabetes. Biomed Res Int. 2018;2018:7468019.","journal-title":"Biomed Res Int"},{"key":"1454_CR39","doi-asserted-by":"publisher","first-page":"e381423","DOI":"10.1590\/acb381423","volume":"38","author":"V Toprak","year":"2023","unstructured":"Toprak V, et al. Histopathological examination of the protective effect of intense exercise in apoptotic germ cell damage due to diabetes. Acta Cir Bras. 2023;38:e381423.","journal-title":"Acta Cir Bras"},{"issue":"2","key":"1454_CR40","first-page":"123","volume":"21","author":"A Shokri","year":"2023","unstructured":"Shokri A, et al. Effects of Glibenclamide and Troxerutin on the sperm parameters and histopathological changes of testis in streptozotocin-induced diabetic male rats: an experimental study. Int J Reprod Biomed. 2023;21(2):123\u201338.","journal-title":"Int J Reprod Biomed"},{"issue":"1","key":"1454_CR41","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","volume":"22","author":"Y An","year":"2023","unstructured":"An Y, et al. The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol. 2023;22(1):237.","journal-title":"Cardiovasc Diabetol"},{"issue":"7","key":"1454_CR42","doi-asserted-by":"publisher","first-page":"e12882","DOI":"10.1111\/micc.12882","volume":"31","author":"X Zhao","year":"2024","unstructured":"Zhao X, et al. Different measures of hyperglycemia are negatively associated with skin microvascular flowmotion: the Maastricht study. Microcirculation. 2024;31(7):e12882.","journal-title":"Microcirculation"},{"issue":"21","key":"1454_CR43","doi-asserted-by":"publisher","first-page":"e2302682","DOI":"10.1002\/adhm.202302682","volume":"13","author":"U Nam","year":"2024","unstructured":"Nam U, et al. Investigation of the dysfunction caused by high glucose, advanced glycation end products, and Interleukin-1 beta and the effects of therapeutic agents on the microphysiological artery model. Adv Healthc Mater. 2024;13(21):e2302682.","journal-title":"Adv Healthc Mater"},{"key":"1454_CR44","doi-asserted-by":"crossref","unstructured":"Wagner IV, et al. Diabetes type 1 negatively influences Leydig cell function in rats, which is partially reversible by insulin treatment. Endocrinology. 2021;162(4):bqab017.","DOI":"10.1210\/endocr\/bqab017"},{"issue":"1","key":"1454_CR45","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.1038\/s41467-022-34990-3","volume":"13","author":"K Song","year":"2022","unstructured":"Song K, et al. Targeting APLN\/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nat Commun. 2022;13(1):7335.","journal-title":"Nat Commun"},{"key":"1454_CR46","doi-asserted-by":"crossref","unstructured":"Zhou Y, et al. Bone marrow mesenchymal stem Cell-Derived exosomes ameliorate Aging-Induced BTB impairment in Porcine testes by activating autophagy and inhibiting ROS\/NLRP3 inflammasomes via the ampk\/mtor signaling pathway. Antioxid (Basel). 2024;13(2):183.","DOI":"10.3390\/antiox13020183"},{"issue":"1","key":"1454_CR47","doi-asserted-by":"publisher","first-page":"14152","DOI":"10.1038\/s41598-023-41291-2","volume":"13","author":"W Zhang","year":"2023","unstructured":"Zhang W, et al. Switching from high-fat diet to normal diet ameliorate BTB integrity and improve fertility potential in obese male mice. Sci Rep. 2023;13(1):14152.","journal-title":"Sci Rep"},{"key":"1454_CR48","doi-asserted-by":"publisher","first-page":"1193150","DOI":"10.3389\/fendo.2023.1193150","volume":"14","author":"K Mehri","year":"2023","unstructured":"Mehri K, et al. The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview. Front Endocrinol (Lausanne). 2023;14:1193150.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"1454_CR49","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S2213-8587(24)00199-2","volume":"12","author":"NL De Silva","year":"2024","unstructured":"De Silva NL, et al. Male hypogonadism: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol. 2024;12(10):761\u201374.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"1454_CR50","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1080\/01443615.2020.1744114","volume":"41","author":"M Imani","year":"2021","unstructured":"Imani M, et al. Sperm parameters, DNA integrity, and Protamine expression in patients with type II diabetes mellitus. J Obstet Gynaecol. 2021;41(3):439\u201346.","journal-title":"J Obstet Gynaecol"},{"issue":"10","key":"1454_CR51","doi-asserted-by":"publisher","first-page":"e13938","DOI":"10.1111\/jfbc.13938","volume":"45","author":"EH Aksu","year":"2021","unstructured":"Aksu EH, Kandemir FM, K\u00fc\u00e7\u00fckler S. Ameliorative effect of hesperidin on streptozotocin-diabetes mellitus-induced testicular DNA damage and sperm quality degradation in Sprague-Dawley rats. J Food Biochem. 2021;45(10):e13938.","journal-title":"J Food Biochem"},{"issue":"1","key":"1454_CR52","doi-asserted-by":"publisher","first-page":"e23593","DOI":"10.1002\/jbt.23593","volume":"38","author":"SR Chilukoti","year":"2024","unstructured":"Chilukoti SR, Sahu C, Jena G. Protective role of Eugenol against diabetes-induced oxidative stress, DNA damage, and apoptosis in rat testes. J Biochem Mol Toxicol. 2024;38(1):e23593.","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"1454_CR53","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.molcel.2019.04.024","volume":"75","author":"E Fouquerel","year":"2019","unstructured":"Fouquerel E, et al. Targeted and persistent 8-Oxoguanine base damage at telomeres promotes telomere loss and crisis. Mol Cell. 2019;75(1):117\u2013e1306.","journal-title":"Mol Cell"},{"issue":"10","key":"1454_CR54","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.2337\/db07-1579","volume":"57","author":"S Simone","year":"2008","unstructured":"Simone S, et al. Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2\u2019-deoxyguanosine-DNA glycosylase. Diabetes. 2008;57(10):2626\u201336.","journal-title":"Diabetes"},{"issue":"1","key":"1454_CR55","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.fertnstert.2019.03.003","volume":"112","author":"DB McQueen","year":"2019","unstructured":"McQueen DB, Zhang J, Robins JC. Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril. 2019;112(1):54\u2013e603.","journal-title":"Fertil Steril"},{"key":"1454_CR56","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.intimp.2019.01.047","volume":"70","author":"Z Khosravi","year":"2019","unstructured":"Khosravi Z, et al. Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through Attenuation of apoptosis, oxidative stress, and inflammation. Int Immunopharmacol. 2019;70:37\u201346.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1454_CR57","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13072-018-0224-y","volume":"11","author":"S Wyck","year":"2018","unstructured":"Wyck S, et al. Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development. Epigenetics Chromatin. 2018;11(1):60.","journal-title":"Epigenetics Chromatin"},{"issue":"5","key":"1454_CR58","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.21873\/invivo.12531","volume":"35","author":"Z He","year":"2021","unstructured":"He Z, et al. Diabetes mellitus causes male reproductive dysfunction: A review of the evidence and mechanisms. Vivo. 2021;35(5):2503\u201311.","journal-title":"Vivo"},{"key":"1454_CR59","doi-asserted-by":"crossref","unstructured":"Maiorino M, et al. From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Invest. 2018;41(11):1249\u201358.","DOI":"10.1007\/s40618-018-0872-6"},{"key":"1454_CR60","doi-asserted-by":"publisher","first-page":"1368079","DOI":"10.3389\/fendo.2024.1368079","volume":"15","author":"D Dilixiati","year":"2024","unstructured":"Dilixiati D, et al. Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2024;15:1368079.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR61","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/B978-0-444-53480-4.00017-5","volume":"126","author":"V Tamas","year":"2014","unstructured":"Tamas V, Kempler P. Sexual dysfunction in diabetes. Handb Clin Neurol. 2014;126:223\u201332.","journal-title":"Handb Clin Neurol"},{"issue":"5","key":"1454_CR62","doi-asserted-by":"publisher","first-page":"155798832412774","DOI":"10.1177\/15579883241277423","volume":"18","author":"X Li","year":"2024","unstructured":"Li X, et al. Mechanisms of Xuefu Zhuyu Tang in the treatment of diabetic erectile dysfunction in rats through the regulation of vascular endothelial function by casr\/plc\/pkc and MEK\/ERK\/RSK pathways. Am J Mens Health. 2024;18(5):15579883241277423.","journal-title":"Am J Mens Health"},{"key":"1454_CR63","doi-asserted-by":"publisher","first-page":"118724","DOI":"10.1016\/j.lfs.2020.118724","volume":"264","author":"T Chen","year":"2021","unstructured":"Chen T, et al. SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway. Life Sci. 2021;264:118724.","journal-title":"Life Sci"},{"key":"1454_CR64","doi-asserted-by":"publisher","first-page":"1359255","DOI":"10.3389\/fendo.2024.1359255","volume":"15","author":"DR Yang","year":"2024","unstructured":"Yang DR, et al. Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications. Front Endocrinol (Lausanne). 2024;15:1359255.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"1454_CR65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ucl.2021.06.009","volume":"48","author":"SM MacDonald","year":"2021","unstructured":"MacDonald SM, Burnett AL. Physiology of erection and pathophysiology of erectile dysfunction. Urol Clin North Am. 2021;48(4):513\u201325.","journal-title":"Urol Clin North Am"},{"key":"1454_CR66","doi-asserted-by":"crossref","unstructured":"Ock J, et al. IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice. Andrology. 2023;11(2):358\u201371.","DOI":"10.1111\/andr.13234"},{"issue":"1","key":"1454_CR67","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","volume":"77","author":"E Barati","year":"2020","unstructured":"Barati E, Nikzad H, Karimian M. Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. Cell Mol Life Sci. 2020;77(1):93\u2013113.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1454_CR68","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ucl.2013.08.018","volume":"41","author":"E Phillips","year":"2014","unstructured":"Phillips E, Carpenter C, Oates RD. Ejaculatory dysfunction. Urol Clin North Am. 2014;41(1):115\u201328.","journal-title":"Urol Clin North Am"},{"key":"1454_CR69","doi-asserted-by":"crossref","unstructured":"Yavetz H, et al. Retrograde ejaculation. Hum Reprod. 1994;9(3):381\u20136.","DOI":"10.1093\/oxfordjournals.humrep.a138513"},{"issue":"3","key":"1454_CR70","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.sxmr.2017.12.005","volume":"6","author":"CM Forbes","year":"2018","unstructured":"Forbes CM, Flannigan R, Paduch DA. Perineal ultrasound: a review in the context of ejaculatory dysfunction. Sex Med Rev. 2018;6(3):419\u201328.","journal-title":"Sex Med Rev"},{"issue":"2","key":"1454_CR71","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/andr.13262","volume":"11","author":"A Desai","year":"2023","unstructured":"Desai A, et al. Understanding and treating ejaculatory dysfunction in men with diabetes mellitus. Andrology. 2023;11(2):379\u201398.","journal-title":"Andrology"},{"issue":"11","key":"1454_CR72","first-page":"e73415","volume":"16","author":"A Hussein Hamad","year":"2024","unstructured":"Hussein Hamad A. The psychological impact of diabetes as a risk factor for erectile dysfunction at the Layla Qasim center in Erbil City. Iraq Cureus. 2024;16(11):e73415.","journal-title":"Iraq Cureus"},{"issue":"1","key":"1454_CR73","doi-asserted-by":"publisher","first-page":"e14676","DOI":"10.1111\/dme.14676","volume":"39","author":"J Van Cauwenberghe","year":"2022","unstructured":"Van Cauwenberghe J, et al. Prevalence of and risk factors for sexual dysfunctions in adults with type 1 or type 2 diabetes: results from diabetes MILES - Flanders. Diabet Med. 2022;39(1):e14676.","journal-title":"Diabet Med"},{"key":"1454_CR74","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.2147\/NDT.S242798","volume":"16","author":"PL Chung","year":"2020","unstructured":"Chung PL, et al. Effect of depression and antidepressants on sexual dysfunction in men with diabetes: A National Population-Based cohort study. Neuropsychiatr Dis Treat. 2020;16:1105\u201312.","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"Suppl 1","key":"1454_CR75","doi-asserted-by":"publisher","first-page":"S228","DOI":"10.1016\/j.jcjd.2017.10.035","volume":"42","author":"R Bebb","year":"2018","unstructured":"Bebb R, Millar A, Brock G. Sexual dysfunction and hypogonadism in men with diabetes. Can J Diabetes. 2018;42(Suppl 1):S228\u201333.","journal-title":"Can J Diabetes"},{"issue":"1","key":"1454_CR76","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41398-025-03234-5","volume":"15","author":"G Fanelli","year":"2025","unstructured":"Fanelli G, et al. The interface of depression and diabetes: treatment considerations. Transl Psychiatry. 2025;15(1):22.","journal-title":"Transl Psychiatry"},{"issue":"4","key":"1454_CR77","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.ucl.2022.07.006","volume":"49","author":"LB Galansky","year":"2022","unstructured":"Galansky LB, Levy JA, Burnett AL. Testosterone and male sexual function. Urol Clin North Am. 2022;49(4):627\u201335.","journal-title":"Urol Clin North Am"},{"issue":"6","key":"1454_CR78","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s11154-022-09748-3","volume":"23","author":"G Corona","year":"2022","unstructured":"Corona G, Maggi M. The role of testosterone in male sexual function. Rev Endocr Metab Disord. 2022;23(6):1159\u201372.","journal-title":"Rev Endocr Metab Disord"},{"issue":"6","key":"1454_CR79","first-page":"509","volume":"25","author":"HL Li","year":"2019","unstructured":"Li HL, et al. [Correlation of male libido with the levels of serum reproductive hormones]. Zhonghua Nan Ke Xue. 2019;25(6):509\u201313.","journal-title":"Zhonghua Nan Ke Xue"},{"key":"1454_CR80","doi-asserted-by":"crossref","unstructured":"Kaltsas A. Oxidative stress and male infertility: the protective role of antioxidants. Med (Kaunas). 2023;59(10):1769.","DOI":"10.3390\/medicina59101769"},{"issue":"5","key":"1454_CR81","doi-asserted-by":"publisher","first-page":"109915","DOI":"10.1016\/j.celrep.2021.109915","volume":"37","author":"H Chen","year":"2021","unstructured":"Chen H, et al. Dissecting mammalian spermatogenesis using Spatial transcriptomics. Cell Rep. 2021;37(5):109915.","journal-title":"Cell Rep"},{"key":"1454_CR82","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ijbiomac.2019.08.129","volume":"140","author":"J Chen","year":"2019","unstructured":"Chen J. Effect of Okra polysaccharide on the spermatogenesis of KKAy mice. Int J Biol Macromol. 2019;140:98\u2013101.","journal-title":"Int J Biol Macromol"},{"key":"1454_CR83","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.coph.2014.10.010","volume":"19","author":"R Chamorro-Garc\u00eda","year":"2014","unstructured":"Chamorro-Garc\u00eda R, Blumberg B. Transgenerational effects of obesogens and the obesity epidemic. Curr Opin Pharmacol. 2014;19:153\u20138.","journal-title":"Curr Opin Pharmacol"},{"issue":"10","key":"1454_CR84","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1096\/fj.12-224048","volume":"27","author":"T Fullston","year":"2013","unstructured":"Fullston T, et al. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm MicroRNA content. Faseb J. 2013;27(10):4226\u201343.","journal-title":"Faseb J"},{"issue":"7","key":"1454_CR85","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/1753-0407.13403","volume":"15","author":"H Zhu","year":"2023","unstructured":"Zhu H, et al. Developmental origins of diabetes mellitus: environmental epigenomics and emerging patterns. J Diabetes. 2023;15(7):569\u201382.","journal-title":"J Diabetes"},{"key":"1454_CR86","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3389\/fgene.2019.00337","volume":"10","author":"C Dupont","year":"2019","unstructured":"Dupont C, et al. Role of MiRNA in the transmission of metabolic diseases associated with paternal Diet-Induced obesity. Front Genet. 2019;10:337.","journal-title":"Front Genet"},{"issue":"11","key":"1454_CR87","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/sj.ejhg.5200859","volume":"10","author":"G Kaati","year":"2002","unstructured":"Kaati G, Bygren LO, Edvinsson S. Cardiovascular and diabetes mortality determined by nutrition during parents\u2019 and grandparents\u2019 slow growth period. Eur J Hum Genet. 2002;10(11):682\u20138.","journal-title":"Eur J Hum Genet"},{"issue":"8","key":"1454_CR88","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.2337\/dc10-0664","volume":"33","author":"A Penesova","year":"2010","unstructured":"Penesova A, et al. Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring. Diabetes Care. 2010;33(8):1823\u20138.","journal-title":"Diabetes Care"},{"issue":"5","key":"1454_CR89","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1073\/pnas.1321195111","volume":"111","author":"Y Wei","year":"2014","unstructured":"Wei Y, et al. Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals. Proc Natl Acad Sci U S A. 2014;111(5):1873\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1454_CR90","doi-asserted-by":"publisher","first-page":"4940","DOI":"10.1038\/s41598-017-05286-0","volume":"7","author":"G Pavlinkova","year":"2017","unstructured":"Pavlinkova G, et al. Transgenerational inheritance of susceptibility to diabetes-induced male subfertility. Sci Rep. 2017;7(1):4940.","journal-title":"Sci Rep"},{"issue":"7","key":"1454_CR91","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s40618-023-02285-z","volume":"47","author":"M Longo","year":"2024","unstructured":"Longo M, et al. Semen quality and metabolic profile in people with type 1 diabetes with and without erectile dysfunction: a cross-sectional study. J Endocrinol Invest. 2024;47(7):1787\u201395.","journal-title":"J Endocrinol Invest"},{"key":"1454_CR92","doi-asserted-by":"publisher","first-page":"150610","DOI":"10.1016\/j.bbrc.2024.150610","volume":"734","author":"H Pacheco-Castillo","year":"2024","unstructured":"Pacheco-Castillo H, et al. Hyperglycemia adversely affects critical physiological events related to rat sperm capacitation. Biochem Biophys Res Commun. 2024;734:150610.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7318","key":"1454_CR93","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nature09491","volume":"467","author":"SF Ng","year":"2010","unstructured":"Ng SF, et al. Chronic high-fat diet in fathers programs \u03b2-cell dysfunction in female rat offspring. Nature. 2010;467(7318):963\u20136.","journal-title":"Nature"},{"issue":"9","key":"1454_CR94","doi-asserted-by":"publisher","first-page":"E805","DOI":"10.1152\/ajpendo.00013.2015","volume":"308","author":"NO McPherson","year":"2015","unstructured":"McPherson NO, et al. Preconception diet or exercise intervention in obese fathers normalizes sperm MicroRNA profile and metabolic syndrome in female offspring. Am J Physiol Endocrinol Metab. 2015;308(9):E805\u201321.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"1454_CR95","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13148-019-0659-4","volume":"11","author":"S Li","year":"2019","unstructured":"Li S, et al. Prenatal epigenetics diets play protective roles against environmental pollution. Clin Epigenetics. 2019;11(1):82.","journal-title":"Clin Epigenetics"},{"key":"1454_CR96","doi-asserted-by":"crossref","unstructured":"Pascoal GFL, et al. Effect of paternal diet on spermatogenesis and offspring health: focus on epigenetics and interventions with food bioactive compounds. Nutrients. 2022;14(10):2150.","DOI":"10.3390\/nu14102150"},{"issue":"5","key":"1454_CR97","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.dsx.2020.07.031","volume":"14","author":"S Barkabi-Zanjani","year":"2020","unstructured":"Barkabi-Zanjani S, et al. Diabetes mellitus and the impairment of male reproductive function: possible signaling pathways. Diabetes Metab Syndr. 2020;14(5):1307\u201314.","journal-title":"Diabetes Metab Syndr"},{"key":"1454_CR98","doi-asserted-by":"crossref","unstructured":"Zheng X, et al. Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes. Elife. 2022;11:e70714.","DOI":"10.7554\/eLife.70714"},{"key":"1454_CR99","doi-asserted-by":"publisher","first-page":"1076690","DOI":"10.3389\/fmed.2023.1076690","volume":"10","author":"A Farhan","year":"2023","unstructured":"Farhan A, et al. Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy. Front Med (Lausanne). 2023;10:1076690.","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"1454_CR100","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1139\/bcb-2022-0008","volume":"101","author":"N Qasim","year":"2023","unstructured":"Qasim N, Arif A, Mahmood R. Hyperglycemia enhances the generation of ROS and RNS that impair antioxidant power and cause oxidative damage in human erythrocytes. Biochem Cell Biol. 2023;101(1):64\u201376.","journal-title":"Biochem Cell Biol"},{"key":"1454_CR101","doi-asserted-by":"crossref","unstructured":"Black HS. A synopsis of the associations of oxidative stress, ROS, and antioxidants with diabetes mellitus. Antioxid (Basel). 2022;11(10):2003.","DOI":"10.3390\/antiox11102003"},{"key":"1454_CR102","doi-asserted-by":"crossref","unstructured":"Yang J, et al. Progress in Understanding oxidative stress, aging, and Aging-Related diseases. Antioxid (Basel). 2024;13(4):394.","DOI":"10.3390\/antiox13040394"},{"key":"1454_CR103","doi-asserted-by":"crossref","unstructured":"Chianese R, Pierantoni R. Mitochondrial reactive oxygen species (ROS) production alters sperm quality. Antioxid (Basel). 2021;10(1):92.","DOI":"10.3390\/antiox10010092"},{"issue":"1","key":"1454_CR104","doi-asserted-by":"publisher","first-page":"e12598","DOI":"10.1002\/rmb2.12598","volume":"23","author":"P Sengupta","year":"2024","unstructured":"Sengupta P, et al. Oxidative stress affects sperm health and fertility-Time to apply facts learned at the bench to help the patient: lessons for busy clinicians. Reprod Med Biol. 2024;23(1):e12598.","journal-title":"Reprod Med Biol"},{"key":"1454_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-031-12966-7_1","volume":"1391","author":"CJ Raj","year":"2022","unstructured":"Raj CJ, et al. Deciphering the nexus between oxidative stress and spermatogenesis: A compendious overview. Adv Exp Med Biol. 2022;1391:1\u201316.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"1454_CR106","doi-asserted-by":"publisher","first-page":"e13577","DOI":"10.1111\/and.13577","volume":"53","author":"S Baskaran","year":"2021","unstructured":"Baskaran S, et al. Reactive oxygen species in male reproduction: A Boon or a bane? Andrologia. 2021;53(1):e13577.","journal-title":"Andrologia"},{"key":"1454_CR107","doi-asserted-by":"crossref","unstructured":"De Luca MN, et al. Oxidative stress and male fertility: role of antioxidants and inositols. Antioxid (Basel). 2021;10(8):1283.","DOI":"10.3390\/antiox10081283"},{"issue":"1","key":"1454_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12958-022-01053-7","volume":"21","author":"J Liu","year":"2023","unstructured":"Liu J, et al. Double-edged sword: effects of human sperm reactive oxygen species on embryo development in IVF cycles. Reprod Biol Endocrinol. 2023;21(1):1.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"1454_CR109","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/2211-5463.13589","volume":"13","author":"J Jing","year":"2023","unstructured":"Jing J, et al. Obesity-induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality. FEBS Open Bio. 2023;13(4):763\u201378.","journal-title":"FEBS Open Bio"},{"key":"1454_CR110","doi-asserted-by":"crossref","unstructured":"Catal\u00e1n J, et al. Impact of seminal plasma antioxidants on DNA fragmentation and lipid peroxidation of Frozen-Thawed horse sperm. Antioxid (Basel). 2024;13(3):322.","DOI":"10.3390\/antiox13030322"},{"key":"1454_CR111","doi-asserted-by":"crossref","unstructured":"Kowalczyk P, et al. Mitochondrial oxidative Stress-A causative factor and therapeutic target in many diseases. Int J Mol Sci. 2021;22(24):13384.","DOI":"10.3390\/ijms222413384"},{"key":"1454_CR112","doi-asserted-by":"publisher","first-page":"102340","DOI":"10.1016\/j.redox.2022.102340","volume":"53","author":"H Xie","year":"2022","unstructured":"Xie H, et al. Electron transfer between cytochrome c and microsomal monooxygenase generates reactive oxygen species that accelerates apoptosis. Redox Biol. 2022;53:102340.","journal-title":"Redox Biol"},{"issue":"4","key":"1454_CR113","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41418-024-01284-8","volume":"31","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, et al. Diverse functions of cytochrome c in cell death and disease. Cell Death Differ. 2024;31(4):387\u2013404.","journal-title":"Cell Death Differ"},{"issue":"3","key":"1454_CR114","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s13668-024-00561-9","volume":"13","author":"S Bayram","year":"2024","unstructured":"Bayram S, K\u0131z\u0131ltan G. The role of Omega- 3 polyunsaturated fatty acids in diabetes mellitus management: A narrative review. Curr Nutr Rep. 2024;13(3):527\u201351.","journal-title":"Curr Nutr Rep"},{"issue":"1","key":"1454_CR115","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, et al. Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther. 2023;8(1):352.","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"1454_CR116","doi-asserted-by":"publisher","first-page":"484","DOI":"10.5534\/wjmh.190038","volume":"38","author":"KK Karna","year":"2020","unstructured":"Karna KK, et al. The role of Endoplasmic reticulum stress response in male reproductive physiology and pathology: A review. World J Mens Health. 2020;38(4):484\u201394.","journal-title":"World J Mens Health"},{"issue":"7","key":"1454_CR117","first-page":"437","volume":"25","author":"M Rahmani","year":"2023","unstructured":"Rahmani M, et al. Role of Endoplasmic reticulum stress in the male reproductive system. Cell J. 2023;25(7):437\u201346.","journal-title":"Cell J"},{"issue":"7","key":"1454_CR118","doi-asserted-by":"publisher","first-page":"e13382","DOI":"10.1111\/acel.13382","volume":"20","author":"Z Shi","year":"2021","unstructured":"Shi Z, et al. C\/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3\/ROS-induced cell apoptosis. Aging Cell. 2021;20(7):e13382.","journal-title":"Aging Cell"},{"key":"1454_CR119","doi-asserted-by":"crossref","unstructured":"Nadel G, et al. JNK Cascade-Induced Apoptosis-A unique role in GqPCR signaling. Int J Mol Sci. 2023;24(17):13527.","DOI":"10.3390\/ijms241713527"},{"key":"1454_CR120","doi-asserted-by":"publisher","first-page":"153193","DOI":"10.1016\/j.tox.2022.153193","volume":"473","author":"J Zhao","year":"2022","unstructured":"Zhao J, et al. Endoplasmic reticulum stress promotes blood-testis barrier impairment in mice with busulfan-induced oligospermia through PERK-eIF2\u03b1 signaling pathway. Toxicology. 2022;473:153193.","journal-title":"Toxicology"},{"issue":"6","key":"1454_CR121","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s40292-023-00611-3","volume":"30","author":"TF Roohi","year":"2023","unstructured":"Roohi TF, et al. Beyond glucose: the dual assault of oxidative and ER stress in diabetic disorders. High Blood Press Cardiovasc Prev. 2023;30(6):513\u201331.","journal-title":"High Blood Press Cardiovasc Prev"},{"key":"1454_CR122","doi-asserted-by":"crossref","unstructured":"Mustapha S, et al. Current status of Endoplasmic reticulum stress in type II diabetes. Molecules. 2021;26(14):4362.","DOI":"10.3390\/molecules26144362"},{"key":"1454_CR123","doi-asserted-by":"publisher","first-page":"105784","DOI":"10.1016\/j.tiv.2024.105784","volume":"96","author":"R Wang","year":"2024","unstructured":"Wang R, et al. PBA alleviates cadmium-induced mouse spermatogonia apoptosis by suppressing Endoplasmic reticulum stress. Toxicol Vitro. 2024;96:105784.","journal-title":"Toxicol Vitro"},{"key":"1454_CR124","doi-asserted-by":"publisher","first-page":"112718","DOI":"10.1016\/j.ecoenv.2021.112718","volume":"225","author":"Y Yang","year":"2021","unstructured":"Yang Y, et al. Nickel chloride induces spermatogenesis disorder by testicular damage and hypothalamic-pituitary-testis axis disruption in mice. Ecotoxicol Environ Saf. 2021;225:112718.","journal-title":"Ecotoxicol Environ Saf"},{"key":"1454_CR125","doi-asserted-by":"publisher","first-page":"115679","DOI":"10.1016\/j.ecoenv.2023.115679","volume":"268","author":"H Guo","year":"2023","unstructured":"Guo H, et al. Apoptosis and DNA damage mediated by ROS involved in male reproductive toxicity in mice induced by nickel. Ecotoxicol Environ Saf. 2023;268:115679.","journal-title":"Ecotoxicol Environ Saf"},{"key":"1454_CR126","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-3-030-77779-1_13","volume":"1288","author":"FTL Neto","year":"2021","unstructured":"Neto FTL, Flannigan R, Goldstein M. Regulation of human spermatogenesis. Adv Exp Med Biol. 2021;1288:255\u201386.","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"1454_CR127","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.fertnstert.2007.01.101","volume":"90","author":"H Aybek","year":"2008","unstructured":"Aybek H, et al. The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress. Fertil Steril. 2008;90(3):755\u201360.","journal-title":"Fertil Steril"},{"key":"1454_CR128","doi-asserted-by":"publisher","first-page":"852661","DOI":"10.3389\/fendo.2022.852661","volume":"13","author":"G Grande","year":"2022","unstructured":"Grande G, et al. The role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency. Front Endocrinol (Lausanne). 2022;13:852661.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR129","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","volume":"30","author":"LB Smith","year":"2014","unstructured":"Smith LB, Walker WH. The regulation of spermatogenesis by androgens. Semin Cell Dev Biol. 2014;30:2\u201313.","journal-title":"Semin Cell Dev Biol"},{"issue":"7","key":"1454_CR130","doi-asserted-by":"publisher","first-page":"109557","DOI":"10.1016\/j.celrep.2021.109557","volume":"36","author":"PS Cooke","year":"2021","unstructured":"Cooke PS, Walker WH. Male fertility in mice requires classical and nonclassical androgen signaling. Cell Rep. 2021;36(7):109557.","journal-title":"Cell Rep"},{"issue":"6","key":"1454_CR131","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1111\/andr.12705","volume":"8","author":"M Grossmann","year":"2020","unstructured":"Grossmann M, Ng Tang M, Fui, Cheung AS. Late-onset hypogonadism: metabolic impact. Andrology. 2020;8(6):1519\u201329.","journal-title":"Andrology"},{"issue":"21","key":"1454_CR132","doi-asserted-by":"publisher","first-page":"13498","DOI":"10.1073\/pnas.212474399","volume":"99","author":"S Yeh","year":"2002","unstructured":"Yeh S, et al. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A. 2002;99(21):13498\u2013503.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1454_CR133","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semcdb.2021.06.016","volume":"121","author":"L O\u2019Donnell","year":"2022","unstructured":"O\u2019Donnell L, Smith LB, Rebourcet D. Sertoli cells as key drivers of testis function. Semin Cell Dev Biol. 2022;121:2\u20139.","journal-title":"Semin Cell Dev Biol"},{"key":"1454_CR134","doi-asserted-by":"publisher","first-page":"838858","DOI":"10.3389\/fendo.2022.838858","volume":"13","author":"JM Wang","year":"2022","unstructured":"Wang JM, Li ZF, Yang WX. What does androgen receptor signaling pathway in Sertoli cells during normal spermatogenesis tell us?? Front Endocrinol (Lausanne). 2022;13:838858.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR135","doi-asserted-by":"publisher","first-page":"1458193","DOI":"10.3389\/fendo.2024.1458193","volume":"15","author":"Y Mei","year":"2024","unstructured":"Mei Y, et al. The relationship between remnant cholesterol and the risk of testosterone deficiency in US adults: a cross-sectional study based on the NHANES database. Front Endocrinol (Lausanne). 2024;15:1458193.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR136","doi-asserted-by":"crossref","unstructured":"Wittert G, Umapathysivam MM. Testosterone and the prevention of type 2 diabetes mellitus: therapeutic implications from recent trials. Curr Opin Endocrinol Diabetes Obes. 2024;31(6):243\u20138.","DOI":"10.1097\/MED.0000000000000884"},{"issue":"1","key":"1454_CR137","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12902-016-0109-7","volume":"16","author":"E Atlantis","year":"2016","unstructured":"Atlantis E, et al. Predictive value of serum testosterone for type 2 diabetes risk assessment in men. BMC Endocr Disord. 2016;16(1):26.","journal-title":"BMC Endocr Disord"},{"issue":"1","key":"1454_CR138","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S2213-8587(20)30367-3","volume":"9","author":"G Wittert","year":"2021","unstructured":"Wittert G, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021;9(1):32\u201345.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1454_CR139","doi-asserted-by":"crossref","unstructured":"Genchi V, et al. Adipose tissue dysfunction and Obesity-Related male hypogonadism. Int J Mol Sci. 2022;23(15):8194.","DOI":"10.3390\/ijms23158194"},{"issue":"7","key":"1454_CR140","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41443-022-00534-y","volume":"34","author":"K Khodamoradi","year":"2022","unstructured":"Khodamoradi K, et al. The role of leptin and low testosterone in obesity. Int J Impot Res. 2022;34(7):704\u201313.","journal-title":"Int J Impot Res"},{"issue":"1","key":"1454_CR141","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2337\/dc15-1518","volume":"39","author":"S Dhindsa","year":"2016","unstructured":"Dhindsa S, et al. Insulin resistance and inflammation in hypogonadotropic hypogonadism and their reduction after testosterone replacement in men with type 2 diabetes. Diabetes Care. 2016;39(1):82\u201391.","journal-title":"Diabetes Care"},{"issue":"11","key":"1454_CR142","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1111\/dom.14122","volume":"22","author":"KS Haider","year":"2020","unstructured":"Haider KS, et al. Remission of type 2 diabetes following long-term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11-year data from a real-world registry study. Diabetes Obes Metab. 2020;22(11):2055\u201368.","journal-title":"Diabetes Obes Metab"},{"issue":"11","key":"1454_CR143","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s13258-023-01444-z","volume":"45","author":"Y Hu","year":"2023","unstructured":"Hu Y, et al. VDR promotes testosterone synthesis in mouse Leydig cells via regulation of cholesterol side chain cleavage cytochrome P450 (Cyp11a1) expression. Genes Genomics. 2023;45(11):1377\u201387.","journal-title":"Genes Genomics"},{"issue":"3","key":"1454_CR144","doi-asserted-by":"publisher","first-page":"102447","DOI":"10.1016\/j.dsx.2022.102447","volume":"16","author":"M Concepcion-Zavaleta","year":"2022","unstructured":"Concepcion-Zavaleta M, et al. Assessment of hormonal status in male infertility. An update. Diabetes Metab Syndr. 2022;16(3):102447.","journal-title":"Diabetes Metab Syndr"},{"key":"1454_CR145","doi-asserted-by":"publisher","first-page":"1022989","DOI":"10.3389\/fendo.2022.1022989","volume":"13","author":"M Armandeh","year":"2022","unstructured":"Armandeh M, et al. A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies. Front Endocrinol (Lausanne). 2022;13:1022989.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"1454_CR146","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/dme.13977","volume":"37","author":"EJ Gianatti","year":"2020","unstructured":"Gianatti EJ, Grossmann M. Testosterone deficiency in men with type 2 diabetes: pathophysiology and treatment. Diabet Med. 2020;37(2):174\u201386.","journal-title":"Diabet Med"},{"issue":"4","key":"1454_CR147","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1093\/bjd\/ljae199","volume":"191","author":"SP Parraga","year":"2024","unstructured":"Parraga SP, Feldman SR. Insulin resistance and psoriasis. Br J Dermatol. 2024;191(4):486\u20137.","journal-title":"Br J Dermatol"},{"key":"1454_CR148","unstructured":"Freeman AM, Acevedo LA, Pennings N. Insulin resistance, in StatPearls. Treasure Island (FL); 2024."},{"issue":"6","key":"1454_CR149","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1016\/j.apsb.2021.12.023","volume":"12","author":"H Xiao","year":"2022","unstructured":"Xiao H, et al. Gentiopicroside targets PAQR3 to activate the PI3K\/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism. Acta Pharm Sin B. 2022;12(6):2887\u2013904.","journal-title":"Acta Pharm Sin B"},{"key":"1454_CR150","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.semcancer.2021.06.019","volume":"85","author":"L Yu","year":"2022","unstructured":"Yu L, Wei J, Liu P. Attacking the PI3K\/Akt\/mTOR signaling pathway for targeted therapeutic treatment in human cancer. Semin Cancer Biol. 2022;85:69\u201394.","journal-title":"Semin Cancer Biol"},{"issue":"7","key":"1454_CR151","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1007\/s43032-024-01507-w","volume":"31","author":"Z Darmishonnejad","year":"2024","unstructured":"Darmishonnejad Z, et al. Effect of advanced glycation end products (AGEs) on sperm parameters and function in C57Bl\/6 mice. Reprod Sci. 2024;31(7):2114\u201322.","journal-title":"Reprod Sci"},{"issue":"6","key":"1454_CR152","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/j.fertnstert.2023.10.017","volume":"120","author":"CA Service","year":"2023","unstructured":"Service CA, et al. The impact of obesity and metabolic health on male fertility: a systematic review. Fertil Steril. 2023;120(6):1098\u2013111.","journal-title":"Fertil Steril"},{"issue":"3","key":"1454_CR153","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000531766","volume":"97","author":"DD De Leon","year":"2024","unstructured":"De Leon DD, et al. International guidelines for the diagnosis and management of hyperinsulinism. Horm Res Paediatr. 2024;97(3):279\u201398.","journal-title":"Horm Res Paediatr"},{"issue":"11","key":"1454_CR154","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S2213-8587(21)00246-1","volume":"9","author":"B Van der Schueren","year":"2021","unstructured":"Van der Schueren B, et al. Obesity in people living with type 1 diabetes. Lancet Diabetes Endocrinol. 2021;9(11):776\u201385.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"1454_CR155","doi-asserted-by":"publisher","first-page":"151974","DOI":"10.1016\/j.acthis.2022.151974","volume":"125","author":"N Andlib","year":"2023","unstructured":"Andlib N, et al. Abnormalities in sex hormones and sexual dysfunction in males with diabetes mellitus: A mechanistic insight. Acta Histochem. 2023;125(1):151974.","journal-title":"Acta Histochem"},{"key":"1454_CR156","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-3-030-89340-8_11","volume":"1358","author":"K Leisegang","year":"2022","unstructured":"Leisegang K. Oxidative stress in men with obesity, metabolic syndrome and type 2 diabetes mellitus: mechanisms and management of reproductive dysfunction. Adv Exp Med Biol. 2022;1358:237\u201356.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"1454_CR157","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1080\/13813455.2020.1812665","volume":"129","author":"D Rahali","year":"2023","unstructured":"Rahali D, et al. Spermatogenesis and steroidogenesis disruption in a model of metabolic syndrome rats. Arch Physiol Biochem. 2023;129(1):222\u201332.","journal-title":"Arch Physiol Biochem"},{"key":"1454_CR158","doi-asserted-by":"crossref","unstructured":"Miller R, et al. TXNIP DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh epidemiology of diabetes complications (EDC) study. BMJ Open Diabetes Res Care. 2023;11(1):e003068.","DOI":"10.1136\/bmjdrc-2022-003068"},{"key":"1454_CR159","doi-asserted-by":"crossref","unstructured":"Papakonstantinou E, et al. Exosomal Epigenetics. EMBnet J. 2024;29:e1049.","DOI":"10.14806\/ej.29.0.1049"},{"key":"1454_CR160","doi-asserted-by":"crossref","unstructured":"Chen X, et al. Mapping epigenetic modifications by sequencing technologies. Cell Death Differ. 2023.","DOI":"10.1038\/s41418-023-01213-1"},{"issue":"3","key":"1454_CR161","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/humrep\/dead266","volume":"39","author":"E Caroppo","year":"2024","unstructured":"Caroppo E, Skinner MK. Could the sperm epigenome become a diagnostic tool for evaluation of the infertile man? Hum Reprod. 2024;39(3):478\u201385.","journal-title":"Hum Reprod"},{"issue":"8","key":"1454_CR162","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1111\/jipb.13155","volume":"63","author":"Z Feng","year":"2021","unstructured":"Feng Z, et al. Genetic analysis implicates a molecular chaperone complex in regulating epigenetic Silencing of methylated genomic regions. J Integr Plant Biol. 2021;63(8):1451\u201361.","journal-title":"J Integr Plant Biol"},{"issue":"10","key":"1454_CR163","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1007\/s10815-022-02618-6","volume":"39","author":"M Liu","year":"2022","unstructured":"Liu M, et al. Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index. J Assist Reprod Genet. 2022;39(10):2255\u201374.","journal-title":"J Assist Reprod Genet"},{"key":"1454_CR164","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s42399-018-0012-9","volume":"1","author":"N Laleethambika","year":"2018","unstructured":"Laleethambika N, et al. Diabetes and sperm DNA damage: efficacy of antioxidants. SN Compr Clin Med. 2018;1:49\u201359.","journal-title":"SN Compr Clin Med"},{"issue":"7","key":"1454_CR165","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s43032-024-01510-1","volume":"31","author":"F Karami Hezarcheshmeh","year":"2024","unstructured":"Karami Hezarcheshmeh F, et al. Methylation status of cAMP-responsive element modulator (CREM) gene in infertile men and its association with sperm parameters. Reprod Sci. 2024;31(7):2001\u20138.","journal-title":"Reprod Sci"},{"issue":"3","key":"1454_CR166","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/andr.12742","volume":"8","author":"KM Sujit","year":"2020","unstructured":"Sujit KM, et al. Increased DNA methylation in the spermatogenesis-associated (SPATA) genes correlates with infertility. Andrology. 2020;8(3):602\u20139.","journal-title":"Andrology"},{"issue":"4","key":"1454_CR167","first-page":"482","volume":"22","author":"A Rezaeian","year":"2021","unstructured":"Rezaeian A, Karimian M, Hossienzadeh Colagar A. Methylation status of MTHFR promoter and oligozoospermia risk: an epigenetic study and in Silico analysis. Cell J. 2021;22(4):482\u201390.","journal-title":"Cell J"},{"key":"1454_CR168","doi-asserted-by":"crossref","unstructured":"Wang F, et al. Dnmt3aa but not Dnmt3ab is required for maintenance of gametogenesis in nile tilapia (Oreochromis niloticus). Int J Mol Sci. 2021;22(18):10170.","DOI":"10.3390\/ijms221810170"},{"issue":"1","key":"1454_CR169","doi-asserted-by":"publisher","first-page":"e13586","DOI":"10.1111\/and.13586","volume":"53","author":"S Gunes","year":"2021","unstructured":"Gunes S, Esteves SC. Role of genetics and epigenetics in male infertility. Andrologia. 2021;53(1):e13586.","journal-title":"Andrologia"},{"issue":"7911","key":"1454_CR170","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41586-022-04756-4","volume":"605","author":"B Chen","year":"2022","unstructured":"Chen B, et al. Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency. Nature. 2022;605(7911):761\u20136.","journal-title":"Nature"},{"key":"1454_CR171","doi-asserted-by":"crossref","unstructured":"Haberman M, et al. Paternal high-fat diet affects weight and DNA methylation of their offspring. Sci Rep. 2024;14(1):19874.","DOI":"10.1038\/s41598-024-70438-y"},{"key":"1454_CR172","doi-asserted-by":"crossref","unstructured":"Henriques M, et al. Smoking induces a decline in semen quality and the activation of stress response pathways in sperm. Antioxid (Basel). 2023;12(10):1828.","DOI":"10.3390\/antiox12101828"},{"issue":"1","key":"1454_CR173","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41421-021-00343-5","volume":"7","author":"X Zheng","year":"2021","unstructured":"Zheng X, et al. Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming. Cell Discov. 2021;7(1):101.","journal-title":"Cell Discov"},{"issue":"1","key":"1454_CR174","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/humupd\/dmac033","volume":"29","author":"V Ashapkin","year":"2023","unstructured":"Ashapkin V, et al. Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development. Hum Reprod Update. 2023;29(1):24\u201344.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"1454_CR175","doi-asserted-by":"publisher","first-page":"19874","DOI":"10.1038\/s41598-024-70438-y","volume":"14","author":"M Haberman","year":"2024","unstructured":"Haberman M, et al. Paternal high-fat diet affects weight and DNA methylation of their offspring. Sci Rep. 2024;14(1):19874.","journal-title":"Sci Rep"},{"key":"1454_CR176","doi-asserted-by":"crossref","unstructured":"Hong S, et al. Comparative analysis of the testes from wild-type and Alkbh5-knockout mice using single-cell RNA sequencing. Volume 3. G; 2022. Bethesda.","DOI":"10.1093\/g3journal\/jkac130"},{"key":"1454_CR177","doi-asserted-by":"crossref","unstructured":"Wang X, et al. Single-Cell RNA sequencing reveals atlas of Yak testis cells. Int J Mol Sci. 2023;24(9):7982.","DOI":"10.3390\/ijms24097982"},{"issue":"1","key":"1454_CR178","doi-asserted-by":"publisher","first-page":"2339220","DOI":"10.1080\/19491034.2024.2339220","volume":"15","author":"M Kitaoka","year":"2024","unstructured":"Kitaoka M, Yamashita YM. Running the gauntlet: challenges to genome integrity in spermiogenesis. Nucleus. 2024;15(1):2339220.","journal-title":"Nucleus"},{"issue":"14","key":"1454_CR179","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1021\/acs.jpcb.3c06116","volume":"128","author":"E Oikeh","year":"2024","unstructured":"Oikeh E, et al. Packaging and polycation length determine DNA susceptibility to free radical damage in condensed DNA. J Phys Chem B. 2024;128(14):3329\u201339.","journal-title":"J Phys Chem B"},{"issue":"7621","key":"1454_CR180","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nature19361","volume":"537","author":"B Zhang","year":"2016","unstructured":"Zhang B, et al. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature. 2016;537(7621):553\u20137.","journal-title":"Nature"},{"issue":"1","key":"1454_CR181","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbamcr.2018.07.016","volume":"1866","author":"RS Gil","year":"2019","unstructured":"Gil RS, Vagnarelli P. Protein phosphatases in chromatin structure and function. Biochim Biophys Acta Mol Cell Res. 2019;1866(1):90\u2013101.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"12","key":"1454_CR182","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.2337\/db18-0124","volume":"67","author":"TA Alghamdi","year":"2018","unstructured":"Alghamdi TA, et al. Histone H3 Serine 10 phosphorylation facilitates endothelial activation in diabetic kidney disease. Diabetes. 2018;67(12):2668\u201381.","journal-title":"Diabetes"},{"key":"1454_CR183","doi-asserted-by":"publisher","first-page":"107545","DOI":"10.1016\/j.intimp.2021.107545","volume":"95","author":"X Li","year":"2021","unstructured":"Li X, et al. Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: involvement of SIRT1-mTOR\/NF-kappaB signaling pathway. Int Immunopharmacol. 2021;95:107545.","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"1454_CR184","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1093\/bfgp\/ell028","volume":"5","author":"L Verdone","year":"2006","unstructured":"Verdone L, et al. Histone acetylation in gene regulation. Brief Funct Genomic Proteomic. 2006;5(3):209\u201321.","journal-title":"Brief Funct Genomic Proteomic"},{"issue":"4","key":"1454_CR185","doi-asserted-by":"publisher","first-page":"731","DOI":"10.4049\/jimmunol.2100928","volume":"209","author":"S Kochumon","year":"2022","unstructured":"Kochumon S, et al. Palmitate potentiates Lipopolysaccharide-Induced IL-6 production via coordinated acetylation of H3K9\/H3K18, p300, and RNA polymerase II. J Immunol. 2022;209(4):731\u201341.","journal-title":"J Immunol"},{"issue":"5","key":"1454_CR186","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","volume":"23","author":"M Shvedunova","year":"2022","unstructured":"Shvedunova M, Akhtar A. Modulation of cellular processes by histone and non-histone protein acetylation. Nat Rev Mol Cell Biol. 2022;23(5):329\u201349.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5\u20136","key":"1454_CR187","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000519237","volume":"15","author":"M Burgos","year":"2021","unstructured":"Burgos M, et al. Non-Coding rnas: lncrnas, mirnas, and PiRNAs in sexual development. Sex Dev. 2021;15(5\u20136):335\u201350.","journal-title":"Sex Dev"},{"issue":"2","key":"1454_CR188","doi-asserted-by":"publisher","first-page":"102162","DOI":"10.1016\/j.omtn.2024.102162","volume":"35","author":"A Yildiz","year":"2024","unstructured":"Yildiz A, et al. Trans-amplifying RNA expressing functional MiRNA mediates target gene suppression and simultaneous transgene expression. Mol Ther Nucleic Acids. 2024;35(2):102162.","journal-title":"Mol Ther Nucleic Acids"},{"key":"1454_CR189","doi-asserted-by":"publisher","first-page":"777510","DOI":"10.3389\/fgene.2021.777510","volume":"12","author":"C He","year":"2021","unstructured":"He C, et al. Roles of noncoding RNA in reproduction. Front Genet. 2021;12:777510.","journal-title":"Front Genet"},{"issue":"1","key":"1454_CR190","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41392-021-00805-y","volume":"6","author":"Y Wang","year":"2021","unstructured":"Wang Y, et al. Natural killer cell-derived Exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes. Signal Transduct Target Ther. 2021;6(1):409.","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"1454_CR191","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1055\/s-0044-1779726","volume":"41","author":"O Olotu","year":"2023","unstructured":"Olotu O, Ahmedani A, Kotaja N. Small Non-Coding RNAs in male reproduction. Semin Reprod Med. 2023;41(6):213\u201325.","journal-title":"Semin Reprod Med"},{"issue":"1","key":"1454_CR192","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/19396368.2024.2364742","volume":"70","author":"N Werry","year":"2024","unstructured":"Werry N, et al. PiRNA expression patterns in high vs. low fertility bovine sperm. Syst Biol Reprod Med. 2024;70(1):183\u201394.","journal-title":"Syst Biol Reprod Med"},{"issue":"1","key":"1454_CR193","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1038\/s41467-023-37820-2","volume":"14","author":"A Lismer","year":"2023","unstructured":"Lismer A, Kimmins S. Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development. Nat Commun. 2023;14(1):2142.","journal-title":"Nat Commun"},{"key":"1454_CR194","doi-asserted-by":"crossref","unstructured":"Xu X et al. Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases. Int J Genomics, 2021. 2021: p. 6632719.","DOI":"10.1155\/2021\/6632719"},{"key":"1454_CR195","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fcell.2018.00050","volume":"6","author":"A Champroux","year":"2018","unstructured":"Champroux A, et al. A decade of exploring the mammalian sperm epigenome: paternal epigenetic and transgenerational inheritance. Front Cell Dev Biol. 2018;6:50.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"1454_CR196","doi-asserted-by":"publisher","first-page":"13074","DOI":"10.1038\/s41598-019-49600-4","volume":"9","author":"CC Maresch","year":"2019","unstructured":"Maresch CC, et al. Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis. Sci Rep. 2019;9(1):13074.","journal-title":"Sci Rep"},{"issue":"1","key":"1454_CR197","first-page":"3","volume":"27","author":"A Minas","year":"2024","unstructured":"Minas A, et al. Effects of diabetes-induced hyperglycemia on epigenetic modifications and DNA packaging and methylation during spermatogenesis; A narrative review. Iran J Basic Med Sci. 2024;27(1):3\u201311.","journal-title":"Iran J Basic Med Sci"},{"issue":"5\u20136","key":"1454_CR198","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00335-020-09839-z","volume":"31","author":"D Kaspar","year":"2020","unstructured":"Kaspar D, et al. Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations. Mamm Genome. 2020;31(5\u20136):119\u201333.","journal-title":"Mamm Genome"},{"key":"1454_CR199","doi-asserted-by":"crossref","unstructured":"Arroyo M, et al. tRNA biology in the pathogenesis of diabetes: role of genetic and environmental factors. Int J Mol Sci. 2021;22(2):496.","DOI":"10.3390\/ijms22020496"},{"issue":"2","key":"1454_CR200","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cmet.2015.11.004","volume":"23","author":"I Donkin","year":"2016","unstructured":"Donkin I, et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab. 2016;23(2):369\u201378.","journal-title":"Cell Metab"},{"key":"1454_CR201","doi-asserted-by":"publisher","first-page":"18193","DOI":"10.1038\/srep18193","volume":"5","author":"V Grandjean","year":"2015","unstructured":"Grandjean V, et al. RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders. Sci Rep. 2015;5:18193.","journal-title":"Sci Rep"},{"key":"1454_CR202","doi-asserted-by":"crossref","unstructured":"McPherson N, et al. An Exercise-Only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and MicroRNA expression in male offspring. Nutrients. 2017;9(2):122.","DOI":"10.3390\/nu9020122"},{"issue":"1","key":"1454_CR203","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1159\/000513370","volume":"14","author":"L Irakoze","year":"2021","unstructured":"Irakoze L, et al. Metabolic syndrome in offspring of parents with metabolic syndrome: A Meta-Analysis. Obes Facts. 2021;14(1):148\u201362.","journal-title":"Obes Facts"},{"issue":"12","key":"1454_CR204","doi-asserted-by":"publisher","first-page":"e0244826","DOI":"10.1371\/journal.pone.0244826","volume":"15","author":"C Eberle","year":"2020","unstructured":"Eberle C, et al. Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review. PLoS ONE. 2020;15(12):e0244826.","journal-title":"PLoS ONE"},{"issue":"1","key":"1454_CR205","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13148-025-01815-1","volume":"17","author":"A Akhatova","year":"2025","unstructured":"Akhatova A, et al. How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health. Clin Epigenetics. 2025;17(1):7.","journal-title":"Clin Epigenetics"},{"issue":"6271","key":"1454_CR206","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1126\/science.aad7977","volume":"351","author":"Q Chen","year":"2016","unstructured":"Chen Q, et al. Sperm TsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 2016;351(6271):397\u2013400.","journal-title":"Science"},{"issue":"8","key":"1454_CR207","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41585-024-00866-y","volume":"21","author":"DF Carrageta","year":"2024","unstructured":"Carrageta DF, et al. Signatures of metabolic diseases on spermatogenesis and testicular metabolism. Nat Rev Urol. 2024;21(8):477\u201394.","journal-title":"Nat Rev Urol"},{"key":"1454_CR208","doi-asserted-by":"crossref","unstructured":"Laleethambika N, et al. Diabetes and sperm DNA damage: efficacy of antioxidants. SN Compr Clin Med. 2019;1(1):49\u201359.","DOI":"10.1007\/s42399-018-0012-9"},{"issue":"6","key":"1454_CR209","doi-asserted-by":"publisher","first-page":"948","DOI":"10.4103\/1008-682X.150844","volume":"17","author":"GL Ding","year":"2015","unstructured":"Ding GL, et al. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015;17(6):948\u201353.","journal-title":"Asian J Androl"},{"key":"1454_CR210","doi-asserted-by":"publisher","first-page":"117830","DOI":"10.1016\/j.lfs.2020.117830","volume":"255","author":"JL Zhu","year":"2020","unstructured":"Zhu JL, et al. The role of advanced glycation end products in human infertility. Life Sci. 2020;255:117830.","journal-title":"Life Sci"},{"key":"1454_CR211","doi-asserted-by":"publisher","first-page":"1256963","DOI":"10.3389\/fmolb.2023.1256963","volume":"10","author":"I Naletova","year":"2023","unstructured":"Naletova I, et al. The role of sperm-specific glyceraldehyde-3-phosphate dehydrogenase in the development of pathologies-from asthenozoospermia to carcinogenesis. Front Mol Biosci. 2023;10:1256963.","journal-title":"Front Mol Biosci"},{"issue":"1","key":"1454_CR212","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00018-023-05094-y","volume":"81","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, et al. Lactic acid promotes nucleus pulposus cell senescence and corresponding intervertebral disc degeneration via interacting with Akt. Cell Mol Life Sci. 2024;81(1):24.","journal-title":"Cell Mol Life Sci"},{"key":"1454_CR213","doi-asserted-by":"publisher","first-page":"106805","DOI":"10.1016\/j.anireprosci.2021.106805","volume":"246","author":"FJ Pena","year":"2022","unstructured":"Pena FJ, et al. An integrated overview on the regulation of sperm metabolism (glycolysis-Krebs cycle-oxidative phosphorylation). Anim Reprod Sci. 2022;246:106805.","journal-title":"Anim Reprod Sci"},{"issue":"1","key":"1454_CR214","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41598-024-51224-2","volume":"14","author":"Z Jin","year":"2024","unstructured":"Jin Z, et al. Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis. Sci Rep. 2024;14(1):641.","journal-title":"Sci Rep"},{"key":"1454_CR215","doi-asserted-by":"publisher","first-page":"102380","DOI":"10.1016\/j.redox.2022.102380","volume":"54","author":"X Ge","year":"2022","unstructured":"Ge X, et al. Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress. Redox Biol. 2022;54:102380.","journal-title":"Redox Biol"},{"issue":"1","key":"1454_CR216","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12958-022-01031-z","volume":"20","author":"Y Li","year":"2022","unstructured":"Li Y, et al. Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice. Reprod Biol Endocrinol. 2022;20(1):161.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"1454_CR217","doi-asserted-by":"publisher","first-page":"100543","DOI":"10.1016\/j.repbio.2021.100543","volume":"21","author":"F Olia Bagheri","year":"2021","unstructured":"Olia Bagheri F, et al. Role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the regulation of fatty acid metabolism related gene expressions in testis of men with impaired spermatogenesis. Reprod Biol. 2021;21(4):100543.","journal-title":"Reprod Biol"},{"key":"1454_CR218","doi-asserted-by":"crossref","unstructured":"Collodel G, et al. Oxidation of polyunsaturated fatty acids as a promising area of research in infertility. Antioxid (Basel). 2022;11(5):1002.","DOI":"10.3390\/antiox11051002"},{"key":"1454_CR219","doi-asserted-by":"crossref","unstructured":"Bravo A, et al. Exogenous oxidative stress in human spermatozoa induces opening of the mitochondrial permeability transition pore: effect on mitochondrial function, sperm motility and induction of cell death. Antioxid (Basel). 2024;13(6):739.","DOI":"10.3390\/antiox13060739"},{"issue":"3","key":"1454_CR220","doi-asserted-by":"publisher","first-page":"109025","DOI":"10.1016\/j.celrep.2021.109025","volume":"35","author":"W Kuang","year":"2021","unstructured":"Kuang W, et al. SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility. Cell Rep. 2021;35(3):109025.","journal-title":"Cell Rep"},{"key":"1454_CR221","doi-asserted-by":"crossref","unstructured":"Holecek M. Role of impaired Glycolysis in perturbations of amino acid metabolism in diabetes mellitus. Int J Mol Sci. 2023;24(2):1724.","DOI":"10.3390\/ijms24021724"},{"key":"1454_CR222","doi-asserted-by":"crossref","unstructured":"Cuomo P, et al. Role of Branched-Chain amino acid metabolism in type 2 diabetes, obesity, cardiovascular disease and Non-Alcoholic fatty liver disease. Int J Mol Sci. 2022;23(8):4325.","DOI":"10.3390\/ijms23084325"},{"key":"1454_CR223","doi-asserted-by":"crossref","unstructured":"Holecek M. Why are Branched-Chain amino acids increased in starvation and diabetes? Nutrients. 2020;12(10):3087.","DOI":"10.3390\/nu12103087"},{"issue":"4","key":"1454_CR224","doi-asserted-by":"publisher","first-page":"237","DOI":"10.15430\/JCP.2021.26.4.237","volume":"26","author":"MK Jung","year":"2021","unstructured":"Jung MK, et al. Role of Branched-chain amino acid metabolism in tumor development and progression. J Cancer Prev. 2021;26(4):237\u201343.","journal-title":"J Cancer Prev"},{"key":"1454_CR225","doi-asserted-by":"crossref","unstructured":"Deng X et al. Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition. Metabolism, 2024: p. 156037.","DOI":"10.1016\/j.metabol.2024.156037"},{"key":"1454_CR226","doi-asserted-by":"crossref","unstructured":"Xu R et al. Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress. Oxid Med Cell Longev, 2023. 2023: p. 4365895.","DOI":"10.1155\/2023\/4365895"},{"issue":"2","key":"1454_CR227","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/humupd\/dmab043","volume":"28","author":"M Wang","year":"2022","unstructured":"Wang M, et al. Autophagy: a multifaceted player in the fate of sperm. Hum Reprod Update. 2022;28(2):200\u201331.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"1454_CR228","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12958-022-00890-w","volume":"20","author":"JY Wang","year":"2022","unstructured":"Wang JY, et al. Effect of spermidine on ameliorating spermatogenic disorders in diabetic mice via regulating Glycolysis pathway. Reprod Biol Endocrinol. 2022;20(1):45.","journal-title":"Reprod Biol Endocrinol"},{"key":"1454_CR229","doi-asserted-by":"publisher","first-page":"113108","DOI":"10.1016\/j.biopha.2022.113108","volume":"151","author":"B Dong","year":"2022","unstructured":"Dong B, et al. Quercetin ameliorates oxidative stress\u2013induced cell apoptosis of seminal vesicles via activating Nrf2 in type 1 diabetic rats. Biomed Pharmacother. 2022;151:113108.","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"1454_CR230","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/sj.cdd.4401088","volume":"9","author":"G van Loo","year":"2002","unstructured":"van Loo G, et al. The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ. 2002;9(10):1031\u201342.","journal-title":"Cell Death Differ"},{"issue":"8","key":"1454_CR231","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0962-8924(98)01321-X","volume":"8","author":"A Kelekar","year":"1998","unstructured":"Kelekar A, Thompson CB. Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol. 1998;8(8):324\u201330.","journal-title":"Trends Cell Biol"},{"issue":"9","key":"1454_CR232","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1292\/jvms.69.969","volume":"69","author":"PO Koh","year":"2007","unstructured":"Koh PO. Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testes. J Vet Med Sci. 2007;69(9):969\u201371.","journal-title":"J Vet Med Sci"},{"key":"1454_CR233","doi-asserted-by":"crossref","unstructured":"Gieleci\u0144ska A, et al. The impact of calcium overload on cellular processes: exploring calcicoptosis and its therapeutic potential in cancer. Int J Mol Sci. 2024;25(24):13727.","DOI":"10.3390\/ijms252413727"},{"issue":"31","key":"1454_CR234","doi-asserted-by":"publisher","first-page":"20796","DOI":"10.1074\/jbc.M109.025353","volume":"284","author":"HK Baumgartner","year":"2009","unstructured":"Baumgartner HK, et al. Calcium elevation in mitochondria is the main Ca2\u2009+\u2009requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem. 2009;284(31):20796\u2013803.","journal-title":"J Biol Chem"},{"key":"1454_CR235","doi-asserted-by":"publisher","first-page":"145847","DOI":"10.1016\/j.gene.2021.145847","volume":"799","author":"A Minas","year":"2021","unstructured":"Minas A, et al. Insulin treatment to type 1 male diabetic rats protects fertility by avoiding testicular apoptosis and cell cycle arrest. Gene. 2021;799:145847.","journal-title":"Gene"},{"key":"1454_CR236","doi-asserted-by":"crossref","unstructured":"Flores-Lopez L, et al. Pancreatic beta\u2013cell apoptosis in type 2 diabetes is related to post\u2013translational modifications of p53 (Review). Mol Med Rep. 2024;30(5):193.","DOI":"10.3892\/mmr.2024.13317"},{"issue":"1","key":"1454_CR237","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1038\/s41598-024-55199-y","volume":"14","author":"D Luo","year":"2024","unstructured":"Luo D, et al. Biomarker screening using integrated bioinformatics for the development of normal-impaired glucose intolerance-type 2 diabetes mellitus. Sci Rep. 2024;14(1):4558.","journal-title":"Sci Rep"},{"issue":"6","key":"1454_CR238","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1046\/j.1365-2559.2001.01279.x","volume":"39","author":"M Ohbu","year":"2001","unstructured":"Ohbu M, Kobayashi N, Okayasu I. Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: Stepwise over-expression of Cyclin E and p53, reduction of p21(WAF1\/CIP1) and dysregulation of Cyclin D1 and p27(KIP1). Histopathology. 2001;39(6):589\u201396.","journal-title":"Histopathology"},{"key":"1454_CR239","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.18203\/2349-2902.isj20211321","volume":"8","author":"P Hota","year":"2021","unstructured":"Hota P. Testicular necrosis: a rare complication of poorly controlled diabetes mellitus. Int Surg J. 2021;8:1340.","journal-title":"Int Surg J"},{"key":"1454_CR240","doi-asserted-by":"crossref","unstructured":"Maruhashi T, Higashi Y. Pathophysiological association between diabetes mellitus and endothelial dysfunction. Antioxid (Basel). 2021;10(8):1306.","DOI":"10.3390\/antiox10081306"},{"key":"1454_CR241","doi-asserted-by":"crossref","unstructured":"Carrizzo A, et al. The main determinants of diabetes mellitus vascular complications: endothelial dysfunction and platelet hyperaggregation. Int J Mol Sci. 2018;19(10):2968.","DOI":"10.3390\/ijms19102968"},{"issue":"5","key":"1454_CR242","doi-asserted-by":"publisher","first-page":"112469","DOI":"10.1016\/j.celrep.2023.112469","volume":"42","author":"L Zhu","year":"2023","unstructured":"Zhu L, et al. Single-microvessel occlusion produces lamina-specific microvascular flow vasodynamics and signs of neurodegenerative change. Cell Rep. 2023;42(5):112469.","journal-title":"Cell Rep"},{"issue":"5","key":"1454_CR243","doi-asserted-by":"publisher","first-page":"H819","DOI":"10.1152\/ajpheart.00603.2021","volume":"322","author":"SA Sabe","year":"2022","unstructured":"Sabe SA, et al. Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature. Am J Physiol Heart Circ Physiol. 2022;322(5):H819\u201341.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1454_CR244","doi-asserted-by":"publisher","first-page":"228","DOI":"10.18008\/1816-5095-2021-2-228-233","volume":"18","author":"I Vorobyeva","year":"2021","unstructured":"Vorobyeva I, et al. Effect of Hemodialysis on diabetic retinopathy. Ophthalmol Russia. 2021;18:228\u201333.","journal-title":"Ophthalmol Russia"},{"issue":"1","key":"1454_CR245","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12933-024-02133-1","volume":"23","author":"M Gamez","year":"2024","unstructured":"Gamez M, et al. Heparanase Inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes. Cardiovasc Diabetol. 2024;23(1):50.","journal-title":"Cardiovasc Diabetol"},{"key":"1454_CR246","doi-asserted-by":"crossref","unstructured":"Ghosh K, et al. Di-(2-ethylhexyl) phthalate triggers DNA methyltransferase 1 expression resulting in elevated CpG-methylation and enrichment of MECP2 in the p21 promoter in vitro. Chemosphere. 2022;293:133569.","DOI":"10.1016\/j.chemosphere.2022.133569"},{"issue":"10","key":"1454_CR247","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/nrendo.2009.179","volume":"5","author":"ES Kilpatrick","year":"2009","unstructured":"Kilpatrick ES, Rigby AS, Atkin SL. The diabetes control and complications trial: the gift that keeps giving. Nat Rev Endocrinol. 2009;5(10):537\u201345.","journal-title":"Nat Rev Endocrinol"},{"key":"1454_CR248","doi-asserted-by":"crossref","unstructured":"Refaie MMM, Ahmed Ibrahim R, Shehata S. Dose dependent effect of cilostazol in induced testicular ischemia reperfusion via modulation of HIF\/VEGF and cAMP\/SIRT1 pathways. Int Immunopharmacol, 2021. 101(Pt A): p. 108197.","DOI":"10.1016\/j.intimp.2021.108197"},{"key":"1454_CR249","doi-asserted-by":"publisher","first-page":"725933","DOI":"10.3389\/fcell.2021.725933","volume":"9","author":"Z Li","year":"2021","unstructured":"Li Z, et al. Effects of environmental and pathological hypoxia on male fertility. Front Cell Dev Biol. 2021;9:725933.","journal-title":"Front Cell Dev Biol"},{"key":"1454_CR250","doi-asserted-by":"publisher","first-page":"850114","DOI":"10.3389\/fgene.2022.850114","volume":"13","author":"K Wang","year":"2022","unstructured":"Wang K, et al. Role of oxidative stress in varicocele. Front Genet. 2022;13:850114.","journal-title":"Front Genet"},{"key":"1454_CR251","doi-asserted-by":"publisher","first-page":"149254","DOI":"10.1016\/j.bbrc.2023.149254","volume":"690","author":"OA Soetan","year":"2024","unstructured":"Soetan OA, Ajao FO, Ajayi AF. Erythritol attenuates testicular dysfunction in diabetic rat via suppression of oxidative stress, inflammation and apoptosis. Biochem Biophys Res Commun. 2024;690:149254.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"1454_CR252","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrurol.2016.23","volume":"13","author":"A Castela","year":"2016","unstructured":"Castela A, Costa C. Molecular mechanisms associated with diabetic endothelial-erectile dysfunction. Nat Rev Urol. 2016;13(5):266\u201374.","journal-title":"Nat Rev Urol"},{"key":"1454_CR253","doi-asserted-by":"publisher","first-page":"p6905217","DOI":"10.1155\/2017\/6905217","volume":"2017","author":"HJ Sun","year":"2017","unstructured":"Sun HJ, et al. Salusin-beta is involved in diabetes Mellitus-Induced endothelial dysfunction via degradation of peroxisome Proliferator-Activated receptor gamma. Oxid Med Cell Longev. 2017;2017:p6905217.","journal-title":"Oxid Med Cell Longev"},{"key":"1454_CR254","doi-asserted-by":"crossref","unstructured":"Jimenez-Castilla L, et al. The synthetic flavonoid hidrosmin improves endothelial dysfunction and atherosclerotic lesions in diabetic mice. Antioxid (Basel). 2022;11(12):2499.","DOI":"10.3390\/antiox11122499"},{"issue":"5","key":"1454_CR255","doi-asserted-by":"publisher","first-page":"480","DOI":"10.5603\/ep.95626","volume":"74","author":"M Rabijewski","year":"2023","unstructured":"Rabijewski M. Male-specific consequences of obesity - functional hypogonadism and fertility disorders. Endokrynol Pol. 2023;74(5):480\u20139.","journal-title":"Endokrynol Pol"},{"issue":"1","key":"1454_CR256","doi-asserted-by":"publisher","first-page":"e13617","DOI":"10.1111\/and.13617","volume":"53","author":"K Leisegang","year":"2021","unstructured":"Leisegang K, et al. Obesity and male infertility: mechanisms and management. Andrologia. 2021;53(1):e13617.","journal-title":"Andrologia"},{"issue":"9\u201310","key":"1454_CR257","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00439-024-02676-z","volume":"143","author":"K Zhang","year":"2024","unstructured":"Zhang K, et al. Retrospective studies and quantitative proteomics reveal that abnormal expression of blood pressure, blood lipids, and coagulation related proteins is associated with hypospadias. Hum Genet. 2024;143(9\u201310):1175\u201391.","journal-title":"Hum Genet"},{"issue":"8","key":"1454_CR258","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1007\/s12012-024-09878-x","volume":"24","author":"A Soloviev","year":"2024","unstructured":"Soloviev A, Sydorenko V. Oxidative and nitrous stress underlies vascular malfunction induced by ionizing radiation and diabetes. Cardiovasc Toxicol. 2024;24(8):776\u201388.","journal-title":"Cardiovasc Toxicol"},{"key":"1454_CR259","doi-asserted-by":"publisher","first-page":"175430","DOI":"10.1016\/j.ejphar.2022.175430","volume":"938","author":"J Wei","year":"2023","unstructured":"Wei J, et al. Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity. Eur J Pharmacol. 2023;938:175430.","journal-title":"Eur J Pharmacol"},{"key":"1454_CR260","doi-asserted-by":"crossref","unstructured":"Elsawy H, Famurewa AC, Sedky A. Resveratrol Mitigates Diabetic Testicular Dysfunction, Endocrine Defic its, and Insulin Resistance via Suppression of Sperm-Endocrine Aberrat ions and Oxidative Inflammation in Rats. Andrologia. 2023: pp. 1\u201310.","DOI":"10.1155\/2023\/6385767"},{"key":"1454_CR261","doi-asserted-by":"crossref","unstructured":"Kalai F, et al. Effects of Isorhamnetin on diabetes and its associated complications: A review of in vitro and in vivo studies and a post hoc transcriptome analysis of involved molecular pathways. Int J Mol Sci. 2022;23(2):704.","DOI":"10.3390\/ijms23020704"},{"issue":"5","key":"1454_CR262","first-page":"591","volume":"130","author":"M Patel","year":"2024","unstructured":"Patel M, et al. Molecular pathology and therapeutics of the diabetic foot ulcer; comprehensive reviews. Arch Physiol Biochem. 2024;130(5):591\u20138.","journal-title":"Arch Physiol Biochem"},{"issue":"2","key":"1454_CR263","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s11033-019-05196-6","volume":"47","author":"G Wang","year":"2020","unstructured":"Wang G, et al. LPS impairs steroidogenesis and ROS metabolism and induces PPAR transcriptional activity to disturb estrogen\/androgen receptor expression in testicular cells. Mol Biol Rep. 2020;47(2):1045\u201356.","journal-title":"Mol Biol Rep"},{"issue":"10\u201312","key":"1454_CR264","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00011-021-01497-4","volume":"70","author":"T Peirouvi","year":"2021","unstructured":"Peirouvi T, et al. COVID-19 disrupts the blood-testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins. Inflamm Res. 2021;70(10\u201312):1165\u201375.","journal-title":"Inflamm Res"},{"key":"1454_CR265","doi-asserted-by":"crossref","unstructured":"Dutta S, et al. Oxidative stress, testicular inflammatory pathways, and male reproduction. Int J Mol Sci. 2021;22(18):10043.","DOI":"10.3390\/ijms221810043"},{"key":"1454_CR266","doi-asserted-by":"publisher","first-page":"114748","DOI":"10.1016\/j.envpol.2020.114748","volume":"264","author":"Z Cao","year":"2020","unstructured":"Cao Z, et al. Deoxynivalenol induced spermatogenesis disorder by blood-testis barrier disruption associated with testosterone deficiency and inflammation in mice. Environ Pollut. 2020;264:114748.","journal-title":"Environ Pollut"},{"issue":"7","key":"1454_CR267","doi-asserted-by":"publisher","first-page":"112737","DOI":"10.1016\/j.celrep.2023.112737","volume":"42","author":"S Rajachandran","year":"2023","unstructured":"Rajachandran S, et al. Dissecting the spermatogonial stem cell niche using Spatial transcriptomics. Cell Rep. 2023;42(7):112737.","journal-title":"Cell Rep"},{"issue":"5","key":"1454_CR268","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1080\/13813455.2018.1543329","volume":"126","author":"VU Nna","year":"2020","unstructured":"Nna VU, et al. Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of Metformin. Arch Physiol Biochem. 2020;126(5):377\u201388.","journal-title":"Arch Physiol Biochem"},{"issue":"5","key":"1454_CR269","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11684-019-0729-1","volume":"14","author":"P Zhang","year":"2020","unstructured":"Zhang P, et al. Oxidative stress and diabetes: antioxidative strategies. Front Med. 2020;14(5):583\u2013600.","journal-title":"Front Med"},{"key":"1454_CR270","doi-asserted-by":"crossref","unstructured":"Ramasamy R, et al. The RAGE\/DIAPH1 signaling axis & implications for the pathogenesis of diabetic complications. Int J Mol Sci. 2022;23(9):4579.","DOI":"10.3390\/ijms23094579"},{"issue":"12","key":"1454_CR271","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.25122\/jml-2022-0079","volume":"15","author":"BR Ali","year":"2022","unstructured":"Ali BR, et al. Correlation between reproductive hormones levels and semen quality in patients with diabetes. J Med Life. 2022;15(12):1507\u201310.","journal-title":"J Med Life"},{"key":"1454_CR272","doi-asserted-by":"crossref","unstructured":"Za\u0144ko A, et al. The influence of lifestyle on male fertility in the context of insulin Resistance-Identification of factors that influence semen quality. J Clin Med. 2024;13(10):2797.","DOI":"10.3390\/jcm13102797"},{"key":"1454_CR273","doi-asserted-by":"publisher","first-page":"1238090","DOI":"10.3389\/fendo.2023.1238090","volume":"14","author":"C Jiang","year":"2023","unstructured":"Jiang C, et al. New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study. Front Endocrinol (Lausanne). 2023;14:1238090.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"1454_CR274","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10815-024-03314-3","volume":"42","author":"OC Badejogbin","year":"2025","unstructured":"Badejogbin OC, et al. Pathogenesis of testicular dysfunction in diabetes: exploring the mechanism and therapeutic interventions. J Assist Reprod Genet. 2025;42(2):367\u201379.","journal-title":"J Assist Reprod Genet"},{"issue":"12","key":"1454_CR275","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/S0891-5849(03)00185-0","volume":"34","author":"P Mart\u00edn-Gall\u00e1n","year":"2003","unstructured":"Mart\u00edn-Gall\u00e1n P, et al. Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications. Free Radic Biol Med. 2003;34(12):1563\u201374.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"1454_CR276","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12902-017-0189-z","volume":"17","author":"C Phosat","year":"2017","unstructured":"Phosat C, et al. Elevated C-reactive protein, Interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural thais: a cross-sectional study. BMC Endocr Disord. 2017;17(1):44.","journal-title":"BMC Endocr Disord"},{"key":"1454_CR277","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1038\/srep04260","volume":"4","author":"H Zhang","year":"2014","unstructured":"Zhang H, et al. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 2014;4:4260.","journal-title":"Sci Rep"},{"issue":"2","key":"1454_CR278","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s10875-007-9071-5","volume":"27","author":"A Perdichizzi","year":"2007","unstructured":"Perdichizzi A, et al. Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis. J Clin Immunol. 2007;27(2):152\u201362.","journal-title":"J Clin Immunol"},{"issue":"3","key":"1454_CR279","doi-asserted-by":"publisher","first-page":"337","DOI":"10.5114\/ceji.2015.54596","volume":"40","author":"A Havrylyuk","year":"2015","unstructured":"Havrylyuk A, et al. Cytokines in the blood and semen of infertile patients. Cent Eur J Immunol. 2015;40(3):337\u201344.","journal-title":"Cent Eur J Immunol"},{"issue":"5","key":"1454_CR280","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.2337\/db21-0660","volume":"71","author":"L Zhao","year":"2022","unstructured":"Zhao L, et al. Restoration of autophagic flux improves endothelial function in diabetes through Lowering mitochondrial ROS-Mediated eNOS monomerization. Diabetes. 2022;71(5):1099\u2013114.","journal-title":"Diabetes"},{"issue":"1","key":"1454_CR281","doi-asserted-by":"publisher","first-page":"17625","DOI":"10.1038\/s41598-023-44904-y","volume":"13","author":"K Baghel","year":"2023","unstructured":"Baghel K, et al. Withaferin-A attenuates diabetes mellitus induced male reproductive dysfunction mediated by ER\u03b1 in brain and testes of Swiss albino mice. Sci Rep. 2023;13(1):17625.","journal-title":"Sci Rep"},{"issue":"1","key":"1454_CR282","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1038\/s41598-025-85691-y","volume":"15","author":"HRH Mohamed","year":"2025","unstructured":"Mohamed HRH, et al. Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells. Sci Rep. 2025;15(1):2220.","journal-title":"Sci Rep"},{"issue":"8","key":"1454_CR283","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/abbs\/gmaa074","volume":"52","author":"F Fadel","year":"2020","unstructured":"Fadel F, et al. JNK Inhibition alleviates oxidative DNA damage, germ cell apoptosis, and mitochondrial dysfunction in testicular ischemia reperfusion injury. Acta Biochim Biophys Sin (Shanghai). 2020;52(8):891\u2013900.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2","key":"1454_CR284","doi-asserted-by":"publisher","first-page":"114388","DOI":"10.1016\/j.yexcr.2024.114388","volume":"444","author":"W Li","year":"2025","unstructured":"Li W, Yin X, Zhang L. FOXA2 regulates Endoplasmic reticulum stress, oxidative stress, and apoptosis in spermatogonial cells by the Nrf2 pathway under hypoxic conditions. Exp Cell Res. 2025;444(2):114388.","journal-title":"Exp Cell Res"},{"key":"1454_CR285","doi-asserted-by":"crossref","unstructured":"Zolla L. On the need to distinguish between Insulin-Normal and Insulin-Resistant patients in testosterone therapy. Int J Mol Sci. 2022;23(21):12730.","DOI":"10.3390\/ijms232112730"},{"key":"1454_CR286","doi-asserted-by":"publisher","first-page":"1357279","DOI":"10.3389\/fendo.2024.1357279","volume":"15","author":"C Fan","year":"2024","unstructured":"Fan C, Zhang J, Qiu D. Causal relationship between genetically predicted type 2 diabetes mellitus and male infertility. Front Endocrinol (Lausanne). 2024;15:1357279.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR287","doi-asserted-by":"publisher","first-page":"106664","DOI":"10.1016\/j.biocel.2024.106664","volume":"176","author":"S Vasishta","year":"2024","unstructured":"Vasishta S, et al. High glucose induces DNA methyltransferase 1 dependent epigenetic reprogramming of the endothelial exosome proteome in type 2 diabetes. Int J Biochem Cell Biol. 2024;176:106664.","journal-title":"Int J Biochem Cell Biol"},{"issue":"14","key":"1454_CR288","doi-asserted-by":"publisher","first-page":"e34043","DOI":"10.1016\/j.heliyon.2024.e34043","volume":"10","author":"I Tahiri","year":"2024","unstructured":"Tahiri I, et al. Paternal obesity induces changes in sperm chromatin accessibility and has a mild effect on offspring metabolic health. Heliyon. 2024;10(14):e34043.","journal-title":"Heliyon"},{"key":"1454_CR289","doi-asserted-by":"publisher","first-page":"107545","DOI":"10.1016\/j.intimp.2021.107545","volume":"95","author":"X Li","year":"2021","unstructured":"Li X, et al. Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: involvement of SIRT1-mTOR\/NF-\u03baB signaling pathway. Int Immunopharmacol. 2021;95:107545.","journal-title":"Int Immunopharmacol"},{"key":"1454_CR290","doi-asserted-by":"crossref","unstructured":"Saez L, et al. Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects. Nat Rev Urol. 2025;22(5):294\u2013312.","DOI":"10.1038\/s41585-024-00952-1"},{"issue":"1","key":"1454_CR291","doi-asserted-by":"publisher","first-page":"30607","DOI":"10.1038\/s41598-024-81949-z","volume":"14","author":"AB Emil","year":"2024","unstructured":"Emil AB, et al. Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role. Sci Rep. 2024;14(1):30607.","journal-title":"Sci Rep"},{"issue":"4","key":"1454_CR292","doi-asserted-by":"publisher","first-page":"100543","DOI":"10.1016\/j.repbio.2021.100543","volume":"21","author":"F Olia Bagheri","year":"2021","unstructured":"Olia Bagheri F, et al. Role of peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in the regulation of fatty acid metabolism related gene expressions in testis of men with impaired spermatogenesis. Reprod Biol. 2021;21(4):100543.","journal-title":"Reprod Biol"},{"key":"1454_CR293","doi-asserted-by":"crossref","unstructured":"Dimou A, et al. The critical role of the branched chain amino acids (BCAAs) Catabolism-Regulating enzymes, branched-Chain aminotransferase (BCAT) and branched-Chain \u03b1-Keto acid dehydrogenase (BCKD), in human pathophysiology. Int J Mol Sci. 2022;23(7):4022.","DOI":"10.3390\/ijms23074022"},{"key":"1454_CR294","doi-asserted-by":"publisher","first-page":"1070692","DOI":"10.3389\/fendo.2023.1070692","volume":"14","author":"T Hussain","year":"2023","unstructured":"Hussain T, et al. Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight. Front Endocrinol (Lausanne). 2023;14:1070692.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR295","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ijbiomac.2022.06.193","volume":"216","author":"M Luo","year":"2022","unstructured":"Luo M, et al. Dendrobium nobile-derived polysaccharides ameliorate spermatogenic disorders in mice with streptozotocin-induced diabetes through regulation of the glycolytic pathway. Int J Biol Macromol. 2022;216:203\u201312.","journal-title":"Int J Biol Macromol"},{"issue":"9","key":"1454_CR296","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/s41419-020-02920-0","volume":"11","author":"A Toth","year":"2020","unstructured":"Toth A, et al. Membrane-tethering of cytochrome c accelerates regulated cell death in yeast. Cell Death Dis. 2020;11(9):722.","journal-title":"Cell Death Dis"},{"key":"1454_CR297","doi-asserted-by":"publisher","first-page":"101799","DOI":"10.1016\/j.redox.2020.101799","volume":"37","author":"Q Kang","year":"2020","unstructured":"Kang Q, Yang C. Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 2020;37:101799.","journal-title":"Redox Biol"},{"key":"1454_CR298","doi-asserted-by":"crossref","unstructured":"Jiang M, et al. PWP1 transcriptionally regulates p53, modulating apoptosis and cell cycle to promote gastric cancer progression. Apoptosis. 2025;30(3-4):693\u2013709.","DOI":"10.1007\/s10495-024-02049-x"},{"issue":"1","key":"1454_CR299","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1038\/s41467-024-46190-2","volume":"15","author":"A Chi","year":"2024","unstructured":"Chi A, et al. Stem Leydig cells support macrophage immunological homeostasis through mitochondrial transfer in mice. Nat Commun. 2024;15(1):2120.","journal-title":"Nat Commun"},{"issue":"8","key":"1454_CR300","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s10815-024-03165-y","volume":"41","author":"T Sonawane","year":"2024","unstructured":"Sonawane T, et al. Interrogating erectile dysfunction and evaluating novel therapeutic frontiers, with emphasis on stem cell strategies. J Assist Reprod Genet. 2024;41(8):2037\u201351.","journal-title":"J Assist Reprod Genet"},{"key":"1454_CR301","doi-asserted-by":"crossref","unstructured":"Oh JH, et al. Therapeutic potential of 4-Hexylresorcinol in preserving testicular function in Streptozotocin-Induced diabetic rats. Int J Mol Sci. 2024;25(8):4316.","DOI":"10.3390\/ijms25084316"},{"key":"1454_CR302","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biocel.2016.08.011","volume":"79","author":"MJ Meneses","year":"2016","unstructured":"Meneses MJ, et al. Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis. Int J Biochem Cell Biol. 2016;79:52\u201360.","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"1454_CR303","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41591-020-0751-5","volume":"26","author":"KS Ruth","year":"2020","unstructured":"Ruth KS, et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med. 2020;26(2):252\u20138.","journal-title":"Nat Med"},{"key":"1454_CR304","doi-asserted-by":"crossref","unstructured":"Lockie A, et al. Diagnosis and treatment of hypogonadism in men seeking to preserve fertility - what are the options? Int J Impot Res. 2025;37(2):109\u201313.","DOI":"10.1038\/s41443-024-00897-4"},{"issue":"8","key":"1454_CR305","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/01.NPR.0000000000000210","volume":"49","author":"JL Gallegos","year":"2024","unstructured":"Gallegos JL. Testosterone replacement therapy for hypogonadism: A primer for primary care. Nurse Pract. 2024;49(8):21\u20137.","journal-title":"Nurse Pract"},{"issue":"4","key":"1454_CR306","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/dom.12430","volume":"17","author":"CO Terranova","year":"2015","unstructured":"Terranova CO, et al. Effectiveness of lifestyle-based weight loss interventions for adults with type 2 diabetes: a systematic review and meta-analysis. Diabetes Obes Metab. 2015;17(4):371\u20138.","journal-title":"Diabetes Obes Metab"},{"key":"1454_CR307","doi-asserted-by":"crossref","unstructured":"Rodrigo-Carbo C, et al. Low-calorie, high-protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity. Diabetes Obes Metab. 2025;27(1):268\u201379.","DOI":"10.1111\/dom.16013"},{"key":"1454_CR308","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.coph.2021.04.002","volume":"58","author":"M Caliber","year":"2021","unstructured":"Caliber M, Saad F. Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone. Curr Opin Pharmacol. 2021;58:83\u20139.","journal-title":"Curr Opin Pharmacol"},{"key":"1454_CR309","doi-asserted-by":"crossref","unstructured":"Robledo K, et al. Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model. Eur J Endocrinol. 2025;192(1):15\u201324.","DOI":"10.1093\/ejendo\/lvae166"},{"key":"1454_CR310","doi-asserted-by":"crossref","unstructured":"Panner Selvam MK, et al. Clomiphene citrate in the management of infertility in oligospermic obese men with hypogonadism: retrospective pilot study. Med (Kaunas). 2023;59(11):1902.","DOI":"10.3390\/medicina59111902"},{"issue":"4","key":"1454_CR311","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.dsx.2018.03.013","volume":"12","author":"AA El-Aal","year":"2018","unstructured":"El-Aal AA, et al. The effect of vitamin C and\/or E supplementations on type 2 diabetic adult males under Metformin treatment: A single-blinded randomized controlled clinical trial. Diabetes Metab Syndr. 2018;12(4):483\u20139.","journal-title":"Diabetes Metab Syndr"},{"issue":"3","key":"1454_CR312","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cmet.2020.06.018","volume":"32","author":"S Cienfuegos","year":"2020","unstructured":"Cienfuegos S, et al. Effects of 4- and 6-h Time-Restricted feeding on weight and cardiometabolic health: A randomized controlled trial in adults with obesity. Cell Metab. 2020;32(3):366\u2013e3783.","journal-title":"Cell Metab"},{"issue":"1","key":"1454_CR313","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12986-021-00613-9","volume":"18","author":"T Che","year":"2021","unstructured":"Che T, et al. Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial. Nutr Metab (Lond). 2021;18(1):88.","journal-title":"Nutr Metab (Lond)"},{"key":"1454_CR314","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.diabres.2019.02.011","volume":"150","author":"Z Hangping","year":"2019","unstructured":"Hangping Z, et al. The impact on glycemic control through progressive resistance training with bioDensity(TM) in Chinese elderly patients with type 2 diabetes: the PReTTy2 (Progressive resistance training in type 2 Diabetes) trial. Diabetes Res Clin Pract. 2019;150:64\u201371.","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"1454_CR315","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.dsx.2020.12.011","volume":"15","author":"C Ranasinghe","year":"2021","unstructured":"Ranasinghe C, et al. Glycemic and cardiometabolic effects of exercise in South Asian Sri Lankans with type 2 diabetes mellitus: A randomized controlled trial Sri Lanka diabetes aerobic and resistance training study (SL-DARTS). Diabetes Metab Syndr. 2021;15(1):77\u201385.","journal-title":"Diabetes Metab Syndr"},{"issue":"3","key":"1454_CR316","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/dom.13571","volume":"21","author":"SA Mason","year":"2019","unstructured":"Mason SA, et al. Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: findings of a randomized cross-over trial. Diabetes Obes Metab. 2019;21(3):674\u201382.","journal-title":"Diabetes Obes Metab"},{"key":"1454_CR317","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.clnesp.2019.10.015","volume":"35","author":"SR Ragheb","year":"2020","unstructured":"Ragheb SR, et al. Impact of Rutin and vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes. Clin Nutr ESPEN. 2020;35:128\u201335.","journal-title":"Clin Nutr ESPEN"},{"issue":"1","key":"1454_CR318","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2337\/dc11-0925","volume":"35","author":"SK Malin","year":"2012","unstructured":"Malin SK, et al. Independent and combined effects of exercise training and Metformin on insulin sensitivity in individuals with prediabetes. Diabetes Care. 2012;35(1):131\u20136.","journal-title":"Diabetes Care"},{"issue":"23","key":"1454_CR319","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1136\/bjsports-2024-108127","volume":"58","author":"T Zhao","year":"2024","unstructured":"Zhao T, et al. Effects of exercise, Metformin and their combination on glucose metabolism in individuals with abnormal glycaemic control: a systematic review and network meta-analysis. Br J Sports Med. 2024;58(23):1452\u201360.","journal-title":"Br J Sports Med"},{"issue":"4","key":"1454_CR320","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3945\/ajcn.2009.28548","volume":"91","author":"K Kempf","year":"2010","unstructured":"Kempf K, et al. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr. 2010;91(4):950\u20137.","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"1454_CR321","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/NEJMoa1900906","volume":"381","author":"AG Pittas","year":"2019","unstructured":"Pittas AG, et al. Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med. 2019;381(6):520\u201330.","journal-title":"N Engl J Med"},{"issue":"7","key":"1454_CR322","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.2337\/dc19-1708","volume":"43","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, et al. Effects of vitamin D supplementation on prevention of type 2 diabetes in patients with prediabetes: A systematic review and Meta-analysis. Diabetes Care. 2020;43(7):1650\u20138.","journal-title":"Diabetes Care"},{"issue":"11","key":"1454_CR323","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1039\/D5FO01018G","volume":"16","author":"Z Nian","year":"2025","unstructured":"Nian Z, et al. Effects of fish oil intervention on type 2 diabetes early risk novel biomarkers in healthy middle-aged and elderly adults: a double-blind randomized controlled trial. Food Funct. 2025;16(11):4451\u201364.","journal-title":"Food Funct"},{"issue":"5","key":"1454_CR324","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.clnu.2021.03.014","volume":"40","author":"DA D\u00edaz-Rizzolo","year":"2021","unstructured":"D\u00edaz-Rizzolo DA, et al. Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: an interventional, randomized and controlled trial. Clin Nutr. 2021;40(5):2587\u201398.","journal-title":"Clin Nutr"},{"issue":"22","key":"1454_CR325","doi-asserted-by":"publisher","first-page":"6152","DOI":"10.1016\/j.cell.2024.09.004","volume":"187","author":"S Wang","year":"2024","unstructured":"Wang S, et al. Transplantation of chemically induced pluripotent stem-cell-derived Islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell. 2024;187(22):6152\u2013e616418.","journal-title":"Cell"},{"issue":"2","key":"1454_CR326","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/dom.14232","volume":"23","author":"L Ji","year":"2021","unstructured":"Ji L, et al. Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as add-on to Metformin in patients with type 2 diabetes in SUSTAIN china: A 30-week, double-blind, phase 3a, randomized trial. Diabetes Obes Metab. 2021;23(2):404\u201314.","journal-title":"Diabetes Obes Metab"},{"issue":"6","key":"1454_CR327","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S2213-8587(22)00085-7","volume":"10","author":"T Heise","year":"2022","unstructured":"Heise T, et al. Effects of subcutaneous Tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial. Lancet Diabetes Endocrinol. 2022;10(6):418\u201329.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"17","key":"1454_CR328","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1001\/jama.2023.20294","volume":"330","author":"J Rosenstock","year":"2023","unstructured":"Rosenstock J, et al. Tirzepatide vs insulin Lispro added to basal insulin in type 2 diabetes: the SURPASS-6 randomized clinical trial. JAMA. 2023;330(17):1631\u201340.","journal-title":"JAMA"},{"issue":"11","key":"1454_CR329","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.2337\/dc23-0728","volume":"46","author":"CK Boughton","year":"2023","unstructured":"Boughton CK, et al. Fully Closed-Loop glucose control compared with insulin pump therapy with continuous glucose monitoring in adults with type 1 diabetes and suboptimal glycemic control: A Single-Center, randomized, crossover study. Diabetes Care. 2023;46(11):1916\u201322.","journal-title":"Diabetes Care"},{"issue":"3","key":"1454_CR330","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S2213-8587(22)00387-4","volume":"11","author":"LM Laffel","year":"2023","unstructured":"Laffel LM, et al. Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial. Lancet Diabetes Endocrinol. 2023;11(3):169\u201381.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"8","key":"1454_CR331","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/S2213-8587(23)00132-8","volume":"11","author":"L Zhang","year":"2023","unstructured":"Zhang L, et al. Safety and effectiveness of Metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2023;11(8):567\u201377.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"1454_CR332","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12888-023-04546-w","volume":"23","author":"Q Abbas","year":"2023","unstructured":"Abbas Q, et al. Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial. BMC Psychiatry. 2023;23(1):86.","journal-title":"BMC Psychiatry"},{"issue":"12","key":"1454_CR333","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.2337\/db21-0526","volume":"70","author":"A Fritsche","year":"2021","unstructured":"Fritsche A, et al. Different effects of lifestyle intervention in High- and Low-Risk prediabetes: results of the randomized controlled prediabetes lifestyle intervention study (PLIS). Diabetes. 2021;70(12):2785\u201395.","journal-title":"Diabetes"},{"issue":"1","key":"1454_CR334","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12933-021-01434-z","volume":"20","author":"Z Song","year":"2021","unstructured":"Song Z, et al. Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension. Cardiovasc Diabetol. 2021;20(1):239.","journal-title":"Cardiovasc Diabetol"},{"issue":"4","key":"1454_CR335","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/1753-0407.12995","volume":"12","author":"YY Chen","year":"2020","unstructured":"Chen YY, et al. Metabolic syndrome and semen quality in adult population. J Diabetes. 2020;12(4):294\u2013304.","journal-title":"J Diabetes"},{"issue":"2","key":"1454_CR336","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1262\/jrd.17028","volume":"52","author":"M Jedlinska-Krakowska","year":"2006","unstructured":"Jedlinska-Krakowska M, et al. Impact of oxidative stress and supplementation with vitamins E and C on testes morphology in rats. J Reprod Dev. 2006;52(2):203\u20139.","journal-title":"J Reprod Dev"},{"key":"1454_CR337","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ejogrb.2014.07.007","volume":"181","author":"AR Talebi","year":"2014","unstructured":"Talebi AR, et al. Vitamin C attenuates detrimental effects of diabetes mellitus on sperm parameters, chromatin quality and rate of apoptosis in mice. Eur J Obstet Gynecol Reprod Biol. 2014;181:32\u20136.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"1454_CR338","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1007\/s40200-023-01237-x","volume":"22","author":"OA Soetan","year":"2023","unstructured":"Soetan OA, Ajao FO, Ajayi AF. Blood glucose Lowering and anti-oxidant potential of erythritol: an in vitro and in vivo study. J Diabetes Metab Disord. 2023;22(2):1217\u201329.","journal-title":"J Diabetes Metab Disord"},{"issue":"6","key":"1454_CR339","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0531-5565(03)00068-8","volume":"38","author":"N Sumien","year":"2003","unstructured":"Sumien N, Forster MJ, Sohal RS. Supplementation with vitamin E fails to attenuate oxidative damage in aged mice. Exp Gerontol. 2003;38(6):699\u2013704.","journal-title":"Exp Gerontol"},{"issue":"4","key":"1454_CR340","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0955-2863(03)00003-2","volume":"14","author":"LK MacDonald-Wicks","year":"2003","unstructured":"MacDonald-Wicks LK, Garg ML. Vitamin E supplementation in the mitigation of carbon tetrachloride induced oxidative stress in rats. J Nutr Biochem. 2003;14(4):211\u20138.","journal-title":"J Nutr Biochem"},{"key":"1454_CR341","doi-asserted-by":"publisher","first-page":"1150951","DOI":"10.3389\/fendo.2023.1150951","volume":"14","author":"M Romano","year":"2023","unstructured":"Romano M, et al. High sperm DNA fragmentation: do we have robust evidence to support antioxidants and testicular sperm extraction to improve fertility outcomes? A narrative review. Front Endocrinol (Lausanne). 2023;14:1150951.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1454_CR342","doi-asserted-by":"publisher","first-page":"116638","DOI":"10.1016\/j.jep.2023.116638","volume":"314","author":"GG Kumar","year":"2023","unstructured":"Kumar GG, et al. Oral administration of Turnera diffusa willd. Ex schult. Extract ameliorates steroidogenesis and spermatogenesis impairment in the testes of rats with type-2 diabetes mellitus. J Ethnopharmacol. 2023;314:116638.","journal-title":"J Ethnopharmacol"},{"key":"1454_CR343","doi-asserted-by":"publisher","first-page":"155217","DOI":"10.1016\/j.phymed.2023.155217","volume":"123","author":"CS Lu","year":"2024","unstructured":"Lu CS, et al. The protective effects of Icariin against testicular dysfunction in type 1 diabetic mice via AMPK-mediated Nrf2 activation and NF-kappaB p65 Inhibition. Phytomedicine. 2024;123:155217.","journal-title":"Phytomedicine"},{"issue":"5","key":"1454_CR344","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/jpp\/rgad099","volume":"76","author":"M Raeeszadeh","year":"2024","unstructured":"Raeeszadeh M, et al. Thyme extract could overcome diabetes-induced reproductive dysfunction by inhibiting oxidative damage and increasing the expression of insulin receptor substrate and pyruvate kinase in the rat sperm. J Pharm Pharmacol. 2024;76(5):534\u201344.","journal-title":"J Pharm Pharmacol"},{"key":"1454_CR345","doi-asserted-by":"publisher","first-page":"101912","DOI":"10.1016\/j.tice.2022.101912","volume":"79","author":"VO Ukwenya","year":"2022","unstructured":"Ukwenya VO, et al. Caffeic acid abrogates amyloidosis, hypospermatogenesis and cell membrane alterations in the testes and epididymis of fructose-diabetic rats by upregulating steroidogenesis, PCNA and Nrf2 expression. Tissue Cell. 2022;79:101912.","journal-title":"Tissue Cell"},{"key":"1454_CR346","doi-asserted-by":"publisher","first-page":"3109294","DOI":"10.1155\/2021\/3109294","volume":"2021","author":"CL Wee","year":"2021","unstructured":"Wee CL, et al. Calcitriol Supplementation Ameliorates Microvascular Endothelial Dysfunction in Vitamin D-Deficient Diabetic Rats by Upregulating the Vascular eNOS Protein Expression and Reducing Oxidative Stress. Oxid Med Cell Longev. 2021;2021:3109294.","journal-title":"Oxid Med Cell Longev"},{"key":"1454_CR347","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2147\/DMSO.S220046","volume":"13","author":"U Pingali","year":"2020","unstructured":"Pingali U, Nutalapati C, Illendulla VS. Evaluation of the effect of fish oil alone and in combination with a proprietary chromium complex on endothelial dysfunction, systemic inflammation and lipid profile in type 2 diabetes Mellitus - A randomized, Double-Blind, Placebo-Controlled clinical study. Diabetes Metab Syndr Obes. 2020;13:31\u201342.","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"1","key":"1454_CR348","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12986-022-00684-2","volume":"19","author":"J Moludi","year":"2022","unstructured":"Moludi J, et al. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial. Nutr Metab (Lond). 2022;19(1):49.","journal-title":"Nutr Metab (Lond)"},{"issue":"2","key":"1454_CR349","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1365-2605.2008.00928.x","volume":"32","author":"S Gur","year":"2009","unstructured":"Gur S, Kadowitz PJ, Hellstrom WJ. A critical appraisal of erectile function in animal models of diabetes mellitus. Int J Androl. 2009;32(2):93\u2013114.","journal-title":"Int J Androl"},{"issue":"5","key":"1454_CR350","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0022-5347(01)64125-9","volume":"158","author":"S Francavilla","year":"1997","unstructured":"Francavilla S, et al. Endothelin-1 in diabetic and nondiabetic men with erectile dysfunction. J Urol. 1997;158(5):1770\u20134.","journal-title":"J Urol"},{"key":"1454_CR351","doi-asserted-by":"publisher","first-page":"102414","DOI":"10.1016\/j.tice.2024.102414","volume":"89","author":"B Du","year":"2024","unstructured":"Du B, et al. Shugan Tongluo Qiangjing recipe protects against varicocele of EVC rats through modulating sperm DNA damage, telomere expression and oxidative stress. Tissue Cell. 2024;89:102414.","journal-title":"Tissue Cell"},{"issue":"3","key":"1454_CR352","doi-asserted-by":"publisher","first-page":"505","DOI":"10.24272\/j.issn.2095-8137.2022.440","volume":"44","author":"MF Zhang","year":"2023","unstructured":"Zhang MF, et al. Transcription factor Dmrt1 triggers the SPRY1-NF-kappaB pathway to maintain testicular immune homeostasis and male fertility. Zool Res. 2023;44(3):505\u201321.","journal-title":"Zool Res"},{"issue":"7","key":"1454_CR353","first-page":"539","volume":"21","author":"CY Deng","year":"2021","unstructured":"Deng CY, et al. The role of the PI3K\/AKT\/mTOR signalling pathway in male reproduction. Curr Mol Med. 2021;21(7):539\u201348.","journal-title":"Curr Mol Med"},{"key":"1454_CR354","doi-asserted-by":"publisher","first-page":"p5681701","DOI":"10.1155\/2019\/5681701","volume":"2019","author":"Y Liu","year":"2019","unstructured":"Liu Y, et al. Metformin ameliorates testicular damage in male mice with Streptozotocin-Induced type 1 diabetes through the PK2\/PKR pathway. Oxid Med Cell Longev. 2019;2019:p5681701.","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"1454_CR355","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1021\/acs.jproteome.0c01044","volume":"20","author":"MG Carvalho","year":"2021","unstructured":"Carvalho MG, et al. Effects of obesity and diabetes on sperm cell proteomics in rats. J Proteome Res. 2021;20(5):2628\u201342.","journal-title":"J Proteome Res"},{"issue":"1","key":"1454_CR356","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12958-022-01034-w","volume":"21","author":"S AbbasiHormozi","year":"2023","unstructured":"AbbasiHormozi S, et al. How much obesity and diabetes do impair male fertility? Reprod Biol Endocrinol. 2023;21(1):48.","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"1454_CR357","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s11010-022-04587-x","volume":"478","author":"K Ramasubbu","year":"2023","unstructured":"Ramasubbu K, Devi Rajeswari V. Impairment of insulin signaling pathway PI3K\/Akt\/mTOR and insulin resistance induced ages on diabetes mellitus and neurodegenerative diseases: a perspective review. Mol Cell Biochem. 2023;478(6):1307\u201324.","journal-title":"Mol Cell Biochem"},{"key":"1454_CR358","doi-asserted-by":"publisher","first-page":"114662","DOI":"10.1016\/j.jep.2021.114662","volume":"282","author":"X Zhou","year":"2022","unstructured":"Zhou X, et al. The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing. J Ethnopharmacol. 2022;282:114662.","journal-title":"J Ethnopharmacol"},{"key":"1454_CR359","doi-asserted-by":"publisher","first-page":"112563","DOI":"10.1016\/j.biopha.2021.112563","volume":"146","author":"M Entezari","year":"2022","unstructured":"Entezari M, et al. AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation. Biomed Pharmacother. 2022;146:112563.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"1454_CR360","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1530\/REP-23-0041","volume":"166","author":"Z Min","year":"2023","unstructured":"Min Z, et al. NR2C2 of macrophages promotes inflammation via NF-kappaB in LPS-induced orchitis in mice. Reproduction. 2023;166(3):209\u201320.","journal-title":"Reproduction"},{"issue":"1","key":"1454_CR361","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s11033-024-10197-1","volume":"52","author":"Z Latifi","year":"2024","unstructured":"Latifi Z, et al. MicroRNAs as diagnostic biomarkers in diabetes male infertility: a systematic review. Mol Biol Rep. 2024;52(1):90.","journal-title":"Mol Biol Rep"},{"issue":"6","key":"1454_CR362","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.cmet.2025.03.006","volume":"37","author":"M Ding","year":"2025","unstructured":"Ding M, et al. O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles. Cell Metab. 2025;37(6):1344\u201363. .e6.","journal-title":"Cell Metab"},{"key":"1454_CR363","doi-asserted-by":"crossref","unstructured":"Sumaiya K, et al. Cardiac metabolism and MiRNA interference. Int J Mol Sci. 2022;24(1):50.","DOI":"10.3390\/ijms24010050"},{"key":"1454_CR364","doi-asserted-by":"crossref","unstructured":"Chua GHI, et al. Vitamin E levels in ethnic communities in Malaysia and its relation to glucose tolerance, insulin resistance and advanced glycation end products: A Cross-Sectional study. Nutrients. 202;12(12):3659.","DOI":"10.3390\/nu12123659"},{"key":"1454_CR365","doi-asserted-by":"crossref","unstructured":"Sugandh F, et al. Advances in the Management of Diabetes Mellitus: A Focus on Personalized Medicine. Cureus. 2023;15(8):e43697.","DOI":"10.7759\/cureus.43697"}],"updated-by":[{"DOI":"10.1186\/s12958-025-01496-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000}}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01454-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-025-01454-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-025-01454-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:02:58Z","timestamp":1762848178000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-025-01454-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":365,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1454"],"URL":"https:\/\/doi.org\/10.1186\/s12958-025-01454-4","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,24]]},"assertion":[{"value":"21 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: the authors found an error list of authors. Author, Jichun Tan, was mistakenly captured twice.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12958-025-01496-8","URL":"https:\/\/doi.org\/10.1186\/s12958-025-01496-8","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"122"}}