{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:39:00Z","timestamp":1776991140635,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-026-01531-2","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:14:23Z","timestamp":1773710063000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction between triglyceride-glucose index and body mass index on pregnancy loss in Chinese women with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Muxin","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baichao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiannan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingshu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"issue":"6","key":"1531_CR1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1210\/endrev\/bnac001","volume":"43","author":"M Dapas","year":"2022","unstructured":"Dapas M, Dunaif A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr Rev. 2022;43(6):927\u201365.","journal-title":"Endocr Rev"},{"issue":"1","key":"1531_CR2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/humrep\/deh098","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41\u20137.","journal-title":"Hum Reprod"},{"issue":"12","key":"1531_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103821","volume":"28","author":"S Kulkarni","year":"2023","unstructured":"Kulkarni S, Gupta K, Ratre P, et al. Polycystic ovary syndrome: current scenario and future insights. Drug Discov Today. 2023;28(12):103821.","journal-title":"Drug Discov Today"},{"issue":"9","key":"1531_CR4","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1093\/humrep\/det262","volume":"28","author":"R Li","year":"2013","unstructured":"Li R, Zhang Q, Yang D, et al. Prevalence of polycystic ovary syndrome in women in china: a large community-based study. Hum Reprod. 2013;28(9):2562\u20139.","journal-title":"Hum Reprod"},{"issue":"6","key":"1531_CR5","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1210\/er.2011-1034","volume":"33","author":"E Diamanti-Kandarakis","year":"2012","unstructured":"Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981\u20131030.","journal-title":"Endocr Rev"},{"issue":"6","key":"1531_CR6","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/humupd\/dms030","volume":"18","author":"SS Lim","year":"2012","unstructured":"Lim SS, Davies MJ, Norman RJ, et al. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(6):618\u201337.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"1531_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01274-x","volume":"20","author":"S Wang","year":"2021","unstructured":"Wang S, Shi J, Peng Y, et al. Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study. Cardiovasc Diabetol. 2021;20(1):82.","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"1531_CR8","first-page":"62","volume":"45","author":"LE Simental-Mend\u00eda","year":"2008","unstructured":"Simental-Mend\u00eda LE, Rodr\u00edguez-Mor\u00e1n M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance. Acta Diabetol. 2008;45(1):62\u20137.","journal-title":"Acta Diabetol"},{"key":"1531_CR9","doi-asserted-by":"crossref","unstructured":"Feng J, Luo R, Gao J, et al. Elevated triglyceride-glucose index is associated with insulin resistance, metabolic syndrome components, nonalcoholic fatty liver disease, and adverse pregnancy outcomes in Chinese women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2025;103(3):317\u201326.","DOI":"10.1111\/cen.15252"},{"issue":"3","key":"1531_CR10","doi-asserted-by":"publisher","first-page":"e0212963","DOI":"10.1371\/journal.pone.0212963","volume":"14","author":"J Lim","year":"2019","unstructured":"Lim J, Kim J, Koo SH, et al. Comparison of triglyceride glucose index, and related parameters to predict insulin resistance in Korean adults: an analysis of the 2007\u20132010 Korean National health and nutrition examination survey. PLoS One. 2019;14(3):e0212963.","journal-title":"PLoS One"},{"issue":"3","key":"1531_CR11","doi-asserted-by":"publisher","first-page":"e0149731","DOI":"10.1371\/journal.pone.0149731","volume":"11","author":"L Er","year":"2016","unstructured":"Er L, Wu S, Chou H, et al. Triglyceride glucose-body mass index is a simple and clinically useful surrogate marker for insulin resistance in nondiabetic individuals. PLoS One. 2016;11(3):e0149731.","journal-title":"PLoS One"},{"key":"1531_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/527303","volume":"2013","author":"H Kuang","year":"2013","unstructured":"Kuang H, Li Y, Wu X, et al. Acupuncture and clomiphene citrate for live birth in polycystic ovary syndrome: study design of a randomized controlled trial. Evid Based Complement Alternat Med. 2013;2013:527303.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"24","key":"1531_CR13","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1001\/jama.2017.7217","volume":"317","author":"X-K Wu","year":"2017","unstructured":"Wu X-K, Stener-Victorin E, Kuang H-Y, et al. Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: A randomized clinical trial. JAMA. 2017;317(24):2502\u201314.","journal-title":"JAMA"},{"issue":"Suppl 1","key":"1531_CR14","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1016\/j.dsx.2016.12.020","volume":"11","author":"R Jayanthi","year":"2017","unstructured":"Jayanthi R, Srinivasan AR, Hanifah M, et al. Associations among insulin Resistance, Triacylglycerol\/High density lipoprotein (TAG\/HDL ratio) and thyroid hormone levels-A study on type 2 diabetes mellitus in obese and overweight subjects. Diabetes Metab Syndr. 2017;11(Suppl 1):S121\u2013126.","journal-title":"Diabetes Metab Syndr"},{"issue":"6","key":"1531_CR15","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","volume":"27","author":"TM Wallace","year":"2004","unstructured":"Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27(6):1487\u201395.","journal-title":"Diabetes Care"},{"issue":"19","key":"1531_CR16","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP)","year":"2001","unstructured":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP). Expert panel on Detection, Evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA. 2001;285(19):2486\u201397. https:\/\/doi.org\/10.1001\/jama.285.19.2486.","journal-title":"JAMA"},{"issue":"3","key":"1531_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1056\/NEJMra1801040","volume":"387","author":"AA Creanga","year":"2022","unstructured":"Creanga AA, Catalano PM, Bateman BT. Obesity in pregnancy. N Engl J Med. 2022;387(3):248\u201359.","journal-title":"N Engl J Med"},{"issue":"1","key":"1531_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.rbmo.2016.09.011","volume":"34","author":"K Tremellen","year":"2017","unstructured":"Tremellen K, Pearce K, Zander-Fox D. Increased miscarriage of euploid pregnancies in obese women undergoing cryopreserved embryo transfer. Reprod Biomed Online. 2017;34(1):90\u20137.","journal-title":"Reprod Biomed Online"},{"issue":"6","key":"1531_CR19","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.fertnstert.2020.09.139","volume":"115","author":"M Cozzolino","year":"2021","unstructured":"Cozzolino M, Garc\u00eda-Velasco JA, Meseguer M, et al. Female obesity increases the risk of miscarriage of euploid embryos. Fertil Steril. 2021;115(6):1495\u2013502.","journal-title":"Fertil Steril"},{"issue":"4","key":"1531_CR20","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.rbmo.2011.06.018","volume":"23","author":"V Rittenberg","year":"2011","unstructured":"Rittenberg V, Seshadri S, Sunkara SK, et al. Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online. 2011;23(4):421\u201339.","journal-title":"Reprod Biomed Online"},{"key":"1531_CR21","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.fertnstert.2015.08.018","volume":"104","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2015","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Obesity and reproduction: a committee opinion. Fertil Steril. 2015;104:1116\u201326.","journal-title":"Fertil Steril"},{"issue":"1","key":"1531_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0336-z","volume":"16","author":"E Silvestris","year":"2018","unstructured":"Silvestris E, de Pergola G, Rosania R, et al. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):22.","journal-title":"Reprod Biol Endocrinol"},{"key":"1531_CR23","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.fertnstert.2007.07.1290","volume":"90","author":"M Metwally","year":"2008","unstructured":"Metwally M, Ong KJ, Ledger WL, et al. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril. 2008;90:714\u201326.","journal-title":"Fertil Steril"},{"key":"1531_CR24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1055\/s-0031-1293204","volume":"29","author":"C Boots","year":"2011","unstructured":"Boots C, Stephenson MD. Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review. Semin Reprod Med. 2011;29:507\u201313.","journal-title":"Semin Reprod Med"},{"key":"1531_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/jog.13799","volume":"45","author":"MB Cavalcante","year":"2019","unstructured":"Cavalcante MB, Sarno M, Peixoto AB, et al. Obesity and recurrent miscarriage: a systematic review and meta-analysis. J Obstet Gynaecol Res. 2019;45:30\u20138.","journal-title":"J Obstet Gynaecol Res"},{"issue":"12","key":"1531_CR26","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"GM Reaven","year":"1988","unstructured":"Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595\u2013607.","journal-title":"Diabetes"},{"issue":"1","key":"1531_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41387-023-00239-1","volume":"13","author":"Q Wu","year":"2023","unstructured":"Wu Q, Chen Y, Ma H, et al. The heterogeneous associations between gestational weight gain and adverse pregnancy outcomes in gestational diabetes mellitus according to abnormal glucose metabolism. Nutr Diabetes. 2023;13(1):10. Published 2023 Jul 4.","journal-title":"Nutr Diabetes"},{"key":"1531_CR28","doi-asserted-by":"crossref","unstructured":"Hansen M, Flatt T, Aguilaniu H. Reproduction, fat metabolism, and life span: what is the connection? [published correction appears in Cell Metab. 2014;19(6):1066]. Cell Metab. 2013;17(1):10\u20139.","DOI":"10.1016\/j.cmet.2012.12.003"},{"issue":"22","key":"1531_CR29","doi-asserted-by":"publisher","first-page":"dev181925","DOI":"10.1242\/dev.181925","volume":"146","author":"R Aizawa","year":"2019","unstructured":"Aizawa R, Ibayashi M, Tatsumi T, et al. Synthesis and maintenance of lipid droplets are essential for mouse preimplantation embryonic development. Development. 2019;146(22):dev181925. Published 2019 Nov 25.","journal-title":"Development"},{"issue":"2","key":"1531_CR30","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s10815-019-01670-z","volume":"37","author":"R Matorras","year":"2020","unstructured":"Matorras R, Martinez-Arranz I, Arretxe E, et al. The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles. J Assist Reprod Genet. 2020;37(2):385\u201394.","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"1531_CR31","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1530\/REP-16-0104","volume":"152","author":"ES Ribeiro","year":"2016","unstructured":"Ribeiro ES, Santos JE, Thatcher WW. Role of lipids on elongation of the preimplantation conceptus in ruminants. Reproduction. 2016;152(4):R115\u201326.","journal-title":"Reproduction"},{"issue":"3","key":"1531_CR32","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1095\/biolreprod.110.090415","volume":"85","author":"KR Dunning","year":"2011","unstructured":"Dunning KR, Akison LK, Russell DL, et al. Increased beta-oxidation and improved oocyte developmental competence in response to l-carnitine during ovarian in vitro follicle development in mice. Biol Reprod. 2011;85(3):548\u201355.","journal-title":"Biol Reprod"},{"key":"1531_CR33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.theriogenology.2020.01.008","volume":"145","author":"G Shafiei","year":"2020","unstructured":"Shafiei G, Almasi M, Nikzad H, et al. L-carnitine reduces the adverse effects of ROS and up-regulates the expression of implantation related genes in in vitro developed mouse embryos. Theriogenology. 2020;145:59\u201366.","journal-title":"Theriogenology"},{"issue":"2","key":"1531_CR34","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1530\/REP-18-0570","volume":"159","author":"JS Beltrame","year":"2020","unstructured":"Beltrame JS, Ca\u00f1umil VA, Sordelli MS, et al. Novel role for lysophosphatidic acid in vascular remodeling at the maternal-fetal interface. Reproduction. 2020;159(2):R55\u201367.","journal-title":"Reproduction"},{"key":"1531_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.placenta.2019.01.020","volume":"77","author":"M Baryla","year":"2019","unstructured":"Baryla M, Kaczynski P, Goryszewska E, et al. Prostaglandin F2\u03b1stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8\/SVneo. Placenta. 2019;77:19\u201329.","journal-title":"Placenta"},{"issue":"4","key":"1531_CR36","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/humupd\/dmaa005","volume":"26","author":"J Maia","year":"2020","unstructured":"Maia J, Fonseca BM, Teixeira N, et al. The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders. Hum Reprod Update. 2020;26(4):586\u2013602.","journal-title":"Hum Reprod Update"},{"key":"1531_CR37","doi-asserted-by":"crossref","unstructured":"Wang H, Guo Y, Wang D, et al. Aberrant cannabinoid signaling impairs oviductal transport of embryos [published correction appears in Nat Med. 2004;10(12):1397]. Nat Med. 2004;10(10):1074\u201380.","DOI":"10.1038\/nm1104"},{"issue":"5","key":"1531_CR38","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mam.2012.12.011","volume":"34","author":"S Zhang","year":"2013","unstructured":"Zhang S, Lin H, Kong S, et al. Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 2013;34(5):939\u201380.","journal-title":"Mol Aspects Med"},{"issue":"12","key":"1531_CR39","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1038\/nm.3012","volume":"18","author":"J Cha","year":"2012","unstructured":"Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nat Med. 2012;18(12):1754\u201367.","journal-title":"Nat Med"},{"key":"1531_CR40","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jprot.2019.03.015","volume":"200","author":"M Chen","year":"2019","unstructured":"Chen M, Zhang B, Cai S, et al. Metabolic disorder of amino acids, fatty acids and purines reflects the decreases in oocyte quality and potential in sows. J Proteomics. 2019;200:134\u201343.","journal-title":"J Proteomics"},{"issue":"12","key":"1531_CR41","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.tem.2021.09.002","volume":"32","author":"Q Ye","year":"2021","unstructured":"Ye Q, Zeng X, Cai S, et al. Mechanisms of lipid metabolism in uterine receptivity and embryo development. Trends Endocrinol Metab. 2021;32(12):1015\u201330.","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"1531_CR42","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1093\/humupd\/dmac026","volume":"28","author":"T Yang","year":"2022","unstructured":"Yang T, Zhao J, Liu F, et al. Lipid metabolism and endometrial receptivity. Hum Reprod Update. 2022;28(6):858\u201389.","journal-title":"Hum Reprod Update"},{"key":"1531_CR43","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7172388","volume":"2021","author":"Q Yin","year":"2021","unstructured":"Yin Q, Zheng J, Cao Y, et al. Evaluation of novel obesity and lipid-related indices as indicators for the diagnosis of metabolic syndrome and premetabolic syndrome in Chinese women with polycystic ovary syndrome. Int J Endocrinol. 2021;2021:7172388.","journal-title":"Int J Endocrinol"},{"issue":"7421","key":"1531_CR44","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1136\/bmj.327.7421.951","volume":"327","author":"JM Lord","year":"2003","unstructured":"Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003;327(7421):951\u20133.","journal-title":"BMJ"},{"issue":"11","key":"1531_CR45","first-page":"CD003053","volume":"11","author":"LC Morley","year":"2017","unstructured":"Morley LC, Tang T, Yasmin E, et al. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev. 2017;11(11):CD003053. Published 2017 Nov 29.","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"1531_CR46","doi-asserted-by":"publisher","first-page":"e2695","DOI":"10.1210\/clinem\/dgaa285","volume":"105","author":"H Cena","year":"2020","unstructured":"Cena H, Chiovato L, Nappi RE. Obesity, polycystic ovary syndrome, and infertility: a new avenue for GLP-1 receptor agonists. J Clin Endocrinol Metab. 2020;105(8):e2695\u2013709. https:\/\/doi.org\/10.1210\/clinem\/dgaa285.","journal-title":"J Clin Endocrinol Metab"},{"key":"1531_CR47","unstructured":"Silver RM, Branch DW. Sporadic and recurrent pregnancy loss. In: Reece EA, Hobbins JC, editors. Medicine of the fetus and mother. 2nd ed. Philadelphia: J.B. Lippincott Company; 1999. p. 195\u2013216."},{"issue":"9937","key":"1531_CR48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0140-6736(14)60157-4","volume":"384","author":"EF Schisterman","year":"2014","unstructured":"Schisterman EF, Silver RM, Lesher LL, et al. Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Lancet. 2014;384(9937):29\u201336.","journal-title":"Lancet"},{"issue":"5","key":"1531_CR49","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1210\/jc.2016-2917","volume":"102","author":"LA Sjaarda","year":"2017","unstructured":"Sjaarda LA, Radin RG, Silver RM, et al. Preconception low-dose aspirin restores diminished pregnancy and live birth rates in women with low-grade inflammation: a secondary analysis of a randomized trial. J Clin Endocrinol Metab. 2017;102(5):1495\u2013504.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1531_CR50","doi-asserted-by":"publisher","first-page":"595","DOI":"10.7326\/M20-0469","volume":"174","author":"AI Naimi","year":"2021","unstructured":"Naimi AI, Perkins NJ, Sjaarda LA, et al. The effect of Preconception-Initiated Low-Dose aspirin on human chorionic Gonadotropin-Detected pregnancy, pregnancy Loss, and live birth: per protocol analysis of a randomized trial. Ann Intern Med. 2021;174(5):595\u2013601.","journal-title":"Ann Intern Med"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-026-01531-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-026-01531-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-026-01531-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:02:50Z","timestamp":1776988970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12958-026-01531-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1531"],"URL":"https:\/\/doi.org\/10.1186\/s12958-026-01531-2","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics Committee of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Ethical review opinion\/approval.Approval No.: 2010HZYLL-010.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45"}}