{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:42:46Z","timestamp":1792788166904,"version":"4.5.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401930"],"award-info":[{"award-number":["82401930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001518"],"award-info":[{"award-number":["82001518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071616"],"award-info":[{"award-number":["82071616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQN25H270002"],"award-info":[{"award-number":["LQN25H270002"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"crossref"}]},{"name":"4+X Clinical Research Project of Women\u2019s Hospital, School of Medicine, Zhejiang University","award":["ZDFY2021-4 X202"],"award-info":[{"award-number":["ZDFY2021-4 X202"]}],"id":[{"id":"https:\/\/ror.org\/042t7yh44","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"DOI":"10.1186\/s12958-026-01584-3","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:45:30Z","timestamp":1783658730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune escape in endometriosis: mechanisms, reprogramming strategies, and precision interventions"],"prefix":"10.1186","volume":"24","author":[{"given":"Huiting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"5 Suppl 1","key":"1584_CR1","doi-asserted-by":"publisher","first-page":"S156","DOI":"10.1016\/j.fertnstert.2006.08.014","volume":"86","author":"Endometriosis and infertility","year":"2006","unstructured":"Endometriosis and infertility. Fertil Steril. 2006;86(5 Suppl 1):S156\u201360. https:\/\/doi.org\/10.1016\/j.fertnstert.2006.08.014.","journal-title":"Fertil Steril"},{"issue":"2","key":"1584_CR2","doi-asserted-by":"publisher","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","volume":"2022","author":"CM Becker","year":"2022","unstructured":"Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009. https:\/\/doi.org\/10.1093\/hropen\/hoac009.","journal-title":"Hum Reprod Open"},{"issue":"1","key":"1584_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ajog.2021.06.102","volume":"226","author":"JS Younis","year":"2022","unstructured":"Younis JS, Shapso N, Ben-Sira Y, Nelson SM, Izhaki I. Endometrioma surgery-a systematic review and meta-analysis of the effect on antral follicle count and anti-M\u00fcllerian hormone. Am J Obstet Gynecol. 2022;226(1):33\u2013e517. https:\/\/doi.org\/10.1016\/j.ajog.2021.06.102.","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"1584_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/1471-0528.17973","volume":"132","author":"P De Corte","year":"2025","unstructured":"De Corte P, Klinghardt M, von Stockum S, Heinemann K. Time to Diagnose Endometriosis: Current Status, Challenges and Regional Characteristics-A Systematic Literature Review. BJOG. 2025;132(2):118\u201330. https:\/\/doi.org\/10.1111\/1471-0528.17973.","journal-title":"BJOG"},{"issue":"11","key":"1584_CR5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3978\/j.issn.2305-5839.2015.06.08","volume":"3","author":"M Kr\u00e1l\u00ed\u010dkov\u00e1","year":"2015","unstructured":"Kr\u00e1l\u00ed\u010dkov\u00e1 M, Vetvicka V. Immunological aspects of endometriosis: a review. Ann Transl Med. 2015;3(11):153. https:\/\/doi.org\/10.3978\/j.issn.2305-5839.2015.06.08.","journal-title":"Ann Transl Med"},{"key":"1584_CR6","doi-asserted-by":"publisher","unstructured":"Reis JL, Rosa NN, \u00c2ngelo-Dias M, Martins C, Borrego LM, Lima J. Natural killer cell receptors and endometriosis: A systematic review. Int J Mol Sci. 2022;24(1). https:\/\/doi.org\/10.3390\/ijms24010331.","DOI":"10.3390\/ijms24010331"},{"issue":"11","key":"1584_CR7","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.ccell.2024.09.010","volume":"42","author":"C Galassi","year":"2024","unstructured":"Galassi C, Chan TA, Vitale I, Galluzzi L. The hallmarks of cancer immune evasion. Cancer Cell. 2024;42(11):1825\u201363. https:\/\/doi.org\/10.1016\/j.ccell.2024.09.010.","journal-title":"Cancer Cell"},{"key":"1584_CR8","doi-asserted-by":"publisher","unstructured":"Li J, Yan S, Li Q, Huang Y, Ji M, Jiao X, et al. Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis. Mol Hum Reprod. 2022;28(5). https:\/\/doi.org\/10.1093\/molehr\/gaac010.","DOI":"10.1093\/molehr\/gaac010"},{"issue":"5","key":"1584_CR9","doi-asserted-by":"publisher","first-page":"108325","DOI":"10.1016\/j.celrep.2020.108325","volume":"33","author":"M Jeljeli","year":"2020","unstructured":"Jeljeli M, Riccio LGC, Chouzenoux S, Moresi F, Toullec L, Doridot L, et al. Macrophage Immune Memory Controls Endometriosis in Mice and Humans. Cell Rep. 2020;33(5):108325. https:\/\/doi.org\/10.1016\/j.celrep.2020.108325.","journal-title":"Cell Rep"},{"issue":"7","key":"1584_CR10","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1093\/humrep\/dez071","volume":"34","author":"LGC Riccio","year":"2019","unstructured":"Riccio LGC, Jeljeli M, Santulli P, Chouzenoux S, Doridot L, Nicco C, et al. B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. Hum Reprod. 2019;34(7):1225\u201334. https:\/\/doi.org\/10.1093\/humrep\/dez071.","journal-title":"Hum Reprod"},{"issue":"12","key":"1584_CR11","doi-asserted-by":"publisher","first-page":"e2489","DOI":"10.1038\/cddis.2016.375","volume":"7","author":"C Wei","year":"2016","unstructured":"Wei C, Mei J, Tang L, Liu Y, Li D, Li M, et al. 1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis. Cell Death Dis. 2016;7(12):e2489. https:\/\/doi.org\/10.1038\/cddis.2016.375.","journal-title":"Cell Death Dis"},{"key":"1584_CR12","doi-asserted-by":"publisher","first-page":"103248","DOI":"10.1016\/j.jri.2020.103248","volume":"143","author":"M Khodarahmian","year":"2021","unstructured":"Khodarahmian M, Amidi F, Moini A, Kashani L, Salahi E, Danaii-Mehrabad S, et al. A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-\u03b1 expression in endometriosis women. J Reprod Immunol. 2021;143:103248. https:\/\/doi.org\/10.1016\/j.jri.2020.103248.","journal-title":"J Reprod Immunol"},{"issue":"4","key":"1584_CR13","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1210\/js.2017-00053","volume":"1","author":"D Mendes da Silva","year":"2017","unstructured":"Mendes da Silva D, Gross LA, Neto EPG, Lessey BA, Savaris RF. The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial. J Endocr Soc. 2017;1(4):359\u201369. https:\/\/doi.org\/10.1210\/js.2017-00053.","journal-title":"J Endocr Soc"},{"key":"1584_CR14","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fimmu.2020.00108","volume":"11","author":"JE Miller","year":"2020","unstructured":"Miller JE, Ahn SH, Marks RM, Monsanto SP, Fazleabas AT, Koti M, et al. IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis. Front Immunol. 2020;11:108. https:\/\/doi.org\/10.3389\/fimmu.2020.00108.","journal-title":"Front Immunol"},{"key":"1584_CR15","doi-asserted-by":"publisher","unstructured":"Ono Y, Kawakita T, Yoshino O, Sato E, Kano K, Ohba M, et al. Sphingosine 1-phosphate (S1P) in the peritoneal fluid skews M2 macrophage and contributes to the development of endometriosis. Biomedicines. 2021;9(11). https:\/\/doi.org\/10.3390\/biomedicines9111519.","DOI":"10.3390\/biomedicines9111519"},{"issue":"3","key":"1584_CR16","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/imm.13574","volume":"168","author":"Y Gou","year":"2023","unstructured":"Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, et al. Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3\/Trib1\/ERK\/STAT3 signalling pathway in endometriosis. Immunology. 2023;168(3):389\u2013402. https:\/\/doi.org\/10.1111\/imm.13574.","journal-title":"Immunology"},{"issue":"3","key":"1584_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1530\/rep-19-0028","volume":"158","author":"YY Liu","year":"2019","unstructured":"Liu YY, Liu YK, Hu WT, Tang LL, Sheng YR, Wei CY, et al. Elevated heme impairs macrophage phagocytosis in endometriosis. Reproduction. 2019;158(3):257\u201366. https:\/\/doi.org\/10.1530\/rep-19-0028.","journal-title":"Reproduction"},{"key":"1584_CR18","doi-asserted-by":"publisher","first-page":"1657605","DOI":"10.3389\/fimmu.2025.1657605","volume":"16","author":"W Jiang","year":"2025","unstructured":"Jiang W, Xu W, Chen F. Dysfunction of natural killer cells promotes immune escape and disease progression in endometriosis. Front Immunol. 2025;16:1657605. https:\/\/doi.org\/10.3389\/fimmu.2025.1657605.","journal-title":"Front Immunol"},{"issue":"5","key":"1584_CR19","doi-asserted-by":"publisher","first-page":"567","DOI":"10.4049\/jimmunol.2300781","volume":"213","author":"E Bj\u00f6rk","year":"2024","unstructured":"Bj\u00f6rk E, Israelsson P, Nagaev I, Nagaeva O, Lundin E, Ottander U, et al. Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis. J Immunol. 2024;213(5):567\u201376. https:\/\/doi.org\/10.4049\/jimmunol.2300781.","journal-title":"J Immunol"},{"issue":"4","key":"1584_CR20","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/humrep\/dex014","volume":"32","author":"Y Du","year":"2017","unstructured":"Du Y, Liu X, Guo SW. Platelets impair natural killer cell reactivity and function in endometriosis through multiple mechanisms. Hum Reprod. 2017;32(4):794\u2013810. https:\/\/doi.org\/10.1093\/humrep\/dex014.","journal-title":"Hum Reprod"},{"key":"1584_CR21","doi-asserted-by":"publisher","unstructured":"Yang S, Wang H, Li D, Li M. An Estrogen-NK cells regulatory axis in endometriosis, related infertility, and miscarriage. Int J Mol Sci. 2024;25(6). https:\/\/doi.org\/10.3390\/ijms25063362.","DOI":"10.3390\/ijms25063362"},{"issue":"4","key":"1584_CR22","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/path.5339","volume":"249","author":"JL Suen","year":"2019","unstructured":"Suen JL, Chang Y, Shiu YS, Hsu CY, Sharma P, Chiu CC, et al. IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis. J Pathol. 2019;249(4):485\u201397. https:\/\/doi.org\/10.1002\/path.5339.","journal-title":"J Pathol"},{"key":"1584_CR23","doi-asserted-by":"publisher","first-page":"103462","DOI":"10.1016\/j.jri.2021.103462","volume":"149","author":"PA Laginha","year":"2022","unstructured":"Laginha PA, Arcoverde FVL, Riccio LGC, Andres MP, Abr\u00e3o MS. The role of dendritic cells in endometriosis: A systematic review. J Reprod Immunol. 2022;149:103462. https:\/\/doi.org\/10.1016\/j.jri.2021.103462.","journal-title":"J Reprod Immunol"},{"issue":"1","key":"1584_CR24","doi-asserted-by":"publisher","first-page":"2411607","DOI":"10.1080\/09513590.2024.2411607","volume":"40","author":"X Yang","year":"2024","unstructured":"Yang X, Jiang L, Xu Y. HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation. Gynecol Endocrinol. 2024;40(1):2411607. https:\/\/doi.org\/10.1080\/09513590.2024.2411607.","journal-title":"Gynecol Endocrinol"},{"key":"1584_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fendo.2020.00007","volume":"11","author":"C Hogg","year":"2020","unstructured":"Hogg C, Horne AW, Greaves E. Endometriosis-Associated Macrophages: Origin, Phenotype, and Function. Front Endocrinol (Lausanne). 2020;11:7. https:\/\/doi.org\/10.3389\/fendo.2020.00007.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1584_CR26","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/s41598-020-79578-3","volume":"11","author":"Y Ono","year":"2021","unstructured":"Ono Y, Yoshino O, Hiraoka T, Sato E, Furue A, Nawaz A, et al. CD206\u2009+\u2009macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model. Sci Rep. 2021;11(1):853. https:\/\/doi.org\/10.1038\/s41598-020-79578-3.","journal-title":"Sci Rep"},{"issue":"1","key":"1584_CR27","doi-asserted-by":"publisher","first-page":"7037","DOI":"10.1038\/s41598-019-43185-8","volume":"9","author":"K Sekiguchi","year":"2019","unstructured":"Sekiguchi K, Ito Y, Hattori K, Inoue T, Hosono K, Honda M, et al. VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues. Sci Rep. 2019;9(1):7037. https:\/\/doi.org\/10.1038\/s41598-019-43185-8.","journal-title":"Sci Rep"},{"issue":"3","key":"1584_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.rbmo.2018.05.017","volume":"37","author":"J Duan","year":"2018","unstructured":"Duan J, Liu X, Wang H, Guo SW. The M2a macrophage subset may be critically involved in the fibrogenesis of endometriosis in mice. Reprod Biomed Online. 2018;37(3):254\u201368. https:\/\/doi.org\/10.1016\/j.rbmo.2018.05.017.","journal-title":"Reprod Biomed Online"},{"key":"1584_CR29","doi-asserted-by":"publisher","unstructured":"Hoogstad-van Evert J, Paap R, Nap A, van der Molen R. The promises of natural killer cell therapy in endometriosis. Int J Mol Sci. 2022;23(10). https:\/\/doi.org\/10.3390\/ijms23105539.","DOI":"10.3390\/ijms23105539"},{"key":"1584_CR30","doi-asserted-by":"publisher","first-page":"1225639","DOI":"10.3389\/fimmu.2023.1225639","volume":"14","author":"A Kisovar","year":"2023","unstructured":"Kisovar A, Becker CM, Granne I, Southcombe JH. The role of CD8\u2009+\u2009T cells in endometriosis: a systematic review. Front Immunol. 2023;14:1225639. https:\/\/doi.org\/10.3389\/fimmu.2023.1225639.","journal-title":"Front Immunol"},{"issue":"3","key":"1584_CR31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/imm.13786","volume":"172","author":"ZX Huang","year":"2024","unstructured":"Huang ZX, Lin DC, Zhang HY, Yang MJ, Chen JH, Ding XY, et al. The dysfunction of CD8(+) T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis. Immunology. 2024;172(3):469\u201385. https:\/\/doi.org\/10.1111\/imm.13786.","journal-title":"Immunology"},{"issue":"1","key":"1584_CR32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1186\/s12916-025-04369-4","volume":"23","author":"S Wang","year":"2025","unstructured":"Wang S, Xu L, Jiao X, Dong X, Zhong Z, Ren Q, et al. Iron overload-induced ferroptosis in CD8\u2009+\u2009T cells leads to functional abnormalities that promote endometriosis progression. BMC Med. 2025;23(1):588. https:\/\/doi.org\/10.1186\/s12916-025-04369-4.","journal-title":"BMC Med"},{"issue":"7","key":"1584_CR33","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1093\/humrep\/dep071","volume":"24","author":"L Schulke","year":"2009","unstructured":"Schulke L, Berbic M, Manconi F, Tokushige N, Markham R, Fraser IS. Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis. Hum Reprod. 2009;24(7):1695\u2013703. https:\/\/doi.org\/10.1093\/humrep\/dep071.","journal-title":"Hum Reprod"},{"issue":"1","key":"1584_CR34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12958-023-01058-w","volume":"21","author":"Z Qiaomei","year":"2023","unstructured":"Qiaomei Z, Ping W, Yanjing Z, Jinhua W, Shaozhan C, Lihong C. Features of peritoneal dendritic cells in the development of endometriosis. Reprod Biol Endocrinol. 2023;21(1):4. https:\/\/doi.org\/10.1186\/s12958-023-01058-w.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"1584_CR35","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.fertnstert.2016.09.036","volume":"107","author":"G Izumi","year":"2017","unstructured":"Izumi G, Koga K, Takamura M, Makabe T, Nagai M, Urata Y, et al. Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis. Fertil Steril. 2017;107(1):167\u2013e732. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.09.036.","journal-title":"Fertil Steril"},{"issue":"2","key":"1584_CR36","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1096\/fj.07-9034com","volume":"22","author":"O Fainaru","year":"2008","unstructured":"Fainaru O, Adini A, Benny O, Adini I, Short S, Bazinet L, et al. Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis. Faseb j. 2008;22(2):522\u20139. https:\/\/doi.org\/10.1096\/fj.07-9034com.","journal-title":"Faseb j"},{"issue":"10","key":"1584_CR37","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1177\/1933719114525267","volume":"21","author":"AK Stanic","year":"2014","unstructured":"Stanic AK, Kim M, Styer AK, Rueda BR. Dendritic cells attenuate the early establishment of endometriosis-like lesions in a murine model. Reprod Sci. 2014;21(10):1228\u201336. https:\/\/doi.org\/10.1177\/1933719114525267.","journal-title":"Reprod Sci"},{"issue":"4","key":"1584_CR38","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.immuni.2024.03.004","volume":"57","author":"T Kawai","year":"2024","unstructured":"Kawai T, Ikegawa M, Ori D, Akira S. Decoding Toll-like receptors: Recent insights and perspectives in innate immunity. Immunity. 2024;57(4):649\u201373. https:\/\/doi.org\/10.1016\/j.immuni.2024.03.004.","journal-title":"Immunity"},{"key":"1584_CR39","doi-asserted-by":"publisher","first-page":"103975","DOI":"10.1016\/j.jri.2023.103975","volume":"158","author":"LY Chang","year":"2023","unstructured":"Chang LY, Shan J, Hou XX, Li DJ, Wang XQ. Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding. J Reprod Immunol. 2023;158:103975. https:\/\/doi.org\/10.1016\/j.jri.2023.103975.","journal-title":"J Reprod Immunol"},{"issue":"10","key":"1584_CR40","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.1210\/jc.2019-00350","volume":"104","author":"KN Khan","year":"2019","unstructured":"Khan KN, Yamamoto K, Fujishita A, Muto H, Koshiba A, Kuroboshi H, et al. Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis. J Clin Endocrinol Metab. 2019;104(10):4715\u201329. https:\/\/doi.org\/10.1210\/jc.2019-00350.","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"1584_CR41","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.4049\/jimmunol.2400018","volume":"212","author":"DJ Sisnett","year":"2024","unstructured":"Sisnett DJ, Zutautas KB, Miller JE, Lingegowda H, Ahn SH, McCallion A, et al. The Dysregulated IL-23\/TH17 Axis in Endometriosis Pathophysiology. J Immunol. 2024;212(9):1428\u201341. https:\/\/doi.org\/10.4049\/jimmunol.2400018.","journal-title":"J Immunol"},{"issue":"8","key":"1584_CR42","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1471-0528.2005.00639.x","volume":"112","author":"X Zhang","year":"2005","unstructured":"Zhang X, Xu H, Lin J, Qian Y, Deng L. Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. BJOG. 2005;112(8):1153\u20135. https:\/\/doi.org\/10.1111\/j.1471-0528.2005.00639.x.","journal-title":"BJOG"},{"issue":"6","key":"1584_CR43","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","volume":"30","author":"M Miyara","year":"2009","unstructured":"Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, et al. Functional delineation and differentiation dynamics of human CD4\u2009+\u2009T cells expressing the FoxP3 transcription factor. Immunity. 2009;30(6):899\u2013911. https:\/\/doi.org\/10.1016\/j.immuni.2009.03.019.","journal-title":"Immunity"},{"key":"1584_CR44","doi-asserted-by":"publisher","first-page":"1582762","DOI":"10.3389\/fimmu.2025.1582762","volume":"16","author":"AE Kedzierska","year":"2025","unstructured":"Kedzierska AE, Lorek D, Slawek A, Karmowski M, Kalota A, Pajak J, et al. IL-24 producing regulatory T and B lymphocytes in endometriosis. Front Immunol. 2025;16:1582762. https:\/\/doi.org\/10.3389\/fimmu.2025.1582762.","journal-title":"Front Immunol"},{"issue":"9","key":"1584_CR45","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1210\/jc.2017-00052","volume":"102","author":"Y Tanaka","year":"2017","unstructured":"Tanaka Y, Mori T, Ito F, Koshiba A, Takaoka O, Kataoka H, et al. Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction. J Clin Endocrinol Metab. 2017;102(9):3206\u201317. https:\/\/doi.org\/10.1210\/jc.2017-00052.","journal-title":"J Clin Endocrinol Metab"},{"key":"1584_CR46","doi-asserted-by":"publisher","unstructured":"Abramiuk M, B\u0119bnowska D, Hrynkiewicz R, Polak PNG, Kotarski J, Roli\u0144ski J, et al. CTLA-4 expression is associated with the maintenance of chronic inflammation in endometriosis and infertility. Cells. 2021;10(3). https:\/\/doi.org\/10.3390\/cells10030487.","DOI":"10.3390\/cells10030487"},{"key":"1584_CR47","doi-asserted-by":"publisher","first-page":"1288263","DOI":"10.3389\/fimmu.2023.1288263","volume":"14","author":"C Zhou","year":"2023","unstructured":"Zhou C, Feng M, Chen Y, Lv S, Zhang Y, Chen J, et al. Unraveling immunotherapeutic targets for endometriosis: a transcriptomic and single-cell analysis. Front Immunol. 2023;14:1288263. https:\/\/doi.org\/10.3389\/fimmu.2023.1288263.","journal-title":"Front Immunol"},{"issue":"12","key":"1584_CR48","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/s41571-022-00689-z","volume":"19","author":"A Chow","year":"2022","unstructured":"Chow A, Perica K, Klebanoff CA, Wolchok JD. Clinical implications of T cell exhaustion for cancer immunotherapy. Nat Rev Clin Oncol. 2022;19(12):775\u201390. https:\/\/doi.org\/10.1038\/s41571-022-00689-z.","journal-title":"Nat Rev Clin Oncol"},{"key":"1584_CR49","doi-asserted-by":"publisher","unstructured":"Suszczyk D, Skiba W, Paw\u0142owska-\u0141achut A, Dymanowska-Dyjak I, W\u0142odarczyk K, Paduch R, et al. Immune checkpoints in endometriosis-a new insight in the pathogenesis. Int J Mol Sci. 2024;25(11). https:\/\/doi.org\/10.3390\/ijms25116266.","DOI":"10.3390\/ijms25116266"},{"key":"1584_CR50","doi-asserted-by":"publisher","unstructured":"Suszczyk D, Skiba W, Zardzewia\u0142y W, Paw\u0142owska A, W\u0142odarczyk K, Polak G, et al. Clinical value of the PD-1\/PD-L1\/PD-L2 pathway in patients suffering from endometriosis. Int J Mol Sci. 2022;23(19). https:\/\/doi.org\/10.3390\/ijms231911607.","DOI":"10.3390\/ijms231911607"},{"key":"1584_CR51","doi-asserted-by":"publisher","unstructured":"Sobstyl M, Mertowska P, Mertowski S, Zaborek-\u0141yczba M, Dudzi\u0144ski D, Polak G, et al. The PD-1\/PD-L1 gateway: peripheral immune regulation in the pathogenesis of endometriosis. Int J Mol Sci. 2024;25(12). https:\/\/doi.org\/10.3390\/ijms25126775.","DOI":"10.3390\/ijms25126775"},{"key":"1584_CR52","doi-asserted-by":"publisher","unstructured":"Wilson TR, Peterson KR, Morris SA, Kuhnell D, Kasper S, Burns KA. Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development. JCI Insight. 2025;10(5). https:\/\/doi.org\/10.1172\/jci.insight.186133.","DOI":"10.1172\/jci.insight.186133"},{"issue":"3","key":"1584_CR53","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/aji.12540","volume":"76","author":"M Takamura","year":"2016","unstructured":"Takamura M, Koga K, Izumi G, Urata Y, Nagai M, Hasegawa A, et al. Neutrophil depletion reduces endometriotic lesion formation in mice. Am J Reprod Immunol. 2016;76(3):193\u20138. https:\/\/doi.org\/10.1111\/aji.12540.","journal-title":"Am J Reprod Immunol"},{"key":"1584_CR54","doi-asserted-by":"publisher","first-page":"1481489","DOI":"10.1155\/2023\/1481489","volume":"2023","author":"X Wang","year":"2023","unstructured":"Wang X, Jia Y, Li D, Guo X, Zhou Z, Qi M, et al. The Abundance and Function of Neutrophils in the Endometriosis Systemic and Pelvic Microenvironment. Mediators Inflamm. 2023;2023:1481489. https:\/\/doi.org\/10.1155\/2023\/1481489.","journal-title":"Mediators Inflamm"},{"key":"1584_CR55","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ejogrb.2014.10.040","volume":"183","author":"E Berkes","year":"2014","unstructured":"Berkes E, Oehmke F, Tinneberg HR, Preissner KT, Saffarzadeh M. Association of neutrophil extracellular traps with endometriosis-related chronic inflammation. Eur J Obstet Gynecol Reprod Biol. 2014;183:193\u2013200. https:\/\/doi.org\/10.1016\/j.ejogrb.2014.10.040.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1584_CR56","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.2147\/ijwh.S504327","volume":"17","author":"Z Xu","year":"2025","unstructured":"Xu Z, Ji R, Wang M, Li T, Hu H. Neutrophil Extracellular Traps and Endometriosis: Insights from a Case-Control Study. Int J Womens Health. 2025;17:2121\u201331. https:\/\/doi.org\/10.2147\/ijwh.S504327.","journal-title":"Int J Womens Health"},{"issue":"1","key":"1584_CR57","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1096\/fj.201902272R","volume":"34","author":"LK Symons","year":"2020","unstructured":"Symons LK, Miller JE, Tyryshkin K, Monsanto SP, Marks RM, Lingegowda H, et al. Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model. Faseb j. 2020;34(1):1558\u201375. https:\/\/doi.org\/10.1096\/fj.201902272R.","journal-title":"Faseb j"},{"issue":"1","key":"1584_CR58","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13048-020-00642-7","volume":"13","author":"H Xu","year":"2020","unstructured":"Xu H, Zhao J, Lu J, Sun X. Ovarian endometrioma infiltrating neutrophils orchestrate immunosuppressive microenvironment. J Ovarian Res. 2020;13(1):44. https:\/\/doi.org\/10.1186\/s13048-020-00642-7.","journal-title":"J Ovarian Res"},{"issue":"5","key":"1584_CR59","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.fertnstert.2006.03.057","volume":"86","author":"V Anaf","year":"2006","unstructured":"Anaf V, Chapron C, El Nakadi I, De Moor V, Simonart T, No\u00ebl JC. Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis. Fertil Steril. 2006;86(5):1336\u201343. https:\/\/doi.org\/10.1016\/j.fertnstert.2006.03.057.","journal-title":"Fertil Steril"},{"key":"1584_CR60","doi-asserted-by":"publisher","first-page":"961599","DOI":"10.3389\/fimmu.2022.961599","volume":"13","author":"A McCallion","year":"2022","unstructured":"McCallion A, Nasirzadeh Y, Lingegowda H, Miller JE, Khalaj K, Ahn S, et al. Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology. Front Immunol. 2022;13:961599. https:\/\/doi.org\/10.3389\/fimmu.2022.961599.","journal-title":"Front Immunol"},{"key":"1584_CR61","doi-asserted-by":"publisher","first-page":"1106771","DOI":"10.3389\/fimmu.2023.1106771","volume":"14","author":"X Xu","year":"2023","unstructured":"Xu X, Wang J, Guo X, Chen Y, Ding S, Zou G, et al. GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2. Front Immunol. 2023;14:1106771. https:\/\/doi.org\/10.3389\/fimmu.2023.1106771.","journal-title":"Front Immunol"},{"issue":"13","key":"1584_CR62","doi-asserted-by":"publisher","first-page":"e70778","DOI":"10.1096\/fj.202501493R","volume":"39","author":"X Mao","year":"2025","unstructured":"Mao X, Wang J, Ding S, Guo X, Xu X, Xu P, et al. MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine\/HRH1\/TRPV1 Signaling Pathway. Faseb j. 2025;39(13):e70778. https:\/\/doi.org\/10.1096\/fj.202501493R.","journal-title":"Faseb j"},{"issue":"2","key":"1584_CR63","doi-asserted-by":"publisher","first-page":"104","DOI":"10.4274\/tjod.galenos.2024.77489","volume":"21","author":"S Fekri","year":"2024","unstructured":"Fekri S, Makoui RH, Ansari N, Makoui MH. Correlation between the existence of serum autoantibodies and the risk of endometriosis: A systematic review and meta-analysis. Turk J Obstet Gynecol. 2024;21(2):104\u201317. https:\/\/doi.org\/10.4274\/tjod.galenos.2024.77489.","journal-title":"Turk J Obstet Gynecol"},{"issue":"1","key":"1584_CR64","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.fertnstert.2023.02.025","volume":"120","author":"S Harden","year":"2023","unstructured":"Harden S, Tan TY, Ku CW, Zhou J, Chen Q, Chan JKY, et al. Peritoneal autoantibody profiling identifies p53 as an autoantibody target in endometriosis. Fertil Steril. 2023;120(1):176\u201387. https:\/\/doi.org\/10.1016\/j.fertnstert.2023.02.025.","journal-title":"Fertil Steril"},{"key":"1584_CR65","doi-asserted-by":"publisher","unstructured":"Kitaya K. B Cell lineage in the human endometrium: physiological and pathological implications. Cells. 2025;14(9). https:\/\/doi.org\/10.3390\/cells14090648.","DOI":"10.3390\/cells14090648"},{"issue":"1","key":"1584_CR66","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12916-022-02500-3","volume":"20","author":"AJ Shih","year":"2022","unstructured":"Shih AJ, Adelson RP, Vashistha H, Khalili H, Nayyar A, Puran R, et al. Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis. BMC Med. 2022;20(1):315. https:\/\/doi.org\/10.1186\/s12916-022-02500-3.","journal-title":"BMC Med"},{"issue":"3","key":"1584_CR67","doi-asserted-by":"publisher","first-page":"e13675","DOI":"10.1111\/aji.13675","volume":"89","author":"A Slawek","year":"2023","unstructured":"Slawek A, Lorek D, Kedzierska AE, Kubik P, Pajak J, Chrobak A, et al. Peripheral blood subpopulations of Bregs producing IL-35 in women with endometriosis. Am J Reprod Immunol. 2023;89(3):e13675. https:\/\/doi.org\/10.1111\/aji.13675.","journal-title":"Am J Reprod Immunol"},{"key":"1584_CR68","doi-asserted-by":"publisher","first-page":"103513","DOI":"10.1016\/j.jri.2022.103513","volume":"151","author":"L Hu","year":"2022","unstructured":"Hu L, Zhang J, Lu Y, Fu B, Hu W. Estrogen receptor beta promotes endometriosis progression by upregulating CD47 expression in ectopic endometrial stromal cells. J Reprod Immunol. 2022;151:103513. https:\/\/doi.org\/10.1016\/j.jri.2022.103513.","journal-title":"J Reprod Immunol"},{"issue":"4","key":"1584_CR69","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.tranon.2018.12.001","volume":"12","author":"P Cabrales","year":"2019","unstructured":"Cabrales P. RRx-001 Acts as a Dual Small Molecule Checkpoint Inhibitor by Downregulating CD47 on Cancer Cells and SIRP-\u03b1 on Monocytes\/Macrophages. Transl Oncol. 2019;12(4):626\u201332. https:\/\/doi.org\/10.1016\/j.tranon.2018.12.001.","journal-title":"Transl Oncol"},{"issue":"4","key":"1584_CR70","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41591-019-0356-z","volume":"25","author":"MEW Logtenberg","year":"2019","unstructured":"Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, et al. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRP\u03b1 axis and a target for cancer immunotherapy. Nat Med. 2019;25(4):612\u20139. https:\/\/doi.org\/10.1038\/s41591-019-0356-z.","journal-title":"Nat Med"},{"issue":"1","key":"1584_CR71","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1038\/s42003-025-08938-4","volume":"8","author":"A van der Plas-van Duijn","year":"2025","unstructured":"van der Plas-van Duijn A, Winkelman LMT, Lensen C, van Duivendijk M, Derksen I, van Veenendaal JMF, et al. Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding. Commun Biol. 2025;8(1):1561. https:\/\/doi.org\/10.1038\/s42003-025-08938-4.","journal-title":"Commun Biol"},{"issue":"1","key":"1584_CR72","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/s41392-023-01715-x","volume":"8","author":"L Yu","year":"2023","unstructured":"Yu L, Zhao P, Sun Y, Zheng Z, Du W, Zhang L, et al. Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy. Signal Transduct Target Ther. 2023;8(1):454. https:\/\/doi.org\/10.1038\/s41392-023-01715-x.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"1584_CR73","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12964-024-01555-4","volume":"22","author":"S Jin","year":"2024","unstructured":"Jin S, Wang H, Li Y, Yang J, Li B, Shi P, et al. Discovery of a novel small molecule as CD47\/SIRP\u03b1 and PD-1\/PD-L1 dual inhibitor for cancer immunotherapy. Cell Commun Signal. 2024;22(1):173. https:\/\/doi.org\/10.1186\/s12964-024-01555-4.","journal-title":"Cell Commun Signal"},{"issue":"7","key":"1584_CR74","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/s12276-022-00793-1","volume":"54","author":"H Peng","year":"2022","unstructured":"Peng H, Weng L, Lei S, Hou S, Yang S, Li M, et al. Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16(-) NK-cell differentiation. Exp Mol Med. 2022;54(7):890\u2013905. https:\/\/doi.org\/10.1038\/s12276-022-00793-1.","journal-title":"Exp Mol Med"},{"key":"1584_CR75","doi-asserted-by":"publisher","unstructured":"Dull AM, Moga MA, Dimienescu OG, Sechel G, Burtea V, Anastasiu CV. Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways. Molecules. 2019;24(4). https:\/\/doi.org\/10.3390\/molecules24040667.","DOI":"10.3390\/molecules24040667"},{"issue":"1","key":"1584_CR76","doi-asserted-by":"publisher","first-page":"42","DOI":"10.7150\/ijms.10076","volume":"12","author":"IC Jeung","year":"2015","unstructured":"Jeung IC, Chung YJ, Chae B, Kang SY, Song JY, Jo HH, et al. Effect of helixor A on natural killer cell activity in endometriosis. Int J Med Sci. 2015;12(1):42\u20137. https:\/\/doi.org\/10.7150\/ijms.10076.","journal-title":"Int J Med Sci"},{"key":"1584_CR77","doi-asserted-by":"publisher","first-page":"5760959","DOI":"10.1155\/2021\/5760959","volume":"2021","author":"R Muharam","year":"2021","unstructured":"Muharam R, Febri RR, Prabowo KA, Bustami A, Mansur IG. Increased Levels of CD107a and Intracellular Cytokines in IL-2 Stimulated PBMCs from Endometriosis Patients. Int J Inflam. 2021;2021:5760959. https:\/\/doi.org\/10.1155\/2021\/5760959.","journal-title":"Int J Inflam"},{"issue":"1","key":"1584_CR78","doi-asserted-by":"publisher","first-page":"2372682","DOI":"10.1080\/01443615.2024.2372682","volume":"44","author":"J Yao","year":"2024","unstructured":"Yao J, Zhang LJ, Zhou Z, Hua MF. NK-92 cells activated by IL-2 inhibit the progression of endometriosis in vitro. J Obstet Gynaecol. 2024;44(1):2372682. https:\/\/doi.org\/10.1080\/01443615.2024.2372682.","journal-title":"J Obstet Gynaecol"},{"issue":"12","key":"1584_CR79","doi-asserted-by":"publisher","first-page":"102464","DOI":"10.1016\/j.xcrm.2025.102464","volume":"6","author":"B Yao","year":"2025","unstructured":"Yao B, Zheng R, Yang Y, Zhao Z, Lash GE, Guo B, et al. Therapeutic targeting of interleukin-17\u00a0C signaling in carcinogenesis of endometriosis. Cell Rep Med. 2025;6(12):102464. https:\/\/doi.org\/10.1016\/j.xcrm.2025.102464.","journal-title":"Cell Rep Med"},{"key":"1584_CR80","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ejps.2016.10.031","volume":"96","author":"Q Liu","year":"2017","unstructured":"Liu Q, Ma P, Liu L, Ma G, Ma J, Liu X, et al. Evaluation of PLGA containing anti-CTLA4 inhibited endometriosis progression by regulating CD4\u2009+\u2009CD25+Treg cells in peritoneal fluid of mouse endometriosis model. Eur J Pharm Sci. 2017;96:542\u201350. https:\/\/doi.org\/10.1016\/j.ejps.2016.10.031.","journal-title":"Eur J Pharm Sci"},{"key":"1584_CR81","doi-asserted-by":"publisher","unstructured":"Camorani S, Tortorella S, Agnello L, Spanu C, d\u2019Argenio A, Nilo R, et al. Aptamer-functionalized nanoparticles mediate PD-L1 siRNA delivery for effective gene silencing in triple-negative breast cancer cells. Pharmaceutics. 2022;14(10). https:\/\/doi.org\/10.3390\/pharmaceutics14102225.","DOI":"10.3390\/pharmaceutics14102225"},{"key":"1584_CR82","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.actbio.2024.09.037","volume":"189","author":"M Zhang","year":"2024","unstructured":"Zhang M, Ye Y, Chen Z, Wu X, Chen Y, Zhao P, et al. Targeting delivery of mifepristone to endometrial dysfunctional macrophages for endometriosis therapy. Acta Biomater. 2024;189:505\u201318. https:\/\/doi.org\/10.1016\/j.actbio.2024.09.037.","journal-title":"Acta Biomater"},{"key":"1584_CR83","doi-asserted-by":"publisher","first-page":"112893","DOI":"10.1016\/j.colsurfb.2022.112893","volume":"220","author":"Q Sun","year":"2022","unstructured":"Sun Q, Lei Y, Zhang H, Ding X, Yang M, Zhang T, et al. A multifunctional nanoparticle for efferocytosis and pro-resolving-mediated endometriosis therapy. Colloids Surf B Biointerfaces. 2022;220:112893. https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112893.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"1584_CR84","doi-asserted-by":"publisher","first-page":"123198","DOI":"10.1016\/j.biomaterials.2025.123198","volume":"319","author":"N Wu","year":"2025","unstructured":"Wu N, Han Z, Lv W, Huang Y, Zhu J, Deng J, et al. Reprogramming peritoneal macrophages with outer membrane vesicle-coated PLGA nanoparticles for endometriosis prevention. Biomaterials. 2025;319:123198. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123198.","journal-title":"Biomaterials"},{"issue":"22","key":"1584_CR85","doi-asserted-by":"publisher","first-page":"5584","DOI":"10.1016\/j.biomaterials.2012.04.041","volume":"33","author":"ES Jang","year":"2012","unstructured":"Jang ES, Shin JH, Ren G, Park MJ, Cheng K, Chen X, et al. The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles. Biomaterials. 2012;33(22):5584\u201392. https:\/\/doi.org\/10.1016\/j.biomaterials.2012.04.041.","journal-title":"Biomaterials"},{"issue":"10","key":"1584_CR86","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1039\/c8bm00588e","volume":"6","author":"L Wu","year":"2018","unstructured":"Wu L, Zhang F, Wei Z, Li X, Zhao H, Lv H, et al. Magnetic delivery of Fe(3)O(4)@polydopamine nanoparticle-loaded natural killer cells suggest a promising anticancer treatment. Biomater Sci. 2018;6(10):2714\u201325. https:\/\/doi.org\/10.1039\/c8bm00588e.","journal-title":"Biomater Sci"},{"issue":"10","key":"1584_CR87","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1038\/s41565-024-01736-9","volume":"19","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Deng Y, Zhai Y, Li Y, Li Y, Li J, et al. A bispecific nanosystem activates endogenous natural killer cells in the bone marrow for haematologic malignancies therapy. Nat Nanotechnol. 2024;19(10):1558\u201368. https:\/\/doi.org\/10.1038\/s41565-024-01736-9.","journal-title":"Nat Nanotechnol"},{"issue":"51","key":"1584_CR88","doi-asserted-by":"publisher","first-page":"56731","DOI":"10.1021\/acsami.0c16357","volume":"12","author":"KS Kim","year":"2020","unstructured":"Kim KS, Han JH, Choi SH, Jung HY, Park JD, An HJ, et al. Cationic Nanoparticle-Mediated Activation of Natural Killer Cells for Effective Cancer Immunotherapy. ACS Appl Mater Interfaces. 2020;12(51):56731\u201340. https:\/\/doi.org\/10.1021\/acsami.0c16357.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"4","key":"1584_CR89","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.ymthe.2025.02.047","volume":"33","author":"J Driscoll","year":"2025","unstructured":"Driscoll J, Gondaliya P, Zinn DA, Jain R, Yan IK, Dong H, et al. Using aptamers for targeted delivery of RNA therapies. Mol Ther. 2025;33(4):1344\u201367. https:\/\/doi.org\/10.1016\/j.ymthe.2025.02.047.","journal-title":"Mol Ther"},{"issue":"1","key":"1584_CR90","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/s12951-024-02744-6","volume":"22","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Wei R, Wang L, Li J, Wang W, Jiang G, et al. Tumor targeting peptide TMTP1 modified Antigen capture Nano-vaccine combined with chemotherapy and PD-L1 blockade effectively inhibits growth of ovarian cancer. J Nanobiotechnol. 2024;22(1):483. https:\/\/doi.org\/10.1186\/s12951-024-02744-6.","journal-title":"J Nanobiotechnol"},{"key":"1584_CR91","doi-asserted-by":"publisher","first-page":"1727183","DOI":"10.3389\/fimmu.2025.1727183","volume":"16","author":"S Shifon","year":"2025","unstructured":"Shifon S, Tyrinova T, Veretelnikova T, Pasman N, Chernykh E. Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies. Front Immunol. 2025;16:1727183. https:\/\/doi.org\/10.3389\/fimmu.2025.1727183.","journal-title":"Front Immunol"},{"key":"1584_CR92","doi-asserted-by":"publisher","unstructured":"Ram\u00edrez-Pavez TN, Mar\u00edn-S\u00e1nchez P, Nebot A, Garc\u00eda-Izquierdo L, Nieto-Meca L, S\u00e1nchez R, et al. Systemic immune and tumor marker profiles in ovarian and deep infiltrating endometriosis: associations with disease severity and symptom burden. Int J Mol Sci. 2025;26(19). https:\/\/doi.org\/10.3390\/ijms26199581.","DOI":"10.3390\/ijms26199581"},{"key":"1584_CR93","doi-asserted-by":"publisher","unstructured":"Chang L, Shan J, Li D, Wang X. Neuroendocrine-immune axis in endometriosis: a review on how the nervous system goes beyond pain perception. Biomolecules. 2025;15(11). https:\/\/doi.org\/10.3390\/biom15111536.","DOI":"10.3390\/biom15111536"},{"key":"1584_CR94","doi-asserted-by":"publisher","first-page":"1613334","DOI":"10.3389\/fendo.2025.1613334","volume":"16","author":"Y Ou","year":"2025","unstructured":"Ou Y, Wang H, Zhou C, Chen Y, Lyu J, Feng M, et al. Endometriosis-associated infertility: Multi-omics insights into pathogenesis and precision therapeutics. Front Endocrinol (Lausanne). 2025;16:1613334. https:\/\/doi.org\/10.3389\/fendo.2025.1613334.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1584_CR95","doi-asserted-by":"publisher","first-page":"1545270","DOI":"10.3389\/fimmu.2025.1545270","volume":"16","author":"M Shirzadian","year":"2025","unstructured":"Shirzadian M, Moori S, Rabbani R, Rahbarizadeh F. SynNotch CAR-T cell, when synthetic biology and immunology meet again. Front Immunol. 2025;16:1545270. https:\/\/doi.org\/10.3389\/fimmu.2025.1545270.","journal-title":"Front Immunol"},{"issue":"5","key":"1584_CR96","doi-asserted-by":"publisher","first-page":"C1473","DOI":"10.1152\/ajpcell.00659.2024","volume":"328","author":"L Song","year":"2025","unstructured":"Song L, Zhang Q, Sui H, Gao C, Jiang Z. Recent advances in synthetic Notch receptors for biomedical application. Am J Physiol Cell Physiol. 2025;328(5):C1473\u201386. https:\/\/doi.org\/10.1152\/ajpcell.00659.2024.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"1584_CR97","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41573-021-00371-6","volume":"21","author":"M B\u00e9k\u00e9s","year":"2022","unstructured":"B\u00e9k\u00e9s M, Langley DR, Crews CM. PROTAC targeted protein degraders: the past is prologue. Nat Rev Drug Discov. 2022;21(3):181\u2013200. https:\/\/doi.org\/10.1038\/s41573-021-00371-6.","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"1584_CR98","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s41419-022-05375-7","volume":"13","author":"MY Dai","year":"2022","unstructured":"Dai MY, Shi YY, Wang AJ, Liu XL, Liu M, Cai HB. High-potency PD-1\/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells. Cell Death Dis. 2022;13(11):924. https:\/\/doi.org\/10.1038\/s41419-022-05375-7.","journal-title":"Cell Death Dis"},{"issue":"7637","key":"1584_CR99","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature21349","volume":"541","author":"DS Chen","year":"2017","unstructured":"Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541(7637):321\u201330. https:\/\/doi.org\/10.1038\/nature21349.","journal-title":"Nature"},{"issue":"7","key":"1584_CR100","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/s12276-025-01487-0","volume":"57","author":"BS Park","year":"2025","unstructured":"Park BS, Lee M, Kim J, Kim T, Perturbomics. CRISPR-Cas screening-based functional genomics approach for drug target discovery. Exp Mol Med. 2025;57(7):1443\u201354. https:\/\/doi.org\/10.1038\/s12276-025-01487-0.","journal-title":"Exp Mol Med"},{"issue":"10427","key":"1584_CR101","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/s0140-6736(23)02268-7","volume":"403","author":"JS Weber","year":"2024","unstructured":"Weber JS, Carlino MS, Khattak A, Meniawy T, Ansstas G, Taylor MH, et al. Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study. Lancet. 2024;403(10427):632\u201344. https:\/\/doi.org\/10.1016\/s0140-6736(23)02268-7.","journal-title":"Lancet"},{"issue":"7662","key":"1584_CR102","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature22991","volume":"547","author":"PA Ott","year":"2017","unstructured":"Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017;547(7662):217\u201321. https:\/\/doi.org\/10.1038\/nature22991.","journal-title":"Nature"},{"issue":"7963","key":"1584_CR103","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41586-023-06063-y","volume":"618","author":"LA Rojas","year":"2023","unstructured":"Rojas LA, Sethna Z, Soares KC, Olcese C, Pang N, Patterson E, et al. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature. 2023;618(7963):144\u201350. https:\/\/doi.org\/10.1038\/s41586-023-06063-y.","journal-title":"Nature"},{"issue":"8","key":"1584_CR104","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.molmed.2024.04.014","volume":"30","author":"B Chen","year":"2024","unstructured":"Chen B, Deng Y, Ren X, Zhao J, Jiang C. CRISPR\/Cas9 screening: unraveling cancer immunotherapy\u2019s \u2018Rosetta Stone\u2019. Trends Mol Med. 2024;30(8):736\u201349. https:\/\/doi.org\/10.1016\/j.molmed.2024.04.014.","journal-title":"Trends Mol Med"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-026-01584-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-026-01584-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-026-01584-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:28:31Z","timestamp":1791160111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12958-026-01584-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":104,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1584"],"URL":"https:\/\/doi.org\/10.1186\/s12958-026-01584-3","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"4 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"93"}}