{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:38:10Z","timestamp":1783690690046,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thrombosis J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>We conducted a prospective observational study for investigating the changes in the 13th member of a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) and its association with the coagulofibrinolytic response in adult trauma patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In 39 trauma patients hospitalized for longer than 7\u2009days, time-course changes in biomarkers of coagulofibrinolysis and systemic inflammation along with ADAMTS13 activity were examined. The patients were stratified into three groups based on ADAMTS13 activities on admission (day 0): normal group (\u226570%), mildly decreased group (\u226550 and\u2009&lt;\u200970%) and moderately decreased group (&lt;\u200950%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 39 patients with a median Injury Severity Score (ISS) of 20, 11 patients developed disseminated intravascular coagulation (DIC) and 16 patients required transfusion. Six of 39 patients (15.4%) showed moderate decreased ADAMTS13 activity to &lt;\u200950%, and 20 patients (51.3%) showed mild drops (\u226550 and\u2009&lt;\u200970%). These changes in ADAMTS13 activity on day 0 were significantly correlated with changes in IL-6 and other coagulofibrinolytic markers such as platelet counts, prothrombin time and fibrin\/fibrinogen degradation product (FDP). Antithrombin activity (AT) and serum albumin (Alb) level showed significantly positive linear correlations with ADAMTS13 activity (AT: <jats:italic>r<\/jats:italic>\u2009=\u20090.513, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; Alb: <jats:italic>r<\/jats:italic>\u2009=\u20090.647, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Simple logistic regression analyses showed that ADAMTS13 activity, if less than 50%, was significantly correlated with the development of DIC (<jats:italic>OR<\/jats:italic> 7.499, 95%<jats:italic>CI<\/jats:italic> 1.121\u201349.242, <jats:italic>p<\/jats:italic>\u2009=\u20090.038) and the need for transfusion of fresh frozen plasma (<jats:italic>OR<\/jats:italic> 9.000, 95%<jats:italic>CI<\/jats:italic> 1.327\u201361.025, <jats:italic>p<\/jats:italic>\u2009=\u20090.028).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>ADAMTS13 activity decreased even in the early phase of trauma, which was complicated by coagulopathy and systemic inflammation. Furthermore, the decrease in ADAMTS13 activity was correlated with DIC and plasma transfusion.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12959-021-00270-1","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:09:10Z","timestamp":1615547350000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["ADAMTS13 activity decreases in the early phase of trauma associated with coagulopathy and systemic inflammation: a prospective observational study"],"prefix":"10.1186","volume":"19","author":[{"given":"Hironori","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takeba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Umakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneaki","family":"Ohshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Annen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuki","family":"Aibiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"issue":"1","key":"270_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1182\/blood-2008-02-078170","volume":"112","author":"JE Sadler","year":"2008","unstructured":"Sadler JE. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood. 2008;112(1):11\u20138.","journal-title":"Blood."},{"issue":"12","key":"270_CR2","doi-asserted-by":"publisher","first-page":"4033","DOI":"10.1182\/blood-2002-05-1401","volume":"100","author":"JF Dong","year":"2002","unstructured":"Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, L\u00f3pez JA. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002;100(12):4033\u20139.","journal-title":"Blood."},{"issue":"10","key":"270_CR3","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1182\/blood-2017-04-636431","volume":"130","author":"JE Sadler","year":"2017","unstructured":"Sadler JE. Pathophysiology of thrombotic thrombocytopenic purpura. Blood. 2017;130(10):1181\u20138.","journal-title":"Blood."},{"issue":"8","key":"270_CR4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1056\/NEJMra020528","volume":"347","author":"JL Moake","year":"2002","unstructured":"Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002;347(8):589\u2013600.","journal-title":"N Engl J Med"},{"issue":"1","key":"270_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/jth.13898","volume":"16","author":"K South","year":"2018","unstructured":"South K, Lane DA. ADAMTS-13 and von Willebrand factor: a dynamic duo. J Thromb Haemost. 2018;16(1):6\u201318.","journal-title":"J Thromb Haemost"},{"issue":"5","key":"270_CR6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s12185-016-2091-2","volume":"104","author":"Y Feng","year":"2016","unstructured":"Feng Y, Li X, Xiao J, Li W, Liu J, Zeng X, Chen X, Chen S. ADAMTS13: more than a regulator of thrombosis. Int J Hematol. 2016;104(5):534\u20139.","journal-title":"Int J Hematol"},{"issue":"10","key":"270_CR7","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1111\/jth.13764","volume":"15","author":"M Saha","year":"2017","unstructured":"Saha M, McDaniel JK, Zheng XL. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017;15(10):1889\u2013900.","journal-title":"J Thromb Haemost"},{"issue":"9","key":"270_CR8","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1182\/blood-2018-02-791533","volume":"132","author":"C Masias","year":"2018","unstructured":"Masias C, Cataland SR. The role of ADAMTS13 testing in the diagnosis and management of thrombotic microangiopathies and thrombosis. Blood. 2018;132(9):903\u201310.","journal-title":"Blood."},{"key":"270_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12959-018-0168-2","volume":"16","author":"H Wada","year":"2018","unstructured":"Wada H, Matsumoto T, Suzuki K, Imai H, Katayama N, Iba T, Matsumoto M. Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy. Thromb J. 2018;16:14.","journal-title":"Thromb J"},{"issue":"4","key":"270_CR10","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1055\/s-0038-1636528","volume":"118","author":"RT Russell","year":"2018","unstructured":"Russell RT, McDaniel JK, Cao W, Shroyer M, Wagener BM, Zheng XL, Pittet JF. Low plasma ADAMTS13 activity is associated with coagulopathy, endothelial cell damage and mortality after severe paediatric trauma. Thromb Haemost. 2018;118(4):676\u201387.","journal-title":"Thromb Haemost"},{"issue":"3","key":"270_CR11","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/jth.14690","volume":"18","author":"HB Moore","year":"2020","unstructured":"Moore HB, Gando S, Iba T, Kim PY, Yeh CH, Brohi K, Hunt BJ, Levy JH, Draxler DF, Stanworth S, G\u00f6rlinger K, Neal MD, Schreiber MA, Barrett CD, Medcalf RL, Moore EE, Mutch NJ, Thachil J, Urano T, Thomas S, Sc\u0103rl\u0103tescu E, Walsh M, Subcommittees on Fibrinolysis, Disseminated Intravascular Coagulation, and Perioperative and Critical Care Thrombosis and Hemostasis. Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH. J Thromb Haemost. 2020;18(3):740\u20137.","journal-title":"J Thromb Haemost"},{"issue":"12","key":"270_CR12","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1111\/jth.12011","volume":"10","author":"S Gando","year":"2012","unstructured":"Gando S, Wada H, Kim HK, Kurosawa S, Nielsen JD, Thachil J, Toh CH, Scientific and Standardization Committee on DIC of the ISTH. Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma\/acute coagulopathy of trauma-shock. J Thromb Haemost. 2012;10(12):2593\u20135.","journal-title":"J Thromb Haemost"},{"issue":"6","key":"270_CR13","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","volume":"101","author":"RC Bone","year":"1992","unstructured":"Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee American College of Chest Physicians\/Society of Critical Care Medicine. Chest. 1992;101(6):1644\u201355.","journal-title":"Chest"},{"issue":"1","key":"270_CR14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/01.CCM.0000295317.97245.2D","volume":"36","author":"S Gando","year":"2008","unstructured":"Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Ikeda T, Ishikura H, Iba T, Ueyama M, Eguchi Y, Ohtomo Y, Okamoto K, Kushimoto S, Endo S, Shimazaki S, Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey. Crit Care Med. 2008;36(1):145\u201350.","journal-title":"Crit Care Med"},{"issue":"8","key":"270_CR15","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1111\/j.1537-2995.2006.00914.x","volume":"46","author":"S Kato","year":"2006","unstructured":"Kato S, Matsumoto M, Matsuyama T, Isonishi A, Hiura H, Fujimura Y. Novel monoclonal antibody-based enzyme immunoassay for determining plasma levels of ADAMTS13 activity. Transfusion. 2006;46(8):1444\u201352.","journal-title":"Transfusion."},{"issue":"1","key":"270_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2169\/internalmedicine.49.2706","volume":"49","author":"Y Fujimura","year":"2010","unstructured":"Fujimura Y, Matsumoto M. Registry of 919 patients with thrombotic microangiopathies across Japan: database of Nara Medical University during 1998-2008. Intern Med. 2010;49(1):7\u201315.","journal-title":"Intern Med"},{"issue":"21","key":"270_CR17","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1182\/blood-2016-11-743104","volume":"129","author":"C Masias","year":"2017","unstructured":"Masias C, Vasu S, Cataland SR. None of the above: thrombotic microangiopathy beyond TTP and HUS. Blood. 2017;129(21):2857\u201363.","journal-title":"Blood."},{"issue":"2","key":"270_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.imbio.2016.10.014","volume":"222","author":"P Farkas","year":"2017","unstructured":"Farkas P, Csuka D, Mikes B, Sinkovits G, R\u00e9ti M, N\u00e9meth E, R\u00e1cz K, Mad\u00e1ch K, Gergely M, Demeter J, Proh\u00e1szka Z. Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies. Immunobiology. 2017;222(2):119\u201327.","journal-title":"Immunobiology."},{"issue":"10","key":"270_CR19","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1097\/01.CCM.0000284508.05247.B3","volume":"35","author":"K Martin","year":"2007","unstructured":"Martin K, Borgel D, Lerolle N, Feys HB, Trinquart L, Vanhoorelbeke K, Deckmyn H, Legendre P, Diehl JL, Baruch D. Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure. Crit Care Med. 2007;35(10):2375\u201382.","journal-title":"Crit Care Med"},{"issue":"2","key":"270_CR20","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1182\/blood-2005-03-1087","volume":"107","author":"T Ono","year":"2006","unstructured":"Ono T, Mimuro J, Madoiwa S, Soejima K, Kashiwakura Y, Ishiwata A, Takano K, Ohmori T, Sakata Y. Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. Blood. 2006;107(2):528\u201334.","journal-title":"Blood."},{"issue":"4","key":"270_CR21","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/jth.13953","volume":"16","author":"M Levi","year":"2018","unstructured":"Levi M, Scully M, Singer M. The role of ADAMTS-13 in the coagulopathy of sepsis. J Thromb Haemost. 2018;16(4):646\u201351.","journal-title":"J Thromb Haemost"},{"issue":"6","key":"270_CR22","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/SHK.0000000000000341","volume":"43","author":"J Aibar","year":"2015","unstructured":"Aibar J, Castro P, Espinosa G, Fern\u00e1ndez S, Hern\u00e1ndez C, Rinaudo M, Butjosa M, T\u00e0ssies D, Reverter JC, Nicol\u00e1s JM. ADAMTS-13 in critically ill patients with septic syndromes and noninfectious systemic inflammatory response syndrome. Shock. 2015;43(6):556\u201362.","journal-title":"Shock."},{"issue":"16","key":"270_CR23","doi-asserted-by":"publisher","first-page":"e3374","DOI":"10.1097\/MD.0000000000003374","volume":"95","author":"JJ Lin","year":"2016","unstructured":"Lin JJ, Chan OW, Hsiao HJ, Wang Y, Hsia SH, Chiu CH. Decreased ADAMTS 13 activity is associated with disease severity and outcome in pediatric severe sepsis. Medicine (Baltimore). 2016;95(16):e3374.","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"270_CR24","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1182\/blood-2005-01-0152","volume":"106","author":"M Uemura","year":"2005","unstructured":"Uemura M, Tatsumi K, Matsumoto M, Fujimoto M, Matsuyama T, Ishikawa M, Iwamoto TA, Mori T, Wanaka A, Fukui H, Fujimura Y. Localization of ADAMTS13 to the stellate cells of human liver. Blood. 2005;106(3):922\u20134.","journal-title":"Blood."},{"issue":"32","key":"270_CR25","doi-asserted-by":"publisher","first-page":"29633","DOI":"10.1074\/jbc.M301385200","volume":"278","author":"JF Dong","year":"2003","unstructured":"Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, L\u00f3pez JA, Cruz MA. ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem. 2003;278(32):29633\u20139.","journal-title":"J Biol Chem"},{"issue":"1","key":"270_CR26","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1182\/blood-2004-01-0107","volume":"104","author":"A Bernardo","year":"2004","unstructured":"Bernardo A, Ball C, Nolasco L, Moake JF, Dong JF. Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow. Blood. 2004;104(1):100\u20136.","journal-title":"Blood."},{"issue":"4","key":"270_CR27","first-page":"403","volume":"148","author":"H Hiura","year":"2010","unstructured":"Hiura H, Matsui T, Matsumoto M, Hori Y, Isonishi A, Kato S, Iwamoto T, Mori T, Fujimura Y. Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody. J Biochem. 2010;148(4):403\u201311.","journal-title":"J Biochem"},{"issue":"3","key":"270_CR28","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1182\/blood-2004-03-1101","volume":"105","author":"JT Crawley","year":"2005","unstructured":"Crawley JT, Lam JK, Rance JB, Mollica LR, O'Donnell JS, Lane DA. Proteolytic inactivation of ADAMTS13 by thrombin and plasmin. Blood. 2005;105(3):1085\u201393.","journal-title":"Blood."},{"issue":"2","key":"270_CR29","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/01.shk.0000239762.90335.68","volume":"27","author":"M Aibiki","year":"2007","unstructured":"Aibiki M, Fukuoka N, Umakoshi K, Ohtsubo S, Kikuchi S. Serum albumin levels anticipate antithrombin III activities before and after antithrombin III agent in critical patients with disseminated intravascular coagulation. Shock. 2007;27(2):139\u201344.","journal-title":"Shock."},{"issue":"3","key":"270_CR30","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1034\/j.1600-0609.2001.5790508.x","volume":"67","author":"H Asakura","year":"2001","unstructured":"Asakura H, Ontachi Y, Mizutani T, Kato M, Ito T, Saito M, Morishita E, Yamazaki M, Aoshima K, Takami A, Yoshida T, Suga Y, Miyamoto K, Nakao S. Decreased plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation. Eur J Haematol. 2001;67(3):170\u20135.","journal-title":"Eur J Haematol"},{"issue":"6","key":"270_CR31","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1177\/1076029609344085","volume":"16","author":"A Kobayashi","year":"2010","unstructured":"Kobayashi A, Matsuda Y, Mitani M, Makino Y, Ohta H. Assessment of the usefulness of antithrombin-III in the management of disseminated intravascular coagulation in obstetrically ill patients. Clin Appl Thromb Hemost. 2010;16(6):688\u201393.","journal-title":"Clin Appl Thromb Hemost"},{"key":"270_CR32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12959-018-0171-7","volume":"16","author":"H Matsumoto","year":"2018","unstructured":"Matsumoto H, Takeba J, Umakoshi K, Kikuchi S, Ohshita M, Annen S, Moriyama N, Nakabayashi Y, Sato N, Aibiki M. Decreased antithrombin activity in the early phase of trauma is strongly associated with extravascular leakage, but not with antithrombin consumption: a prospective observational study. Thromb J. 2018;16:17.","journal-title":"Thromb J"},{"issue":"8","key":"270_CR33","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1046\/j.1365-2044.1998.00438.x","volume":"53","author":"MP Margarson","year":"1998","unstructured":"Margarson MP, Soni N. Serum albumin: touchstone or totem? Anaesthesia. 1998;53(8):789\u2013803.","journal-title":"Anaesthesia."},{"issue":"3","key":"270_CR34","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/bja\/aep393","volume":"104","author":"J Boldt","year":"2010","unstructured":"Boldt J. Use of albumin: an update. Br J Anaesth. 2010;104(3):276\u201384.","journal-title":"Br J Anaesth"},{"issue":"9","key":"270_CR35","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1084\/jem.20080130","volume":"205","author":"AK Chauhan","year":"2008","unstructured":"Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD. ADAMTS13: a new link between thrombosis and inflammation. J Exp Med. 2008;205(9):2065\u201374.","journal-title":"J Exp Med"},{"key":"270_CR36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13054-015-0828-6","volume":"19","author":"M Straat","year":"2015","unstructured":"Straat M, M\u00fcller MC, Meijers JC, Arbous MS, Spoelstra-de Man AM, Beurskens CJ, Vroom MB, Juffermans NP. Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial. Crit Care. 2015;19:163.","journal-title":"Crit Care"}],"container-title":["Thrombosis Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-021-00270-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12959-021-00270-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-021-00270-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:14:34Z","timestamp":1615547674000},"score":1,"resource":{"primary":{"URL":"https:\/\/thrombosisjournal.biomedcentral.com\/articles\/10.1186\/s12959-021-00270-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["270"],"URL":"https:\/\/doi.org\/10.1186\/s12959-021-00270-1","relation":{},"ISSN":["1477-9560"],"issn-type":[{"value":"1477-9560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]},"assertion":[{"value":"7 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Local Ethics Committee for Clinical Studies at Ehime University Graduate School of Medicine. Informed consent was obtained from all patients or next of kin in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from all patients or next of kin for publication of their individual details in this manuscript. The consent form is held by the authors and is available for review by the Editor-in-Chief.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}