{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:53:54Z","timestamp":1789012434247,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thrombosis J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is limited guidance regarding the use of anticoagulation in patients on intra-aortic balloon pumps (IABP). The purpose of this study is to compare the safety outcomes in anticoagulated versus non-anticoagulated patients with an IABP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single center, retrospective chart review of patients admitted to the coronary care unit or cardiac surgery unit who received an IABP from May 2015 to July 2018. Patients who were anticoagulated with heparin while on an IABP were compared to those who were not anticoagulated. Major endpoints included a composite of thrombotic events and a composite of bleeding events. The major composite endpoint of thrombotic events included the incidence of ischemic stroke, any venous thromboembolism, device thrombosis, and limb ischemia. The major composite endpoint of bleeding events included major access site bleeding, minor access site bleeding, major non-access site bleeding, and minor non-access site bleeding. Minor endpoints included any major endpoint events occurring within 24 and 48\u2009h of IABP insertion, hospital length of stay, intensive care unit length of stay, and in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 185 patients were evaluated for inclusion and 147 were included in the final analysis. There were 82 and 65 patients in the heparin and non-heparin groups, respectively. The composite endpoint of thrombotic events occurred in 7.3 and 7.7% in the heparin and non-heparin groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091). The composite bleeding endpoint occurred in 20.7 and 20.0% in the heparin and non-heparin groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.91). There were no differences found in minor endpoints between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There were no significant differences found in major endpoints of bleeding and thrombotic events in patients who received anticoagulation while on an IABP versus those who did not receive anticoagulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12959-021-00295-6","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T08:02:42Z","timestamp":1624953762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of anticoagulated versus non-anticoagulated patients with intra-aortic balloon pumps"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-5741","authenticated-orcid":false,"given":"Julie","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhynn","family":"Malloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"3","key":"295_CR1","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/0002-9149(77)90165-5","volume":"40","author":"AA Lefemine","year":"1977","unstructured":"Lefemine AA, Kosowsky B, Madoff I, Black H, Lewis M. Results and complications of intra-aortic balloon pumping in surgical and medical patients. Am J Cardiol. 1977;40(3):416\u201320. https:\/\/doi.org\/10.1016\/0002-9149(77)90165-5.","journal-title":"Am J Cardiol"},{"key":"295_CR2","doi-asserted-by":"crossref","unstructured":"Sjauw KD, Engstrom AE, Vis MM, van der Schaaf RJ, Baan J Jr., Koch KT, de winter RJ, Piek JJ, Tijssen JG, Henriques JP. A systematic review and meta-analysis of intra-aortic balloon pump therapy in ST-elevation myocardial infarction: should we change the guidelines? Eur Heart J 2009;30:459\u201368.","DOI":"10.1093\/eurheartj\/ehn602"},{"issue":"11","key":"295_CR3","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1016\/S0735-1097(03)00400-5","volume":"41","author":"GW Stone","year":"2003","unstructured":"Stone GW, Ohman EM, Miller MF, Joseph DL, Christenson JT, Cohen M, et al. Contemporary utilization and outcomes of intra-aortic balloon counterpulsation in acute myocardial infarction: the benchmark registry. J Am Coll Cardiol. 2003;41(11):1940\u20135. https:\/\/doi.org\/10.1016\/S0735-1097(03)00400-5.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"295_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cardfail.2015.03.002","volume":"21","author":"CS Rihal","year":"2015","unstructured":"Rihal CS, Naidu SS, Givertz MM, Szeto WY, Burke JA, Kapur NK, et al. 2015 SCAI\/ACC\/HFSA\/STS clinical expert consensus statement on the use of percutaneous mechanical circulatory support devices in cardiovascular care. J Card Fail. 2015;21(6):499\u2013518. https:\/\/doi.org\/10.1016\/j.cardfail.2015.03.002.","journal-title":"J Card Fail"},{"issue":"2","key":"295_CR5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S0003-4975(98)01139-4","volume":"67","author":"HL Lazar","year":"1999","unstructured":"Lazar HL, Bao Y, Rivers S, Treanor PR, Shemin RJ. Decreased incidence of arterial thrombosis using heparin-bonded intraaortic balloons. Ann Thorac Surg. 1999;67(2):446\u20139. https:\/\/doi.org\/10.1016\/S0003-4975(98)01139-4.","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"295_CR6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1631\/jzus.2003.0607","volume":"4","author":"CY Jiang","year":"2003","unstructured":"Jiang CY, Zhao LL, Wang JA, Mohammod B. Anticoagulation therapy in intra-aortic balloon counterpulsation: does IABP really need anti-coagulation? J Zhejiang Univ Sci. 2003;4(5):607\u201311. https:\/\/doi.org\/10.1631\/jzus.2003.0607.","journal-title":"J Zhejiang Univ Sci"},{"issue":"4","key":"295_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/17482940802483048","volume":"10","author":"HA Cooper","year":"2008","unstructured":"Cooper HA, Thompson E, Panza JA. The role of heparin anticoagulation during intra-aortic balloon counterpulsation in the coronary care unit. Acute Card Care. 2008;10(4):214\u201320. https:\/\/doi.org\/10.1080\/17482940802483048.","journal-title":"Acute Card Care"},{"issue":"4","key":"295_CR8","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"S Schulman","year":"2005","unstructured":"Schulman S, Kearon C. Subcommittee on control of anticoagulation of the scientific and standardization Committee of the International Society on thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005;3(4):692\u20134. https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01204.x.","journal-title":"J Thromb Haemost"},{"key":"295_CR9","first-page":"A10175","volume":"122","author":"CT Chin","year":"2010","unstructured":"Chin CT, Kelly R, et al. The Impact of Anticoagulation During Intra-Aortic Balloon Counterpulsation Pump Placement on In-Hospital Outcomes in 18,875 Patients Undergoing Cardiac Revascularization. Circulation. 2010;122:A10175.","journal-title":"Circulation"},{"issue":"9872","key":"295_CR10","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0140-6736(12)62177-1","volume":"381","author":"WJ Dewilde","year":"2013","unstructured":"Dewilde WJ, Oirbans T, Verheugt FW, et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet. 2013;381(9872):1107\u201315. https:\/\/doi.org\/10.1016\/S0140-6736(12)62177-1.","journal-title":"Lancet."},{"key":"295_CR11","doi-asserted-by":"publisher","unstructured":"Tompkins C, Cheng A, Dalal D, Brinker JA, Leng CT, Marine JE, et al. Dual antiplatelet therapy and heparin \"bridging\" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation. J Am Coll Cardiol. 2010;55(21):2376\u201382. https:\/\/doi.org\/10.1016\/j.jacc.2009.12.056.","DOI":"10.1016\/j.jacc.2009.12.056"},{"key":"295_CR12","doi-asserted-by":"publisher","unstructured":"Mehta RH, Sheng S, O\u2019Brien SM, Grover FL, Gammie JS, Ferguson TB, et al. 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