{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:23:13Z","timestamp":1772166193689,"version":"3.50.1"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thrombosis J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiac embolism plays a very significant role in acute ischemic strokes (AIS), constituting approximately one-third of cases. The origin of these emboli often stems from intracardiac thrombi in the left atrium or left ventricle. Utilizing the National Readmission Database from 2016 to 2019, we investigate the prevalence of cardiac thrombi in AIS patients and explore their potential correlation with endovascular thrombectomy (EVT) utilization, and mortality rates. Among 1,272,456 AIS patients, 0.6% had concurrent cardiac thrombus, with an increasing trend observed over the study period (P value\u2009&lt;\u20090.001). The cardiac thrombus cohort showed a higher prevalence of comorbidities such as congestive heart failure and atrial fibrillation. After propensity-score matching, groups were well-balanced in terms of baseline characteristics. Patients within the cardiac thrombus cohort experienced a longer hospital stay (median 5 days vs. 3 days), but no significant difference in mortality was noted. Importantly, the cardiac thrombus cohort demonstrated a higher frequency of EVT utilization, suggesting a link to larger vessel occlusions. Despite matching based on atrial fibrillation, the EVT utilization in the cardiac thrombus cohort remained high, highlighting a significant association. While 30-day readmission rates were comparable, cardiac thrombus patients faced a higher risk of gastrointestinal bleeding and hemorrhagic stroke, likely attributed to anticoagulation use. Limitations include potential miscoding in the administrative database and a lack of detailed imaging findings. In conclusion, this study highlights the increased likelihood of EVT in AIS patients with cardiac thrombus, possibly indicative of larger vessel occlusion associated with cardiac thrombus.<\/jats:p>","DOI":"10.1186\/s12959-024-00650-3","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:01:42Z","timestamp":1727438502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac thrombus in acute ischemic stroke: impact on endovascular thrombectomy utilization"],"prefix":"10.1186","volume":"22","author":[{"given":"Zafar","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Wali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam","family":"Shatla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayyeda Aleena","family":"Mufarrih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rithvik","family":"Talluri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talal","family":"Asif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"issue":"12","key":"650_CR1","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1161\/hs1201.100209","volume":"32","author":"PL Kolominsky-Rabas","year":"2001","unstructured":"Kolominsky-Rabas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. 2001;32(12):2735\u201340.","journal-title":"Stroke"},{"issue":"1, Cerebrovascu","key":"650_CR2","first-page":"111","volume":"23","author":"CB O\u2019Carroll","year":"2017","unstructured":"O\u2019Carroll CB, Barrett KM. Cardioembolic Stroke. Continuum (Minneap Minn). 2017;23(1, Cerebrovascular Disease):111\u201332.","journal-title":"Continuum (Minneap Minn)"},{"issue":"4","key":"650_CR3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.12669\/pjms.36.4.1972","volume":"36","author":"NN Aljaber","year":"2020","unstructured":"Aljaber NN, Mattash ZA, Alshoabi SA, Alhazmi FH. The prevalence of left ventricular thrombus among patients with low ejection fraction by trans-thoracic echocardiography. Pak J Med Sci. 2020;36(4):673\u20137.","journal-title":"Pak J Med Sci"},{"issue":"4","key":"650_CR4","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.10.021","volume":"27","author":"M Inoue","year":"2018","unstructured":"Inoue M, Noda R, Yamaguchi S, Tamai Y, Miyahara M, Yanagisawa S, et al. Specific factors to Predict large-vessel occlusion in Acute Stroke patients. J Stroke Cerebrovasc Dis. 2018;27(4):886\u201391.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"650_CR5","unstructured":"Cost H, Project U. January. Overview of the nationwide readmissions database (NRD). Agency for Healthcare Research and Quality Accessed 2023;3."},{"key":"650_CR6","doi-asserted-by":"publisher","first-page":"175394472211077","DOI":"10.1177\/17539447221107737","volume":"16","author":"P Chang","year":"2022","unstructured":"Chang P, Xiao J, Hu Z, Kwan AC, Fan Z. Imaging of left heart intracardiac thrombus: clinical needs, current imaging, and emerging cardiac magnetic resonance techniques. Ther Adv Cardiovasc Dis. 2022;16:17539447221107737.","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"1","key":"650_CR7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/23969873221130838","volume":"8","author":"LA Rinkel","year":"2023","unstructured":"Rinkel LA, Beemsterboer CF, Groeneveld NS, Lobe NH, Boekholdt SM, Bouma BJ, et al. Cardiac thrombi detected by CT in patients with acute ischemic stroke: a substudy of mind the heart. Eur Stroke J. 2023;8(1):168\u201374.","journal-title":"Eur Stroke J"},{"issue":"6","key":"650_CR8","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1161\/CIRCULATIONAHA.118.036248","volume":"139","author":"N van Rein","year":"2019","unstructured":"van Rein N, Heide-Jorgensen U, Lijfering WM, Dekkers OM, Sorensen HT, Cannegieter SC. Major bleeding rates in Atrial Fibrillation patients on single, dual, or Triple Antithrombotic Therapy. Circulation. 2019;139(6):775\u201386.","journal-title":"Circulation"}],"container-title":["Thrombosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-024-00650-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12959-024-00650-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-024-00650-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:02:51Z","timestamp":1727438571000},"score":1,"resource":{"primary":{"URL":"https:\/\/thrombosisjournal.biomedcentral.com\/articles\/10.1186\/s12959-024-00650-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["650"],"URL":"https:\/\/doi.org\/10.1186\/s12959-024-00650-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4370239\/v1","asserted-by":"object"}]},"ISSN":["1477-9560"],"issn-type":[{"value":"1477-9560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]},"assertion":[{"value":"5 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"83"}}