{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:45:41Z","timestamp":1784951141747,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thrombosis J"],"DOI":"10.1186\/s12959-025-00755-3","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T22:02:31Z","timestamp":1750629751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Procoagulant effect of phosphatidylserine-exposed blood cells, endothelial cells and extracellular vesicles in patients with aortic stenosis"],"prefix":"10.1186","volume":"23","author":[{"given":"Haiyang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaona","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxia","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"755_CR1","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1093\/cvr\/cvac192","volume":"119","author":"A Trimaille","year":"2023","unstructured":"Trimaille A, Hmadeh S, Matsushita K, Marchandot B, Kauffenstein G, Morel O. Aortic stenosis and the haemostatic system. Cardiovasc Res. 2023;119:1310\u201323. https:\/\/doi.org\/10.1093\/cvr\/cvac192","journal-title":"Cardiovasc Res"},{"key":"755_CR2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/000331979804900310","volume":"49","author":"H Kaul","year":"1998","unstructured":"Kaul H, Gutzwiller JP, Schneider K, Dirsch O, H\u00e4usermann M. Aortic valve stenosis as a cause of major systemic embolism\u2013a case report. Angiology. 1998;49:231\u20134. https:\/\/doi.org\/10.1177\/000331979804900310","journal-title":"Angiology"},{"key":"755_CR3","doi-asserted-by":"publisher","unstructured":"Alajaji W, Hornick JM, Malek E, Klein AL. The characteristics and outcomes of native aortic valve thrombosis: A systematic review. J Am Coll Cardiol. 2021;78. https:\/\/doi.org\/10.1016\/j.jacc.2021.06.023. 811\u2013\u200924.","DOI":"10.1016\/j.jacc.2021.06.023"},{"key":"755_CR4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.2459\/JCM.0b013e328344bcc7","volume":"12","author":"F Natale","year":"2011","unstructured":"Natale F, Aronne L, Credendino M, Siciliano A, Allocca F, Weizs SH, Martone F, di Marco GM, Calabr\u00f2 P, Tedesco MA, Russo MG, Calabr\u00f2 R. Which is the correct management of patients with asymptomatic severe calcific aortic stenosis after symptomatic spontaneous calcium cerebral embolism? J Cardiovasc Med. 2011;12:428\u20139. https:\/\/doi.org\/10.2459\/JCM.0b013e328344bcc7","journal-title":"J Cardiovasc Med"},{"key":"755_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3121\/cmr.2020.1548","volume":"18","author":"D Soodi","year":"2020","unstructured":"Soodi D, VanWormer JJ, Rezkalla SH. Aspirin in primary prevention of cardiovascular events, clin. Med Res. 2020;18:89\u201394. https:\/\/doi.org\/10.3121\/cmr.2020.1548","journal-title":"Med Res"},{"key":"755_CR6","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1056\/NEJMoa2017815","volume":"383","author":"J Brouwer","year":"2020","unstructured":"Brouwer J, Nijenhuis VJ, Delewi R, Hermanides RS, Holvoet W, Dubois C, Frambach P, De Bruyne B, van Houwelingen GK, Van Der Heyden J, Tou\u0161ek P, van der Kley F, Buysschaert I, Schotborgh CE, Ferdinande B, van der Harst P, Roosen J, Peper J, Thielen F, Veenstra L, Chan PYD, Swaans MJ, Rensing B, van T HA, Timmers L, Kelder JC, Stella PR, Baan J. Ten, aspirin with or without clopidogrel after transcatheter Aortic-Valve implantation, N. Engl. J Med. 2020;383:1447\u201357. https:\/\/doi.org\/10.1056\/NEJMoa2017815","journal-title":"J Med"},{"key":"755_CR7","doi-asserted-by":"publisher","first-page":"764861","DOI":"10.3389\/fimmu.2021.764861","volume":"12","author":"EI Tognarelli","year":"2021","unstructured":"Tognarelli EI, Retamal-D\u00edaz A, Far\u00edas MA, Duarte LF, Palomino TF, Iba\u00f1ez FJ, Riedel CA, Kalergis AM, Bueno SM, Gonz\u00e1lez PA. Pharmacological Inhibition of IRE-1 alpha activity in herpes simplex virus type 1 and type 2-Infected dendritic cells enhances T cell activation. Front Immunol. 2021;12:764861. https:\/\/doi.org\/10.3389\/fimmu.2021.764861","journal-title":"Front Immunol"},{"key":"755_CR8","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.3324\/haematol.2009.013375","volume":"94","author":"F Cervantes","year":"2009","unstructured":"Cervantes F, Arellano-Rodrigo E, Alvarez-Larr\u00e1n A. Blood cell activation in myeloproliferative neoplasms. Haematologica. 2009;94:1484\u20138. https:\/\/doi.org\/10.3324\/haematol.2009.013375","journal-title":"Haematologica"},{"key":"755_CR9","doi-asserted-by":"publisher","unstructured":"Matte A, Federti E, De Franceschi L. Erythrocyte pyruvate kinase activation in red cell disorders. Curr Opin Hematol. 2023;30. https:\/\/doi.org\/10.1097\/MOH.0000000000000758. 93\u2013\u20098.","DOI":"10.1097\/MOH.0000000000000758"},{"key":"755_CR10","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1111\/j.1537-2995.2010.02950.x","volume":"51","author":"FK Keating","year":"2011","unstructured":"Keating FK, Butenas S, Fung MK, Schneider DJ. Platelet-white blood cell (WBC) interaction, WBC apoptosis, and procoagulant activity in stored red blood cells. Transfusion. 2011;51:1086\u201395. https:\/\/doi.org\/10.1111\/j.1537-2995.2010.02950.x","journal-title":"Transfusion"},{"key":"755_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/09537100701817232","volume":"19","author":"O Morel","year":"2008","unstructured":"Morel O, Morel N, Freyssinet JM, Toti F. Platelet microparticles and vascular cells interactions: a checkpoint between the haemostatic and thrombotic responses. Platelets. 2008;19:9\u201323. https:\/\/doi.org\/10.1080\/09537100701817232","journal-title":"Platelets"},{"key":"755_CR12","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1007\/s10439-016-1577-7","volume":"44","author":"K Vahidkhah","year":"2016","unstructured":"Vahidkhah K, Cordasco D, Abbasi M, Ge L, Tseng E, Bagchi P, Azadani AN. Flow-Induced damage to blood cells in aortic valve stenosis. Ann Biomed Eng. 2016;44:2724\u201336. https:\/\/doi.org\/10.1007\/s10439-016-1577-7","journal-title":"Ann Biomed Eng"},{"key":"755_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1126\/science.1230719","volume":"339","author":"FK Swirski","year":"2013","unstructured":"Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339:161\u20136. https:\/\/doi.org\/10.1126\/science.1230719","journal-title":"Science"},{"key":"755_CR14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ijcard.2018.01.116","volume":"258","author":"L Wang","year":"2018","unstructured":"Wang L, Bi Y, Yu M, Li T, Tong D, Yang X, Zhang C, Guo L, Wang C, Kou Y, Dong Z, Novakovic VA, Tian Y, Kou J, Shammas MA, Shi J. Phosphatidylserine-exposing blood cells and microparticles induce procoagulant activity in non-valvular atrial fibrillation. Int J Cardiol. 2018;258:138\u201343. https:\/\/doi.org\/10.1016\/j.ijcard.2018.01.116","journal-title":"Int J Cardiol"},{"key":"755_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10753-012-9579-6","volume":"36","author":"N Cot\u00e9","year":"2013","unstructured":"Cot\u00e9 N, Mahmut A, Bosse Y, Couture C, Pag\u00e9 S, Trahan S, Boulanger MC, Fournier D, Pibarot P, Mathieu P. Inflammation is associated with the remodeling of calcific aortic valve disease. Inflammation. 2013;36:573\u201381. https:\/\/doi.org\/10.1007\/s10753-012-9579-6","journal-title":"Inflammation"},{"key":"755_CR16","doi-asserted-by":"publisher","unstructured":"\u00c1lvarez-Heredia P, Dom\u00ednguez-Del-Castillo JJ, Reina-Alfonso I, Guti\u00e9rrez-Gonz\u00e1lez C, Hassouneh F, Batista-Duharte A, Trujillo-Aguilera A, L\u00f3pez-Romero R, Mu\u00f1oz I, Solana R, Pera A. A straightforward Cytometry-Based protocol for the comprehensive analysis of the inflammatory valve infiltrate in aortic stenosis. Int J Mol Sci. 2023;24. https:\/\/doi.org\/10.3390\/ijms24032194","DOI":"10.3390\/ijms24032194"},{"key":"755_CR17","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1161\/CIRCULATIONAHA.120.045536","volume":"142","author":"S Baratchi","year":"2020","unstructured":"Baratchi S, Zaldivia M, Wallert M, Loseff-Silver J, Al-Aryahi S, Zamani J, Thurgood P, Salim A, Htun NM, Stub D, Vahidi P, Duffy SJ, Walton A, Nguyen TH, Jaworowski A, Khoshmanesh K, Peter K. Transcatheter aortic valve implantation represents an Anti-Inflammatory therapy via reduction of shear Stress-Induced, Piezo-1-Mediated monocyte activation. Circulation. 2020;142:1092\u2013105. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.045536","journal-title":"Circulation"},{"key":"755_CR18","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/MAT.0000000000001296","volume":"67","author":"CS Jhun","year":"2021","unstructured":"Jhun CS, Newswanger R, Cysyk JP, Ponnaluri S, Good B, Manning KB, Rosenberg G. Dynamics of blood flows in aortic stenosis: mild, moderate, and severe. ASAIO J. 2021;67:666\u201374. https:\/\/doi.org\/10.1097\/MAT.0000000000001296","journal-title":"ASAIO J"},{"key":"755_CR19","first-page":"2420","volume":"17","author":"ZH Wu","year":"2013","unstructured":"Wu ZH, Ji CL, Li H, Qiu GX, Gao CJ, Weng XS. Membrane microparticles and diseases. Eur Rev Med Pharmacol Sci. 2013;17:2420\u20137.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"755_CR20","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1182\/blood.2019001643","volume":"135","author":"DF Noubouossie","year":"2020","unstructured":"Noubouossie DF, Henderson MW, Mooberry M, Ilich A, Ellsworth P, Piegore M, Skinner SC, Pawlinski R, Welsby I, Renn\u00e9 T, Hoffman M, Monroe DM, Key NS. Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways. Blood. 2020;135:755\u201365. https:\/\/doi.org\/10.1182\/blood.2019001643","journal-title":"Blood"},{"key":"755_CR21","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/ATVBAHA.117.309846","volume":"38","author":"SP Grover","year":"2018","unstructured":"Grover SP, Mackman N, Factor T. An essential mediator of hemostasis and trigger of thrombosis, arterioscler. Thromb Vasc Biol. 2018;38:709\u201325. https:\/\/doi.org\/10.1161\/ATVBAHA.117.309846","journal-title":"Thromb Vasc Biol"},{"key":"755_CR22","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1160\/TH12-11-0811","volume":"109","author":"X Tan","year":"2013","unstructured":"Tan X, Shi J, Fu Y, Gao C, Yang X, Li J, Wang W, Hou J, Li H, Zhou J. Role of erythrocytes and platelets in the hypercoagulable status in polycythemia vera through phosphatidylserine exposure and microparticle generation. Thromb Haemost. 2013;109:1025\u201332. https:\/\/doi.org\/10.1160\/TH12-11-0811","journal-title":"Thromb Haemost"},{"key":"755_CR23","doi-asserted-by":"publisher","unstructured":"Falk V, Baumgartner H, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Mu\u00f1oz DR, Rosenhek R, Sj\u00f6gren J, Tornos MP, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL. 2017 ESC\/EACTS guidelines for the management of valvular heart disease. Eur J Cardiothorac Surg. 2017;52. https:\/\/doi.org\/10.1093\/ejcts\/ezx324. 616\u2013\u200964.","DOI":"10.1093\/ejcts\/ezx324"},{"key":"755_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bbamem.2004.09.006","volume":"1667","author":"J Shi","year":"2004","unstructured":"Shi J, Heegaard CW, Rasmussen JT, Gilbert GE. Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta. 2004;1667:82\u201390. https:\/\/doi.org\/10.1016\/j.bbamem.2004.09.006","journal-title":"Biochim Biophys Acta"},{"key":"755_CR25","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s11239-023-02835-5","volume":"56","author":"H Chi","year":"2023","unstructured":"Chi H, Shao Y, Xie F, Zhang J, Zhang G, Jiang G, Tong D, Li J. Procoagulant effect of extracellular vesicles in patients after transcatheter aortic valve replacement or transcatheter aortic valve replacement with percutaneous coronary intervention. J Thromb Thrombolysis. 2023;56:264\u201374. https:\/\/doi.org\/10.1007\/s11239-023-02835-5","journal-title":"J Thromb Thrombolysis"},{"key":"755_CR26","doi-asserted-by":"publisher","unstructured":"He Z, Zhang Y, Cao M, Ma R, Meng H, Yao Z, Zhao L, Liu Y, Wu X, Deng R, Dong Z, Bi Y, Kou J, Novakovic V, Shi J, Hao L. Increased phosphatidylserine-exposing microparticles and their originating cells are associated with the coagulation process in patients with IgA nephropathy. Nephrol Dial Transpl. 2016;31. https:\/\/doi.org\/10.1093\/ndt\/gfv403. 747\u2013\u200959.","DOI":"10.1093\/ndt\/gfv403"},{"key":"755_CR27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0021-9150(01)00433-6","volume":"158","author":"S Nomura","year":"2001","unstructured":"Nomura S, Tandon NN, Nakamura T, Cone J, Fukuhara S, Kambayashi J. High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis. 2001;158:277\u201387. https:\/\/doi.org\/10.1016\/s0021-9150(01)00433-6","journal-title":"Atherosclerosis"},{"key":"755_CR28","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1160\/TH07-05-0334","volume":"99","author":"P Diehl","year":"2008","unstructured":"Diehl P, Nagy F, Sossong V, Helbing T, Beyersdorf F, Olschewski M, Bode C, Moser M. Increased levels of Circulating microparticles in patients with severe aortic valve stenosis. Thromb Haemost. 2008;99:711\u20139. https:\/\/doi.org\/10.1160\/TH07-05-0334","journal-title":"Thromb Haemost"},{"key":"755_CR29","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.112.300818","volume":"112","author":"AC Vion","year":"2013","unstructured":"Vion AC, Ramkhelawon B, Loyer X, Chironi G, Devue C, Loirand G, Tedgui A, Lehoux S, Boulanger CM. Shear stress regulates endothelial microparticle release. Circ Res. 2013;112:1323\u201333. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.300818","journal-title":"Circ Res"},{"key":"755_CR30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3233\/CH-200928","volume":"77","author":"H Kanda","year":"2021","unstructured":"Kanda H, Yamakuchi M, Matsumoto K, Mukaihara K, Shigehisa Y, Tachioka S, Okawa M, Takenouchi K, Oyama Y, Hashiguchi T, Imoto Y. Dynamic changes in platelets caused by shear stress in aortic valve stenosis. Clin Hemorheol Microcirc. 2021;77:71\u201381. https:\/\/doi.org\/10.3233\/CH-200928","journal-title":"Clin Hemorheol Microcirc"},{"key":"755_CR31","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1093\/eurheartj\/ehab247","volume":"42","author":"A Anselmo","year":"2021","unstructured":"Anselmo A, Frank D, Papa L, Viviani AC, Di Pasquale E, Mazzola M, Panico C, Clemente F, Soldani C, Pagiatakis C, Hinkel R, Thalmann R, Kozlik-Feldmann R, Miragoli M, Carullo P, Vacchiano M, Chaves-Sanjuan A, Santo N, Losi MA, Ferrari MC, Puca AA, Christiansen V, Seoudy H, Freitag-Wolf S, Frey N, Dempfle A, Mercola M, Esposito G, Briguori C, Kupatt C, Condorelli G. Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release. Eur Heart J. 2021;42:2780\u201392. https:\/\/doi.org\/10.1093\/eurheartj\/ehab247","journal-title":"Eur Heart J"},{"key":"755_CR32","doi-asserted-by":"publisher","first-page":"1246910","DOI":"10.3389\/fphys.2023.1246910","volume":"14","author":"GS Sangha","year":"2023","unstructured":"Sangha GS, Weber CM, Sapp RM, Setua S, Thangaraju K, Pettebone M, Rogers SC, Doctor A, Buehler PW, Clyne AM. Mechanical stimuli such as shear stress and piezo1 stimulation generate red blood cell extracellular vesicles. Front Physiol. 2023;14:1246910. https:\/\/doi.org\/10.3389\/fphys.2023.1246910","journal-title":"Front Physiol"},{"key":"755_CR33","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1161\/01.ATV.0000246775.14471.26","volume":"26","author":"O Morel","year":"2006","unstructured":"Morel O, Toti F, Hugel B, Bakouboula B, Camoin-Jau L, Dignat-George F, Freyssinet JM. Procoagulant microparticles: disrupting the vascular homeostasis equation? Arterioscler. Thromb Vasc Biol. 2006;26:2594\u2013604. https:\/\/doi.org\/10.1161\/01.ATV.0000246775.14471.26","journal-title":"Thromb Vasc Biol"},{"key":"755_CR34","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.3390\/s110201744","volume":"11","author":"JG Kay","year":"2011","unstructured":"Kay JG, Grinstein S. Sensing phosphatidylserine in cellular membranes. Sensors. 2011;11:1744\u201355. https:\/\/doi.org\/10.3390\/s110201744","journal-title":"Sensors"},{"key":"755_CR35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1537-2995.2008.01933.x","volume":"49","author":"AM Albanyan","year":"2009","unstructured":"Albanyan AM, Murphy MF, Rasmussen JT, Heegaard CW, Harrison P. Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with Annexin V. Transfusion. 2009;49:99\u2013107. https:\/\/doi.org\/10.1111\/j.1537-2995.2008.01933.x","journal-title":"Transfusion"},{"key":"755_CR36","doi-asserted-by":"publisher","unstructured":"He Z, Si Y, Jiang T, Ma R, Zhang Y, Cao M, Li T, Yao Z, Zhao L, Fang S, Yu B, Dong Z, Thatte HS, Bi Y, Kou J, Yang S, Piao D, Hao L, Zhou J, Shi J. Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease. Thromb Haemost. 2016;115. https:\/\/doi.org\/10.1160\/TH15-09-0710. 738\u2013\u200951.","DOI":"10.1160\/TH15-09-0710"},{"key":"755_CR37","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/cdd.2016.7","volume":"23","author":"S Nagata","year":"2016","unstructured":"Nagata S, Suzuki J, Segawa K, Fujii T. Exposure of phosphatidylserine on the cell surface. Cell Death Differ. 2016;23:952\u201361. https:\/\/doi.org\/10.1038\/cdd.2016.7","journal-title":"Cell Death Differ"},{"key":"755_CR38","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00277-018-3228-6","volume":"97","author":"D Tong","year":"2018","unstructured":"Tong D, Yu M, Guo L, Li T, Li J, Novakovic VA, Dong Z, Tian Y, Kou J, Bi Y, Wang J, Zhou J, Shi J. Phosphatidylserine-exposing blood and endothelial cells contribute to the hypercoagulable state in essential thrombocythemia patients. Ann Hematol. 2018;97:605\u201316. https:\/\/doi.org\/10.1007\/s00277-018-3228-6","journal-title":"Ann Hematol"},{"key":"755_CR39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/FJC.0000000000000737","volume":"74","author":"S Li","year":"2019","unstructured":"Li S, Xu L, Liu B. The neglected role of neutrophils in the severity of aortic valve stenosis. J Cardiovasc Pharmacol. 2019;74:367\u20138. https:\/\/doi.org\/10.1097\/FJC.0000000000000737","journal-title":"J Cardiovasc Pharmacol"},{"key":"755_CR40","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s40520-020-01681-2","volume":"33","author":"M Conte","year":"2021","unstructured":"Conte M, Petraglia L, Campana P, Gerundo G, Caruso A, Grimaldi MG, Russo V, Attena E, Leosco D, Parisi V. The role of inflammation and metabolic risk factors in the pathogenesis of calcific aortic valve stenosis, aging clin. Exp Res. 2021;33:1765\u201370. https:\/\/doi.org\/10.1007\/s40520-020-01681-2","journal-title":"Exp Res"},{"key":"755_CR41","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1016\/j.atherosclerosis.2008.12.029","volume":"204","author":"PP Dimitrow","year":"2009","unstructured":"Dimitrow PP, Hlawaty M, Undas A, Sniezek-Maciejewska M, Sobie\u0144 B, Stepie\u0144 E, Tracz W. Effect of aortic valve stenosis on haemostasis is independent from vascular atherosclerotic burden. Atherosclerosis. 2009;204:e103\u20138. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2008.12.029","journal-title":"Atherosclerosis"},{"key":"755_CR42","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s11239-020-02342-x","volume":"51","author":"J Li","year":"2021","unstructured":"Li J, Tong D, Chen F, Song B, Wang Y, Liu Y, Zhang X, Liu N, Xu Y, Li Y, Yin X, Liu W. Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension. J Thromb Thrombolysis. 2021;51:933\u201340. https:\/\/doi.org\/10.1007\/s11239-020-02342-x","journal-title":"J Thromb Thrombolysis"},{"key":"755_CR43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12872-019-1148-6","volume":"19","author":"AH Usta","year":"2019","unstructured":"Usta AH, Akbas F, Aral H. Relationship between Circulating microparticles and hypertension and other cardiac disease biomarkers in the elderly. BMC Cardiovasc Disord. 2019;19:164. https:\/\/doi.org\/10.1186\/s12872-019-1148-6","journal-title":"BMC Cardiovasc Disord"},{"issue":"1","key":"755_CR44","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/jth.12228","volume":"11","author":"VM Chen","year":"2013","unstructured":"Chen VM, Hogg PJ. Encryption and decryption of tissue factor. J Thromb Haemost. 2013;11(1):277\u201384. https:\/\/doi.org\/10.1111\/jth.12228","journal-title":"J Thromb Haemost"},{"key":"755_CR45","doi-asserted-by":"publisher","unstructured":"Kay JG, Grinstein S. Phosphatidylserine-mediated cellular signaling, Adv. Exp. Med. Biol. 991 (2013) 177\u2013\u200993. https:\/\/doi.org\/10.1007\/978-94-007-6331-9_10","DOI":"10.1007\/978-94-007-6331-9_10"}],"container-title":["Thrombosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-025-00755-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12959-025-00755-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-025-00755-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T22:02:32Z","timestamp":1750629752000},"score":1,"resource":{"primary":{"URL":"https:\/\/thrombosisjournal.biomedcentral.com\/articles\/10.1186\/s12959-025-00755-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["755"],"URL":"https:\/\/doi.org\/10.1186\/s12959-025-00755-3","relation":{},"ISSN":["1477-9560"],"issn-type":[{"value":"1477-9560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the individual(s) for the publication of any data included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}],"article-number":"70"}}