{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:02:08Z","timestamp":1780275728209,"version":"3.54.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hebei Province Medical Applicable Technology Tracking Project","award":["GZ2024020"],"award-info":[{"award-number":["GZ2024020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thrombosis J"],"DOI":"10.1186\/s12959-026-00863-8","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:26:16Z","timestamp":1776356776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acquired circulating heparin-like anticoagulants associated with multiple myeloma: three cases reports and literature review"],"prefix":"10.1186","volume":"24","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuquan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"issue":"1","key":"863_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-024-00529-7","volume":"10","author":"F Malard","year":"2024","unstructured":"Malard F, Neri P, Bahlis NJ, Terpos E, Moukalled N, Hungria VTM, Manier S, Mohty M. Multiple myeloma. Nat Rev Dis Primers. 2024;10(1):45.","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"863_CR2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/ajh.26806","volume":"98","author":"C Charalampous","year":"2023","unstructured":"Charalampous C, Goel U, Kapoor P, Binder M, Buadi FK, Dingli D, Dispenzieri A, Fonder AL, Gertz MA, Gonsalves W, Hayman SR, Hobbs MA, Hwa YL, Kourelis T, Lacy MQ, Leung N, Lin Y, Warsame R, Kyle RA, Rajkumar SV, Kumar S. Thrombosis in multiple myeloma: Risk estimation by induction regimen and association with overall survival. Am J Hematol. 2023;98(3):413\u201320.","journal-title":"Am J Hematol"},{"issue":"8","key":"863_CR3","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1055\/s-0031-1297372","volume":"37","author":"A Coppola","year":"2011","unstructured":"Coppola A, Tufano A, Di Capua M, Franchini M. Bleeding and thrombosis in multiple myeloma and related plasma cell disorders. Semin Thromb Hemost. 2011;37(8):929\u201345.","journal-title":"Semin Thromb Hemost"},{"issue":"17","key":"863_CR4","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1182\/blood.2020005604","volume":"136","author":"A Saadalla","year":"2020","unstructured":"Saadalla A, Seheult J, Ladwig P, Tange J, Leger R, Kohlhagen M, Ashrani A, Murray D. Sialic acid-bearing paraproteins are implicated in heparin-like coagulopathy in patients with myeloma. Blood. 2020;136(17):1988\u201392.","journal-title":"Blood"},{"issue":"3","key":"863_CR5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1172\/JCI109712","volume":"65","author":"MS Khoory","year":"1980","unstructured":"Khoory MS, Nesheim ME, Bowie EJ, Mann KG. Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder. J Clin Invest. 1980;65(3):666\u201374.","journal-title":"J Clin Invest"},{"issue":"1","key":"863_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1182\/blood.V74.1.252.252","volume":"74","author":"A Tefferi","year":"1989","unstructured":"Tefferi A, Owen BA, Nichols WL, Witzig TE, Owen WG. Isolation of a heparin-like anticoagulant from the plasma of a patient with metastatic bladder carcinoma. Blood. 1989;74(1):252\u20134.","journal-title":"Blood"},{"key":"863_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.thromres.2024.04.008","volume":"238","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Zhou X, Guo Y, Gao Y, Niu Z, Wu Y, Wang Y, Zhang J. Small intestinal angiodysplasia and hemorrhage associated with acquired von Willebrand syndrome type 2A secondary to multiple myeloma: Reversal after treatment with IRD regimen (a case report and a brief review of the literature). Thromb Res. 2024;238:37\u201340.","journal-title":"Thromb Res"},{"issue":"11","key":"863_CR8","doi-asserted-by":"publisher","first-page":"7366","DOI":"10.21037\/tcr-20-1968","volume":"9","author":"H Shen","year":"2020","unstructured":"Shen H, Wu C, Chen L, Zhang R. Acquired heparin-like anticoagulation process in a patient with multiple myeloma: a case report and literature review. Transl Cancer Res. 2020;9(11):7366\u201371.","journal-title":"Transl Cancer Res"},{"issue":"1","key":"863_CR9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1365-2141.1997.d01-2145.x","volume":"97","author":"NS Colwell","year":"1997","unstructured":"Colwell NS, Tollefsen DM, Blinder MA. Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder. Br J Haematol. 1997;97(1):219\u201326.","journal-title":"Br J Haematol"},{"issue":"3","key":"863_CR10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1136\/jcp.47.3.266","volume":"47","author":"MJ O\u2019Kane","year":"1994","unstructured":"O\u2019Kane MJ, Wisdom GB, Desai ZR, Archbold GR. Inhibition of fibrin polymerization by myeloma immunoglobulin. J Clin Pathol. 1994;47(3):266\u20138.","journal-title":"J Clin Pathol"},{"issue":"8","key":"863_CR11","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3324\/haematol.2020.255117","volume":"105","author":"M Franchini","year":"2020","unstructured":"Franchini M, Mannucci PM. Acquired von Willebrand syndrome: focused for hematologists. Haematologica. 2020;105(8):2032\u20137.","journal-title":"Haematologica"},{"issue":"14","key":"863_CR12","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1056\/NEJM198104023041407","volume":"304","author":"B Furie","year":"1981","unstructured":"Furie B, Voo L, McAdam KP, Furie BC. Mechanism of factor X deficiency in systemic amyloidosis. N Engl J Med. 1981;304(14):827\u201330.","journal-title":"N Engl J Med"},{"issue":"3","key":"863_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s12185-021-03143-5","volume":"114","author":"S Inano","year":"2021","unstructured":"Inano S, Oku Y, Aiba A, Kawasaki N, Okamoto Y, Yuhi N, Shibata S, Takiuchi Y, Tabata S, Kitano T. Acquired hypofibrinogenemia in a patient with multiple myeloma. Int J Hematol. 2021;114(3):395\u2013400.","journal-title":"Int J Hematol"},{"issue":"1","key":"863_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.transci.2012.06.021","volume":"48","author":"GR Post","year":"2013","unstructured":"Post GR, James L, Alapat D, Guillory V, Cottler-Fox M, Nakagawa M. A case of acquired dysfibrinogenemia in multiple myeloma treated with therapeutic plasma exchange. Transfus Apher Sci. 2013;48(1):35\u20138.","journal-title":"Transfus Apher Sci"}],"container-title":["Thrombosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12959-026-00863-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-026-00863-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-026-00863-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:49:32Z","timestamp":1780274972000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12959-026-00863-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["863"],"URL":"https:\/\/doi.org\/10.1186\/s12959-026-00863-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8562672\/v1","asserted-by":"object"}]},"ISSN":["1477-9560"],"issn-type":[{"value":"1477-9560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"9 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Second Hospital of Hebei Medical University. All patients were informed about the experimental nature of this study and gave their consent to participation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication have been obtained from the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"52"}}