{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:18:29Z","timestamp":1788311909720,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":74,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Thrombosis J"],"DOI":"10.1186\/s12959-026-00891-4","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:57:29Z","timestamp":1781949449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypofibrinogenemia caused by a heterozygous variant in the FGA gene: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Haoyu","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"891_CR1","doi-asserted-by":"crossref","unstructured":"Neerman-Arbez M, de Moerloose P, Casini A. Laboratory and genetic investigation of mutations accounting for congenital fibrinogen disorders. Semin Thromb Hemost. 2016:356\u201365.","DOI":"10.1055\/s-0036-1571340"},{"key":"891_CR2","unstructured":"Imperato C, Dettori AG. Ipofibrinogenemia congenita con fibrinoastenia. Helv Paediatr Acta. 1958:380\u201399."},{"key":"891_CR3","doi-asserted-by":"crossref","unstructured":"Casini A, Undas A, Palla R, Thachil J, de Moerloose P. Diagnosis and classification of congenital fibrinogen disorders: communication from the SSC of the ISTH. J Thromb Haemost. 2018:1887\u201390.","DOI":"10.1111\/jth.14216"},{"key":"891_CR4","doi-asserted-by":"crossref","unstructured":"Haisma B, Rijpma SR, Cnossen MH et al. Phenotype, genotype, and laboratory assessment of congenital fibrinogen disorders: data from the rare bleeding disorders in the netherlands study. Thromb Res. 2025:109317.","DOI":"10.1016\/j.thromres.2025.109317"},{"key":"891_CR5","doi-asserted-by":"crossref","unstructured":"Richard M, Celeny D, Neerman-Arbez M. Mutations accounting for congenital fibrinogen disorders: an update. Semin Thromb Hemost. 2022:889\u2013903.","DOI":"10.1055\/s-0041-1742170"},{"key":"891_CR6","doi-asserted-by":"crossref","unstructured":"Vu D, Neerman-Arbez M. Molecular mechanisms accounting for fibrinogen deficiency: from large deletions to intracellular retention of misfolded proteins. J Thromb Haemost. 2007:125\u201331.","DOI":"10.1111\/j.1538-7836.2007.02465.x"},{"key":"891_CR7","unstructured":"Huang LY, Zhang DL, Fu RF, Liu W, Chen YF, Xue F et al. Analysis of gene mutation spectrum and pharmacokinetics of fibrinogen infusion in 146 cases of congenital fibrinogen disorders. Zhonghua Xue Ye Xue Za Zhi. 2021:555\u201362."},{"key":"891_CR8","doi-asserted-by":"crossref","unstructured":"Wolberg AS. Fibrinogen and fibrin: synthesis, structure, and function in health and disease. J Thromb Haemost. 2023:3005\u201315.","DOI":"10.1016\/j.jtha.2023.08.014"},{"key":"891_CR9","doi-asserted-by":"crossref","unstructured":"Nagler M, Kremer Hovinga JA, Alberio L et al. Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thromb Haemost 2016:722\u201332.","DOI":"10.1160\/TH16-02-0082"},{"key":"891_CR10","doi-asserted-by":"crossref","unstructured":"Nathoo N, Rydz N, Poon MC, Metz LM. Ischemic strokes in a man with congenital afibrinogenemia. Can J Neurol Sci. 2018:590\u20132.","DOI":"10.1017\/cjn.2018.57"},{"key":"891_CR11","doi-asserted-by":"crossref","unstructured":"Peyvandi F, Palla R, Menegatti M et al. Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders. J Thromb Haemost. 2012:615\u201321.","DOI":"10.1111\/j.1538-7836.2012.04653.x"},{"key":"891_CR12","doi-asserted-by":"crossref","unstructured":"Undas A. Determination of Fibrinogen and Thrombin Time (TT). Methods Mol Biol. 2017:105\u201310.","DOI":"10.1007\/978-1-4939-7196-1_8"},{"key":"891_CR13","doi-asserted-by":"crossref","unstructured":"Zhang Y, Zuo X, Teng Y. Women with congenital hypofibrinogenemia\/afibrinogenemia: from birth to death. Clin Appl Thromb. 2020:1\u20137.","DOI":"10.1177\/1076029620912819"},{"key":"891_CR14","doi-asserted-by":"crossref","unstructured":"Casini A, de Moerloose P. Management of congenital quantitative fibrinogen disorders: a delphi consensus. Haemophilia. 2016:898\u2013905.","DOI":"10.1111\/hae.13061"}],"container-title":["Thrombosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12959-026-00891-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-026-00891-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12959-026-00891-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:08:57Z","timestamp":1788311337000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12959-026-00891-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["891"],"URL":"https:\/\/doi.org\/10.1186\/s12959-026-00891-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9423361\/v1","asserted-by":"object"}]},"ISSN":["1477-9560"],"issn-type":[{"value":"1477-9560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]},"assertion":[{"value":"15 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of the Affiliated Hospital of Chengde Medical College. All participants provided written informed consent prior to genetic testing and data collection. All procedures were carried out in accordance with the Declaration of Helsinki. Consent for publication Written informed consent for the publication of clinical data, laboratory findings and genetic information was obtained from the proband and her mother. All personal identifiable details have been removed to protect patient confidentiality.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"81"}}