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The ESCAPE trial is a randomised controlled trial for the evaluation of a BCC approach in five European countries. For the economic evaluation of alongside this trial, the four main objectives were: (i) to document the costs of delivering the intervention, (ii) to assess the running costs across study sites, (iii) to evaluate short-term cost-effectiveness and cost-utility compared to providers\u2019 usual care, and (iv) to examine the budgetary implications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The trial-based economic analyses will include cross-country cost-effectiveness and cost-utility assessments from a payer perspective. The cost-utility analysis will calculate quality-adjusted life years (QALYs) using the EQ-5D-5L and national value sets. Cost-effectiveness will include the cost per hospital admission avoided and the cost per depression-free days (DFD). Resource use will be measured from different sources, including electronic medical health records, standardised questionnaires, patient receipts and a care manager survey. Uncertainty will be addressed using bootstrapping.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The various methods and approaches used for data acquisition should provide insights into the potential benefits and cost-effectiveness of a BCC intervention. Providing the economic evaluation of ESCAPE will contribute to a country-based structural and organisational planning of BCC (e.g., the number of patients that may benefit, how many care managers are needed). Improved care is expected to enhance health-related quality of life at little or no extra cost.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The study follows CHEERS2022 and is registered at the German Clinical Trials Register (DRKS00025120).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12962-024-00535-2","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T10:01:47Z","timestamp":1713002507000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Health economic evaluation of blended collaborative care for older multimorbid heart failure patients: study protocol"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-9471","authenticated-orcid":false,"given":"Lisa","family":"Derendorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1726-9300","authenticated-orcid":false,"given":"Stephanie","family":"Stock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-9481","authenticated-orcid":false,"given":"Dusan","family":"Simic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-3493","authenticated-orcid":false,"given":"Arim","family":"Shukri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2922-2278","authenticated-orcid":false,"given":"Christine","family":"Zelenak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-1188","authenticated-orcid":false,"given":"Jonas","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-7441","authenticated-orcid":false,"given":"Tim","family":"Friede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-9896","authenticated-orcid":false,"given":"Birgit","family":"Herbeck Belnap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-7045","authenticated-orcid":false,"given":"Christoph","family":"Herrmann-Lingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-3251","authenticated-orcid":false,"given":"Susanne S.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-0192","authenticated-orcid":false,"given":"Dirk","family":"M\u00fcller and on behalf of the ESCAPE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"535_CR1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","volume":"118","author":"G Savarese","year":"2023","unstructured":"Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GM, Coats AJ. 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The following authors declare conflicts of interest: Christoph Herrmann-Lingen declares that he is receiving royalties from Hogrefe Publishers for the German version of the Hospital Anxiety and Depression Scale. During the last 3 years, he has received a lecture honorarium from Novartis. His research is funded by the German Ministry of Education and Research, the German Research Foundation, and the EU Commission. Susanne S. Pedersen has received a lecture honorarium from Bayer in 2021, and consultancy fees from ReCor Medical (Ultrasound Denervation Therapies), Boston Scientific, Medtronic, St. Jude Medical, Sanofi-Aventis, Astra-Zeneca, Servier and the Lundbeck Foundation in the past. Tim Friede reports personal fees from Actimed, Bayer, BiosenseWebster, Bristol Myers Squibb, Cardior, CSL Behring, Enanta, Fresenius Kabi, Galapagos, IQVIA, Janssen, KyowaKirin, Lilly, LivaNova, Minoryx, Novartis, r-connect, Recardio, Recordati, Relaxera, Roche, Servier, Viatris and Vifor for statistical consultancies including data monitoring committees, all outside the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study has been registered and approved at the University Medical Centre G\u00f6ttingen (UMG Reg. No 02853) and the German Clinical Trials Register (DRKS00025120). The informed consent forms and the study protocol (current version in G\u00f6ttingen V1.2\/16 February 2022) have been approved by the responsible ethics committees of all participating study sites before inclusion of the first patient. The findings of this study will be disseminated in national and international peer-reviewed journals and conferences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and dissemination"}},{"value":"The following authors declare they have no conflicts of interest: Lisa Derendorf, Stephanie Stock, Dusan Simic, Dirk M\u00fcller, Arim Shukri, Christine Zelenak, Jonas Nagel, Birgit Herbeck Belnap and Jan S\u00f8rensen have no competing interests. The following authors declare conflicts of interest: <b>Christoph Herrmann-Lingen<\/b> declares that he is receiving royalties from Hogrefe Publishers for the German version of the Hospital Anxiety and Depression Scale. During the last 3 years, he has received a lecture honorarium from Novartis. His research is funded by the German Ministry of Education and Research, the German Research Foundation, and the EU Commission. <b>Susanne S. Pedersen<\/b> has received a lecture honorarium from Bayer in 2021, and consultancy fees from ReCor Medical (Ultrasound Denervation Therapies), Boston Scientific, Medtronic, St. Jude Medical, Sanofi-Aventis, Astra-Zeneca, Servier and the Lundbeck Foundation in the past. <b>Tim Friede<\/b> reports personal fees from Actimed, Bayer, BiosenseWebster, Bristol Myers Squibb, Cardior, CSL Behring, Enanta, Fresenius Kabi, Galapagos, IQVIA, Janssen, KyowaKirin, Lilly, LivaNova, Minoryx, Novartis, r-connect, Recardio, Recordati, Relaxera, Roche, Servier, Viatris and Vifor for statistical consultancies including data monitoring committees, all outside the submitted work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"29"}}