{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:00:40Z","timestamp":1780275640620,"version":"3.54.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100020955","name":"GlaxoSmithKline Biologicals","doi-asserted-by":"publisher","award":["GSK study ID: IDP17877 \/ VEO-000712"],"award-info":[{"award-number":["GSK study ID: IDP17877 \/ VEO-000712"]}],"id":[{"id":"10.13039\/100020955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cost Eff Resour Alloc"],"DOI":"10.1186\/s12962-026-00746-9","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:57:55Z","timestamp":1775552275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How much do lower respiratory tract infections in adults cost? A hospital-based cost analysis in Colombia"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-0697","authenticated-orcid":false,"given":"Paula Andrea","family":"Castro Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Fernanda","family":"Moyano Ariza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban Orlando","family":"Vanegas Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Quintero Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Patricia","family":"Aguirre Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2023-785X","authenticated-orcid":false,"given":"Dar\u00edo","family":"Londo\u00f1o Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"issue":"1","key":"746_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/17476348.2019.1555040","volume":"2","author":"C Feldman","year":"2019","unstructured":"Feldman C, Shaddock E. Epidemiology of lower respiratory tract infections in adults. Expert Rev Respir Med January. 2019;2(1):63\u201377.","journal-title":"Expert Rev Respir Med January"},{"issue":"10258","key":"746_CR2","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"T Vos","year":"2020","unstructured":"Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Oct. 2020;396(10258):1204\u201322.","journal-title":"Lancet Oct"},{"issue":"3","key":"746_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4104\/pcrj.2011.00034","volume":"20","author":"G Greene","year":"2011","unstructured":"Greene G, Hood K, Little P, Verheij T, Goossens H, Coenen S, et al. Towards clinical definitions of lower respiratory tract infection (LRTI) for research and primary care practice in Europe: an international consensus study. Prim Care Respir J September. 2011;20(3):299\u2013306.","journal-title":"Prim Care Respir J September"},{"key":"746_CR4","doi-asserted-by":"publisher","unstructured":"Patel DA, Marcum ZA, Chansakul A, Toyip A, Nerney K, Panozzo CA, et al. Economic burden of cardiorespiratory hospitalizations associated with respiratory syncytial virus among United States adults in 2017\u20132019. Hum Vaccines Immunother. 2024;20(1):2364493. https:\/\/doi.org\/10.1080\/21645515.2024.2364493.","DOI":"10.1080\/21645515.2024.2364493"},{"issue":"1","key":"746_CR5","first-page":"2","volume":"10","author":"F Fusco","year":"2022","unstructured":"Fusco F, Hocking L, Stockwell S, Bonsu M, Marjanovic S, Morris S, et al. The burden of respiratory syncytial virus: Understanding impacts on the NHS, society and economy. Rand Health Q. 2022;10(1):2.","journal-title":"Rand Health Q"},{"issue":"4","key":"746_CR6","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s40266-015-0258-9","volume":"32","author":"AR Branche","year":"2015","unstructured":"Branche AR, Falsey AR. Respiratory syncytial virus infection in older adults: an under-recognized problem. Drugs Aging April. 2015;32(4):261\u20139.","journal-title":"Drugs Aging April"},{"issue":"Suppl 7","key":"746_CR7","doi-asserted-by":"publisher","first-page":"S680","DOI":"10.1093\/infdis\/jiz683","volume":"7","author":"S Zhang","year":"2020","unstructured":"Zhang S, Akmar LZ, Bailey F, Rath BA, Alchikh M, Schweiger B, et al. Cost of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection Management in Young Children at the Regional and Global Level: A Systematic Review and Meta-Analysis. J Infect Dis Oct. 2020;7(Suppl 7):S680\u20137.","journal-title":"J Infect Dis Oct"},{"key":"746_CR8","doi-asserted-by":"crossref","unstructured":"Bernal-Aguirre C, Carvajal-Sierra H, Santo Tom\u00e1s University. Bogot\u00e1, Colombia, Alvis-Zakzuk NJ, Santo Tom\u00e1s University. Bogot\u00e1, Colombia, ALZAK Foundation. Cartagena. Bol\u00edvar, Colombia. Economic Cost of Acute Respiratory Infection in a Municipality in Colombia. Rev Univ Ind Santander Health. 2017 Sep 30;49(3):470\u20137.","DOI":"10.18273\/revsal.v49n3-2017005"},{"issue":"4","key":"746_CR9","first-page":"568","volume":"7","author":"CA Lara Oliveros","year":"2016","unstructured":"Lara Oliveros CA, De Graeve D, Franco F, Daza SP. Disease burden and medical cost-analysis of Acute Respiratory Infections in a low-income district of Bogota. Public Health Magazine Oct. 2016;7(4):568.","journal-title":"Public Health Magazine Oct"},{"key":"746_CR10","first-page":"1","volume":"14","author":"GBG Mosegui","year":"2023","unstructured":"Mosegui GBG, Anto\u00f1anzas F, De Mello Vianna CM. Cost of lost productivity from acute respiratory infections in South America. Rev Panam Public Health April. 2023;14:47:1.","journal-title":"Rev Panam Public Health April"},{"issue":"1","key":"746_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jval.2021.11.1351","volume":"25","author":"D Husereau","year":"2022","unstructured":"Husereau D, Drummond M, Augustovski F, de Bekker-Grob E, Briggs AH, Carswell C, Caulley L, Chaiyakunapruk N, Greenberg D, Loder E, Mauskopf J, Mullins CD, Petrou S, Pwu RF, Staniszewska S. CHEERS 2022 ISPOR Good Research Practices Task Force. Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations. Value Health. 2022;25(1):3\u20139.","journal-title":"Value Health"},{"key":"746_CR12","unstructured":"Ministry of Health and Social Protection of Colombia. Sufficiency study and risk adjustment mechanisms for the calculation of the capitation payment unit 2024. 2024."},{"key":"746_CR13","doi-asserted-by":"crossref","unstructured":"Taborda A, Chamorro C, Londo\u00f1o D. Unit costs for health procedures in Colombia: a key input for health economic evaluations value health reg issues. 2022 Jul 1;30:161\u20135.","DOI":"10.1016\/j.vhri.2021.10.008"},{"key":"746_CR14","unstructured":"Bank of the Republic of Colombia. Economic Statistics [Internet]. [cited November 28, 2024]. Available at: https:\/\/suameca.banrep.gov.co\/estadisticas-economicas\/#\/informacionSerie\/100002\/%C3%8Dndice%20de%20Precios%20al%20Consumidor%20%28IPC%29."},{"key":"746_CR15","unstructured":"World Bank. PPP conversion factor, GDP (LCU per international $) [Internet]. World Development Indicators; 2025 [cited 2025 Dec 1]. Available from: https:\/\/data.worldbank.org\/indicator\/PA.NUS.PPP?locations=CO."},{"key":"746_CR16","doi-asserted-by":"publisher","unstructured":"Zhang S, Wahi-Singh P, Wahi-Singh B, Chisholm A, Keeling P, Nair H. Costs of management of acute respiratory infections in older adults: a systematic review and meta-analysis. J Glob Health. 2022;12:04096. https:\/\/doi.org\/10.7189\/jogh.12.04096.","DOI":"10.7189\/jogh.12.04096"},{"issue":"1","key":"746_CR17","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1186\/s12913-019-4412-7","volume":"19","author":"C Trucchi","year":"2019","unstructured":"Trucchi C, Paganino C, Orsi A, Amicizia D, Tisa V, Piazza MF, et al. Hospital and economic burden of influenza-like illness and lower respiratory tract infection in adults\u2009\u2265\u200950 years old. BMC Health Serv Res August. 2019;19(1):585.","journal-title":"BMC Health Serv Res August"},{"issue":"7","key":"746_CR18","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1164\/rccm.201908-1581ST","volume":"200","author":"JP Metlay","year":"2019","unstructured":"Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45\u201367.","journal-title":"Am J Respir Crit Care Med"},{"key":"746_CR19","first-page":"e52","volume":"19","author":"L Moyano Ariza","year":"2023","unstructured":"Moyano Ariza L, Ochoa B, Shewade HD, Edwards JK, Trujillo Trujillo J, Cuellar CM, et al. Adherence to guidelines on the use of amoxicillin for treatment of ambulatory pneumonia in children younger than 5 years, Colombia, 2017\u20132019. Rev Panam Salud P\u00fablica April. 2023;19:47:e52.","journal-title":"Rev Panam Salud P\u00fablica April"},{"key":"746_CR20","doi-asserted-by":"publisher","first-page":"1403168","DOI":"10.3389\/fmicb.2024.1403168","volume":"29","author":"S Sharma","year":"2024","unstructured":"Sharma S, Chauhan A, Ranjan A, Mathkor DM, Haque S, Ramniwas S, et al. Emerging challenges in antimicrobial resistance: implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability. Front Microbiol April. 2024;29:15:1403168.","journal-title":"Front Microbiol April"},{"issue":"8","key":"746_CR21","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s10096-021-04217-2","volume":"40","author":"L Chen","year":"2021","unstructured":"Chen L, Han X, Li Y, Zhang C, Xing X. Comparison of clinical characteristics and outcomes between respiratory syncytial virus and influenza-related pneumonia in China from 2013 to 2019. Eur J Clin Microbiol Infect Dis. 2021;40(8):1633\u201343.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"746_CR22","doi-asserted-by":"publisher","first-page":"12106","DOI":"10.1038\/s41598-020-69017-8","volume":"21","author":"JG Yoon","year":"2020","unstructured":"Yoon JG, Noh JY, Choi WS, Park JJ, Suh YB, Song JY, et al. Clinical characteristics and disease burden of respiratory syncytial virus infection among hospitalized adults. Sci Rep July. 2020;21:10:12106.","journal-title":"Sci Rep July"},{"issue":"6","key":"746_CR23","doi-asserted-by":"publisher","first-page":"e0234235","DOI":"10.1371\/journal.pone.0234235","volume":"15","author":"N Prasad","year":"2020","unstructured":"Prasad N, Newbern EC, Trenholme AA, Thompson MG, McArthur C, Wong CA, et al. The health and economic burden of respiratory syncytial virus associated hospitalizations in adults. PLoS ONE. 2020;15(6):e0234235.","journal-title":"PLoS ONE"},{"issue":"6","key":"746_CR24","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1093\/infdis\/jiaa183","volume":"17","author":"B Ackerson","year":"2020","unstructured":"Ackerson B, An J, Sy LS, Solano Z, Slezak J, Tseng HF. Cost of Hospitalization Associated With Respiratory Syncytial Virus Infection Versus Influenza Infection in Hospitalized Older Adults. J Infect Dis August. 2020;17(6):962\u20136.","journal-title":"J Infect Dis August"},{"issue":"1","key":"746_CR25","doi-asserted-by":"publisher","first-page":"ofw270","DOI":"10.1093\/ofid\/ofw270","volume":"9","author":"ST Pastula","year":"2017","unstructured":"Pastula ST, Hackett J, Coalson J, Jiang X, Villafana T, Ambrose C, et al. Hospitalizations for Respiratory Syncytial Virus Among Adults in the United States, 1997\u20132012. Open Forum Infect Dis January. 2017;9(1):ofw270.","journal-title":"Open Forum Infect Dis January"},{"key":"746_CR26","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s12889-015-1685-6","volume":"15","author":"SK Peasah","year":"2015","unstructured":"Peasah SK, Purakayastha DR, Koul PA, Dawood FS, Saha S, Amarchand R, Broor S, Rastogi V, Assad R, Kaul KA, Widdowson MA, Lal RB, Krishnan A. The cost of acute respiratory infections in Northern India: a multi-site study. BMC Public Health. 2015;15:330.","journal-title":"BMC Public Health"},{"key":"746_CR27","unstructured":"Ministerio de Salud y Protecci\u00f3n Social. Informe anual Consejo Nacional de Personas Mayores 2023: Decreto 163 de 2021. Informe al Congreso de la Rep\u00fablica. Bogot\u00e1: Ministerio de Salud y Protecci\u00f3n Social; 2024 Apr [Internet]. Available from: https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/DE\/PS\/informe-anual-cnpm-2023.pdf."}],"container-title":["Cost Effectiveness and Resource Allocation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12962-026-00746-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12962-026-00746-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12962-026-00746-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:02:34Z","timestamp":1780272154000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12962-026-00746-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["746"],"URL":"https:\/\/doi.org\/10.1186\/s12962-026-00746-9","relation":{},"ISSN":["1478-7547"],"issn-type":[{"value":"1478-7547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"12 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Corporate Research Ethics Committee approved the study. Minute19 of September 11th, 2023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}