{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:33:38Z","timestamp":1759602818199,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005849","name":"Baqiyatallah University of Medical Sciences","doi-asserted-by":"publisher","award":["91002804","91002804"],"award-info":[{"award-number":["91002804","91002804"]}],"id":[{"id":"10.13039\/501100005849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12964-019-0350-6","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T16:06:26Z","timestamp":1556035586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Imatinib independent aberrant methylation of NOV\/CCN3 in chronic myelogenous leukemia patients: a mechanism upstream of BCR-ABL1 function?"],"prefix":"10.1186","volume":"17","author":[{"given":"Mousa","family":"Vatanmakanian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Tavallaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Ghadami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"issue":"1","key":"350_CR1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1182\/blood.V58.1.158.158","volume":"58","author":"PJ Fialkow","year":"1981","unstructured":"Fialkow PJ, Martin PJ, Najfeld V, Penfold GK, Jacobson RJ, Hansen JA. Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood. 1981;58(1):158\u201363.","journal-title":"Blood."},{"issue":"5777","key":"350_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/287049a0","volume":"287","author":"PJ Martin","year":"1980","unstructured":"Martin PJ, Najfeld V, Hansen JA, Penfold GK, Jacobson RJ, Fialkow PJ. Involvement of the B-lymphoid system in chronic myelogenous leukaemia. Nature. 1980;287(5777):49.","journal-title":"Nature."},{"issue":"3","key":"350_CR3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1182\/blood.V49.3.367.367","volume":"49","author":"DW Golde","year":"1977","unstructured":"Golde DW, Burgaleta C, Sparkes R, Cline M. The Philadelphia chromosome in human macrophages. Blood. 1977;49(3):367\u201370.","journal-title":"Blood."},{"issue":"10","key":"350_CR4","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","volume":"96","author":"MW Deininger","year":"2000","unstructured":"Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood. 2000;96(10):3343\u201356.","journal-title":"Blood."},{"issue":"1","key":"350_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0959-437X(05)80338-7","volume":"3","author":"JY Wang","year":"1993","unstructured":"Wang JY. Abl tyrosine kinase in signal transduction and cell-cycle regulation. Curr Opin Genet Dev. 1993;3(1):35\u201343.","journal-title":"Curr Opin Genet Dev"},{"issue":"6632","key":"350_CR6","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/387520a0","volume":"387","author":"T Shafman","year":"1997","unstructured":"Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, et al. Interaction between ATM protein and c-Abl in response to DNA damage. Nature. 1997;387(6632):520.","journal-title":"Nature."},{"issue":"6","key":"350_CR7","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1084\/jem.191.6.977","volume":"191","author":"M Horita","year":"2000","unstructured":"Horita M, Andreu EJ, Benito A, Arbona C, Sanz C, Benet I, et al. Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5\u2013dependent expression of Bcl-xL. J Exp Med. 2000;191(6):977\u201384.","journal-title":"J Exp Med"},{"issue":"7","key":"350_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022110","volume":"6","author":"J Jelinek","year":"2011","unstructured":"Jelinek J, Gharibyan V, Estecio MR, Kondo K, He R, Chung W, et al. Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia. PLoS One. 2011;6(7):e22110.","journal-title":"PLoS One"},{"issue":"3","key":"350_CR9","first-page":"172","volume":"11","author":"T Rahmani","year":"2017","unstructured":"Rahmani T, Azad M, Chahardouli B, Nasiri H, Vatanmakanian M, Kaviani S. Patterns of DNMT1 promoter methylation in patients with acute lymphoblastic leukemia. International journal of hematology-oncology and stem cell research. 2017;11(3):172.","journal-title":"International journal of hematology-oncology and stem cell research"},{"issue":"35","key":"350_CR10","doi-asserted-by":"publisher","first-page":"36931","DOI":"10.1074\/jbc.M404073200","volume":"279","author":"A Gellhaus","year":"2004","unstructured":"Gellhaus A, Dong X, Propson S, Maass K, Klein-Hitpass L, Kibschull M, et al. Connexin43 interacts with NOV a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J Biol Chem. 2004;279(35):36931\u201342.","journal-title":"J Biol Chem"},{"issue":"9","key":"350_CR11","doi-asserted-by":"publisher","first-page":"8229","DOI":"10.1074\/jbc.M404903200","volume":"280","author":"CG Lin","year":"2005","unstructured":"Lin CG, Chen C-C, Leu S-J, Grzeszkiewicz TM, Lau LF. Integrin-dependent functions of the Angiogenic inducer NOV (CCN3) IMPLICATION IN WOUND HEALING. J Biol Chem. 2005;280(9):8229\u201337.","journal-title":"J Biol Chem"},{"issue":"26","key":"350_CR12","doi-asserted-by":"publisher","first-page":"24200","DOI":"10.1074\/jbc.M302028200","volume":"278","author":"CG Lin","year":"2003","unstructured":"Lin CG, Leu S-J, Chen N, Tebeau CM, Lin S-X, Yeung C-Y, et al. CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 2003;278(26):24200\u20138.","journal-title":"J Biol Chem"},{"issue":"12","key":"350_CR13","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1002\/jcp.22672","volume":"226","author":"HE Tzeng","year":"2011","unstructured":"Tzeng HE, Chen JC, Tsai CH, Kuo CC, Hsu HC, Hwang WL, et al. CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway. J Cell Physiol. 2011;226(12):3181\u20139.","journal-title":"J Cell Physiol"},{"issue":"5824","key":"350_CR14","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1126\/science.1136031","volume":"316","author":"R Gupta","year":"2007","unstructured":"Gupta R, Hong D, Iborra F, Sarno S, Enver T. NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science. 2007;316(5824):590\u20133.","journal-title":"Science."},{"key":"350_CR15","doi-asserted-by":"crossref","unstructured":"Fu CT, Bechberger JF, Ozog MA, Perbal B, Naus CC. CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. J Biol Chem. 2004.","DOI":"10.1074\/jbc.M403952200"},{"issue":"3","key":"350_CR16","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1158\/1078-0432.CCR-07-0806","volume":"14","author":"B Perbal","year":"2008","unstructured":"Perbal B, Zuntini M, Zambelli D, Serra M, Sciandra M, Cantiani L, et al. Prognostic value of CCN3 in osteosarcoma. Clin Cancer Res. 2008;14(3):701\u20139.","journal-title":"Clin Cancer Res"},{"issue":"4","key":"350_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1136\/mp.54.4.275","volume":"54","author":"M Maillard","year":"2001","unstructured":"Maillard M, Cadot B, Ball R, Sethia K, Edwards D, Perbal B, et al. Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues. Mol Pathol. 2001;54(4):275.","journal-title":"Mol Pathol"},{"issue":"5","key":"350_CR18","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1016\/j.ajpath.2011.01.033","volume":"178","author":"V Ouellet","year":"2011","unstructured":"Ouellet V, Tiedemann K, Mourskaia A, Fong JE, Tran-Thanh D, Amir E, et al. CCN3 impairs osteoblast and stimulates osteoclast differentiation to favor breast cancer metastasis to bone. Am J Pathol. 2011;178(5):2377\u201388.","journal-title":"Am J Pathol"},{"issue":"7","key":"350_CR19","doi-asserted-by":"publisher","first-page":"6749","DOI":"10.1007\/s13277-014-1919-8","volume":"35","author":"J Chen","year":"2014","unstructured":"Chen J, Gao Y, Xu B, Cui X, Xu D. NOV is upregulated and promotes migration and invasion in bladder cancer. Tumor Biol. 2014;35(7):6749\u201355.","journal-title":"Tumor Biol"},{"issue":"5","key":"350_CR20","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1182\/blood-2006-04-016113","volume":"108","author":"L McCallum","year":"2006","unstructured":"McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton AD, et al. A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood. 2006;108(5):1716\u201323.","journal-title":"Blood."},{"issue":"2","key":"350_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s12079-009-0058-2","volume":"3","author":"L McCallum","year":"2009","unstructured":"McCallum L, Lu W, Price S, Lazar N, Perbal B, Irvine AE. CCN3: a key growth regulator in chronic myeloid Leukaemia. Journal of cell communication and signaling. 2009;3(2):115\u201324.","journal-title":"Journal of cell communication and signaling."},{"issue":"3","key":"350_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s12079-011-0139-x","volume":"5","author":"S Suresh","year":"2011","unstructured":"Suresh S, McCallum L, Lu W, Lazar N, Perbal B, Irvine AE. MicroRNAs 130a\/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML. Journal of cell communication and signaling. 2011;5(3):183\u201391.","journal-title":"Journal of cell communication and signaling"},{"issue":"2","key":"350_CR23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2217\/epi.14.80","volume":"7","author":"T Hamidi","year":"2015","unstructured":"Hamidi T, Singh AK, Chen T. Genetic alterations of DNA methylation machinery in human diseases. Epigenomics. 2015;7(2):247\u201365.","journal-title":"Epigenomics."},{"issue":"2","key":"350_CR24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1080\/15592294.2014.1003746","volume":"10","author":"D Sarkar","year":"2015","unstructured":"Sarkar D, Leung EY, Baguley BC, Finlay GJ, Askarian-Amiri ME. Epigenetic regulation in human melanoma: past and future. Epigenetics. 2015;10(2):103\u201321.","journal-title":"Epigenetics."},{"issue":"21","key":"350_CR25","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1093\/bioinformatics\/bti652","volume":"21","author":"C Bock","year":"2005","unstructured":"Bock C, Reither S, Mikeska T, Paulsen M, Walter J, Lengauer T. BiQ analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics. 2005;21(21):4067\u20138.","journal-title":"Bioinformatics."},{"issue":"3","key":"350_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ng.2556","volume":"45","author":"XS Puente","year":"2013","unstructured":"Puente XS, L\u00f3pez-Ot\u00edn C. The evolutionary biography of chronic lymphocytic leukemia. Nat Genet. 2013;45(3):229.","journal-title":"Nat Genet"},{"issue":"1","key":"350_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/leu.2013.248","volume":"28","author":"DA Landau","year":"2014","unstructured":"Landau DA, Carter SL, Getz G, Wu CJ. Clonal evolution in hematological malignancies and therapeutic implications. Leukemia. 2014;28(1):34.","journal-title":"Leukemia."},{"issue":"3","key":"350_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nrc.2016.3","volume":"16","author":"M Greaves","year":"2016","unstructured":"Greaves M. Leukaemia'firsts' in cancer research and treatment. Nat Rev Cancer. 2016;16(3):163.","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"350_CR29","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1182\/blood.V94.7.2452.419k23_2452_2460","volume":"94","author":"FA Asimakopoulos","year":"1999","unstructured":"Asimakopoulos FA, Shteper PJ, Krichevsky S, Fibach E, Polliack A, Rachmilewitz E, et al. ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia. Blood. 1999;94(7):2452\u201360.","journal-title":"Blood."},{"issue":"9","key":"350_CR30","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1038\/leu.2016.143","volume":"30","author":"G Heller","year":"2016","unstructured":"Heller G, Topakian T, Altenberger C, Cerny-Reiterer S, Herndlhofer S, Ziegler B, et al. Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia. Leukemia. 2016;30(9):1861.","journal-title":"Leukemia."},{"issue":"D1","key":"350_CR31","doi-asserted-by":"publisher","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","volume":"44","author":"NA O'Leary","year":"2015","unstructured":"O'Leary NA, Wright MW, Brister JR, Ciufo S, Haddad D, McVeigh R, et al. Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucleic Acids Res. 2015;44(D1):D733\u2013D45.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"350_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12079-011-0142-2","volume":"6","author":"L McCallum","year":"2012","unstructured":"McCallum L, Lu W, Price S, Lazar N, Perbal B, Irvine AE. CCN3 suppresses mitogenic signalling and reinstates growth control mechanisms in chronic myeloid leukaemia. Journal of cell communication and signaling. 2012;6(1):27\u201335.","journal-title":"Journal of cell communication and signaling."}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-019-0350-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12964-019-0350-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-019-0350-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T23:10:55Z","timestamp":1587510655000},"score":1,"resource":{"primary":{"URL":"https:\/\/biosignaling.biomedcentral.com\/articles\/10.1186\/s12964-019-0350-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,23]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["350"],"URL":"https:\/\/doi.org\/10.1186\/s12964-019-0350-6","relation":{},"ISSN":["1478-811X"],"issn-type":[{"type":"electronic","value":"1478-811X"}],"subject":[],"published":{"date-parts":[[2019,4,23]]},"assertion":[{"value":"6 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A written consent was provided for each individual participant and the study was approved by the Medical Ethics Committee of Baqiyatallah University of Medical Sciences.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"38"}}