{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:45Z","timestamp":1762102425246,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["MRC2017R1A5A2015541"],"award-info":[{"award-number":["MRC2017R1A5A2015541"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12964-019-0424-5","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:02:42Z","timestamp":1566468162000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through \u03b2-catenin accumulation"],"prefix":"10.1186","volume":"17","author":[{"given":"Dong Hun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Ju","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Yeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Bae","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-9575","authenticated-orcid":false,"given":"Jin Tae","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"424_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4103\/0253-7613.96297","volume":"44","author":"K Rasineni","year":"2012","unstructured":"Rasineni K, Casey CA. Molecular mechanism of alcoholic fatty liver. Indian J Pharmacol. 2012;44:299\u2013303.","journal-title":"Indian J Pharmacol"},{"key":"424_CR2","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","volume":"141","author":"B Gao","year":"2011","unstructured":"Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141:1572\u201385.","journal-title":"Gastroenterology"},{"key":"424_CR3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-2275(20)40613-3","volume":"20","author":"E Baraona","year":"1979","unstructured":"Baraona E, Lieber CS. Effects of ethanol on lipid metabolism. J Lipid Res. 1979;20:289\u2013315.","journal-title":"J Lipid Res"},{"key":"424_CR4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/ncb1534","volume":"9","author":"A Kaidi","year":"2007","unstructured":"Kaidi A, Williams AC, Paraskeva C. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol. 2007;9:210\u20137.","journal-title":"Nat Cell Biol"},{"key":"424_CR5","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1053\/j.gastro.2009.02.063","volume":"136","author":"ZD Burke","year":"2009","unstructured":"Burke ZD, Reed KR, Phesse TJ, Sansom OJ, Clarke AR, Tosh D. Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology. 2009;136:2316\u201324 e2311\u20132313.","journal-title":"Gastroenterology"},{"key":"424_CR6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1053\/j.gastro.2011.04.051","volume":"141","author":"N Lehwald","year":"2011","unstructured":"Lehwald N, Tao GZ, Jang KY, Sorkin M, Knoefel WT, Sylvester KG. Wnt-beta-catenin signaling protects against hepatic ischemia and reperfusion injury in mice. Gastroenterology. 2011;141:707\u201318 718 e701\u2013705.","journal-title":"Gastroenterology"},{"key":"424_CR7","doi-asserted-by":"publisher","first-page":"17214","DOI":"10.1074\/jbc.M112.445965","volume":"288","author":"GZ Tao","year":"2013","unstructured":"Tao GZ, Lehwald N, Jang KY, Baek J, Xu B, Omary MB, Sylvester KG. Wnt\/beta-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem. 2013;288:17214\u201324.","journal-title":"J Biol Chem"},{"key":"424_CR8","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3389\/fphys.2018.00792","volume":"9","author":"N Chen","year":"2018","unstructured":"Chen N, Wang J. Wnt\/beta-catenin signaling and obesity. Front Physiol. 2018;9:792.","journal-title":"Front Physiol"},{"key":"424_CR9","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1002\/stem.1659","volume":"32","author":"EC Keats","year":"2014","unstructured":"Keats EC, Dominguez JM 2nd, Grant MB, Khan ZA. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells. 2014;32:1649\u201360.","journal-title":"Stem Cells"},{"key":"424_CR10","first-page":"ra6","volume":"4","author":"H Liu","year":"2011","unstructured":"Liu H, Fergusson MM, Wu JJ, Rovira II, Liu J, Gavrilova O, Lu T, Bao J, Han D, Sack MN, Finkel T. Wnt signaling regulates hepatic metabolism. Sci Signal. 2011;4:ra6.","journal-title":"Sci Signal"},{"key":"424_CR11","doi-asserted-by":"publisher","first-page":"744","DOI":"10.2353\/ajpath.2010.090667","volume":"176","author":"J Behari","year":"2010","unstructured":"Behari J, Yeh TH, Krauland L, Otruba W, Cieply B, Hauth B, Apte U, Wu T, Evans R, Monga SP. Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis. Am J Pathol. 2010;176:744\u201353.","journal-title":"Am J Pathol"},{"key":"424_CR12","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1002\/hep.24766","volume":"55","author":"S Liu","year":"2012","unstructured":"Liu S, Yeh TH, Singh VP, Shiva S, Krauland L, Li H, Zhang P, Kharbanda K, Ritov V, Monga SP, et al. Beta-catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice. Hepatology. 2012;55:931\u201340.","journal-title":"Hepatology"},{"key":"424_CR13","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1101\/gad.1924910","volume":"24","author":"JC Yoon","year":"2010","unstructured":"Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010;24:1507\u201318.","journal-title":"Genes Dev"},{"key":"424_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1006\/geno.1997.5196","volume":"49","author":"H Matsumine","year":"1998","unstructured":"Matsumine H, Yamamura Y, Hattori N, Kobayashi T, Kitada T, Yoritaka A, Mizuno Y. A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2). Genomics. 1998;49:143\u20136.","journal-title":"Genomics"},{"key":"424_CR15","first-page":"002","volume":"S10","author":"A Sandebring","year":"2012","unstructured":"Sandebring A, Cedazo-M\u00ednguez A. Parkin- an E3 ubiquitin ligase with multiple substrates. J Alzheimers Dis Parkinsonism. 2012;S10:002.","journal-title":"J Alzheimers Dis Parkinsonism"},{"key":"424_CR16","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"T Kitada","year":"1998","unstructured":"Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998;392:605\u20138.","journal-title":"Nature"},{"key":"424_CR17","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1093\/aje\/kwg073","volume":"157","author":"H Chen","year":"2003","unstructured":"Chen H, Zhang SM, Hernan MA, Willett WC, Ascherio A. Dietary intakes of fat and risk of Parkinson's disease. Am J Epidemiol. 2003;157:1007\u201314.","journal-title":"Am J Epidemiol"},{"key":"424_CR18","first-page":"203930","volume":"2014","author":"J Chen","year":"2014","unstructured":"Chen J, Guan Z, Wang L, Song G, Ma B, Wang Y. Meta-analysis: overweight, obesity, and Parkinson's disease. Int J Endocrinol. 2014;2014:203930.","journal-title":"Int J Endocrinol"},{"key":"424_CR19","doi-asserted-by":"publisher","first-page":"G324","DOI":"10.1152\/ajpgi.00108.2015","volume":"309","author":"JA Williams","year":"2015","unstructured":"Williams JA, Ni HM, Ding Y, Ding WX. Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice. Am J Physiol Gastrointest Liver Physiol. 2015;309:G324\u201340.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"424_CR20","first-page":"1143","volume":"31","author":"N Eid","year":"2016","unstructured":"Eid N, Ito Y, Horibe A, Otsuki Y. Ethanol-induced mitophagy in liver is associated with activation of the PINK1-Parkin pathway triggered by oxidative DNA damage. Histol Histopathol. 2016;31:1143\u201359.","journal-title":"Histol Histopathol"},{"key":"424_CR21","doi-asserted-by":"publisher","first-page":"18614","DOI":"10.1074\/jbc.M401135200","volume":"279","author":"JJ Palacino","year":"2004","unstructured":"Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem. 2004;279:18614\u201322.","journal-title":"J Biol Chem"},{"key":"424_CR22","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1172\/JCI44736","volume":"121","author":"KY Kim","year":"2011","unstructured":"Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, et al. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest. 2011;121:3701\u201312.","journal-title":"J Clin Invest"},{"key":"424_CR23","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.bbrc.2009.07.014","volume":"388","author":"N Rawal","year":"2009","unstructured":"Rawal N, Corti O, Sacchetti P, Ardilla-Osorio H, Sehat B, Brice A, Arenas E. Parkin protects dopaminergic neurons from excessive Wnt\/beta-catenin signaling. Biochem Biophys Res Commun. 2009;388:473\u20138.","journal-title":"Biochem Biophys Res Commun"},{"key":"424_CR24","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1038\/sj.bjc.6605642","volume":"102","author":"P Workman","year":"2010","unstructured":"Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, et al. Guidelines for the welfare and use of animals in cancer research. Br J Cancer. 2010;102:1555\u201377.","journal-title":"Br J Cancer"},{"key":"424_CR25","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/hep.23837","volume":"52","author":"SH Ki","year":"2010","unstructured":"Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology. 2010;52:1291\u2013300.","journal-title":"Hepatology"},{"key":"424_CR26","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nprot.2013.032","volume":"8","author":"A Bertola","year":"2013","unstructured":"Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc. 2013;8:627\u201337.","journal-title":"Nat Protoc"},{"key":"424_CR27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10616-011-9407-0","volume":"64","author":"M Severgnini","year":"2012","unstructured":"Severgnini M, Sherman J, Sehgal A, Jayaprakash NK, Aubin J, Wang G, Zhang L, Peng CG, Yucius K, Butler J, Fitzgerald K. A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development. Cytotechnology. 2012;64:187\u201395.","journal-title":"Cytotechnology"},{"key":"424_CR28","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/ana.10277","volume":"52","author":"MA Hernan","year":"2002","unstructured":"Hernan MA, Takkouche B, Caamano-Isorna F, Gestal-Otero JJ. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann Neurol. 2002;52:276\u201384.","journal-title":"Ann Neurol"},{"key":"424_CR29","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/ana.10611","volume":"54","author":"MA Hernan","year":"2003","unstructured":"Hernan MA, Chen H, Schwarzschild MA, Ascherio A. Alcohol consumption and the incidence of Parkinson's disease. Ann Neurol. 2003;54:170\u20135.","journal-title":"Ann Neurol"},{"key":"424_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/1471-2377-10-111","volume":"10","author":"W Fukushima","year":"2010","unstructured":"Fukushima W, Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, et al. Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan. BMC Neurol. 2010;10:111.","journal-title":"BMC Neurol"},{"key":"424_CR31","doi-asserted-by":"publisher","first-page":"e66452","DOI":"10.1371\/journal.pone.0066452","volume":"8","author":"R Liu","year":"2013","unstructured":"Liu R, Guo X, Park Y, Wang J, Huang X, Hollenbeck A, Blair A, Chen H. Alcohol consumption, types of alcohol, and Parkinson's disease. PLoS One. 2013;8:e66452.","journal-title":"PLoS One"},{"key":"424_CR32","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.1073\/pnas.0931262100","volume":"100","author":"R Cesari","year":"2003","unstructured":"Cesari R, Martin ES, Calin GA, Pentimalli F, Bichi R, McAdams H, Trapasso F, Drusco A, Shimizu M, Masciullo V, et al. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci U S A. 2003;100:5956\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"424_CR33","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1242\/dev.01095","volume":"131","author":"Y Pesah","year":"2004","unstructured":"Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G. Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development. 2004;131:2183\u201394.","journal-title":"Development"},{"key":"424_CR34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1126\/science.1168974","volume":"325","author":"N Zelcer","year":"2009","unstructured":"Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100\u20134.","journal-title":"Science"},{"key":"424_CR35","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1172\/JCI21480","volume":"114","author":"JC Molero","year":"2004","unstructured":"Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CB, Langdon WY, Walder K, Murphy MA, Bowtell DD, et al. c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action. J Clin Invest. 2004;114:1326\u201333.","journal-title":"J Clin Invest"},{"key":"424_CR36","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.2337\/db06-0955","volume":"55","author":"JC Molero","year":"2006","unstructured":"Molero JC, Turner N, Thien CB, Langdon WY, James DE, Cooney GJ. Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. Diabetes. 2006;55:3411\u20137.","journal-title":"Diabetes"},{"key":"424_CR37","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/hep.23801","volume":"52","author":"TH Yeh","year":"2010","unstructured":"Yeh TH, Krauland L, Singh V, Zou B, Devaraj P, Stolz DB, Franks J, Monga SP, Sasatomi E, Behari J. Liver-specific beta-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis. Hepatology. 2010;52:1410\u20139.","journal-title":"Hepatology"},{"key":"424_CR38","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1053\/j.gastro.2012.05.048","volume":"143","author":"N Lehwald","year":"2012","unstructured":"Lehwald N, Tao GZ, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG. Beta-catenin regulates hepatic mitochondrial function and energy balance in mice. Gastroenterology. 2012;143:754\u201364.","journal-title":"Gastroenterology"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-019-0424-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12964-019-0424-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-019-0424-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T06:02:37Z","timestamp":1610863357000},"score":1,"resource":{"primary":{"URL":"https:\/\/biosignaling.biomedcentral.com\/articles\/10.1186\/s12964-019-0424-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["424"],"URL":"https:\/\/doi.org\/10.1186\/s12964-019-0424-5","relation":{},"ISSN":["1478-811X"],"issn-type":[{"type":"electronic","value":"1478-811X"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"10 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All studies were approved by and performed according to the ethical guidelines by the Chungbuk National University Animal Care Committee (Approval no. CBNUA-1073-17-01).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All of the authors agree to submit this manuscript to Cell Communication and Signaling.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"104"}}