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Albeit we know that VDR expression is reduced in the mucosal epithelial layers of autoimmune diseases, the mechanism by which VDR is decreased remains elusive.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>VDR and zinc finger protein 36 (ZFP36) levels in human samples and cell lines were detected by real-time PCR, western blot and immunostaining. Luciferase report assay was used to test cis-elements in <jats:italic>VDR<\/jats:italic> gene promoter, real-time PCR was applied to measure mRNA decay and western blot was performed to evaluate protein degradation. RNA affinity chromatography assay was used to test protein-mRNA interaction. Co-immunoprecipitation was used to detect protein\u2013protein interaction. The role of ZFP36 in AU-rich elements (AREs) in the 3\u2032 untranslated region (UTR) of <jats:italic>VDR<\/jats:italic> mRNA was also measured by luciferase report assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identify ZFP36 can bind with the AREs in the 3\u2019UTR of <jats:italic>VDR<\/jats:italic> mRNA, leading to mRNA degradation in oral and colonic epithelial cells under inflammatory circumstance. Either ZFP36 protein or AREs of <jats:italic>VDR<\/jats:italic> mRNA mutation abolishes this protein-mRNA binding process. After the key amino acid\u2019s mutation, ZFP36 fails to decrease <jats:italic>VDR<\/jats:italic> mRNA expression. We also find that VDR physically binds with Y box-binding protein 1 (YBX-1) to block YBX-1\u2019s nuclear translocation and ameliorate cell death in the presence of inflammation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These findings provide insights into the cause of VDR decrease in oral and colonic epithelial cells under inflammatory condition and explain how VDR maintains cell viability in these cells.<\/jats:p>\n                \n                \n              <\/jats:sec>","DOI":"10.1186\/s12964-021-00765-4","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T10:09:28Z","timestamp":1628676568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["ZFP36 promotes VDR mRNA degradation to facilitate cell death in oral and colonic epithelial cells"],"prefix":"10.1186","volume":"19","author":[{"given":"Xiangyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-2497","authenticated-orcid":false,"given":"Jie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"765_CR1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.5051\/jpis.2018.48.5.284","volume":"48","author":"YS Choi","year":"2018","unstructured":"Choi YS, Baek K, Choi Y. 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