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If it is not treated promptly, this lymphoproliferative disease has a significant fatality rate. Buparvaquone (BPQ) is the only chemotherapy-based treatment available right now. However, with the emergence of BPQ resistance on the rise and no backup therapy available, it is critical to identify imperative drugs and new targets against\n                      <jats:italic>Theileria<\/jats:italic>\n                      parasites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Artemisinin and its derivatives artesunate (ARS), artemether (ARM), or dihydroartemisinin (DHART) are the primary defence line against malaria parasites. This study has analysed artemisinin and its derivatives for their anti-\n                      <jats:italic>Theileria<\/jats:italic>\n                      l activity and mechanism of action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ARS and DHART showed potent activity against the\n                      <jats:italic>Theileria-<\/jats:italic>\n                      infected cells. BPQ in combination with ARS or DHART showed a synergistic effect. The compounds act specifically on the parasitised cells and have minimal cytotoxicity against the uninfected host cells. Treatment with ARS or DHART induces ROS-mediated oxidative DNA damage leading to cell death. Further blocking intracellular ROS by its scavengers antagonised the anti-parasitic activity of the compounds. Increased ROS production induces oxidative stress and DNA damage causing\n                      <jats:italic>p53<\/jats:italic>\n                      activation followed by caspase-dependent apoptosis in the\n                      <jats:italic>Theileria-<\/jats:italic>\n                      infected cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings give unique insights into the previously unknown molecular pathways underpinning the anti-\n                      <jats:italic>Theileria<\/jats:italic>\n                      l action of artemisinin derivatives, which may aid in formulating new therapies against this deadly parasite.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12964-023-01067-7","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T08:02:41Z","timestamp":1681718561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata-transformed cells"],"prefix":"10.1186","volume":"21","author":[{"given":"Madhumanti","family":"Barman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Dandasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhra","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam","family":"Kamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Subudhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"1067_CR1","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1007\/s11756-021-00966-9","volume":"77","author":"D Hromn\u00edkov\u00e1","year":"2022","unstructured":"Hromn\u00edkov\u00e1 D, Furka D, Furka S, Santana JAD, Ravingerov\u00e1 T, Kl\u00f6cklerov\u00e1 V, et al. 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