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An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of <jats:italic>Lactobacillus acidophilus<\/jats:italic> (<jats:italic>L<\/jats:italic>. <jats:italic>acidophilus<\/jats:italic>) and propionate on the development and progression of SS in mouse model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We compared the gut microbiomes of young and old mice. We administered <jats:italic>L<\/jats:italic>. <jats:italic>acidophilus<\/jats:italic> and propionate up to 24\u00a0weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Lactobacillaceae and <jats:italic>Lactobacillus<\/jats:italic> were decreased in aged mice. SS symptoms were ameliorated by <jats:italic>L<\/jats:italic>. <jats:italic>acidophilus<\/jats:italic>. The abundance of propionate-producing bacterial was increased by <jats:italic>L<\/jats:italic>. <jats:italic>acidophilus<\/jats:italic>. Propionate ameliorated the development and progression of SS by inhibiting the STIM1-STING signaling pathway.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The findings suggest that <jats:italic>Lactobacillus acidophilus<\/jats:italic> and propionate have therapeutic potential for SS.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1186\/s12964-023-01141-0","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:02:19Z","timestamp":1686733339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lactobacillus acidophilus and propionate attenuate Sj\u00f6gren\u2019s syndrome by modulating the STIM1-STING signaling pathway"],"prefix":"10.1186","volume":"21","author":[{"given":"Jin Seok","family":"Woo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SeungCheon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Su","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Sil","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JooYeon","family":"Jhun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-La","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"issue":"1","key":"1141_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S1542-0124(12)70212-4","volume":"8","author":"J Murube","year":"2010","unstructured":"Murube J. 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