{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:05:57Z","timestamp":1789070757535,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province of China","doi-asserted-by":"crossref","award":["2024JJ4077"],"award-info":[{"award-number":["2024JJ4077"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the health research project of Hunan Provincial Health Commission of China","award":["W20243055"],"award-info":[{"award-number":["W20243055"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473530"],"award-info":[{"award-number":["82473530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-024-01885-3","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T07:02:16Z","timestamp":1729148536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["D1-like dopamine receptors promote B-cell differentiation in systemic lupus erythematosus"],"prefix":"10.1186","volume":"22","author":[{"given":"Zhongyuan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenen","family":"liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"issue":"10188","key":"1885_CR1","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/S0140-6736(19)30237-5","volume":"393","author":"L Durcan","year":"2019","unstructured":"Durcan L, O\u2019Dwyer T, Petri M. Management strategies and future directions for systemic lupus erythematosus in adults. Lancet (London England). 2019;393(10188):2332\u201343.","journal-title":"Lancet (London England)"},{"issue":"22","key":"1885_CR2","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1056\/NEJMra1100359","volume":"365","author":"GC Tsokos","year":"2011","unstructured":"Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011;365(22):2110\u201321.","journal-title":"N Engl J Med"},{"issue":"6989","key":"1885_CR3","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1136\/bmj.310.6989.1257","volume":"310","author":"EM Hay","year":"1995","unstructured":"Hay EM, Snaith ML. ABC of rheumatology. Systemic lupus erythematosus and lupus-like syndromes. BMJ (Clinical Res ed). 1995;310(6989):1257\u201361.","journal-title":"BMJ (Clinical Res ed)"},{"issue":"6","key":"1885_CR4","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1001\/jama.2011.765","volume":"306","author":"S Ringold","year":"2011","unstructured":"Ringold S, Lynm C, Golub RM. JAMA patient page. Systemic lupus erythematosus. JAMA. 2011;306(6):668.","journal-title":"JAMA"},{"issue":"1","key":"1885_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nri2217","volume":"8","author":"U Klein","year":"2008","unstructured":"Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol. 2008;8(1):22\u201333.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"1885_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrrheum.2013.184","volume":"10","author":"NJ Olsen","year":"2014","unstructured":"Olsen NJ, Karp DR. Autoantibodies and SLE: the threshold for disease. Nat Rev Rheumatol. 2014;10(3):181\u20136.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"1885_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.autrev.2010.08.016","volume":"10","author":"PP Smith","year":"2010","unstructured":"Smith PP, Gordon C. Systemic lupus erythematosus: clinical presentations. Autoimmun rev. 2010;10(1):43\u20135.","journal-title":"Autoimmun rev"},{"issue":"6052","key":"1885_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1209985","volume":"334","author":"M Rosas-Ballina","year":"2011","unstructured":"Rosas-Ballina M, Olofsson PS, Ochani M, et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Sci (New York NY). 2011;334(6052):98\u2013101.","journal-title":"Sci (New York NY)"},{"issue":"3","key":"1885_CR9","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41583-021-00555-4","volume":"23","author":"S Udit","year":"2022","unstructured":"Udit S, Blake K, Chiu IM. Somatosensory and autonomic neuronal regulation of the immune response. Nat Rev Neurosci. 2022;23(3):157\u201371.","journal-title":"Nat Rev Neurosci"},{"issue":"20","key":"1885_CR10","doi-asserted-by":"publisher","first-page":"6512","DOI":"10.1002\/anie.201811122","volume":"58","author":"E Monzani","year":"2019","unstructured":"Monzani E, Nicolis S, Dell\u2019Acqua S, et al. Dopamine, oxidative stress and protein-quinone modifications in Parkinson\u2019s and other neurodegenerative diseases. Angewandte Chemie (International ed English). 2019;58(20):6512\u201327.","journal-title":"Angewandte Chemie (International ed English)"},{"issue":"1","key":"1885_CR11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","volume":"78","author":"C Missale","year":"1998","unstructured":"Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. Dopamine receptors: from structure to function. Physiol Rev. 1998;78(1):189\u2013225.","journal-title":"Physiol Rev"},{"issue":"8","key":"1885_CR12","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.2174\/1570159X19666210823103859","volume":"20","author":"M Melnikov","year":"2022","unstructured":"Melnikov M, Sviridova A, Rogovskii V, et al. The role of D(2)-like dopaminergic receptor in dopamine-mediated modulation of Th17-cells in multiple sclerosis. Curr Neuropharmacol. 2022;20(8):1632\u20139.","journal-title":"Curr Neuropharmacol"},{"issue":"27","key":"1885_CR13","doi-asserted-by":"publisher","first-page":"6133","DOI":"10.1523\/JNEUROSCI.0600-04.2004","volume":"24","author":"J Kipnis","year":"2004","unstructured":"Kipnis J, Cardon M, Avidan H, et al. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4\u2009+\u2009CD25\u2009+\u2009regulatory T-cell activity: implications for neurodegeneration. J Neuroscience: Official J Soc Neurosci. 2004;24(27):6133\u201343.","journal-title":"J Neuroscience: Official J Soc Neurosci"},{"issue":"2","key":"1885_CR14","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s12035-016-9717-5","volume":"54","author":"V Lieberknecht","year":"2017","unstructured":"Lieberknecht V, Junqueira SC, Cunha MP, et al. Pramipexole, a dopamine D2\/D3 receptor-preferring agonist, prevents experimental autoimmune Encephalomyelitis Development in mice. Mol Neurobiol. 2017;54(2):1033\u201345.","journal-title":"Mol Neurobiol"},{"key":"1885_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fncel.2018.00192","volume":"12","author":"F Osorio-Barrios","year":"2018","unstructured":"Osorio-Barrios F, Prado C, Contreras F, Pacheco R. Dopamine receptor D5 signaling plays a dual role in experimental autoimmune Encephalomyelitis Potentiating Th17-Mediated immunity and favoring suppressive activity of Regulatory T-Cells. Front Cell Neurosci. 2018;12:192.","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"1885_CR16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13075-023-03071-1","volume":"25","author":"XQ Wang","year":"2023","unstructured":"Wang XQ, Cai HH, Deng QW, Chang YZ, Peng YP, Qiu YH. Dopamine D2 receptor on CD4(+) T cells is protective against inflammatory responses and signs in a mouse model of rheumatoid arthritis. Arthritis Res Therapy. 2023;25(1):87.","journal-title":"Arthritis Res Therapy"},{"issue":"1\u20132","key":"1885_CR17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0165-5728(02)00280-1","volume":"132","author":"F McKenna","year":"2002","unstructured":"McKenna F, McLaughlin PJ, Lewis BJ, et al. Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study. J Neuroimmunol. 2002;132(1\u20132):34\u201340.","journal-title":"J Neuroimmunol"},{"issue":"9","key":"1885_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrrheum.2011.108","volume":"7","author":"DS Pisetsky","year":"2011","unstructured":"Pisetsky DS, Grammer AC, Ning TC, Lipsky PE. Are autoantibodies the targets of B-cell-directed therapy? Nat Rev Rheumatol. 2011;7(9):551\u20136.","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"1885_CR19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/ard.45.5.359","volume":"45","author":"AJ Swaak","year":"1986","unstructured":"Swaak AJ, Groenwold J, Bronsveld W. Predictive value of complement profiles and anti-dsDNA in systemic lupus erythematosus. Ann Rheum Dis. 1986;45(5):359\u201366.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1885_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1365-2567.2009.03152.x","volume":"129","author":"MP Bernard","year":"2010","unstructured":"Bernard MP, Phipps RP. Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation. Immunology. 2010;129(1):87\u201396.","journal-title":"Immunology"},{"issue":"1","key":"1885_CR21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12865-021-00469-x","volume":"22","author":"Y Zeng","year":"2021","unstructured":"Zeng Y, Lin Q, Yu L, et al. Chemokine CXCL1 as a potential marker of disease activity in systemic lupus erythematosus. BMC Immunol. 2021;22(1):82.","journal-title":"BMC Immunol"},{"issue":"7852","key":"1885_CR22","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41586-021-03239-2","volume":"592","author":"B Liu","year":"2021","unstructured":"Liu B, Lin Y, Yan J, et al. Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature. 2021;592(7852):133\u20137.","journal-title":"Nature"},{"issue":"11","key":"1885_CR23","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1002\/eji.201141558","volume":"41","author":"K Huse","year":"2011","unstructured":"Huse K, Bakkeb\u00f8 M, Oksvold MP, et al. Bone morphogenetic proteins inhibit CD40L\/IL-21-induced ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur J Immunol. 2011;41(11):3135\u201345.","journal-title":"Eur J Immunol"},{"issue":"9","key":"1885_CR24","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1182\/blood-2009-05-220251","volume":"115","author":"G Maarof","year":"2010","unstructured":"Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A. Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood. 2010;115(9):1718\u201326.","journal-title":"Blood"},{"issue":"2","key":"1885_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/cmi.2012.64","volume":"10","author":"VS Chan","year":"2013","unstructured":"Chan VS, Tsang HH, Tam RC, Lu L, Lau CS. B-cell-targeted therapies in systemic lupus erythematosus. Cell Mol Immunol. 2013;10(2):133\u201342.","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"1885_CR26","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nrrheum.2010.68","volume":"6","author":"I Sanz","year":"2010","unstructured":"Sanz I, Lee FE. B cells as therapeutic targets in SLE. Nat Rev Rheumatol. 2010;6(6):326\u201337.","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"1885_CR27","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41385-020-00354-7","volume":"14","author":"V Ugalde","year":"2021","unstructured":"Ugalde V, Contreras F, Prado C, Chovar O, Espinoza A, Pacheco R. Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation. Mucosal Immunol. 2021;14(3):652\u201366.","journal-title":"Mucosal Immunol"},{"issue":"6","key":"1885_CR28","doi-asserted-by":"publisher","first-page":"e65860","DOI":"10.1371\/journal.pone.0065860","volume":"8","author":"W Zhao","year":"2013","unstructured":"Zhao W, Huang Y, Liu Z, Cao BB, Peng YP, Qiu YH. Dopamine receptors modulate cytotoxicity of natural killer cells via cAMP-PKA-CREB signaling pathway. PLoS ONE. 2013;8(6):e65860.","journal-title":"PLoS ONE"},{"issue":"7","key":"1885_CR29","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.imbio.2012.11.002","volume":"218","author":"M Jafari","year":"2013","unstructured":"Jafari M, Ahangari G, Saberi M, Samangoui S, Torabi R, Zouali M. Distorted expression of dopamine receptor genes in systemic lupus erythematosus. Immunobiology. 2013;218(7):979\u201383.","journal-title":"Immunobiology"},{"issue":"3","key":"1885_CR30","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/eji.200939858","volume":"40","author":"EE Donovan","year":"2010","unstructured":"Donovan EE, Pelanda R, Torres RM. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol. 2010;40(3):688\u201398.","journal-title":"Eur J Immunol"},{"issue":"2","key":"1885_CR31","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1073\/pnas.98.2.603","volume":"98","author":"D Filipp","year":"2001","unstructured":"Filipp D, Alizadeh-Khiavi K, Richardson C, et al. Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. Proc Natl Acad Sci USA. 2001;98(2):603\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"1885_CR32","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1182\/blood-2009-12-256446","volume":"116","author":"H Guan","year":"2010","unstructured":"Guan H, Xie L, Leith\u00e4user F, et al. KLF4 is a tumor suppressor in B-cell non-hodgkin lymphoma and in classic Hodgkin lymphoma. Blood. 2010;116(9):1469\u201378.","journal-title":"Blood"},{"issue":"1","key":"1885_CR33","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1038\/s41467-021-24609-4","volume":"12","author":"T Ban","year":"2021","unstructured":"Ban T, Kikuchi M, Sato GR, et al. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun. 2021;12(1):4379.","journal-title":"Nat Commun"},{"issue":"8","key":"1885_CR34","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1038\/s41423-020-0472-1","volume":"18","author":"X Jin","year":"2021","unstructured":"Jin X, Xu Q, Pu C, et al. Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus. Cell Mol Immunol. 2021;18(8):1896\u2013903.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"1885_CR35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41392-021-00867-y","volume":"7","author":"X Han","year":"2022","unstructured":"Han X, Xu T, Ding C, et al. Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus. Signal Transduct Target Therapy. 2022;7(1):50.","journal-title":"Signal Transduct Target Therapy"},{"issue":"3","key":"1885_CR36","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00281-019-00741-8","volume":"41","author":"L G\u00f6schl","year":"2019","unstructured":"G\u00f6schl L, Scheinecker C, Bonelli M. Treg cells in autoimmunity: from identification to Treg-based therapies. Semin Immunopathol. 2019;41(3):301\u201314.","journal-title":"Semin Immunopathol"},{"issue":"Suppl 1","key":"1885_CR37","doi-asserted-by":"publisher","first-page":"i65","DOI":"10.1136\/ard.2009.117135","volume":"69","author":"M Bonelli","year":"2010","unstructured":"Bonelli M, Smolen JS, Scheinecker C. Treg and lupus. Ann Rheum Dis. 2010;69(Suppl 1):i65\u20136.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"1885_CR38","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00281-019-00733-8","volume":"41","author":"K Yasuda","year":"2019","unstructured":"Yasuda K, Takeuchi Y, Hirota K. The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. 2019;41(3):283\u201397.","journal-title":"Semin Immunopathol"},{"issue":"2","key":"1885_CR39","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.bbrc.2008.06.012","volume":"373","author":"K Nakano","year":"2008","unstructured":"Nakano K, Higashi T, Hashimoto K, Takagi R, Tanaka Y, Matsushita S. Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun. 2008;373(2):286\u201391.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1885_CR40","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1159\/000225902","volume":"30","author":"H Okada","year":"2009","unstructured":"Okada H, Inoue T, Hashimoto K, Suzuki H, Matsushita S. D1-like receptor antagonist inhibits IL-17 expression and attenuates crescent formation in nephrotoxic serum nephritis. Am J Nephrol. 2009;30(3):274\u20139.","journal-title":"Am J Nephrol"},{"key":"1885_CR41","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3389\/fimmu.2012.00281","volume":"3","author":"Y Wang","year":"2012","unstructured":"Wang Y, Rothstein TL. Induction of Th17 cell differentiation by B-1 cells. Front Immunol. 2012;3:281.","journal-title":"Front Immunol"},{"issue":"3","key":"1885_CR42","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s41419-020-2362-y","volume":"11","author":"J Yang","year":"2020","unstructured":"Yang J, Yang X, Wang L, Li M. B cells control lupus autoimmunity by inhibiting Th17 and promoting Th22 cells. Cell Death Dis. 2020;11(3):164.","journal-title":"Cell Death Dis"},{"issue":"11","key":"1885_CR43","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nrd.2018.135","volume":"17","author":"AP Campbell","year":"2018","unstructured":"Campbell AP, Smrcka AV. Targeting G protein-coupled receptor signalling by blocking G proteins. Nat Rev Drug Discovery. 2018;17(11):789\u2013803.","journal-title":"Nat Rev Drug Discovery"},{"issue":"3","key":"1885_CR44","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cell.2017.07.009","volume":"170","author":"D Wacker","year":"2017","unstructured":"Wacker D, Stevens RC, Roth BL. How ligands Illuminate GPCR Molecular Pharmacology. Cell. 2017;170(3):414\u201327.","journal-title":"Cell"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-024-01885-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-024-01885-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-024-01885-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T19:03:41Z","timestamp":1729191821000},"score":1,"resource":{"primary":{"URL":"https:\/\/biosignaling.biomedcentral.com\/articles\/10.1186\/s12964-024-01885-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1885"],"URL":"https:\/\/doi.org\/10.1186\/s12964-024-01885-3","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"2 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of the Second Xiangya Hospital of Central South University (No. 2019044). Informed consent was obtained from all individuals included in this study or from their legal guardians or wards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to publish this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"502"}}