{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:49:37Z","timestamp":1789469377614,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Postdoctoral Innovation Fund Project of Shandong Province","award":["SDCX-ZG-202203044"],"award-info":[{"award-number":["SDCX-ZG-202203044"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200709"],"award-info":[{"award-number":["32200709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82171748"],"award-info":[{"award-number":["No. 82171748"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QC061"],"award-info":[{"award-number":["ZR2022QC061"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Distinguished Professor of Taishan Scholars","award":["No. tstp20221109"],"award-info":[{"award-number":["No. tstp20221109"]}]},{"name":"Shandong Provincial Natural Science Foundation Joint Fund","award":["ZR2023LZL010"],"award-info":[{"award-number":["ZR2023LZL010"]}]},{"name":"the Major Innovation Project of Shandong Province","award":["No. 2021GXGC011305"],"award-info":[{"award-number":["No. 2021GXGC011305"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-024-01992-1","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:25:10Z","timestamp":1734686710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases"],"prefix":"10.1186","volume":"22","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueke","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"issue":"9","key":"1992_CR1","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18(9):2114\u201327. https:\/\/doi.org\/10.1038\/s41423-021-00740-6.","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"1992_CR2","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","volume":"18","author":"S Paik","year":"2021","unstructured":"Paik S, Kim JK, Silwal P, Sasakawa C, Jo EK. An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol. 2021;18(5):1141\u201360. https:\/\/doi.org\/10.1038\/s41423-021-00670-3.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"1992_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/ctm2.13","volume":"10","author":"Y Wang","year":"2020","unstructured":"Wang Y, Liu X, Shi H, Yu Y, Yu Y, Li M, et al. NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases. Clin Transl Med. 2020;10(1):91\u2013106. https:\/\/doi.org\/10.1002\/ctm2.13.","journal-title":"Clin Transl Med"},{"key":"1992_CR4","doi-asserted-by":"publisher","first-page":"100889","DOI":"10.1016\/j.mam.2020.100889","volume":"76","author":"L Wang","year":"2020","unstructured":"Wang L, Hauenstein AV. The NLRP3 inflammasome: Mechanism of action, role in disease and therapies. Mol Aspects Med. 2020;76:100889. https:\/\/doi.org\/10.1016\/j.mam.2020.100889.","journal-title":"Mol Aspects Med"},{"key":"1992_CR5","doi-asserted-by":"publisher","unstructured":"Qin Y, Meng X, Wang M, Liang W, Xu R, Chen J, et al. Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation. J Clin Invest. 2023;133(20). https:\/\/doi.org\/10.1172\/JCI161935.","DOI":"10.1172\/JCI161935"},{"issue":"3","key":"1992_CR6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41580-018-0081-3","volume":"20","author":"T Narita","year":"2019","unstructured":"Narita T, Weinert BT, Choudhary C. Functions and mechanisms of non-histone protein acetylation. Nat Rev Mol Cell Biol. 2019;20(3):156\u201374. https:\/\/doi.org\/10.1038\/s41580-018-0081-3.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1992_CR7","doi-asserted-by":"publisher","first-page":"8396","DOI":"10.1038\/s41467-023-44203-0","volume":"14","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Luo L, Xu X, Wu J, Wang F, Lu Y, et al. Acetylation is required for full activation of the NLRP3 inflammasome. Nat Commun. 2023;14(1):8396. https:\/\/doi.org\/10.1038\/s41467-023-44203-0.","journal-title":"Nat Commun"},{"issue":"17","key":"1992_CR8","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1182\/blood.2020007401","volume":"138","author":"Y Wang","year":"2021","unstructured":"Wang Y, Li W, Schulz VP, Zhao H, Qu X, Qi Q, et al. Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency. Blood. 2021;138(17):1615\u201327. https:\/\/doi.org\/10.1182\/blood.2020007401.","journal-title":"Blood"},{"issue":"1","key":"1992_CR9","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s13046-021-02125-z","volume":"40","author":"O Schmidt","year":"2021","unstructured":"Schmidt O, Nehls N, Prexler C, von Heyking K, Groll T, Pardon K, et al. Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis. J Exp Clin Cancer Res. 2021;40(1):322. https:\/\/doi.org\/10.1186\/s13046-021-02125-z.","journal-title":"J Exp Clin Cancer Res"},{"key":"1992_CR10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.redox.2018.09.013","volume":"20","author":"N J\u00e4nsch","year":"2019","unstructured":"J\u00e4nsch N, Meyners C, Muth M, Kopranovic A, Witt O, Oehme I, et al. The enzyme activity of histone deacetylase 8 is modulated by a redox-switch. Redox Biol. 2019;20:60\u20137. https:\/\/doi.org\/10.1016\/j.redox.2018.09.013.","journal-title":"Redox Biol"},{"issue":"5","key":"1992_CR11","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/nar\/30.5.1114","volume":"30","author":"JJ Tong","year":"2002","unstructured":"Tong JJ, Liu J, Bertos NR, Yang X-J. Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 2002;30(5):1114\u201323.","journal-title":"Nucleic Acids Res"},{"key":"1992_CR12","doi-asserted-by":"publisher","first-page":"15368","DOI":"10.1038\/ncomms15368","volume":"8","author":"Y Hai","year":"2017","unstructured":"Hai Y, Shinsky SA, Porter NJ, Christianson DW. Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat Commun. 2017;8:15368. https:\/\/doi.org\/10.1038\/ncomms15368.","journal-title":"Nat Commun"},{"issue":"10","key":"1992_CR13","doi-asserted-by":"publisher","first-page":"102407","DOI":"10.1016\/j.jbc.2022.102407","volume":"298","author":"TM Stewart","year":"2022","unstructured":"Stewart TM, Foley JR, Holbert CE, Klinke G, Poschet G, Steimbach RR, et al. Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth. J Biol Chem. 2022;298(10):102407. https:\/\/doi.org\/10.1016\/j.jbc.2022.102407.","journal-title":"J Biol Chem"},{"issue":"765","key":"1992_CR14","doi-asserted-by":"publisher","first-page":"eabo4356","DOI":"10.1126\/scisignal.abo4356","volume":"15","author":"W Zhou","year":"2022","unstructured":"Zhou W, Wang J, Wang X, Wang B, Zhao Z, Fu J, et al. Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses. Sci Signal. 2022;15(765):eabo4356. https:\/\/doi.org\/10.1126\/scisignal.abo4356.","journal-title":"Sci Signal"},{"issue":"24","key":"1992_CR15","doi-asserted-by":"publisher","first-page":"11997","DOI":"10.1073\/pnas.1816399116","volume":"116","author":"Y Lu","year":"2019","unstructured":"Lu Y, Stuart JH, Talbot-Cooper C, Agrawal-Singh S, Huntly B, Smid AI, et al. Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A. 2019;116(24):11997\u20132006. https:\/\/doi.org\/10.1073\/pnas.1816399116.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"1992_CR16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/labinvest.2015.63","volume":"95","author":"Q Wei","year":"2015","unstructured":"Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, et al. Estrogen suppresses hepatocellular carcinoma cells through ER\u03b2-mediated upregulation of the NLRP3 inflammasome. Lab Invest. 2015;95(7):804\u201316. https:\/\/doi.org\/10.1038\/labinvest.2015.63.","journal-title":"Lab Invest"},{"issue":"11","key":"1992_CR17","doi-asserted-by":"publisher","first-page":"e54569","DOI":"10.15252\/embr.202154569","volume":"23","author":"Y Lin","year":"2022","unstructured":"Lin Y, Lv X, Sun C, Sun Y, Yang M, Ma D, et al. TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization. EMBO Rep. 2022;23(11):e54569. https:\/\/doi.org\/10.15252\/embr.202154569.","journal-title":"EMBO Rep"},{"key":"1992_CR18","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.1038\/ncomms5738","volume":"5","author":"W Huai","year":"2014","unstructured":"Huai W, Zhao R, Song H, Zhao J, Zhang L, Zhang L, et al. Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription. Nat Commun. 2014;5:4738. https:\/\/doi.org\/10.1038\/ncomms5738.","journal-title":"Nat Commun"},{"issue":"6","key":"1992_CR19","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41419-018-0644-4","volume":"9","author":"X Ma","year":"2018","unstructured":"Ma X, Ma X, Qiu Y, Zhu L, Lin Y, You Y, et al. TRIM50 suppressed hepatocarcinoma progression through directly targeting SNAIL for ubiquitous degradation. Cell Death Dis. 2018;9(6):608. https:\/\/doi.org\/10.1038\/s41419-018-0644-4.","journal-title":"Cell Death Dis"},{"issue":"5","key":"1992_CR20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","volume":"23","author":"M Shvedunova","year":"2022","unstructured":"Shvedunova M, Akhtar A. Modulation of cellular processes by histone and non-histone protein acetylation. Nat Rev Mol Cell Biol. 2022;23(5):329\u201349. https:\/\/doi.org\/10.1038\/s41580-021-00441-y.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"1992_CR21","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.bpj.2014.08.033","volume":"107","author":"IA Vakser","year":"2014","unstructured":"Vakser IA. Protein-protein docking: from interaction to interactome. Biophys J. 2014;107(8):1785. https:\/\/doi.org\/10.1016\/j.bpj.2014.08.033.","journal-title":"Biophys J"},{"issue":"6","key":"1992_CR22","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1002\/med.21972","volume":"43","author":"A Ferro","year":"2023","unstructured":"Ferro A, Pantazaka E, Athanassopoulos CM, Cuendet M. Histone deacetylase-based dual targeted inhibition in multiple myeloma. Med Res Rev. 2023;43(6):2177\u2013236. https:\/\/doi.org\/10.1002\/med.21972.","journal-title":"Med Res Rev"},{"issue":"7329","key":"1992_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221\u20135. https:\/\/doi.org\/10.1038\/nature09663.","journal-title":"Nature"},{"key":"1992_CR24","doi-asserted-by":"publisher","unstructured":"Tang J, Tu S, Lin G, Guo H, Yan C, Liu Q, et al. Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia. J Exp Med. 2020;217(4). https:\/\/doi.org\/10.1084\/jem.20182091.","DOI":"10.1084\/jem.20182091"},{"key":"1992_CR25","doi-asserted-by":"publisher","unstructured":"Fischer FA, Mies LFM, Nizami S, Pantazi E, Danielli S, Demarco B, et al. TBK1 and IKK\u03b5 act like an OFF switch to limit NLRP3 inflammasome pathway activation. Proc Natl Acad Sci U S A. 2021;118(38). https:\/\/doi.org\/10.1073\/pnas.2009309118.","DOI":"10.1073\/pnas.2009309118"},{"issue":"3","key":"1992_CR26","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cmet.2020.01.009","volume":"31","author":"M He","year":"2020","unstructured":"He M, Chiang HH, Luo H, Zheng Z, Qiao Q, Wang L, et al. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metab. 2020;31(3):580\u201391. https:\/\/doi.org\/10.1016\/j.cmet.2020.01.009.","journal-title":"Cell Metab"},{"issue":"1","key":"1992_CR27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12943-019-1127-7","volume":"19","author":"P Wang","year":"2020","unstructured":"Wang P, Wang Z, Liu J. Role of HDACs in normal and malignant hematopoiesis. Mol Cancer. 2020;19(1):5. https:\/\/doi.org\/10.1186\/s12943-019-1127-7.","journal-title":"Mol Cancer"},{"key":"1992_CR28","doi-asserted-by":"publisher","unstructured":"Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369(6510). https:\/\/doi.org\/10.1126\/science.aas8995.","DOI":"10.1126\/science.aas8995"},{"issue":"1","key":"1992_CR29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41420-022-00906-9","volume":"8","author":"F Yao","year":"2022","unstructured":"Yao F, Jin Z, Zheng Z, Lv X, Ren L, Yang J, et al. HDAC11 promotes both NLRP3\/caspase-1\/GSDMD and caspase-3\/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells. Cell Death Discov. 2022;8(1):112. https:\/\/doi.org\/10.1038\/s41420-022-00906-9.","journal-title":"Cell Death Discov"},{"issue":"1","key":"1992_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.molcel.2020.08.015","volume":"80","author":"Z Chi","year":"2020","unstructured":"Chi Z, Chen S, Xu T, Zhen W, Yu W, Jiang D, et al. Histone Deacetylase 3 Couples Mitochondria to Drive IL-1beta-Dependent Inflammation by Configuring Fatty Acid Oxidation. Mol Cell. 2020;80(1):43\u201358. https:\/\/doi.org\/10.1016\/j.molcel.2020.08.015.","journal-title":"Mol Cell"},{"issue":"4","key":"1992_CR31","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.bbrc.2015.10.033","volume":"467","author":"I Hwang","year":"2015","unstructured":"Hwang I, Lee E, Jeon SA, Yu JW. Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation. Biochem Biophys Res Commun. 2015;467(4):973\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.033.","journal-title":"Biochem Biophys Res Commun"},{"key":"1992_CR32","doi-asserted-by":"publisher","unstructured":"Sanchez-Fernandez C, Lorda-Diez CI, Duarte-Olivenza C, Hurle JM, Montero JA. Histone Epigenetic Signatures in Embryonic Limb Interdigital Cells Fated to Die. Cells. 2021;10(4). https:\/\/doi.org\/10.3390\/cells10040911.","DOI":"10.3390\/cells10040911"},{"issue":"16","key":"1992_CR33","doi-asserted-by":"publisher","first-page":"7878","DOI":"10.1093\/nar\/gkv707","volume":"43","author":"Y Wu","year":"2015","unstructured":"Wu Y, Chen H, Lu J, Zhang M, Zhang R, Duan T, et al. Acetylation-dependent function of human single-stranded DNA binding protein 1. Nucleic Acids Res. 2015;43(16):7878\u201387. https:\/\/doi.org\/10.1093\/nar\/gkv707.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"1992_CR34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/cr.2016.39","volume":"26","author":"KN Swatek","year":"2016","unstructured":"Swatek KN, Komander D. Ubiquitin modifications. Cell Res. 2016;26(4):399\u2013422. https:\/\/doi.org\/10.1038\/cr.2016.39.","journal-title":"Cell Res"},{"issue":"1","key":"1992_CR35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12964-020-00688-6","volume":"19","author":"Z Liang","year":"2021","unstructured":"Liang Z, Damianou A, Di Daniel E, Kessler BM. Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities. Cell Commun Signal. 2021;19(1):23. https:\/\/doi.org\/10.1186\/s12964-020-00688-6.","journal-title":"Cell Commun Signal"},{"issue":"1","key":"1992_CR36","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.1038\/s41467-018-05321-2","volume":"9","author":"R Barry","year":"2018","unstructured":"Barry R, John SW, Liccardi G, Tenev T, Jaco I, Chen C-H, et al. SUMO-mediated regulation of NLRP3 modulates inflammasome activity. Nat Commun. 2018;9(1):3001. https:\/\/doi.org\/10.1038\/s41467-018-05321-2.","journal-title":"Nat Commun"},{"issue":"4","key":"1992_CR37","doi-asserted-by":"publisher","first-page":"5793","DOI":"10.1096\/fj.201801681R","volume":"33","author":"P Wan","year":"2019","unstructured":"Wan P, Zhang Q, Liu W, Jia Y, Ai S, Wang T, et al. Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation. FASEB J. 2019;33(4):5793\u2013807. https:\/\/doi.org\/10.1096\/fj.201801681R.","journal-title":"FASEB J"},{"key":"1992_CR38","doi-asserted-by":"publisher","DOI":"10.1101\/2019.12.31.891556","author":"K Zhao","year":"2019","unstructured":"Zhao K, Zhang Y, Xu X, Liu L, Huang L, Luo R, et al. Acetylation is required for NLRP3 self-aggregation and full activation of the inflammasome. bioRxiv. 2019. https:\/\/doi.org\/10.1101\/2019.12.31.891556.","journal-title":"bioRxiv"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-024-01992-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-024-01992-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-024-01992-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T10:03:13Z","timestamp":1734688993000},"score":1,"resource":{"primary":{"URL":"https:\/\/biosignaling.biomedcentral.com\/articles\/10.1186\/s12964-024-01992-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1992"],"URL":"https:\/\/doi.org\/10.1186\/s12964-024-01992-1","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"25 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All mouse experiments were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee, and were approved by the Medical Ethics Committee of Shandong University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"615"}}