{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:54:28Z","timestamp":1784919268506,"version":"3.55.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82471277"],"award-info":[{"award-number":["82471277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation of Hunan Province","award":["2024JJ5471"],"award-info":[{"award-number":["2024JJ5471"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-025-02136-9","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T11:49:26Z","timestamp":1741607366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neuroprotective role and mechanistic insights of DJ-1 dimerization in Parkinson\u2019s disease"],"prefix":"10.1186","volume":"23","author":[{"given":"Lingling","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hainan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"issue":"10291","key":"2136_CR1","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/s0140-6736(21)00218-x","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C. Parkinson\u2019s disease. The Lancet. 2021;397(10291):2284\u2013303. https:\/\/doi.org\/10.1016\/s0140-6736(21)00218-x.","journal-title":"The Lancet"},{"issue":"1","key":"2136_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/s1474-4422(07)70327-7","volume":"7","author":"AHV Schapira","year":"2008","unstructured":"Schapira AHV. Mitochondria in the aetiology and pathogenesis of Parkinson\u2019s disease. The Lancet Neurology. 2008;7(1):97\u2013109. https:\/\/doi.org\/10.1016\/s1474-4422(07)70327-7.","journal-title":"The Lancet Neurology"},{"issue":"2","key":"2136_CR3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/s1474-4422(19)30287-x","volume":"19","author":"C Blauwendraat","year":"2020","unstructured":"Blauwendraat C, Nalls MA, Singleton AB. The genetic architecture of Parkinson\u2019s disease. The Lancet Neurology. 2020;19(2):170\u20138. https:\/\/doi.org\/10.1016\/s1474-4422(19)30287-x.","journal-title":"The Lancet Neurology"},{"issue":"4","key":"2136_CR4","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1152\/physrev.00022.2010","volume":"91","author":"O Corti","year":"2011","unstructured":"Corti O, Lesage S, Brice A. What Genetics Tells us About the Causes and Mechanisms of Parkinson\u2019s Disease. Physiol Rev. 2011;91(4):1161\u2013218. https:\/\/doi.org\/10.1152\/physrev.00022.2010.","journal-title":"Physiol Rev"},{"key":"2136_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/683920","volume":"2013","author":"H Ariga","year":"2013","unstructured":"Ariga H, Takahashi-Niki K, Kato I, Maita H, Niki T, Iguchi-Ariga SMM. Neuroprotective Function of DJ-1 in Parkinson\u2019s Disease. Oxid Med Cell Longev. 2013;2013:1\u20139. https:\/\/doi.org\/10.1155\/2013\/683920.","journal-title":"Oxid Med Cell Longev"},{"key":"2136_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.nbd.2017.08.005","volume":"108","author":"A Biosa","year":"2017","unstructured":"Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M. Recent findings on the physiological function of DJ-1: Beyond Parkinson\u2019s disease. Neurobiol Dis. 2017;108:65\u201372. https:\/\/doi.org\/10.1016\/j.nbd.2017.08.005.","journal-title":"Neurobiol Dis"},{"issue":"10","key":"2136_CR7","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.freeradbiomed.2009.08.003","volume":"47","author":"PJ Kahle","year":"2009","unstructured":"Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson\u2019s disease and other age-related disorders. Free Radical Biol Med. 2009;47(10):1354\u201361. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2009.08.003.","journal-title":"Free Radical Biol Med"},{"issue":"2","key":"2136_CR8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","volume":"231","author":"DTT Nagakubo","year":"1997","unstructured":"Nagakubo DTT, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation with ras. Biochem Biophys Res Commun. 1997;231(2):509\u201313. https:\/\/doi.org\/10.1006\/bbrc.1997.6132. PMID: 9070310.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5604","key":"2136_CR9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1126\/science.1077209","volume":"299","author":"V Bonifati","year":"2003","unstructured":"Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, et al. Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism. Science. 2003;299(5604):256\u20139. https:\/\/doi.org\/10.1126\/science.1077209.","journal-title":"Science"},{"issue":"2","key":"2136_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/molbev\/msl186","volume":"24","author":"JI Lucas","year":"2006","unstructured":"Lucas JI, Marin I. A New Evolutionary Paradigm for the Parkinson Disease Gene DJ-1. Mol Biol Evol. 2006;24(2):551\u201361. https:\/\/doi.org\/10.1093\/molbev\/msl186.","journal-title":"Mol Biol Evol"},{"key":"2136_CR11","doi-asserted-by":"publisher","unstructured":"Cookson MR. DJ\u20101, PINK1, and their effects on mitochondrial pathways. Movement Disorders. 2010;25(S1). https:\/\/doi.org\/10.1002\/mds.22713.","DOI":"10.1002\/mds.22713"},{"key":"2136_CR12","doi-asserted-by":"publisher","unstructured":"Neves M, Gr\u00e3os M, Anjo SI, Manadas B. Modulation of signaling pathways by DJ-1: An updated overview. Redox Biology. 2022;51. https:\/\/doi.org\/10.1016\/j.redox.2022.102283.","DOI":"10.1016\/j.redox.2022.102283"},{"key":"2136_CR13","doi-asserted-by":"publisher","unstructured":"Huang M, Chen S. DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application. Progress in Neurobiology. 2021;204. https:\/\/doi.org\/10.1016\/j.pneurobio.2021.102114.","DOI":"10.1016\/j.pneurobio.2021.102114"},{"key":"2136_CR14","doi-asserted-by":"publisher","unstructured":"Wilson MA CJ, Hod Y, Ringe D, Petsko GA. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. . Proc Natl Acad Sci U S A 2003;100(16):9256\u201361. . https:\/\/doi.org\/10.1073\/pnas.1133288100.","DOI":"10.1073\/pnas.1133288100"},{"issue":"4","key":"2136_CR15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/10715762.2017.1324201","volume":"51","author":"T Yasuda","year":"2017","unstructured":"Yasuda T, Niki T, Ariga H, Iguchi-Ariga SMM. Free radicals impair the anti-oxidative stress activity of DJ-1 through the formation of SDS-resistant dimer. Free Radical Res. 2017;51(4):397\u2013412. https:\/\/doi.org\/10.1080\/10715762.2017.1324201.","journal-title":"Free Radical Res"},{"key":"2136_CR16","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1385\/JMN\/29:03:215","volume":"29","author":"N Lev","year":"2006","unstructured":"Lev N, Roncevich D, Ickowicz D, Melamed E, Offen D. Role of DJ-1 in Parkinson\u2019s disease. J Mol Neurosci. 2006;29:215\u201325. https:\/\/doi.org\/10.1385\/JMN\/29:03:215.","journal-title":"J Mol Neurosci"},{"issue":"33","key":"2136_CR17","doi-asserted-by":"publisher","first-page":"31380","DOI":"10.1074\/jbc.M305878200","volume":"278","author":"K Honbou","year":"2003","unstructured":"Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, et al. The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson\u2019s Disease. J Biol Chem. 2003;278(33):31380\u20134. https:\/\/doi.org\/10.1074\/jbc.M305878200.","journal-title":"J Biol Chem"},{"issue":"5","key":"2136_CR18","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1110\/ps.073411608","volume":"17","author":"G Malgieri","year":"2009","unstructured":"Malgieri G, Eliezer D. Structural effects of Parkinson\u2019s disease linked DJ-1 mutations. Protein Sci. 2009;17(5):855\u201368. https:\/\/doi.org\/10.1110\/ps.073411608.","journal-title":"Protein Sci"},{"issue":"6","key":"2136_CR19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00401-004-0834-2","volume":"107","author":"M Neumann","year":"2004","unstructured":"Neumann M, M\u00fcller V, G\u00f6rner K, Kretzschmar HA, Haass C, Kahle PJ. Pathological properties of the Parkinson\u2019s disease-associated protein DJ-1 in \u03b1-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick\u2019s disease. Acta Neuropathol. 2004;107(6):489\u201396. https:\/\/doi.org\/10.1007\/s00401-004-0834-2.","journal-title":"Acta Neuropathol"},{"key":"2136_CR20","doi-asserted-by":"crossref","unstructured":"Patrizia Rizzu, David A Hinkle VZ, Vincenzo Bonifati, Lies-Anne Severijnen, Daniel Martinez, Rivka Ravid, , Wouter Kamphorst JHE, Virginia M-Y Lee, John Q Trojanowski, Peter Heutink. DJ-1 Colocalizes with Tau Inclusions: A Link between Parkinsonism and Dementia. Annals Neurol, 2004;55(1):113\u20138.","DOI":"10.1002\/ana.10782"},{"issue":"1","key":"2136_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/hmg\/ddi007","volume":"14","author":"DJ Moore","year":"2005","unstructured":"Moore DJ, Zhang L, Troncoso J, Lee MK, Hattori N, Mizuno Y, et al. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Hum Mol Genet. 2005;14(1):71\u201384. https:\/\/doi.org\/10.1093\/hmg\/ddi007.","journal-title":"Hum Mol Genet"},{"key":"2136_CR22","doi-asserted-by":"publisher","unstructured":"Skou LD, Johansen SK, Okarmus J, Meyer M. Pathogenesis of DJ-1\/PARK7-Mediated Parkinson\u2019s Disease. Cells. 2024;13(4). https:\/\/doi.org\/10.3390\/cells13040296.","DOI":"10.3390\/cells13040296"},{"issue":"12","key":"2136_CR23","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1093\/hmg\/ddq113","volume":"19","author":"J Chen","year":"2010","unstructured":"Chen J, Li L, Chin L-S. Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum Mol Genet. 2010;19(12):2395\u2013408. https:\/\/doi.org\/10.1093\/hmg\/ddq113.","journal-title":"Hum Mol Genet"},{"issue":"3","key":"2136_CR24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10863-019-09798-4","volume":"51","author":"LP Dolgacheva","year":"2019","unstructured":"Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY. Role of DJ-1 in the mechanism of pathogenesis of Parkinson\u2019s disease. J Bioenerg Biomembr. 2019;51(3):175\u201388. https:\/\/doi.org\/10.1007\/s10863-019-09798-4.","journal-title":"J Bioenerg Biomembr"},{"issue":"33","key":"2136_CR25","doi-asserted-by":"publisher","first-page":"31372","DOI":"10.1074\/jbc.M304221200","volume":"278","author":"X Tao","year":"2003","unstructured":"Tao X, Tong L. Crystal Structure of Human DJ-1, a Protein Associated with Early Onset Parkinson\u2019s Disease. J Biol Chem. 2003;278(33):31372\u20139. https:\/\/doi.org\/10.1074\/jbc.M304221200.","journal-title":"J Biol Chem"},{"issue":"1\u20133","key":"2136_CR26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/s0014-5793(03)00764-6","volume":"549","author":"Q Huai","year":"2003","unstructured":"Huai Q, Sun Y, Wang H, Chin L-S, Li L, Robinson H, et al. Crystal structure of DJ-1\/RS and implication on familial Parkinson\u2019s disease. FEBS Lett. 2003;549(1\u20133):171\u20135. https:\/\/doi.org\/10.1016\/s0014-5793(03)00764-6.","journal-title":"FEBS Lett"},{"key":"2136_CR27","doi-asserted-by":"publisher","unstructured":"Jiang L, Chen X-b, Wu Q, Zhu H-y, Du C-y, Ying M-d, et al. The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis. Acta Pharmacologica Sinica. 2020;42(7):1150\u20139. https:\/\/doi.org\/10.1038\/s41401-020-00531-1.","DOI":"10.1038\/s41401-020-00531-1"},{"issue":"45","key":"2136_CR28","doi-asserted-by":"publisher","first-page":"44552","DOI":"10.1074\/jbc.M304517200","volume":"278","author":"SJ Lee","year":"2003","unstructured":"Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, et al. Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain. J Biol Chem. 2003;278(45):44552\u20139. https:\/\/doi.org\/10.1074\/jbc.M304517200.","journal-title":"J Biol Chem"},{"issue":"14","key":"2136_CR29","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1002\/jnr.22477","volume":"88","author":"CP Ramsey","year":"2010","unstructured":"Ramsey CP, Giasson BI. L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments. J Neurosci Res. 2010;88(14):3111\u201324. https:\/\/doi.org\/10.1002\/jnr.22477.","journal-title":"J Neurosci Res"},{"key":"2136_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pharmthera.2015.09.005","volume":"156","author":"JYH Chan","year":"2015","unstructured":"Chan JYH, Chan SHH. Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1. Pharmacol Ther. 2015;156:69\u201374. https:\/\/doi.org\/10.1016\/j.pharmthera.2015.09.005.","journal-title":"Pharmacol Ther"},{"issue":"24","key":"2136_CR31","doi-asserted-by":"publisher","first-page":"9103","DOI":"10.1073\/pnas.0402959101","volume":"101","author":"RM Canet-Avil\u00e9s","year":"2004","unstructured":"Canet-Avil\u00e9s RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, et al. The Parkinson\u2019s disease protein DJ-1 is neuroprotective due to cysteine sulfinic acid-driven mitochondrial localization. P Natl Acad Sci USA. 2004;101(24):9103\u20138. https:\/\/doi.org\/10.1073\/pnas.0402959101.","journal-title":"P Natl Acad Sci USA"},{"issue":"18","key":"2136_CR32","doi-asserted-by":"publisher","first-page":"13680","DOI":"10.1074\/jbc.M609821200","volume":"282","author":"K G\u00f6rner","year":"2007","unstructured":"G\u00f6rner K, Holtorf E, Waak J, Pham T-T, Vogt-Weisenhorn DM, Wurst W, et al. Structural Determinants of the C-terminal Helix-Kink-Helix Motif Essential for Protein Stability and Survival Promoting Activity of DJ-1. J Biol Chem. 2007;282(18):13680\u201391. https:\/\/doi.org\/10.1074\/jbc.M609821200.","journal-title":"J Biol Chem"},{"issue":"36","key":"2136_CR33","doi-asserted-by":"publisher","first-page":"9380","DOI":"10.1021\/bi800677k","volume":"47","author":"PC Anderson","year":"2008","unstructured":"Anderson PC, Daggett V. Molecular Basis for the Structural Instability of Human DJ-1 Induced by the L166P Mutation Associated with Parkinson\u2019s Disease. Biochemistry. 2008;47(36):9380\u201393. https:\/\/doi.org\/10.1021\/bi800677k.","journal-title":"Biochemistry"},{"issue":"34","key":"2136_CR34","doi-asserted-by":"publisher","first-page":"24905","DOI":"10.1074\/jbc.M701013200","volume":"282","author":"FE Herrera","year":"2007","unstructured":"Herrera FE, Zucchelli S, Jezierska A, Lavina ZS, Gustincich S, Carloni P. On the Oligomeric State of DJ-1 Protein and Its Mutants Associated with Parkinson Disease. J Biol Chem. 2007;282(34):24905\u201314. https:\/\/doi.org\/10.1074\/jbc.M701013200.","journal-title":"J Biol Chem"},{"issue":"11","key":"2136_CR35","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1016\/j.bbagen.2017.08.017","volume":"1861","author":"R Kiss","year":"2017","unstructured":"Kiss R, Zhu M, J\u00f3j\u00e1rt B, Czajlik A, Solti K, F\u00f3rizs B, et al. Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease. Biochim Biophys Acta Gen Subj. 2017;1861(11):2619\u201329.","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"3","key":"2136_CR36","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.mcn.2004.06.014","volume":"27","author":"S Baulac","year":"2004","unstructured":"Baulac S, LaVoie MJ, Strahle J, Schlossmacher MG, Xia W. Dimerization of Parkinson\u2019s disease-causing DJ-1 and formation of high molecular weight complexes in human brain. Mol Cell Neurosci. 2004;27(3):236\u201346. https:\/\/doi.org\/10.1016\/j.mcn.2004.06.014.","journal-title":"Mol Cell Neurosci"},{"issue":"21","key":"2136_CR37","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1093\/hmg\/ddg304","volume":"12","author":"MG Macedo","year":"2003","unstructured":"Macedo MG. The DJ-1L166P mutant protein associated with early onset Parkinson\u2019s disease is unstable and forms higher-order protein complexes. Hum Mol Genet. 2003;12(21):2807\u201316. https:\/\/doi.org\/10.1093\/hmg\/ddg304.","journal-title":"Hum Mol Genet"},{"issue":"9","key":"2136_CR38","doi-asserted-by":"publisher","first-page":"8506","DOI":"10.1074\/jbc.M311017200","volume":"279","author":"JA Olzmann","year":"2004","unstructured":"Olzmann JA, Brown K, Wilkinson KD, Rees HD, Huai Q, Ke H, et al. Familial Parkinson\u2019s Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function. J Biol Chem. 2004;279(9):8506\u201315. https:\/\/doi.org\/10.1074\/jbc.M311017200.","journal-title":"J Biol Chem"},{"issue":"2","key":"2136_CR39","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/jnc.12126","volume":"125","author":"EH Rannikko","year":"2013","unstructured":"Rannikko EH, Vesterager LB, Shaik JHA, Weber SS, Cornejo Castro EM, Fog K, et al. Loss of DJ-1 protein stability and cytoprotective function by Parkinson\u2019s disease-associated proline-158 deletion. J Neurochem. 2013;125(2):314\u201327. https:\/\/doi.org\/10.1111\/jnc.12126.","journal-title":"J Neurochem"},{"key":"2136_CR40","doi-asserted-by":"publisher","unstructured":"Waller RF, Maita C, Maita H, Iguchi-Ariga SMM, Ariga H. Monomer DJ-1 and Its N-Terminal Sequence Are Necessary for Mitochondrial Localization of DJ-1 Mutants. PLoS ONE. 2013;8(1). https:\/\/doi.org\/10.1371\/journal.pone.0054087.","DOI":"10.1371\/journal.pone.0054087"},{"issue":"5","key":"2136_CR41","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00109-012-0976-y","volume":"91","author":"M Repici","year":"2012","unstructured":"Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F. Parkinson\u2019s disease-associated mutations in DJ-1 modulate its dimerization in living cells. J Mol Med. 2012;91(5):599\u2013611. https:\/\/doi.org\/10.1007\/s00109-012-0976-y.","journal-title":"J Mol Med"},{"issue":"4","key":"2136_CR42","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1021\/acs.jcim.8b00687","volume":"59","author":"A Kumar","year":"2019","unstructured":"Kumar A, Mukherjee D, Satpati P. Mutations in Parkinson\u2019s Disease Associated Protein DJ-1 Alter the Energetics of DJ-1 Dimerization. J Chem Inf Model. 2019;59(4):1497\u2013507. https:\/\/doi.org\/10.1021\/acs.jcim.8b00687.","journal-title":"J Chem Inf Model"},{"issue":"6","key":"2136_CR43","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1046\/j.1471-4159.2003.02265.x","volume":"87","author":"DJ Moore","year":"2003","unstructured":"Moore DJ, Zhang L, Dawson TM, Dawson VL. A missense mutation (L166P) in DJ-1, linked to familial Parkinson\u2019s disease, confers reduced protein stability and impairs homo-oligomerization. J Neurochem. 2003;87(6):1558\u201367. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.02265.x.","journal-title":"J Neurochem"},{"issue":"10","key":"2136_CR44","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1089\/ars.2013.5446","volume":"21","author":"J Cao","year":"2014","unstructured":"Cao J, Ying M, Xie N, Lin G, Dong R, Zhang J, et al. The Oxidation States of DJ-1 Dictate the Cell Fate in Response to Oxidative Stress Triggered by 4-HPR: Autophagy or Apoptosis? Antioxid Redox Signal. 2014;21(10):1443\u201359. https:\/\/doi.org\/10.1089\/ars.2013.5446.","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"2136_CR45","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1089\/ars.2009.2490","volume":"11","author":"JMM Tan","year":"2009","unstructured":"Tan JMM, Wong ESP, Lim K-L. Protein Misfolding and Aggregation in Parkinson\u2019s Disease. Antioxid Redox Signal. 2009;11(9):2119\u201334. https:\/\/doi.org\/10.1089\/ars.2009.2490.","journal-title":"Antioxid Redox Signal"},{"key":"2136_CR46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.parkreldis.2019.07.029","volume":"66","author":"YU Ko","year":"2019","unstructured":"Ko YU, Kim S-J, Lee J, Song M-Y, Park K-S, Park JB, et al. Protein kinase A-induced phosphorylation at the Thr154 affects stability of DJ-1. Parkinsonism Relat Disord. 2019;66:143\u201350. https:\/\/doi.org\/10.1016\/j.parkreldis.2019.07.029.","journal-title":"Parkinsonism Relat Disord"},{"issue":"4","key":"2136_CR47","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1083\/jcb.200904103","volume":"188","author":"S Deeg","year":"2010","unstructured":"Deeg S, Gralle M, Sroka K, B\u00e4hr M, Wouters FS, Kermer P. BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. J Cell Biol. 2010;188(4):505\u201313. https:\/\/doi.org\/10.1083\/jcb.200904103.","journal-title":"J Cell Biol"},{"issue":"4","key":"2136_CR48","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3233\/jpd-130230","volume":"3","author":"V Dias","year":"2013","unstructured":"Dias V, Junn E, Mouradian MM. The Role of Oxidative Stress in Parkinson\u2019s Disease. J Parkinsons Dis. 2013;3(4):461\u201391. https:\/\/doi.org\/10.3233\/jpd-130230.","journal-title":"J Parkinsons Dis"},{"issue":"7","key":"2136_CR49","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1073\/pnas.0914876107","volume":"107","author":"H Aleyasin","year":"2010","unstructured":"Aleyasin H, Rousseaux MWC, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, et al. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc Natl Acad Sci. 2010;107(7):3186\u201391. https:\/\/doi.org\/10.1073\/pnas.0914876107.","journal-title":"Proc Natl Acad Sci"},{"key":"2136_CR50","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.brainresbull.2019.01.007","volume":"146","author":"X-L Zhang","year":"2019","unstructured":"Zhang X-L, Wang Z-Z, Shao Q-H, Zhang Z, Li L, Guo Z-Y, et al. RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt\/GSK-3\u00df and JNK signaling pathways in dopaminergic neuron-like cells. Brain Res Bull. 2019;146:228\u201336. https:\/\/doi.org\/10.1016\/j.brainresbull.2019.01.007.","journal-title":"Brain Res Bull"},{"issue":"41","key":"2136_CR51","doi-asserted-by":"publisher","first-page":"15091","DOI":"10.1073\/pnas.0607260103","volume":"103","author":"CM Clements","year":"2006","unstructured":"Clements CM, McNally RS, Conti BJ, Mak TW, Ting JPY. DJ-1, a cancer- and Parkinson\u2019s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. P Natl Acad Sci USA. 2006;103(41):15091\u20136. https:\/\/doi.org\/10.1073\/pnas.0607260103.","journal-title":"P Natl Acad Sci USA"},{"issue":"13","key":"2136_CR52","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1093\/hmg\/dds131","volume":"21","author":"J-Y Im","year":"2012","unstructured":"Im J-Y, Lee K-W, Woo J-M, Junn E, Mouradian MM. DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum Mol Genet. 2012;21(13):3013\u201324. https:\/\/doi.org\/10.1093\/hmg\/dds131.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"2136_CR53","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"M Pickrell Alicia","year":"2015","unstructured":"Pickrell Alicia M, Youle RJ. The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson\u2019s Disease. Neuron. 2015;85(2):257\u201373. https:\/\/doi.org\/10.1016\/j.neuron.2014.12.007.","journal-title":"Neuron"},{"issue":"4","key":"2136_CR54","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","volume":"46","author":"AB Malpartida","year":"2021","unstructured":"Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ. Mitochondrial Dysfunction and Mitophagy in Parkinson\u2019s Disease: From Mechanism to Therapy. Trends Biochem Sci. 2021;46(4):329\u201343. https:\/\/doi.org\/10.1016\/j.tibs.2020.11.007.","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"2136_CR55","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","volume":"26","author":"DP Narendra","year":"2024","unstructured":"Narendra DP, Youle RJ. The role of PINK1\u2013Parkin in mitochondrial quality control. Nat Cell Biol. 2024;26(10):1639\u201351. https:\/\/doi.org\/10.1038\/s41556-024-01513-9.","journal-title":"Nat Cell Biol"},{"issue":"12","key":"2136_CR56","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1093\/brain\/awac313","volume":"145","author":"D Imberechts","year":"2022","unstructured":"Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1\/parkin-dependent mitophagy. Brain. 2022;145(12):4368\u201384. https:\/\/doi.org\/10.1093\/brain\/awac313.","journal-title":"Brain"},{"issue":"10","key":"2136_CR57","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.molmed.2024.07.003","volume":"30","author":"Y Xiong","year":"2024","unstructured":"Xiong Y, Yu J. LRRK2 in Parkinson\u2019s disease: upstream regulation and therapeutic targeting. Trends Mol Med. 2024;30(10):982\u201396. https:\/\/doi.org\/10.1016\/j.molmed.2024.07.003.","journal-title":"Trends Mol Med"},{"issue":"3","key":"2136_CR58","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.tins.2021.12.002","volume":"45","author":"EM Rocha","year":"2022","unstructured":"Rocha EM, Keeney MT, Di Maio R, De Miranda BR, Greenamyre JT. LRRK2 and idiopathic Parkinson\u2019s disease. Trends Neurosci. 2022;45(3):224\u201336. https:\/\/doi.org\/10.1016\/j.tins.2021.12.002.","journal-title":"Trends Neurosci"},{"key":"2136_CR59","doi-asserted-by":"publisher","unstructured":"Pang SY-Y, Lo RCN, Ho PW-L, Liu H-F, Chang EES, Leung C-T, et al. LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease. Translational Neurodegeneration. 2022;11(1). https:\/\/doi.org\/10.1186\/s40035-022-00281-6.","DOI":"10.1186\/s40035-022-00281-6"},{"issue":"3","key":"2136_CR60","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1385\/Nmm:5:3:235","volume":"5","author":"G Gardian","year":"2004","unstructured":"Gardian G, Yang LC, Cleren C, Calingasan NY, Klivenyi P, Beal MF. Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity. Neuromol Med. 2004;5(3):235\u201341. https:\/\/doi.org\/10.1385\/Nmm:5:3:235.","journal-title":"Neuromol Med"},{"key":"2136_CR61","doi-asserted-by":"crossref","unstructured":"Gonchar O, Mankovska, Rozova K, Bratus L, Karaban I. Nonel approaches to correction of mitochondrial dysfunction and oxidative disorders in Parkinson's disease. Physiological Journal\/Fiziologichnyi Zhurnal. 2019;65(3):61\u201372.","DOI":"10.15407\/fz65.03.061"},{"issue":"01","key":"2136_CR62","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1055\/s-0033-1351097","volume":"80","author":"K Wu","year":"2013","unstructured":"Wu K, McDonald P, Liu J, Klaassen C. Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway. Planta Med. 2013;80(01):97\u2013104. https:\/\/doi.org\/10.1055\/s-0033-1351097.","journal-title":"Planta Med"},{"key":"2136_CR63","doi-asserted-by":"publisher","unstructured":"Lin M-W, Lin CC, Chen Y-H, Yang H-B, Hung S-Y. Celastrol Inhibits Dopaminergic Neuronal Death of Parkinson\u2019s Disease through Activating Mitophagy. Antioxidants. 2019;9(1). https:\/\/doi.org\/10.3390\/antiox9010037.","DOI":"10.3390\/antiox9010037"},{"key":"2136_CR64","doi-asserted-by":"publisher","unstructured":"Prasertsuksri P, Kraokaew P, Pranweerapaiboon K, Sobhon P, Chaithirayanon K. Neuroprotection of Andrographolide against Neurotoxin MPP+-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities. International Journal of Molecular Sciences. 2023;24(10). https:\/\/doi.org\/10.3390\/ijms24108528.","DOI":"10.3390\/ijms24108528"},{"key":"2136_CR65","doi-asserted-by":"publisher","unstructured":"Ashok A, Andrabi SS, Mansoor S, Kuang Y, Kwon BK, Labhasetwar V. Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation. Antioxidants. 2022;11(2). https:\/\/doi.org\/10.3390\/antiox11020408.","DOI":"10.3390\/antiox11020408"},{"issue":"1","key":"2136_CR66","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1749-6632.2010.05627.x","volume":"1201","author":"RAJ Smith","year":"2010","unstructured":"Smith RAJ, Murphy MP. Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci. 2010;1201(1):96\u2013103. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05627.x.","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"2136_CR67","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","volume":"25","author":"BJ Snow","year":"2010","unstructured":"Snow BJ, Rolfe FL, Lockhart MM, Frampton CM, O\u2019Sullivan JD, Fung V, et al. A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson\u2019s disease. Mov Disord. 2010;25(11):1670\u20134. https:\/\/doi.org\/10.1002\/mds.23148.","journal-title":"Mov Disord"},{"issue":"2","key":"2136_CR68","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.bbrc.2005.11.058","volume":"339","author":"G Ito","year":"2006","unstructured":"Ito G, Ariga H, Nakagawa Y, Iwatsubo T. Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. Biochem Biophys Res Commun. 2006;339(2):667\u201372. https:\/\/doi.org\/10.1016\/j.bbrc.2005.11.058.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2136_CR69","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1523\/jneurosci.1833-10.2011","volume":"31","author":"SZ Imam","year":"2011","unstructured":"Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M, et al. Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson\u2019s Disease. J Neurosci. 2011;31(1):157\u201363. https:\/\/doi.org\/10.1523\/jneurosci.1833-10.2011.","journal-title":"J Neurosci"},{"key":"2136_CR70","doi-asserted-by":"publisher","unstructured":"Junqueira SC, Centeno EGZ, Wilkinson KA, Cimarosti H. Post-translational modifications of Parkinson's disease-related proteins: Phosphorylation, SUMOylation and Ubiquitination. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019;1865(8):2001\u20137. https:\/\/doi.org\/10.1016\/j.bbadis.2018.10.025.","DOI":"10.1016\/j.bbadis.2018.10.025"},{"key":"2136_CR71","doi-asserted-by":"publisher","unstructured":"Tsai C-F, Wang Y-T, Yen H-Y, Tsou C-C, Ku W-C, Lin P-Y, et al. Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nature Communications. 2015;6(1). https:\/\/doi.org\/10.1038\/ncomms7622.","DOI":"10.1038\/ncomms7622"},{"issue":"20","key":"2136_CR72","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.935","volume":"3","author":"H-T Lai","year":"2013","unstructured":"Lai H-T, Chiang C-M. Bimolecular Fluorescence Complementation (BiFC) Assay for Direct Visualization of Protein-Protein Interaction in vivo. Bio-Protoc. 2013;3(20): e935. https:\/\/doi.org\/10.21769\/bioprotoc.935.","journal-title":"Bio-Protoc"},{"issue":"3","key":"2136_CR73","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1007\/s12031-014-0481-6","volume":"55","author":"Z Song","year":"2015","unstructured":"Song Z, Xu S, Song B, Zhang Q. Bcl-2-Associated Athanogene 2 Prevents the Neurotoxicity of MPP+ via Interaction with DJ-1. J Mol Neurosci. 2015;55(3):798\u2013802. https:\/\/doi.org\/10.1007\/s12031-014-0481-6.","journal-title":"J Mol Neurosci"},{"issue":"1","key":"2136_CR74","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/hmg\/ddq430","volume":"20","author":"KJ Thomas","year":"2011","unstructured":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, et al. DJ-1 acts in parallel to the PINK1\/parkin pathway to control mitochondrial function and autophagy. Hum Mol Genet. 2011;20(1):40\u201350. https:\/\/doi.org\/10.1093\/hmg\/ddq430.","journal-title":"Hum Mol Genet"},{"key":"2136_CR75","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.toxlet.2017.02.022","volume":"271","author":"X-L Zhang","year":"2017","unstructured":"Zhang X-L, Yuan Y-H, Shao Q-H, Wang Z-Z, Zhu C-G, Shi J-G, et al. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult. Toxicol Lett. 2017;271:74\u201383. https:\/\/doi.org\/10.1016\/j.toxlet.2017.02.022.","journal-title":"Toxicol Lett"},{"issue":"16","key":"2136_CR76","doi-asserted-by":"publisher","first-page":"10816","DOI":"10.1074\/jbc.M509079200","volume":"281","author":"J Choi","year":"2006","unstructured":"Choi J, Sullards MC, Olzmann JA, Rees HD, Weintraub ST, Bostwick DE, et al. Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases. J Biol Chem. 2006;281(16):10816\u201324. https:\/\/doi.org\/10.1074\/jbc.M509079200.","journal-title":"J Biol Chem"},{"issue":"3","key":"2136_CR77","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.bbrc.2006.05.011","volume":"345","author":"M Waragai","year":"2006","unstructured":"Waragai M, Wei J, Fujita M, Nakai M, Ho GJ, Masliah E, et al. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson\u2019s disease. Biochem Biophys Res Commun. 2006;345(3):967\u201372. https:\/\/doi.org\/10.1016\/j.bbrc.2006.05.011.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2136_CR78","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.parkreldis.2015.07.021","volume":"21","author":"JM Masters","year":"2015","unstructured":"Masters JM, Noyce AJ, Warner TT, Giovannoni G, Proctor GB. Elevated salivary protein in Parkinson\u2019s disease and salivary DJ-1 as a potential marker of disease severity. Parkinsonism Relat Disord. 2015;21(10):1251\u20135. https:\/\/doi.org\/10.1016\/j.parkreldis.2015.07.021.","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"2136_CR79","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neulet.2007.08.010","volume":"425","author":"M Waragai","year":"2007","unstructured":"Waragai M, Nakai M, Wei J, Fujita M, Mizuno H, Ho G, et al. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson\u2019s disease. Neurosci Lett. 2007;425(1):18\u201322. https:\/\/doi.org\/10.1016\/j.neulet.2007.08.010.","journal-title":"Neurosci Lett"},{"key":"2136_CR80","doi-asserted-by":"publisher","unstructured":"Kang W-Y, Yang Q, Jiang X-F, Chen W, Zhang L-Y, Wang X-Y, et al. Salivary DJ-1 could be an indicator of Parkinson's disease progression. Frontiers in Aging Neuroscience. 2014;6. https:\/\/doi.org\/10.3389\/fnagi.2014.00102.","DOI":"10.3389\/fnagi.2014.00102"},{"issue":"11","key":"2136_CR81","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.3390\/ijms11114257","volume":"11","author":"M Waragai","year":"2010","unstructured":"Waragai M, Sekiyama K, Sekigawa A, Takamatsu Y, Fujita M, Hashimoto M. \u03b1-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson\u2019s Disease. Int J Mol Sci. 2010;11(11):4257\u201366. https:\/\/doi.org\/10.3390\/ijms11114257.","journal-title":"Int J Mol Sci"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-025-02136-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-025-02136-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-025-02136-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T11:49:31Z","timestamp":1741607371000},"score":1,"resource":{"primary":{"URL":"https:\/\/biosignaling.biomedcentral.com\/articles\/10.1186\/s12964-025-02136-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2136"],"URL":"https:\/\/doi.org\/10.1186\/s12964-025-02136-9","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"9 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}