{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:58:07Z","timestamp":1791503887007,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No82400077"],"award-info":[{"award-number":["No82400077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82270058, No. 82241028"],"award-info":[{"award-number":["No. 82270058, No. 82241028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Year 2022 Science and Technology Innovation Action Plan Medical Innovation Research Special Project","award":["No. 22Y11900600"],"award-info":[{"award-number":["No. 22Y11900600"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-025-02566-5","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:17:24Z","timestamp":1764325044000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The interplay between M2-like macrophages and Th17.1 cells promotes the progression of early-stage sarcoidosis"],"prefix":"10.1186","volume":"24","author":[{"given":"Yu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daibing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulinuer","family":"Wumaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfeng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzetuoheti","family":"Yiminniyaze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"9","key":"2566_CR1","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1001\/jama.2022.1570","volume":"327","author":"JA BELPERIO","year":"2022","unstructured":"BELPERIO JA, SHAIKH F, ABTIN F G, et al. Diagnosis and treatment of pulmonary sarcoidosis: A review [J]. JAMA. 2022;327(9):856\u201367.","journal-title":"JAMA"},{"issue":"11","key":"2566_CR2","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJMra2101555","volume":"385","author":"M DRENT","year":"2021","unstructured":"DRENT M, CROUSER E D GRUNEWALDJ. Challenges of sarcoidosis and its management [J]. N Engl J Med. 2021;385(11):1018\u201332.","journal-title":"N Engl J Med"},{"issue":"1","key":"2566_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-019-0096-x","volume":"5","author":"J GRUNEWALD","year":"2019","unstructured":"GRUNEWALD J, GRUTTERS J C, ARKEMA E V, et al. Sarcoidosis [J]. Nat Rev Dis Primers. 2019;5(1):45.","journal-title":"Nat Rev Dis Primers"},{"key":"2566_CR4","doi-asserted-by":"crossref","unstructured":"ZHOU E R ARCES. Key players and biomarkers of the adaptive immune system in the pathogenesis of sarcoidosis. Int J Mol Sci. 2020;21(19):7398.","DOI":"10.3390\/ijms21197398"},{"issue":"2","key":"2566_CR5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1084\/jem.20050648","volume":"203","author":"M MIYARA","year":"2006","unstructured":"MIYARA M, AMOURA Z, PARIZOT C, et al. The immune paradox of sarcoidosis and regulatory T cells [J]. J Exp Med. 2006;203(2):359\u201370.","journal-title":"J Exp Med"},{"key":"2566_CR6","doi-asserted-by":"publisher","first-page":"788502","DOI":"10.3389\/fimmu.2021.788502","volume":"12","author":"H ZHANG","year":"2021","unstructured":"ZHANG H, COSTABEL U. The role of diverse immune cells in sarcoidosis [J]. Front Immunol. 2021;12:788502.","journal-title":"Front Immunol"},{"issue":"3","key":"2566_CR7","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.ajpath.2010.11.065","volume":"178","author":"S PROKOP","year":"2011","unstructured":"PROKOP S, HEPPNER F L, GOEBEL H H, et al. M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis [J]. Am J Pathol. 2011;178(3):1279\u201386.","journal-title":"Am J Pathol"},{"key":"2566_CR8","doi-asserted-by":"crossref","unstructured":"LEPZIEN R, LIU S, CZARNEWSKI P et al. Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome. Eur Respir J. 2021;58(1):2003468.","DOI":"10.1183\/13993003.03468-2020"},{"issue":"4","key":"2566_CR9","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ccm.2015.08.016","volume":"36","author":"G ZISSEL","year":"2015","unstructured":"ZISSEL G, M\u00fcLLER-QUERNHEIM J. Cellular players in the Immunopathogenesis of sarcoidosis [J]. Clin Chest Med. 2015;36(4):549\u201360.","journal-title":"Clin Chest Med"},{"key":"2566_CR10","doi-asserted-by":"crossref","unstructured":"BROOS C E, KOTH L L, VAN NIMWEGEN M et al. Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes. Eur Respir J. 2018;51(3):1701124.","DOI":"10.1183\/13993003.01124-2017"},{"key":"2566_CR11","doi-asserted-by":"crossref","unstructured":"FRANKEN A, VAN MOL P VANMASSENHOVES et al. Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis. J Immunother Cancer. 2022;10(9):e005323.","DOI":"10.1136\/jitc-2022-005323"},{"issue":"11","key":"2566_CR12","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1164\/rccm.201507-1499OC","volume":"193","author":"J RAMSTEIN","year":"2016","unstructured":"RAMSTEIN J, BROOS C E, SIMPSON L J, et al. IFN-\u03b3-Producing T-Helper 17.1 cells are increased in sarcoidosis and are more prevalent than T-Helper type 1 cells [J]. Am J Respir Crit Care Med. 2016;193(11):1281\u201391.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2566_CR13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.immuni.2023.01.014","volume":"56","author":"T KRAUSGRUBER","year":"2023","unstructured":"KRAUSGRUBER T, REDL A, BARRECA D, et al. Single-cell and Spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation [J]. Immunity. 2023;56(2):289\u2013e3067.","journal-title":"Immunity"},{"key":"2566_CR14","doi-asserted-by":"crossref","unstructured":"CHEN E S. Reassessing Th1 versus Th17.1 in sarcoidosis: new tricks for old dogma. Eur Respir J. 2018;51(3):1800010.","DOI":"10.1183\/13993003.00010-2018"},{"issue":"3","key":"2566_CR15","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1365-2249.1994.tb07027.x","volume":"95","author":"FAZEL S B","year":"1994","unstructured":"FAZEL S B, HOWIE S E, KRAJEWSKI A S, et al. Increased CD45RO expression on T lymphocytes in mediastinal lymph node and pulmonary lesions of patients with pulmonary sarcoidosis [J]. Clin Exp Immunol. 1994;95(3):509\u201313.","journal-title":"Clin Exp Immunol"},{"key":"2566_CR16","doi-asserted-by":"publisher","first-page":"1080556","DOI":"10.3389\/fimmu.2022.1080556","volume":"13","author":"BERGANTINI","year":"2022","unstructured":"BERGANTINI, L, D\u2019ALESSANDRO M, DEL ZOTTO G, et al. Characterization of natural killer and T cells in Bronchoalveolar lavage and peripheral blood of sarcoidosis patients [J]. Front Immunol. 2022;13:1080556.","journal-title":"Front Immunol"},{"issue":"5","key":"2566_CR17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1136\/thx.52.5.431","volume":"52","author":"K IIDA","year":"1997","unstructured":"IIDA K, KADOTA J, KAWAKAMI K, et al. Analysis of T cell subsets and beta chemokines in patients with pulmonary sarcoidosis [J]. Thorax. 1997;52(5):431\u20137.","journal-title":"Thorax"},{"issue":"10","key":"2566_CR18","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1016\/j.jid.2019.04.006","volume":"139","author":"J HAUB","year":"2019","unstructured":"HAUB J, ROEHRIG N, UHRIN P, et al. Intervention of inflammatory monocyte activity limits dermal fibrosis [J]. J Invest Dermatol. 2019;139(10):2144\u201353.","journal-title":"J Invest Dermatol"},{"key":"2566_CR19","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.2147\/JIR.S355881","volume":"15","author":"K SINGH","year":"2022","unstructured":"SINGH K, RATHORE U RAIMK, et al. Novel Th17 lymphocyte Populations, Th17.1 and PD1\u2009+\u2009Th17, are increased in Takayasu Arteritis, and both Th17 and Th17.1 Sub-Populations associate with active disease [J]. J Inflamm Res. 2022;15:1521\u201341.","journal-title":"J Inflamm Res"},{"issue":"33","key":"2566_CR20","doi-asserted-by":"publisher","first-page":"14751","DOI":"10.1073\/pnas.1003852107","volume":"107","author":"K NISTALA","year":"2010","unstructured":"NISTALA K, ADAMS S, CAMBROOK H, et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment [J]. Proc Natl Acad Sci U S A. 2010;107(33):14751\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"2566_CR21","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","volume":"21","author":"A MANTOVANI","year":"2022","unstructured":"MANTOVANI A, ALLAVENA P, MARCHESI F, et al. Macrophages as tools and targets in cancer therapy [J]. Nat Rev Drug Discov. 2022;21(11):799\u2013820.","journal-title":"Nat Rev Drug Discov"},{"key":"2566_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fimmu.2020.00018","volume":"11","author":"W ZHANG","year":"2020","unstructured":"ZHANG W, HUANG Q, XIAO W, et al. Advances in Anti-Tumor treatments targeting the CD47\/SIRP\u03b1 axis [J]. Front Immunol. 2020;11:18.","journal-title":"Front Immunol"},{"key":"2566_CR23","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ejca.2017.02.013","volume":"76","author":"WEISKOPF K","year":"2017","unstructured":"WEISKOPF K. Cancer immunotherapy targeting the CD47\/SIRP\u03b1 axis [J]. Eur J Cancer. 2017;76:100\u20139.","journal-title":"Eur J Cancer"},{"issue":"2","key":"2566_CR24","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.immuni.2020.07.008","volume":"53","author":"MA MORRISSEY","year":"2020","unstructured":"MORRISSEY MA, KERN N, VALE RD. CD47 ligation repositions the inhibitory receptor SIRPA to suppress integrin activation and phagocytosis [J]. Immunity. 2020;53(2):290\u2013e3026.","journal-title":"Immunity"},{"issue":"2","key":"2566_CR25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tcb.2008.12.001","volume":"19","author":"T MATOZAKI","year":"2009","unstructured":"MATOZAKI T, MURATA Y, OKAZAWA H, et al. Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway [J]. Trends Cell Biol. 2009;19(2):72\u201380.","journal-title":"Trends Cell Biol"},{"key":"2566_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-immunol-032713-120142","volume":"32","author":"BARCLAY A N","year":"2014","unstructured":"BARCLAY A N, VAN DEN BERG T, K. The interaction between signal regulatory protein alpha (SIRP\u03b1) and CD47: structure, function, and therapeutic target [J]. Annu Rev Immunol. 2014;32:25\u201350.","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"2566_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13045-016-0381-z","volume":"10","author":"X LIU","year":"2017","unstructured":"LIU X, KWON H, LI Z, et al. Is CD47 an innate immune checkpoint for tumor evasion? [J]. J Hematol Oncol. 2017;10(1):12.","journal-title":"J Hematol Oncol"},{"key":"2566_CR28","doi-asserted-by":"crossref","unstructured":"LI Y, ZHOU H, LIU P et al. SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47\/SIRP\u03b1 axis. J Clin Invest. 2023;133(4):e162870.","DOI":"10.1172\/JCI162870"},{"issue":"8","key":"2566_CR29","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1161\/CIRCRESAHA.121.320449","volume":"131","author":"J LIU","year":"2022","unstructured":"LIU J, MA P. Transcriptional and immune landscape of cardiac sarcoidosis [J]. Circ Res. 2022;131(8):654\u201369.","journal-title":"Circ Res"},{"issue":"3","key":"2566_CR30","doi-asserted-by":"publisher","first-page":"102462","DOI":"10.1016\/j.autrev.2020.102462","volume":"19","author":"A TARASIDIS","year":"2020","unstructured":"TARASIDIS A, ARCE S. Immune response biomarkers as indicators of sarcoidosis presence, prognosis, and possible treatment: an immunopathogenic perspective [J]. Autoimmun Rev. 2020;19(3):102462.","journal-title":"Autoimmun Rev"},{"key":"2566_CR31","doi-asserted-by":"publisher","first-page":"1185443","DOI":"10.3389\/fimmu.2023.1185443","volume":"14","author":"H ZHANG","year":"2023","unstructured":"ZHANG H, JIANG D, ZHU L, et al. Imbalanced distribution of regulatory T cells and Th17.1 cells in the peripheral blood and BALF of sarcoidosis patients: relationship to disease activity and the fibrotic radiographic phenotype [J]. Front Immunol. 2023;14:1185443.","journal-title":"Front Immunol"},{"issue":"1","key":"2566_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1164\/ajrccm.163.1.9906071","volume":"163","author":"J WAHLSTR\u00f6M","year":"2001","unstructured":"WAHLSTR\u00f6M J, KATCHAR K, WIGZELL H, et al. Analysis of intracellular cytokines in CD4\u2009+\u2009and CD8\u2009+\u2009lung and blood T cells in sarcoidosis [J]. Am J Respir Crit Care Med. 2001;163(1):115\u201321.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2566_CR33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1046\/j.1365-2249.2000.01365.x","volume":"122","author":"A PRASSE","year":"2000","unstructured":"PRASSE A, GEORGES C G, BILLER H, et al. Th1 cytokine pattern in sarcoidosis is expressed by Bronchoalveolar CD4\u2009+\u2009and CD8\u2009+\u2009T cells [J]. Clin Exp Immunol. 2000;122(2):241\u20138.","journal-title":"Clin Exp Immunol"},{"key":"2566_CR34","doi-asserted-by":"crossref","unstructured":"PAPANIKOLAOU I C, CHYTOPOULOS K, KAITATZIS D et al. Phenotypes and endotypes in sarcoidosis: unraveling prognosis and disease course. Biomedicines. 2025;13(2):287.","DOI":"10.3390\/biomedicines13020287"},{"issue":"7","key":"2566_CR35","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/cup.13675","volume":"47","author":"T ISOHISA","year":"2020","unstructured":"ISOHISA T, ASAI J, KANEMARU M, et al. CD163-positive macrophage infiltration predicts systemic involvement in sarcoidosis [J]. J Cutan Pathol. 2020;47(7):584\u201391.","journal-title":"J Cutan Pathol"},{"issue":"1","key":"2566_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.humimm.2017.10.009","volume":"79","author":"M SHAMAEI","year":"2018","unstructured":"SHAMAEI M, MORTAZ E, POURABDOLLAH M, et al. Evidence for M2 macrophages in granulomas from pulmonary sarcoidosis: A new aspect of macrophage heterogeneity [J]. Hum Immunol. 2018;79(1):63\u20139.","journal-title":"Hum Immunol"},{"issue":"1","key":"2566_CR37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1165\/rcmb.2018-0298ED","volume":"60","author":"TJ STANDIFORD","year":"2019","unstructured":"STANDIFORD TJ. Macrophage polarization in sarcoidosis: an unexpected accomplice? [J]. Am J Respir Cell Mol Biol. 2019;60(1):9\u201310.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"13","key":"2566_CR38","doi-asserted-by":"publisher","first-page":"6044","DOI":"10.7150\/thno.109211","volume":"15","author":"P GAJAWADA","year":"2025","unstructured":"GAJAWADA P, G\u00fcNTHER S, ROLF A, et al. Transcriptomic profiling of granuloma in patients with cardiac sarcoidosis [J]. Theranostics. 2025;15(13):6044\u201357.","journal-title":"Theranostics"},{"issue":"3","key":"2566_CR39","first-page":"206","volume":"13","author":"AS TEIRSTEIN","year":"1998","unstructured":"TEIRSTEIN AS. Kveim antigen: what does it tell Us about causation of sarcoidosis? [J]. Semin Respir Infect. 1998;13(3):206\u201311.","journal-title":"Semin Respir Infect"},{"issue":"1","key":"2566_CR40","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1097\/00002281-200101000-00014","volume":"13","author":"J BARNARD","year":"2001","unstructured":"BARNARD J, NEWMAN LS. Sarcoidosis: immunology, rheumatic involvement, and therapeutics [J]. Curr Opin Rheumatol. 2001;13(1):84\u201391.","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"2566_CR41","first-page":"300","volume":"13","author":"P MORTAZ E, MASJEDI M R, TABARSI","year":"2014","unstructured":"MORTAZ E, MASJEDI M R, TABARSI P, et al. Immunopathology of sarcoidosis [J]. Iran J Allergy Asthma Immunol. 2014;13(5):300\u20136.","journal-title":"Iran J Allergy Asthma Immunol"},{"issue":"8","key":"2566_CR42","doi-asserted-by":"publisher","first-page":"101130","DOI":"10.1016\/j.xcrm.2023.101130","volume":"4","author":"MM XIE","year":"2023","unstructured":"XIE MM, HACKNEY DAIB. An agonistic anti-signal regulatory protein \u03b1 antibody for chronic inflammatory diseases [J]. Cell Rep Med. 2023;4(8):101130.","journal-title":"Cell Rep Med"},{"issue":"19","key":"2566_CR43","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1158\/0008-5472.CAN-24-0176","volume":"84","author":"B LI","year":"2024","unstructured":"LI B, HAO Y, HE H, et al. CD47-SIRP\u03b1 Blockade sensitizes head and neck squamous cell carcinoma to cetuximab by enhancing macrophage adhesion to cancer cells [J]. Cancer Res. 2024;84(19):3189\u2013206.","journal-title":"Cancer Res"},{"issue":"1","key":"2566_CR44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12929-025-01124-y","volume":"32","author":"LIN Y K","year":"2025","unstructured":"LIN Y K, PAN Y F, JIANG T Y, et al. Blocking the SIRP\u03b1-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice [J]. J Biomed Sci. 2025;32(1):31.","journal-title":"J Biomed Sci"},{"key":"2566_CR45","doi-asserted-by":"publisher","first-page":"114723","DOI":"10.1016\/j.intimp.2025.114723","volume":"156","author":"Y ZHAO","year":"2025","unstructured":"ZHAO Y, DUAN M, QI Y, et al. Innate immune checkpoint SIRP\u03b1\/CD47 Blockade ameliorates silica-induced pulmonary fibrosis by modulating macrophage immunity [J]. Int Immunopharmacol. 2025;156:114723.","journal-title":"Int Immunopharmacol"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-025-02566-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-025-02566-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-025-02566-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T21:02:02Z","timestamp":1767474122000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-025-02566-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2566"],"URL":"https:\/\/doi.org\/10.1186\/s12964-025-02566-5","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"26 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human mediastinal lymph nodes and serum samples were collected by Huashan Hospital affiliated to Fudan University, and the study protocol was approved by the Ethics Review Committee Office on the ninth floor of Huashan Hospital Affiliated to Fudan University (No. (2016) No. (396)). All animal care and experimental procedures conformed to the NIH Guide for the Care and Use of Laboratory Animals and were approved by Department of Laboratory Animal Science, Fudan University (No. 202308019\u00a0S).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}