{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T04:59:15Z","timestamp":1794373155224,"version":"4.9.0"},"reference-count":260,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Youth Innovation Science Foundation of PLA General Hospital","award":["22QNCZ038"],"award-info":[{"award-number":["22QNCZ038"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100694"],"award-info":[{"award-number":["32100694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222182"],"award-info":[{"award-number":["7222182"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-02658-w","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:15:20Z","timestamp":1768482920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent perspectives on macrophage memory: types, mechanisms, and characteristics in pulmonary diseases"],"prefix":"10.1186","volume":"24","author":[{"given":"Shuyong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"6","key":"2658_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","volume":"21","author":"RJ Hewitt","year":"2021","unstructured":"Hewitt RJ, Lloyd CM. Regulation of immune responses by the airway epithelial cell landscape. Nat Rev Immunol. 2021;21(6):347\u201362.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2658_CR2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cell.2020.08.020","volume":"183","author":"AS Neupane","year":"2020","unstructured":"Neupane AS, Willson M, Chojnacki AK, Vargas ESCF, Morehouse C, Carestia A, et al. Patrolling alveolar macrophages conceal bacteria from the immune system to maintain homeostasis. Cell. 2020;183(1):110-25.e11.","journal-title":"Cell"},{"issue":"5","key":"2658_CR3","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/s41385-021-00415-5","volume":"14","author":"N Oikonomou","year":"2021","unstructured":"Oikonomou N, Schuijs MJ, Chatzigiagkos A, Androulidaki A, Aidinis V, Hammad H, et al. Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunol. 2021;14(5):1160\u201371.","journal-title":"Mucosal Immunol"},{"key":"2658_CR4","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2147\/JAA.S324080","volume":"15","author":"N Noureddine","year":"2022","unstructured":"Noureddine N, Chalubinski M, Wawrzyniak P. The role of defective epithelial barriers in allergic lung disease and asthma development. J Asthma Allergy. 2022;15:487\u2013504.","journal-title":"J Asthma Allergy"},{"issue":"7","key":"2658_CR5","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3390\/cells11071105","volume":"11","author":"CE Whetstone","year":"2022","unstructured":"Whetstone CE, Ranjbar M, Omer H, Cusack RP, Gauvreau GM. The role of airway epithelial cell alarmins in asthma. Cells. 2022;11(7):1105.","journal-title":"Cells"},{"key":"2658_CR6","doi-asserted-by":"publisher","first-page":"108562","DOI":"10.1016\/j.pharmthera.2023.108562","volume":"252","author":"SE Mutsaers","year":"2023","unstructured":"Mutsaers SE, Miles T, Pr\u00eale CM, Hoyne GF. Emerging role of immune cells as drivers of pulmonary fibrosis. Pharmacol Ther. 2023;252:108562.","journal-title":"Pharmacol Ther"},{"issue":"1","key":"2658_CR7","doi-asserted-by":"publisher","first-page":"7143","DOI":"10.1038\/s41598-017-07101-2","volume":"7","author":"JA Dewhurst","year":"2017","unstructured":"Dewhurst JA, Lea S, Hardaker E, Dungwa JV, Ravi AK, Singh D. Characterisation of lung macrophage subpopulations in COPD patients and controls. Sci Rep. 2017;7(1):7143.","journal-title":"Sci Rep"},{"key":"2658_CR8","doi-asserted-by":"publisher","first-page":"1268939","DOI":"10.3389\/fimmu.2023.1268939","volume":"14","author":"CY Chang","year":"2023","unstructured":"Chang CY, Armstrong D, Corry DB, Kheradmand F. Alveolar macrophages in lung cancer: opportunities challenges. Front Immunol. 2023;14:1268939.","journal-title":"Front Immunol"},{"issue":"4","key":"2658_CR9","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s41423-020-00530-6","volume":"18","author":"J Varad\u00e9","year":"2021","unstructured":"Varad\u00e9 J, Magad\u00e1n S, Gonz\u00e1lez-Fern\u00e1ndez \u00c1. Human immunology and immunotherapy: main achievements and challenges. Cell Mol Immunol. 2021;18(4):805\u201328.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"2658_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.chom.2018.12.006","volume":"25","author":"MG Netea","year":"2019","unstructured":"Netea MG, Schlitzer A, Placek K, Joosten LAB, Schultze JL. Innate and adaptive immune memory: an evolutionary continuum in the host\u2019s response to pathogens. Cell Host Microbe. 2019;25(1):13\u201326.","journal-title":"Cell Host Microbe"},{"issue":"4","key":"2658_CR11","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3390\/immuno4040023","volume":"4","author":"NAB Taher","year":"2024","unstructured":"Taher NAB, Isaza-Correa JM, Melo AM, Kelly LA, Al-Harbi AI, O\u2019Dea MI, et al. Dynamics of peripheral lymphocyte subsets from birth until old age. Immuno. 2024;4(4):358\u201373.","journal-title":"Immuno"},{"issue":"6284","key":"2658_CR12","doi-asserted-by":"publisher","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","volume":"352","author":"MG Netea","year":"2016","unstructured":"Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, et al. Trained immunity: a program of innate immune memory in health and disease. Science. 2016;352(6284):aaf1098.","journal-title":"Science"},{"issue":"10","key":"2658_CR13","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","volume":"17","author":"RJW Arts","year":"2016","unstructured":"Arts RJW, Carvalho A, La Rocca C, Palma C, Rodrigues F, Silvestre R, et al. Immunometabolic pathways in BCG-induced trained immunity. Cell Rep. 2016;17(10):2562\u201371.","journal-title":"Cell Rep"},{"issue":"5","key":"2658_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","volume":"9","author":"MG Netea","year":"2011","unstructured":"Netea MG, Quintin J, van der Meer JW. Trained immunity: a memory for innate host defense. Cell Host Microbe. 2011;9(5):355\u201361.","journal-title":"Cell Host Microbe"},{"issue":"3","key":"2658_CR15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.chom.2017.02.003","volume":"21","author":"MG Netea","year":"2017","unstructured":"Netea MG, van der Meer JW. Trained Immunity: An Ancient Way of Remembering. Cell Host Microbe. 2017;21(3):297\u2013300.","journal-title":"Cell Host Microbe"},{"issue":"9","key":"2658_CR16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.it.2013.04.004","volume":"34","author":"CS Benn","year":"2013","unstructured":"Benn CS, Netea MG, Selin LK, Aaby P. A small jab - a big effect: nonspecific immunomodulation by vaccines. Trends Immunol. 2013;34(9):431\u20139.","journal-title":"Trends Immunol"},{"issue":"2","key":"2658_CR17","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3390\/ijms19020456","volume":"19","author":"P Rusek","year":"2018","unstructured":"Rusek P, Wala M, Druszczyn\u0301ska M, Fol M. Infectious Agents as Stimuli of Trained Innate Immunity. Int J Mol Sci. 2018;19(2):456. https:\/\/doi.org\/10.3390\/ijms19020456.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2658_CR18","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1462-5822.2010.01544.x","volume":"13","author":"MN Brooks","year":"2011","unstructured":"Brooks MN, Rajaram MV, Azad AK, Amer AO, Valdivia-Arenas MA, Park JH, et al. NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol. 2011;13(3):402\u201318.","journal-title":"Cell Microbiol."},{"key":"2658_CR19","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1146\/annurev-immunol-102119-073855","volume":"39","author":"S Bekkering","year":"2021","unstructured":"Bekkering S, Dom\u00ednguez-Andr\u00e9s J, Joosten LAB, Riksen NP, Netea MG. Trained immunity: reprogramming innate immunity in health and disease. Annu Rev Immunol. 2021;39:667\u201393.","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"2658_CR20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","volume":"20","author":"MG Netea","year":"2020","unstructured":"Netea MG, Dom\u00ednguez-Andr\u00e9s J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, et al. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020;20(6):375\u201388.","journal-title":"Nat Rev Immunol"},{"issue":"7701","key":"2658_CR21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41586-018-0023-4","volume":"556","author":"AC Wendeln","year":"2018","unstructured":"Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556(7701):332\u20138.","journal-title":"Nature"},{"key":"2658_CR22","doi-asserted-by":"crossref","unstructured":"Zhu B, Wu Y, Huang S, Zhang R, Son YM, Li C, et al. Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection. Immunity. 2021, 54(6):1200-18 e9.","DOI":"10.1016\/j.immuni.2021.04.001"},{"key":"2658_CR23","doi-asserted-by":"publisher","first-page":"1201658","DOI":"10.3389\/fimmu.2023.1201658","volume":"14","author":"KL Raby","year":"2023","unstructured":"Raby KL, Michaeloudes C, Tonkin J, Chung KF, Bhavsar PK. Mechanisms of airway epithelial injury and abnormal repair in asthma and COPD. Front Immunol. 2023;14:1201658.","journal-title":"Front Immunol"},{"key":"2658_CR24","doi-asserted-by":"crossref","unstructured":"Lim PN, Cervantes MM, Pham LK, Rothchild AC. Alveolar macrophages: novel therapeutic targets for respiratory diseases. Expert Rev Mol Med. 2021;23:e18.","DOI":"10.1017\/erm.2021.21"},{"issue":"3","key":"2658_CR25","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/mi.2012.88","volume":"6","author":"M Toussaint","year":"2013","unstructured":"Toussaint M, Fievez L, Drion PV, Cataldo D, Bureau F, Lekeux P, et al. Myeloid hypoxia-inducible factor 1\u03b1 prevents airway allergy in mice through macrophage-mediated immunoregulation. Mucosal Immunol. 2013;6(3):485\u201397.","journal-title":"Mucosal Immunol"},{"issue":"12","key":"2658_CR26","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1172\/JCI39717","volume":"119","author":"D Bedoret","year":"2009","unstructured":"Bedoret D, Wallemacq H, Marichal T, Desmet C, Quesada Calvo F, Henry E, et al. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest. 2009;119(12):3723\u201338.","journal-title":"J Clin Invest"},{"issue":"1","key":"2658_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1165\/rcmb.2017-0150ED","volume":"57","author":"CM Koch","year":"2017","unstructured":"Koch CM, Chiu SF, Misharin AV, Ridge KM. Lung interstitial macrophages: establishing identity and uncovering heterogeneity. Am J Respir Cell Mol Biol. 2017;57(1):7\u20139.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"23","key":"2658_CR28","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1016\/j.cell.2022.10.007","volume":"185","author":"MD Park","year":"2022","unstructured":"Park MD, Silvin A, Ginhoux F, Merad M. Macrophages in health and disease. Cell. 2022;185(23):4259\u201379.","journal-title":"Cell"},{"issue":"1","key":"2658_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","volume":"41","author":"S Epelman","year":"2014","unstructured":"Epelman S, Lavine KJ, Randolph GJ. Origin and functions of tissue macrophages. Immunity. 2014;41(1):21\u201335.","journal-title":"Immunity"},{"issue":"1","key":"2658_CR30","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/ijms19010092","volume":"19","author":"D Hirayama","year":"2017","unstructured":"Hirayama D, Iida T, Nakase H. The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis. Int J Mol Sci. 2017;19(1):92. https:\/\/doi.org\/10.3390\/ijms19010092.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2658_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1182\/blood-2010-08-265892","volume":"118","author":"P Lacy","year":"2011","unstructured":"Lacy P, Stow JL. Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood. 2011;118(1):9\u201318.","journal-title":"Blood"},{"key":"2658_CR32","doi-asserted-by":"crossref","unstructured":"Gaudino SJ, Kumar P. Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis. Front Immunol. 2019;10:360.","DOI":"10.3389\/fimmu.2019.00360"},{"key":"2658_CR33","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.3389\/fimmu.2020.01276","volume":"11","author":"EM Muntjewerff","year":"2020","unstructured":"Muntjewerff EM, Meesters LD, van den Bogaart G. Antigen cross-presentation by macrophages. Front Immunol. 2020;11:1276.","journal-title":"Front Immunol"},{"key":"2658_CR34","doi-asserted-by":"crossref","unstructured":"Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, et al. Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell. 2019, 178(6):1509-25 e19.","DOI":"10.1016\/j.cell.2019.08.009"},{"issue":"7966","key":"2658_CR35","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/s41586-023-06002-x","volume":"618","author":"T Lazarov","year":"2023","unstructured":"Lazarov T, Juarez-Carre\u00f1o S, Cox N, Geissmann F. Physiology and diseases of tissue-resident macrophages. Nature. 2023;618(7966):698\u2013707.","journal-title":"Nature"},{"issue":"6","key":"2658_CR36","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2020.05.014","volume":"52","author":"C Bl\u00e9riot","year":"2020","unstructured":"Bl\u00e9riot C, Chakarov S, Ginhoux F. Determinants of Resident Tissue Macrophage Identity and Function. Immunity. 2020;52(6):957\u201370.","journal-title":"Immunity"},{"issue":"4","key":"2658_CR37","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41569-019-0265-3","volume":"17","author":"T Kuznetsova","year":"2020","unstructured":"Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ. Transcriptional and epigenetic regulation of macrophages in atherosclerosis. Nat Rev Cardiol. 2020;17(4):216\u201328.","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"2658_CR38","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","volume":"44","author":"TA Wynn","year":"2016","unstructured":"Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44(3):450\u201362.","journal-title":"Immunity"},{"issue":"12","key":"2658_CR39","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1111\/febs.16465","volume":"290","author":"GVN Davuluri","year":"2023","unstructured":"Davuluri GVN, Chan CH. Regulation of intrinsic and extrinsic metabolic pathways in tumour-associated macrophages. FEBS J. 2023;290(12):3040\u201358.","journal-title":"FEBS J"},{"key":"2658_CR40","doi-asserted-by":"publisher","first-page":"768695","DOI":"10.3389\/fimmu.2021.768695","volume":"12","author":"MD Reece","year":"2021","unstructured":"Reece MD, Taylor RR, Song C, Gavegnano C. Targeting macrophage dysregulation for viral infections: novel targets for immunomodulators. Front Immunol. 2021;12:768695.","journal-title":"Front Immunol"},{"issue":"10","key":"2658_CR41","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","volume":"11","author":"SK Biswas","year":"2010","unstructured":"Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889\u201396.","journal-title":"Nat Immunol"},{"issue":"12","key":"2658_CR42","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nri1733","volume":"5","author":"S Gordon","year":"2005","unstructured":"Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5(12):953\u201364.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2658_CR43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","volume":"41","author":"PJ Murray","year":"2014","unstructured":"Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14\u201320.","journal-title":"Immunity"},{"issue":"4","key":"2658_CR44","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/ni.3398","volume":"17","author":"SC Cheng","year":"2016","unstructured":"Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, et al. Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol. 2016;17(4):406\u201313.","journal-title":"Nat Immunol"},{"key":"2658_CR45","doi-asserted-by":"publisher","first-page":"837524","DOI":"10.3389\/fimmu.2022.837524","volume":"13","author":"JM Brueggeman","year":"2022","unstructured":"Brueggeman JM, Zhao J, Schank M, Yao ZQ, Moorman JP. Trained immunity: an overview and the impact on COVID-19. Front Immunol. 2022;13:837524.","journal-title":"Front Immunol"},{"key":"2658_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010038","author":"M Kloc","year":"2022","unstructured":"Kloc M, Kubiak JZ, Zdanowski R, Ghobrial RM. Memory Macrophages. Int J Mol Sci. 2022;24(1):38. https:\/\/doi.org\/10.3390\/ijms24010038.","journal-title":"Int J Mol Sci"},{"key":"2658_CR47","doi-asserted-by":"publisher","first-page":"922702","DOI":"10.3389\/fimmu.2022.922702","volume":"13","author":"C Liu","year":"2022","unstructured":"Liu C, Xiao K, Xie L. Progress in preclinical studies of macrophage autophagy in the regulation of ALI\/ARDS. Front Immunol. 2022;13:922702.","journal-title":"Front Immunol"},{"issue":"6","key":"2658_CR48","first-page":"845","volume":"46","author":"R van Furth","year":"1972","unstructured":"van Furth R, Cohn ZA, Hirsch JG, Humphrey JH, Spector WG, Langevoort HL. The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bull World Health Organ. 1972;46(6):845\u201352.","journal-title":"Bull World Health Organ"},{"issue":"7540","key":"2658_CR49","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","volume":"518","author":"E Gomez Perdiguero","year":"2015","unstructured":"Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature. 2015;518(7540):547\u201351.","journal-title":"Nature"},{"key":"2658_CR50","doi-asserted-by":"crossref","unstructured":"Kieusseian A, Brunet de la Grange P, Burlen-Defranoux O, Godin I, Cumano A. Immature hematopoietic stem cells undergo maturation in the fetal liver. Development. 2012, 139(19):3521-30.","DOI":"10.1242\/dev.079210"},{"key":"2658_CR51","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4238","author":"E Mass","year":"2016","unstructured":"Mass E, Ballesteros I, Farlik M, Halbritter F, Gu\u0308nther P, Crozet L, et al. Speciication of tissue-resident macrophages during organogenesis. Science. 2016;353(6304):aaf4238. https:\/\/doi.org\/10.1126\/science.aaf4238.","journal-title":"Science"},{"issue":"6077","key":"2658_CR52","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1126\/science.1219179","volume":"336","author":"C Schulz","year":"2012","unstructured":"Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336(6077):86\u201390.","journal-title":"Science"},{"issue":"6274","key":"2658_CR53","doi-asserted-by":"publisher","first-page":"aad5510","DOI":"10.1126\/science.aad5510","volume":"351","author":"EL Soucie","year":"2016","unstructured":"Soucie EL, Weng Z, Geirsd\u00f3ttir L, Molawi K, Maurizio J, Fenouil R, et al. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science. 2016;351(6274):aad5510.","journal-title":"Science"},{"issue":"1","key":"2658_CR54","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","volume":"38","author":"S Yona","year":"2013","unstructured":"Yona S, Kim KW, Wolf Y, Mildner A, Varol D, Breker M, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity. 2013;38(1):79\u201391.","journal-title":"Immunity"},{"key":"2658_CR55","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1146\/annurev-immunol-093019-111748","volume":"39","author":"N Cox","year":"2021","unstructured":"Cox N, Pokrovskii M, Vicario R, Geissmann F. Origins, biology, and diseases of tissue macrophages. Annu Rev Immunol. 2021;39:313\u201344.","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"2658_CR56","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1084\/jem.20131199","volume":"210","author":"M Guilliams","year":"2013","unstructured":"Guilliams M, De Kleer I, Henri S, Post S, Vanhoutte L, De Prijck S, et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J Exp Med. 2013;210(10):1977\u201392.","journal-title":"J Exp Med"},{"key":"2658_CR57","doi-asserted-by":"crossref","unstructured":"Evren E, Ringqvist E, Tripathi KP, Sleiers N, Rives IC, Alisjahbana A, et al. Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity. 2021, 54(2):259-75 e7.","DOI":"10.1016\/j.immuni.2020.12.003"},{"key":"2658_CR58","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210987","author":"E Evren","year":"2022","unstructured":"Evren E, Ringqvist E, Doisne JM, Thaller A, Sleiers N, Flavell RA, et al. CD116+ fetal precursors migrate to the perinatal lung and give rise to humanalveolar macrophages. J Exp Med. 2022;219(2):e20210987. https:\/\/doi.org\/10.1084\/jem.20210987.","journal-title":"J Exp Med"},{"issue":"3","key":"2658_CR59","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.immuni.2017.02.016","volume":"46","author":"C Sabatel","year":"2017","unstructured":"Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, et al. Exposure to bacterial CpG DNA protects from airway allergic inflammation by expanding regulatory lung interstitial macrophages. Immunity. 2017;46(3):457\u201373.","journal-title":"Immunity"},{"key":"2658_CR60","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0964","author":"S Chakarov","year":"2019","unstructured":"Chakarov S, Lim HY, Tan L, Lim SY, See P, Lum J, et al. Two distinct interstitial macrophage populations coexist across tissues inspeciic subtissular niches. Science. 2019;363(6432):eaau0964. https:\/\/doi.org\/10.1126\/science.aau0964.","journal-title":"Science"},{"issue":"8","key":"2658_CR61","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1111\/ajt.13819","volume":"16","author":"DK Nayak","year":"2016","unstructured":"Nayak DK, Zhou F, Xu M, Huang J, Tsuji M, Hachem R, et al. Long-term persistence of donor alveolar macrophages in human lung transplant recipients that influences donor-specific immune responses. Am J Transplant. 2016;16(8):2300\u201311.","journal-title":"Am J Transplant"},{"issue":"16","key":"2658_CR62","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1056\/NEJM197404182901603","volume":"290","author":"DW Golde","year":"1974","unstructured":"Golde DW, Finley TN, Cline MJ. The pulmonary macrophage in acute leukemia. N Engl J Med. 1974;290(16):875\u20138.","journal-title":"N Engl J Med"},{"issue":"2","key":"2658_CR63","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41590-019-0568-x","volume":"21","author":"H Aegerter","year":"2020","unstructured":"Aegerter H, Kulikauskaite J, Crotta S, Patel H, Kelly G, Hessel EM, et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol. 2020;21(2):145\u201357.","journal-title":"Nat Immunol"},{"issue":"5","key":"2658_CR64","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1164\/rccm.201011-1891OC","volume":"184","author":"WJ Janssen","year":"2011","unstructured":"Janssen WJ, Barthel L, Muldrow A, Oberley-Deegan RE, Kearns MT, Jakubzick C, et al. Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med. 2011;184(5):547\u201360.","journal-title":"Am J Respir Crit Care Med"},{"issue":"73","key":"2658_CR65","doi-asserted-by":"publisher","first-page":"eabj5761","DOI":"10.1126\/sciimmunol.abj5761","volume":"7","author":"F Li","year":"2022","unstructured":"Li F, Piattini F, Pohlmeier L, Feng Q, Rehrauer H, Kopf M. Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection. Sci Immunol. 2022;7(73):eabj5761.","journal-title":"Sci Immunol"},{"issue":"5","key":"2658_CR66","doi-asserted-by":"publisher","first-page":"115571","DOI":"10.1016\/j.celrep.2025.115571","volume":"44","author":"J Zhang","year":"2025","unstructured":"Zhang J, Wang T, Wang Y, Li Y, Wang L, Wang J, et al. Bacterial pneumonia induces senescence in resident alveolar macrophages that are outcompeted by monocytes. Cell Rep. 2025;44(5):115571.","journal-title":"Cell Rep"},{"key":"2658_CR67","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cellimm.2018.01.005","volume":"330","author":"N Joshi","year":"2018","unstructured":"Joshi N, Walter JM, Misharin AV. Alveolar Macrophages. Cell Immunol. 2018;330:86\u201390.","journal-title":"Cell Immunol"},{"key":"2658_CR68","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126556","author":"KJ Mould","year":"2019","unstructured":"Mould KJ, Jackson ND, Henson PM, Seibold M, Janssen WJ. Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets. JCI Insight. 2019;4(5):e126556. https:\/\/doi.org\/10.1172\/jci.insight.126556.","journal-title":"JCI Insight"},{"key":"2658_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102720","author":"FP Martin","year":"2021","unstructured":"Martin FP, Jacqueline C, Poschmann J, Roquilly A. Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation. Cells. 2021;10(10):2720. https:\/\/doi.org\/10.3390\/cells10102720.","journal-title":"Cells"},{"issue":"5","key":"2658_CR70","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.immuni.2017.10.006","volume":"47","author":"AW Roberts","year":"2017","unstructured":"Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM. Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells. Immunity. 2017;47(5):913-27 e6.","journal-title":"Immunity."},{"issue":"3","key":"2658_CR71","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1165\/rcmb.2017-0061OC","volume":"57","author":"KJ Mould","year":"2017","unstructured":"Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, et al. Cell origin dictates programming of resident versus recruited macrophages during acute lung injury. Am J Respir Cell Mol Biol. 2017;57(3):294\u2013306.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"2658_CR72","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1164\/rccm.201009-1431OC","volume":"183","author":"S Herold","year":"2011","unstructured":"Herold S, Tabar TS, Janssen H, Hoegner K, Cabanski M, Lewe-Schlosser P, et al. Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia. Am J Respir Crit Care Med. 2011;183(10):1380\u201390.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2658_CR73","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.jaci.2020.10.005","volume":"147","author":"H Miki","year":"2021","unstructured":"Miki H, Pei H, Gracias DT, Linden J, Croft M. Clearance of apoptotic cells by lung alveolar macrophages prevents development of house dust mite-induced asthmatic lung inflammation. J Allergy Clin Immunol. 2021;147(3):1087-92 e3.","journal-title":"J Allergy Clin Immunol."},{"issue":"23","key":"2658_CR74","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"DC Fajgenbaum","year":"2020","unstructured":"Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020;383(23):2255\u201373.","journal-title":"N Engl J Med"},{"key":"2658_CR75","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3389\/fphar.2020.01169","volume":"11","author":"JP Hussman","year":"2020","unstructured":"Hussman JP. Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention. Front Pharmacol. 2020;11:1169.","journal-title":"Front Pharmacol"},{"issue":"10","key":"2658_CR76","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1164\/rccm.201911-2105OC","volume":"201","author":"PS Hume","year":"2020","unstructured":"Hume PS, Gibbings SL, Jakubzick CV, Tuder RM, Curran-Everett D, Henson PM, et al. Localization of macrophages in the human lung via design-based stereology. Am J Respir Crit Care Med. 2020;201(10):1209\u201317.","journal-title":"Am J Respir Crit Care Med"},{"key":"2658_CR77","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax8756","author":"BB Ural","year":"2020","unstructured":"Ural BB, Yeung ST, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, et al. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties. Sci Immunol.2020;5(45):eaax8756. https:\/\/doi.org\/10.1126\/sciimmunol.aax8756.","journal-title":"Sci Immunol"},{"issue":"5","key":"2658_CR78","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.immuni.2025.04.001","volume":"58","author":"ST Yeung","year":"2025","unstructured":"Yeung ST, Damani-Yokota P, Thannickal SA, Bartnicki E, Bernier ED, Barnett CR, et al. Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling. Immunity. 2025;58(5):1327-42.e5.","journal-title":"Immunity"},{"issue":"6","key":"2658_CR79","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/s41590-024-01826-9","volume":"25","author":"X Li","year":"2024","unstructured":"Li X, Mara AB, Musial SC, Kolling FW, Gibbings SL, Gerebtsov N, et al. Coordinated chemokine expression defines macrophage subsets across tissues. Nat Immunol. 2024;25(6):1110\u201322.","journal-title":"Nat Immunol"},{"issue":"1","key":"2658_CR80","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1038\/s41467-022-31596-7","volume":"13","author":"Y Fu","year":"2022","unstructured":"Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, et al. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nat Commun. 2022;13(1):3811.","journal-title":"Nat Commun"},{"issue":"2","key":"2658_CR81","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41385-021-00480-w","volume":"15","author":"CC Bain","year":"2022","unstructured":"Bain CC, MacDonald AS. The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity. Mucosal Immunol. 2022;15(2):223\u201334.","journal-title":"Mucosal Immunol"},{"key":"2658_CR82","doi-asserted-by":"publisher","first-page":"753940","DOI":"10.3389\/fimmu.2021.753940","volume":"12","author":"F Hou","year":"2021","unstructured":"Hou F, Xiao K, Tang L, Xie L. Diversity of macrophages in lung homeostasis and diseases. Front Immunol. 2021;12:753940.","journal-title":"Front Immunol."},{"issue":"6","key":"2658_CR83","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1165\/rcmb.2012-0263OC","volume":"48","author":"MM Coleman","year":"2013","unstructured":"Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH. Alveolar macrophages contribute to respiratory tolerance by inducing FoxP3 expression in naive T cells. Am J Respir Cell Mol Biol. 2013;48(6):773\u201380.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"2658_CR84","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1067\/mai.2001.112845","volume":"107","author":"RL Blumenthal","year":"2001","unstructured":"Blumenthal RL, Campbell DE, Hwang P, DeKruyff RH, Frankel LR, Umetsu DT. Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells. J Allergy Clin Immunol. 2001;107(2):258\u201364.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"2658_CR85","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1164\/rccm.200711-1661OC","volume":"178","author":"WJ Janssen","year":"2008","unstructured":"Janssen WJ, McPhillips KA, Dickinson MG, Linderman DJ, Morimoto K, Xiao YQ, et al. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am J Respir Crit Care Med. 2008;178(2):158\u201367.","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"2658_CR86","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1164\/rccm.201512-2424OC","volume":"194","author":"E Bernasconi","year":"2016","unstructured":"Bernasconi E, Pattaroni C, Koutsokera A, Pison C, Kessler R, Benden C, et al. Airway microbiota determines innate cell inflammatory or tissue remodeling profiles in lung transplantation. Am J Respir Crit Care Med. 2016;194(10):1252\u201363.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2658_CR87","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/s41467-017-01803-x","volume":"8","author":"RL Brown","year":"2017","unstructured":"Brown RL, Sequeira RP, Clarke TB. The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017;8(1):1512.","journal-title":"Nat Commun"},{"key":"2658_CR88","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev-immunol-101320-031555","volume":"40","author":"KM Sheu","year":"2022","unstructured":"Sheu KM, Hoffmann A. Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance. Annu Rev Immunol. 2022;40:295\u2013321.","journal-title":"Annu Rev Immunol."},{"issue":"9","key":"2658_CR89","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.immuni.2022.08.010","volume":"55","author":"H Aegerter","year":"2022","unstructured":"Aegerter H, Lambrecht BN, Jakubzick CV. Biology of lung macrophages in health and disease. Immunity. 2022;55(9):1564\u201380.","journal-title":"Immunity"},{"issue":"11","key":"2658_CR90","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ni.2419","volume":"13","author":"EL Gautier","year":"2012","unstructured":"Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol. 2012;13(11):1118\u201328.","journal-title":"Nat Immunol"},{"key":"2658_CR91","doi-asserted-by":"publisher","first-page":"1149015","DOI":"10.3389\/fimmu.2023.1149015","volume":"14","author":"L Rodriguez-Rodriguez","year":"2023","unstructured":"Rodriguez-Rodriguez L, Gillet L, Machiels B. Shaping of the alveolar landscape by respiratory infections and long-term consequences for lung immunity. Front Immunol. 2023;14:1149015.","journal-title":"Front Immunol"},{"issue":"4","key":"2658_CR92","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1165\/rcmb.2013-0086MA","volume":"49","author":"AV Misharin","year":"2013","unstructured":"Misharin AV, Morales-Nebreda L, Mutlu GM, Budinger GR, Perlman H. Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol. 2013;49(4):503\u201310.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"2658_CR93","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1165\/rcmb.2015-0147LE","volume":"54","author":"A Bharat","year":"2016","unstructured":"Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, et al. Flow cytometry reveals similarities between lung macrophages in humans and mice. Am J Respir Cell Mol Biol. 2016;54(1):147\u20139.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2658_CR94","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.trsl.2024.05.012","volume":"272","author":"J Wang","year":"2024","unstructured":"Wang J, Peng X, Yuan N, Wang B, Chen S, Wang B, et al. Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI\/ARDS. Transl Res. 2024;272:111\u201325.","journal-title":"Transl Res"},{"key":"2658_CR95","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210745","author":"J Gschwend","year":"2021","unstructured":"Gschwend J, Sherman SPM, Ridder F, Feng X, Liang HE, Locksley RM, et al. Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and afterbirth. J Exp Med. 2021;218(10):e20210745. https:\/\/doi.org\/10.1084\/jem.20210745.","journal-title":"J Exp Med"},{"issue":"9","key":"2658_CR96","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/ni.1637","volume":"9","author":"RJ Snelgrove","year":"2008","unstructured":"Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, Edwards L, et al. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol. 2008;9(9):1074\u201383.","journal-title":"Nat Immunol"},{"issue":"3","key":"2658_CR97","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.immuni.2023.01.011","volume":"56","author":"SK Wculek","year":"2023","unstructured":"Wculek SK, Heras-Murillo I, Mastrangelo A, Ma\u00f1anes D, Gal\u00e1n M, Miguel V, et al. Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis. Immunity. 2023;56(3):516-30 e9.","journal-title":"Immunity."},{"issue":"2","key":"2658_CR98","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/imm.13154","volume":"160","author":"E Evren","year":"2020","unstructured":"Evren E, Ringqvist E, Willinger T. Origin and ontogeny of lung macrophages: from mice to humans. Immunology. 2020;160(2):126\u201338.","journal-title":"Immunology"},{"issue":"2","key":"2658_CR99","doi-asserted-by":"publisher","first-page":"e57082","DOI":"10.1371\/journal.pone.0057082","volume":"8","author":"L Fossati-Jimack","year":"2013","unstructured":"Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, et al. Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PLoS ONE. 2013;8(2):e57082.","journal-title":"PLoS ONE"},{"issue":"11","key":"2658_CR100","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1038\/ni.3005","volume":"15","author":"C Schneider","year":"2014","unstructured":"Schneider C, Nobs SP, Kurrer M, Rehrauer H, Thiele C, Kopf M. Induction of the nuclear receptor PPAR-\u03b3 by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat Immunol. 2014;15(11):1026\u201337.","journal-title":"Nat Immunol"},{"issue":"5","key":"2658_CR101","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.immuni.2017.10.007","volume":"47","author":"X Yu","year":"2017","unstructured":"Yu X, Buttgereit A, Lelios I, Utz SG, Cansever D, Becher B, et al. The Cytokine TGF-\u03b2 Promotes the development and homeostasis of alveolar macrophages. Immunity. 2017;47(5):903-12 e4.","journal-title":"Immunity."},{"issue":"6","key":"2658_CR102","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1194\/jlr.M001651","volume":"51","author":"AD Baker","year":"2010","unstructured":"Baker AD, Malur A, Barna BP, Ghosh S, Kavuru MS, Malur AG, et al. Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism. J Lipid Res. 2010;51(6):1325\u201331.","journal-title":"J Lipid Res"},{"key":"2658_CR103","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0263-2023","author":"L Pervizaj-Oruqaj","year":"2024","unstructured":"Pervizaj-Oruqaj L, Ferrero MR, Matt U, Herold S. The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis. Eur Respir Rev. 2024;33(172):230263. https:\/\/doi.org\/10.1183\/16000617.0263-2023.","journal-title":"Eur Respir Rev"},{"issue":"2","key":"2658_CR104","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1165\/rcmb.2019-0244OC","volume":"62","author":"PS Woods","year":"2020","unstructured":"Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O\u2019Leary EM, et al. Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. Am J Respir Cell Mol Biol. 2020;62(2):243\u201355.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"2658_CR105","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/JLB.MR0318-104R","volume":"105","author":"J Dominguez-Andres","year":"2019","unstructured":"Dominguez-Andres J, Netea MG. Long-term reprogramming of the innate immune system. J Leukoc Biol. 2019;105(2):329\u201338.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2658_CR106","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41577-020-0337-y","volume":"20","author":"LAJ O'Neill","year":"2020","unstructured":"O\u2019Neill LAJ, Netea MG. BCG-induced trained immunity: can it offer protection against COVID-19? Nat Rev Immunol. 2020;20(6):335\u20137.","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"2658_CR107","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.cell.2020.04.042","volume":"181","author":"MG Netea","year":"2020","unstructured":"Netea MG, Giamarellos-Bourboulis EJ, Dom\u00ednguez-Andr\u00e9s J, Curtis N, van Crevel R, van de Veerdonk FL, et al. Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection. Cell. 2020;181(5):969\u201377.","journal-title":"Cell"},{"issue":"2","key":"2658_CR108","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1128\/iai.51.2.668-674.1986","volume":"51","author":"F Bistoni","year":"1986","unstructured":"Bistoni F, Vecchiarelli A, Cenci E, Puccetti P, Marconi P, Cassone A. Evidence for macrophage-mediated protection against lethal Candida albicans infection. Infect Immun. 1986;51(2):668\u201374.","journal-title":"Infect Immun"},{"issue":"1","key":"2658_CR109","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41581-022-00633-5","volume":"19","author":"J Ochando","year":"2023","unstructured":"Ochando J, Mulder WJM, Madsen JC, Netea MG, Duivenvoorden R. Trained immunity - basic concepts and contributions to immunopathology. Nat Rev Nephrol. 2023;19(1):23\u201337.","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"2658_CR110","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.chom.2012.06.006","volume":"12","author":"J Quintin","year":"2012","unstructured":"Quintin J, Saeed S, Martens JHA, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe. 2012;12(2):223\u201332.","journal-title":"Cell Host Microbe"},{"issue":"1","key":"2658_CR111","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","volume":"23","author":"RJW Arts","year":"2018","unstructured":"Arts RJW, Moorlag S, Novakovic B, Li Y, Wang SY, Oosting M, et al. Bcg vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity. Cell Host Microbe. 2018;23(1):89-100 e5.","journal-title":"Cell Host Microbe"},{"issue":"1","key":"2658_CR112","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41590-020-00845-6","volume":"22","author":"M Divangahi","year":"2021","unstructured":"Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, et al. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021;22(1):2\u20136.","journal-title":"Nat Immunol"},{"key":"2658_CR113","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax4517","author":"B Brook","year":"2020","unstructured":"Brook B, Harbeson DJ, Shannon CP, Cai B, He D, Ben-Othman R, et al. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. Sci Transl Med. 2020;12(542):eaax4517. https:\/\/doi.org\/10.1126\/scitranslmed.aax4517.","journal-title":"Sci Transl Med"},{"key":"2658_CR114","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","volume":"15","author":"M Locati","year":"2020","unstructured":"Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123\u201347.","journal-title":"Annu Rev Pathol"},{"issue":"8","key":"2658_CR115","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1161\/CIRCULATIONAHA.116.020838","volume":"134","author":"FM van der Valk","year":"2016","unstructured":"van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, et al. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016;134(8):611\u201324.","journal-title":"Circulation"},{"issue":"8","key":"2658_CR116","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","volume":"34","author":"S Bekkering","year":"2014","unstructured":"Bekkering S, Quintin J, Joosten LA, van der Meer JW, Netea MG, Riksen NP. Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes. Arterioscler Thromb Vasc Biol. 2014;34(8):1731\u20138.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2658_CR117","doi-asserted-by":"publisher","first-page":"320168","DOI":"10.1155\/2013\/320168","volume":"2013","author":"H Rogers","year":"2013","unstructured":"Rogers H, Williams DW, Feng GJ, Lewis MA, Wei XQ. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clin Dev Immunol. 2013;2013:320168.","journal-title":"Clin Dev Immunol"},{"key":"2658_CR118","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.3389\/fimmu.2018.02818","volume":"9","author":"J Leonhardt","year":"2018","unstructured":"Leonhardt J, Gro\u00dfe S, Marx C, Siwczak F, Stengel S, Bruns T, et al. Candida albicans \u03b2-Glucan differentiates human monocytes into a specific subset of macrophages. Front Immunol. 2018;9:2818.","journal-title":"Front Immunol"},{"issue":"7","key":"2658_CR119","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/s41590-019-0399-9","volume":"20","author":"G Natoli","year":"2019","unstructured":"Natoli G, Ostuni R. Adaptation and memory in immune responses. Nat Immunol. 2019;20(7):783\u201392.","journal-title":"Nat Immunol"},{"issue":"1","key":"2658_CR120","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1189\/jlb.3MR0316-118RR","volume":"101","author":"JJ Seeley","year":"2017","unstructured":"Seeley JJ, Ghosh S. Molecular mechanisms of innate memory and tolerance to LPS. J Leukoc Biol. 2017;101(1):107\u201319.","journal-title":"J Leukoc Biol"},{"issue":"10","key":"2658_CR121","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","volume":"30","author":"SK Biswas","year":"2009","unstructured":"Biswas SK, Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 2009;30(10):475\u201387.","journal-title":"Trends Immunol"},{"issue":"6204","key":"2658_CR122","doi-asserted-by":"publisher","first-page":"1251086","DOI":"10.1126\/science.1251086","volume":"345","author":"S Saeed","year":"2014","unstructured":"Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 2014;345(6204):1251086.","journal-title":"Science"},{"issue":"5","key":"2658_CR123","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.cell.2016.09.034","volume":"167","author":"B Novakovic","year":"2016","unstructured":"Novakovic B, Habibi E, Wang SY, Arts RJW, Davar R, Megchelenbrink W, et al. \u03b2-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance. Cell. 2016;167(5):1354-68.e14.","journal-title":"Cell"},{"issue":"4","key":"2658_CR124","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1128\/CVI.00688-13","volume":"21","author":"DC Ifrim","year":"2014","unstructured":"Ifrim DC, Quintin J, Joosten LA, Jacobs C, Jansen T, Jacobs L, et al. Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors. Clin Vaccine Immunol. 2014;21(4):534\u201345.","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"2658_CR125","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/imm.13697","volume":"171","author":"XH Fang","year":"2024","unstructured":"Fang XH, Li ZJ, Liu CY, Mor G, Liao AH. Macrophage memory: types, mechanisms, and its role in health and disease. Immunology. 2024;171(1):18\u201330.","journal-title":"Immunology"},{"issue":"1","key":"2658_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1189\/jlb.0306164","volume":"81","author":"ME Bianchi","year":"2007","unstructured":"Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol. 2007;81(1):1\u20135.","journal-title":"J Leukoc Biol"},{"issue":"5","key":"2658_CR127","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol. 2010;11(5):373\u201384.","journal-title":"Nat Immunol"},{"key":"2658_CR128","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1034\/j.1600-065X.2000.917309.x","volume":"173","author":"R Medzhitov","year":"2000","unstructured":"Medzhitov R, Janeway C Jr. Innate immune recognition: mechanisms and pathways. Immunol Rev. 2000;173:89\u201397.","journal-title":"Immunol Rev"},{"issue":"9","key":"2658_CR129","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1182\/blood-2006-05-024406","volume":"108","author":"M Yadav","year":"2006","unstructured":"Yadav M, Schorey JS. The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood. 2006;108(9):3168\u201375.","journal-title":"Blood"},{"key":"2658_CR130","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89157","author":"MT Shaku","year":"2024","unstructured":"Shaku MT, Um PK, Ocius KL, Apostolos AJ, Pires MM, Bishai WR, et al. Amodified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice. Elife. 2024;13:e89157. https:\/\/doi.org\/10.7554\/eLife.89157.","journal-title":"Elife"},{"issue":"43","key":"2658_CR131","doi-asserted-by":"publisher","first-page":"17537","DOI":"10.1073\/pnas.1202870109","volume":"109","author":"J Kleinnijenhuis","year":"2012","unstructured":"Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Ifrim DC, Saeed S, et al. Bacille Calmette-guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci U S A. 2012;109(43):17537\u201342.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"2658_CR132","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cell.2012.12.018","volume":"152","author":"R Ostuni","year":"2013","unstructured":"Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, et al. Latent enhancers activated by stimulation in differentiated cells. Cell. 2013;152(1\u20132):157\u201371.","journal-title":"Cell"},{"key":"2658_CR133","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-981-15-3449-2_1","volume":"1253","author":"L Zhang","year":"2020","unstructured":"Zhang L, Lu Q, Chang C. Epigenetics in Health and Disease. Adv Exp Med Biol. 2020;1253:3\u201355.","journal-title":"Adv Exp Med Biol."},{"issue":"7","key":"2658_CR134","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41577-019-0151-6","volume":"19","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Cao X. Epigenetic regulation of the innate immune response to infection. Nat Rev Immunol. 2019;19(7):417\u201332.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"2658_CR135","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.smim.2016.06.003","volume":"28","author":"C Logie","year":"2016","unstructured":"Logie C, Stunnenberg HG. Epigenetic memory: a macrophage perspective. Semin Immunol. 2016;28(4):359\u201367.","journal-title":"Semin Immunol"},{"key":"2658_CR136","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3389\/fcell.2020.00701","volume":"8","author":"WA Scott","year":"2020","unstructured":"Scott WA, Campos EI. Interactions With Histone H3 & Tools to Study Them. Front Cell Dev Biol. 2020;8:701.","journal-title":"Front Cell Dev Biol."},{"issue":"1","key":"2658_CR137","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41423-019-0315-0","volume":"17","author":"S Chen","year":"2020","unstructured":"Chen S, Yang J, Wei Y, Wei X. Epigenetic regulation of macrophages: from homeostasis maintenance to host defense. Cell Mol Immunol. 2020;17(1):36\u201349.","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"2658_CR138","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41576-019-0173-8","volume":"21","author":"R Andersson","year":"2020","unstructured":"Andersson R, Sandelin A. Determinants of enhancer and promoter activities of regulatory elements. Nat Rev Genet. 2020;21(2):71\u201387.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"2658_CR139","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.immuni.2020.10.011","volume":"54","author":"S Fanucchi","year":"2021","unstructured":"Fanucchi S, Dom\u00ednguez-Andr\u00e9s J, Joosten LAB, Netea MG, Mhlanga MM. The intersection of epigenetics and metabolism in trained immunity. Immunity. 2021;54(1):32\u201343.","journal-title":"Immunity"},{"issue":"1","key":"2658_CR140","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1038\/s41467-019-13636-x","volume":"10","author":"M Jeljeli","year":"2019","unstructured":"Jeljeli M, Riccio LGC, Doridot L, Ch\u00eane C, Nicco C, Chouzenoux S, et al. Trained immunity modulates inflammation-induced fibrosis. Nat Commun. 2019;10(1):5670.","journal-title":"Nat Commun"},{"issue":"11","key":"2658_CR141","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1016\/j.cell.2025.03.048","volume":"188","author":"A Ziogas","year":"2025","unstructured":"Ziogas A, Novakovic B, Ventriglia L, Galang N, Tran KA, Li W, et al. Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory. Cell. 2025;188(11):2992-3012.e16.","journal-title":"Cell"},{"issue":"6","key":"2658_CR142","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1080\/15592294.2019.1603963","volume":"14","author":"J Das","year":"2019","unstructured":"Das J, Verma D, Gustafsson M, Lerm M. Identification of DNA methylation patterns predisposing for an efficient response to BCG vaccination in healthy BCG-na\u00efve subjects. Epigenetics. 2019;14(6):589\u2013601.","journal-title":"Epigenetics"},{"issue":"1","key":"2658_CR143","doi-asserted-by":"publisher","first-page":"19418","DOI":"10.1038\/s41598-021-98542-3","volume":"11","author":"L Karlsson","year":"2021","unstructured":"Karlsson L, Das J, Nilsson M, Tyr\u00e9n A, Pehrson I, Idh N, et al. A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection. Sci Rep. 2021;11(1):19418.","journal-title":"Sci Rep"},{"issue":"5","key":"2658_CR144","doi-asserted-by":"publisher","first-page":"e0052221","DOI":"10.1128\/iai.00522-21","volume":"90","author":"K Madden","year":"2022","unstructured":"Madden K, Liang YC, Rajabalee N, Alvarez GG, Sun J. Surveying the epigenetic landscape of tuberculosis in alveolar macrophages. Infect Immun. 2022;90(5):e0052221.","journal-title":"Infect Immun"},{"key":"2658_CR145","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093180","author":"YC Chen","year":"2020","unstructured":"Chen YC, Hsiao CC, Chen TW, Wu CC, Chao TY, Leung SY, et al. Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: PARP9\/miR-505\/RASGRP4\/GNG12 Gene Methylation and Clinical Phenotypes. Int J Mol Sci. 2020;21(9):3180. https:\/\/doi.org\/10.3390\/ijms21093180.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2658_CR146","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/ni.2636","volume":"14","author":"S Monticelli","year":"2013","unstructured":"Monticelli S, Natoli G. Short-term memory of danger signals and environmental stimuli in immune cells. Nat Immunol. 2013;14(8):777\u201384.","journal-title":"Nat Immunol"},{"issue":"7712","key":"2658_CR147","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41586-018-0253-5","volume":"559","author":"JJ Seeley","year":"2018","unstructured":"Seeley JJ, Baker RG, Mohamed G, Bruns T, Hayden MS, Deshmukh SD, et al. Induction of innate immune memory via microrna targeting of chromatin remodelling factors. Nature. 2018;559(7712):114\u20139.","journal-title":"Nature"},{"issue":"5","key":"2658_CR148","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.celrep.2018.09.092","volume":"25","author":"P Saz-Leal","year":"2018","unstructured":"Saz-Leal P, Del Fresno C, Brandi P, Mart\u00ednez-Cano S, Dungan OM, Chisholm JD, et al. Targeting SHIP-1 in myeloid cells enhances trained immunity and boosts response to infection. Cell Rep. 2018;25(5):1118\u201326.","journal-title":"Cell Rep"},{"issue":"1","key":"2658_CR149","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41588-018-0298-2","volume":"51","author":"S Fanucchi","year":"2019","unstructured":"Fanucchi S, Fok ET, Dalla E, Shibayama Y, B\u00f6rner K, Chang EY, et al. Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments. Nat Genet. 2019;51(1):138\u201350.","journal-title":"Nat Genet"},{"issue":"1","key":"2658_CR150","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41588-023-01598-2","volume":"56","author":"ET Fok","year":"2024","unstructured":"Fok ET, Moorlag S, Negishi Y, Groh LA, Dos Santos JC, Gr\u00e4we C, et al. A chromatin-regulated biphasic circuit coordinates IL-1\u03b2-mediated inflammation. Nat Genet. 2024;56(1):85\u201399.","journal-title":"Nat Genet"},{"issue":"1","key":"2658_CR151","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nri978","volume":"3","author":"S Gordon","year":"2003","unstructured":"Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3(1):23\u201335.","journal-title":"Nat Rev Immunol"},{"key":"2658_CR152","doi-asserted-by":"publisher","first-page":"109216","DOI":"10.1016\/j.clim.2022.109216","volume":"246","author":"S Gupta","year":"2023","unstructured":"Gupta S, Sarangi PP. Inflammation driven metabolic regulation and adaptation in macrophages. Clin Immunol. 2023;246:109216.","journal-title":"Clin Immunol"},{"issue":"6204","key":"2658_CR153","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","volume":"345","author":"SC Cheng","year":"2014","unstructured":"Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, et al. mTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345(6204):1250684.","journal-title":"Science"},{"issue":"4","key":"2658_CR154","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","volume":"21","author":"GY Liu","year":"2020","unstructured":"Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol. 2020;21(4):183\u2013203.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"31","key":"2658_CR155","doi-asserted-by":"publisher","first-page":"25758","DOI":"10.1074\/jbc.M112.362343","volume":"287","author":"TF Liu","year":"2012","unstructured":"Liu TF, Vachharajani VT, Yoza BK, McCall CE. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem. 2012;287(31):25758\u201369.","journal-title":"J Biol Chem"},{"issue":"1","key":"2658_CR156","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1042\/EBC20180067","volume":"63","author":"TO Tolsma","year":"2019","unstructured":"Tolsma TO, Hansen JC. Post-translational modifications and chromatin dynamics. Essays Biochem. 2019;63(1):89\u201396.","journal-title":"Essays Biochem"},{"key":"2658_CR157","doi-asserted-by":"publisher","first-page":"117295","DOI":"10.1016\/j.biopha.2024.117295","volume":"179","author":"SY Zhang","year":"2024","unstructured":"Zhang SY, Zhang LY, Wen R, Yang N, Zhang TN. Histone deacetylases and their inhibitors in inflammatory diseases. Biomed Pharmacother. 2024;179:117295.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2658_CR158","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","volume":"24","author":"RJ Arts","year":"2016","unstructured":"Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, et al. Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity. Cell Metab. 2016;24(6):807\u201319.","journal-title":"Cell Metab"},{"issue":"7539","key":"2658_CR159","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nature13981","volume":"518","author":"BW Carey","year":"2015","unstructured":"Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB. Intracellular \u03b1-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518(7539):413\u20136.","journal-title":"Nature"},{"issue":"9","key":"2658_CR160","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ni.3796","volume":"18","author":"PS Liu","year":"2017","unstructured":"Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, et al. \u0391-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18(9):985\u201394.","journal-title":"Nat Immunol"},{"issue":"1\u20132","key":"2658_CR161","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","volume":"172","author":"I Mitroulis","year":"2018","unstructured":"Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, et al. Modulation of myelopoiesis progenitors is an integral component of trained immunity. Cell. 2018;172(1\u20132):147-61 e12.","journal-title":"Cell."},{"issue":"1","key":"2658_CR162","doi-asserted-by":"publisher","first-page":"e121","DOI":"10.1002\/mco2.121","volume":"3","author":"Z Hu","year":"2022","unstructured":"Hu Z, Lu SH, Lowrie DB, Fan XY. Trained immunity: a Yin-Yang balance. MedComm. 2022;3(1):e121.","journal-title":"MedComm"},{"issue":"1","key":"2658_CR163","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03944-8","volume":"21","author":"J Chen","year":"2023","unstructured":"Chen J, Gao L, Wu X, Fan Y, Liu M, Peng L, et al. BCG-induced trained immunity: history, mechanisms and potential applications. J Transl Med. 2023;21(1):106.","journal-title":"J Transl Med"},{"key":"2658_CR164","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.2147\/JIR.S363995","volume":"15","author":"H Zhou","year":"2022","unstructured":"Zhou H, Lu X, Huang J, Jordan P, Ma S, Xu L, et al. Induction of trained immunity protects neonatal mice against microbial sepsis by boosting both the inflammatory response and antimicrobial activity. J Inflamm Res. 2022;15:3829\u201345.","journal-title":"J Inflamm Res."},{"issue":"5","key":"2658_CR165","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.cell.2016.09.034","volume":"167","author":"B Novakovic","year":"2016","unstructured":"Novakovic B, Habibi E, Wang SY, Arts RJW, Davar R, Megchelenbrink W, et al. \u03b2-Glucan reverses the epigenetic state of LPS-induced immunological tolerance. Cell. 2016;167(5):1354-68 e14.","journal-title":"Cell."},{"key":"2658_CR166","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006221","author":"MR Woeste","year":"2023","unstructured":"Woeste MR, Shrestha R, Geller AE, Li S, Montoya-Durango D, Ding C, et al. Irreversible electroporation augments \u03b2-glucan induced trained innate immunity for the treatment of pancreatic ductal adenocarcinoma. J Immunother Cancer. 2023;11(4):e006221. https:\/\/doi.org\/10.1136\/jitc-2022-006221.","journal-title":"J Immunother Cancer"},{"issue":"3","key":"2658_CR167","doi-asserted-by":"publisher","first-page":"e210025","DOI":"10.20900\/immunometab20210025","volume":"3","author":"LA Groh","year":"2021","unstructured":"Groh LA, Ferreira AV, Helder L, van der Heijden C, Novakovic B, van de Westerlo E, et al. oxLDL-Induced Trained Immunity Is Dependent on Mitochondrial Metabolic Reprogramming. Immunometabolism. 2021;3(3):e210025.","journal-title":"Immunometabolism"},{"key":"2658_CR168","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116166","author":"HM Findeisen","year":"2022","unstructured":"Findeisen HM, Voges VC, Braun LC, Sonnenberg J, Schwarz D, K\u00f6rner H, et al. LXR\u03b1 regulates oxLDL-induced trained immunity in macrophages. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23116166.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2658_CR169","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/eurheartj\/ehad787","volume":"45","author":"Z Dong","year":"2024","unstructured":"Dong Z, Hou L, Luo W, Pan LH, Li X, Tan HP, et al. Myocardial infarction drives trained immunity of monocytes, accelerating atherosclerosis. Eur Heart J. 2024;45(9):669\u201384.","journal-title":"Eur Heart J"},{"issue":"2","key":"2658_CR170","first-page":"317","volume":"116","author":"C van der Heijden","year":"2020","unstructured":"van der Heijden C, Keating ST, Groh L, Joosten LAB, Netea MG, Riksen NP. Aldosterone induces trained immunity: the role of fatty acid synthesis. Cardiovasc Res. 2020;116(2):317\u201328.","journal-title":"Cardiovasc Res"},{"key":"2658_CR171","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76744","author":"AL Seufert","year":"2022","unstructured":"Seufert AL, Hickman JW, Traxler SK, Peterson RM, Waugh TA, Lashley SJ, et al. Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection. Elife. 2022;11:e76744. https:\/\/doi.org\/10.7554\/eLife.76744.","journal-title":"Elife"},{"issue":"12","key":"2658_CR172","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.120.046464","volume":"144","author":"L Edgar","year":"2021","unstructured":"Edgar L, Akbar N, Braithwaite AT, Krausgruber T, Gallart-Ayala H, Bailey J, et al. Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis. Circulation. 2021;144(12):961\u201382.","journal-title":"Circulation"},{"issue":"6","key":"2658_CR173","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/s41590-020-0673-x","volume":"21","author":"A Roquilly","year":"2020","unstructured":"Roquilly A, Jacqueline C, Davieau M, Moll\u00e9 A, Sadek A, Fourgeux C, et al. Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis. Nat Immunol. 2020;21(6):636\u201348.","journal-title":"Nat Immunol"},{"issue":"1\u20132","key":"2658_CR174","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","volume":"172","author":"A Christ","year":"2018","unstructured":"Christ A, G\u00fcnther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, et al. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018;172(1\u20132):162-75 e14.","journal-title":"Cell."},{"key":"2658_CR175","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.3389\/fimmu.2018.03155","volume":"9","author":"Y Sohrabi","year":"2018","unstructured":"Sohrabi Y, Lagache SMM, Schnack L, Godfrey R, Kahles F, Bruemmer D, et al. mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes. Front Immunol. 2018;9:3155.","journal-title":"Front Immunol."},{"issue":"813","key":"2658_CR176","doi-asserted-by":"publisher","first-page":"eadp5653","DOI":"10.1126\/scitranslmed.adp5653","volume":"17","author":"SJ McCright","year":"2025","unstructured":"McCright SJ, Harding O, Chini J, DeMarco N, Hung LY, Pastore CF, et al. Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1\u03b2-mediated inflammation in mice and humans. Sci Transl Med. 2025;17(813):eadp5653.","journal-title":"Sci Transl Med"},{"issue":"10","key":"2658_CR177","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1172\/JCI133935","volume":"130","author":"VA Koeken","year":"2020","unstructured":"Koeken VA, de Bree LCJ, Mourits VP, Moorlag SJ, Walk J, Cirovic B, et al. BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner. J Clin Invest. 2020;130(10):5591\u2013602.","journal-title":"J Clin Invest"},{"issue":"10","key":"2658_CR178","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.1172\/JCI133934","volume":"130","author":"LCJ de Bree","year":"2020","unstructured":"de Bree LCJ, Mourits VP, Koeken VA, Moorlag SJ, Janssen R, Folkman L, et al. Circadian rhythm influences induction of trained immunity by BCG vaccination. J Clin Invest. 2020;130(10):5603\u201317.","journal-title":"J Clin Invest"},{"key":"2658_CR179","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.641224","volume":"12","author":"J Kiefer","year":"2021","unstructured":"Kiefer J, Zeller J, Bogner B, H\u00f6rbrand IA, Lang F, Deiss E, et al. An unbiased flow cytometry-based approach to assess subset-specific circulating monocyte activation and cytokine profile in whole blood. Front Immunol. 2021;12:641224.","journal-title":"Front Immunol"},{"key":"2658_CR180","doi-asserted-by":"crossref","unstructured":"Dos Santos JC, Barroso de Figueiredo AM, Teodoro Silva MV, Cirovic B, de Bree LCJ, Damen M, et al. \u03b2-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32. Cell Rep. 2019, 28(10):2659-72 e6.","DOI":"10.1016\/j.celrep.2019.08.004"},{"issue":"9","key":"2658_CR181","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni.3509","volume":"17","author":"J Garaude","year":"2016","unstructured":"Garaude J, Ac\u00edn-P\u00e9rez R, Mart\u00ednez-Cano S, Enamorado M, Ugolini M, Nistal-Vill\u00e1n E, et al. Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense. Nat Immunol. 2016;17(9):1037\u201345.","journal-title":"Nat Immunol"},{"key":"2658_CR182","doi-asserted-by":"publisher","first-page":"100938","DOI":"10.1016\/j.mex.2020.100938","volume":"7","author":"LB Monteiro","year":"2020","unstructured":"Monteiro LB, Davanzo GG, de Aguiar CF, Moraes-Vieira PMM. Using flow cytometry for mitochondrial assays. MethodsX. 2020;7:100938.","journal-title":"MethodsX"},{"issue":"11","key":"2658_CR183","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/ni.3268","volume":"16","author":"J Geng","year":"2015","unstructured":"Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16(11):1142\u201352.","journal-title":"Nat Immunol"},{"issue":"5","key":"2658_CR184","first-page":"361","volume":"2","author":"ME Kauffman","year":"2016","unstructured":"Kauffman ME, Kauffman MK, Traore K, Zhu H, Trush MA, Jia Z, et al. MitoSOX-based flow cytometry for detecting mitochondrial ros. React Oxyg Species (Apex). 2016;2(5):361\u201370.","journal-title":"React Oxyg Species (Apex)"},{"issue":"7952","key":"2658_CR185","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/s41586-023-05720-6","volume":"615","author":"A Hooftman","year":"2023","unstructured":"Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, et al. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature. 2023;615(7952):490\u20138.","journal-title":"Nature"},{"key":"2658_CR186","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/978-1-62703-706-8_24","volume":"1094","author":"J Rodr\u00edguez-Ubreva","year":"2014","unstructured":"Rodr\u00edguez-Ubreva J, Ballestar E. Chromatin immunoprecipitation. Methods Mol Biol. 2014;1094:309\u201318.","journal-title":"Methods Mol Biol."},{"issue":"5","key":"2658_CR187","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/nprot.2018.015","volume":"13","author":"PJ Skene","year":"2018","unstructured":"Skene PJ, Henikoff JG, Henikoff S. Targeted in situ genome-wide profiling with high efficiency for low cell numbers. Nat Protoc. 2018;13(5):1006\u201319.","journal-title":"Nat Protoc"},{"issue":"1","key":"2658_CR188","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09982-5","volume":"10","author":"HS Kaya-Okur","year":"2019","unstructured":"Kaya-Okur HS, Wu SJ, Codomo CA, Pledger ES, Bryson TD, Henikoff JG, et al. CUT&tag for efficient epigenomic profiling of small samples and single cells. Nat Commun. 2019;10(1):1930.","journal-title":"Nat Commun"},{"issue":"12","key":"2658_CR189","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/nmeth.2688","volume":"10","author":"JD Buenrostro","year":"2013","unstructured":"Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat Methods. 2013;10(12):1213\u20138.","journal-title":"Nat Methods"},{"key":"2658_CR190","doi-asserted-by":"publisher","DOI":"10.1172\/JCI147719","author":"B Zhang","year":"2022","unstructured":"Zhang B, Moorlag SJ, Dominguez-Andres J, Bulut \u00d6\u00d6, Kilic G, Liu Z, et al. Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes. J Clin Invest. 2022;132(7):e147719. https:\/\/doi.org\/10.1172\/JCI147719.","journal-title":"J Clin Invest"},{"issue":"1","key":"2658_CR191","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1038\/s41467-025-58450-w","volume":"16","author":"JS Kang","year":"2025","unstructured":"Kang JS, Lee Y, Lee Y, Gil D, Kim MJ, Wood C, et al. Generation of induced alveolar assembloids with functional alveolar-like macrophages. Nat Commun. 2025;16(1):3346.","journal-title":"Nat Commun"},{"issue":"2","key":"2658_CR192","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41591-024-03489-3","volume":"31","author":"MMA Verstegen","year":"2025","unstructured":"Verstegen MMA, Coppes RP, Beghin A, De Coppi P, Gerli MFM, de Graeff N, et al. Clinical applications of human organoids. Nat Med. 2025;31(2):409\u201321.","journal-title":"Nat Med"},{"issue":"2","key":"2658_CR193","doi-asserted-by":"publisher","first-page":"788","DOI":"10.7150\/thno.90492","volume":"14","author":"H Wang","year":"2024","unstructured":"Wang H, Ning X, Zhao F, Zhao H, Li D. Human organoids-on-chips for biomedical research and applications. Theranostics. 2024;14(2):788\u2013818.","journal-title":"Theranostics"},{"issue":"11","key":"2658_CR194","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1016\/j.immuni.2024.08.018","volume":"57","author":"A Lercher","year":"2024","unstructured":"Lercher A, Cheong JG, Bale MJ, Jiang C, Hoffmann HH, Ashbrook AW, et al. Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease. Immunity. 2024;57(11):2530-46 e13.","journal-title":"Immunity."},{"issue":"2","key":"2658_CR195","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jiph.2022.12.016","volume":"16","author":"E Tayar","year":"2023","unstructured":"Tayar E, Abdeen S, Abed Alah M, Chemaitelly H, Bougmiza I, Ayoub HH, et al. Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar. J Infect Public Health. 2023;16(2):250\u20136.","journal-title":"J Infect Public Health"},{"issue":"10","key":"2658_CR196","doi-asserted-by":"publisher","first-page":"e1009928","DOI":"10.1371\/journal.ppat.1009928","volume":"17","author":"PA Debisarun","year":"2021","unstructured":"Debisarun PA, G\u00f6ssling KL, Bulut O, Kilic G, Zoodsma M, Liu Z, et al. Induction of trained immunity by influenza vaccination - impact on COVID-19. PLoS Pathog. 2021;17(10):e1009928.","journal-title":"PLoS Pathog"},{"issue":"2","key":"2658_CR197","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1056\/NEJMoa1714021","volume":"379","author":"E Nemes","year":"2018","unstructured":"Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, et al. Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination. N Engl J Med. 2018;379(2):138\u201349.","journal-title":"N Engl J Med"},{"issue":"2","key":"2658_CR198","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.cell.2020.08.051","volume":"183","author":"EJ Giamarellos-Bourboulis","year":"2020","unstructured":"Giamarellos-Bourboulis EJ, Tsilika M, Moorlag S, Antonakos N, Kotsaki A, Dom\u00ednguez-Andr\u00e9s J, et al. Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly. Cell. 2020;183(2):315-23 e9.","journal-title":"Cell."},{"issue":"1","key":"2658_CR199","doi-asserted-by":"publisher","first-page":"e1011871","DOI":"10.1371\/journal.ppat.1011871","volume":"20","author":"D Mai","year":"2024","unstructured":"Mai D, Jahn A, Murray T, Morikubo M, Lim PN, Cervantes MM, et al. Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection. PLoS Pathog. 2024;20(1):e1011871.","journal-title":"PLoS Pathog"},{"issue":"1","key":"2658_CR200","doi-asserted-by":"publisher","first-page":"110184","DOI":"10.1016\/j.celrep.2021.110184","volume":"38","author":"P Brandi","year":"2022","unstructured":"Brandi P, Conejero L, Cueto FJ, Mart\u00ednez-Cano S, Dunphy G, G\u00f3mez MJ, et al. Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections. Cell Rep. 2022;38(1):110184.","journal-title":"Cell Rep"},{"key":"2658_CR201","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133042","author":"A Guillon","year":"2020","unstructured":"Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, et al. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020;5(4):e133042. https:\/\/doi.org\/10.1172\/jci.insight.133042.","journal-title":"JCI Insight"},{"key":"2658_CR202","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150239","author":"EI Arafa","year":"2022","unstructured":"Arafa EI, Shenoy AT, Barker KA, Etesami NS, Martin IM, Lyon De Ana C, et al. Recruitment and training of alveolar macrophages after pneumococcal pneumonia. JCI Insight. 2022;7(5):e150239. https:\/\/doi.org\/10.1172\/jci.insight.150239.","journal-title":"JCI Insight"},{"key":"2658_CR203","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1756-8722-2-25","volume":"2","author":"GC Chan","year":"2009","unstructured":"Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25.","journal-title":"J Hematol Oncol"},{"issue":"1\u20132","key":"2658_CR204","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","volume":"172","author":"I Mitroulis","year":"2018","unstructured":"Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, et al. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018;172(1\u20132):147-61.e12.","journal-title":"Cell"},{"issue":"6","key":"2658_CR205","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/s41590-024-01830-z","volume":"25","author":"H Theobald","year":"2024","unstructured":"Theobald H, Bejarano DA, Katzmarski N, Haub J, Schulte-Schrepping J, Yu J, et al. Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary \u03b2-glucan-induced inflammatory adaptation. Nat Immunol. 2024;25(6):994\u20131006.","journal-title":"Nat Immunol"},{"issue":"5","key":"2658_CR206","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1001\/jama.2022.12366","volume":"328","author":"JP Daily","year":"2022","unstructured":"Daily JP, Minuti A, Khan N. Diagnosis, treatment, and prevention of malaria in the US: a review. JAMA. 2022;328(5):460\u201371.","journal-title":"JAMA"},{"issue":"4","key":"2658_CR207","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.4049\/jimmunol.1701010","volume":"200","author":"JE Schrum","year":"2018","unstructured":"Schrum JE, Crabtree JN, Dobbs KR, Kiritsy MC, Reed GW, Gazzinelli RT, et al. Cutting edge: Plasmodium falciparum induces trained innate immunity. J Immunol. 2018;200(4):1243\u20138.","journal-title":"J Immunol"},{"issue":"6","key":"2658_CR208","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.cell.2018.09.042","volume":"175","author":"Y Yao","year":"2018","unstructured":"Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, et al. Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity. Cell. 2018;175(6):1634-50.e17.","journal-title":"Cell"},{"issue":"5","key":"2658_CR209","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/s41385-022-00528-5","volume":"15","author":"S Zahalka","year":"2022","unstructured":"Zahalka S, Starkl P, Watzenboeck ML, Farhat A, Radhouani M, Deckert F, et al. Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling. Mucosal Immunol. 2022;15(5):896\u2013907.","journal-title":"Mucosal Immunol"},{"issue":"11","key":"2658_CR210","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1016\/j.immuni.2024.08.018","volume":"57","author":"A Lercher","year":"2024","unstructured":"Lercher A, Cheong JG, Bale MJ, Jiang C, Hoffmann HH, Ashbrook AW, et al. Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease. Immunity. 2024;57(11):2530-46.e13.","journal-title":"Immunity"},{"key":"2658_CR211","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221388","author":"S Chakraborty","year":"2023","unstructured":"Chakraborty S, Singh A, Wang L, Wang X, Sanborn MA, Ye Z, et al. Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis. J Exp Med.2023;220(11):e20221388. https:\/\/doi.org\/10.1084\/jem.20221388.","journal-title":"J Exp Med"},{"issue":"8","key":"2658_CR212","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1038\/s41590-022-01267-2","volume":"23","author":"A Christofides","year":"2022","unstructured":"Christofides A, Strauss L, Yeo A, Cao C, Charest A, Boussiotis VA. The complex role of tumor-infiltrating macrophages. Nat Immunol. 2022;23(8):1148\u201356.","journal-title":"Nat Immunol"},{"issue":"4","key":"2658_CR213","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/s43018-022-00354-5","volume":"3","author":"J Li","year":"2022","unstructured":"Li J, Ye Y, Liu Z, Zhang G, Dai H, Li J, et al. Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition. Nat Cancer. 2022;3(4):453\u201370.","journal-title":"Nat Cancer"},{"issue":"9","key":"2658_CR214","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/s41423-023-01061-6","volume":"20","author":"M Bied","year":"2023","unstructured":"Bied M, Ho WW, Ginhoux F, Bl\u00e9riot C. Roles of macrophages in tumor development: a spatiotemporal perspective. Cell Mol Immunol. 2023;20(9):983\u201392.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"2658_CR215","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41392-021-00484-9","volume":"6","author":"X Xiang","year":"2021","unstructured":"Xiang X, Wang J, Lu D, Xu X. Targeting tumor-associated macrophages to synergize tumor immunotherapy. Signal Transduct Target Ther. 2021;6(1):75.","journal-title":"Signal Transduct Target Ther"},{"key":"2658_CR216","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3389\/fimmu.2018.00341","volume":"9","author":"M Zhang","year":"2018","unstructured":"Zhang M, Kim JA, Huang AY. Optimizing Tumor Microenvironment for Cancer Immunotherapy: \u03b2-Glucan-Based Nanoparticles. Front Immunol. 2018;9:341.","journal-title":"Front Immunol."},{"issue":"2","key":"2658_CR217","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41590-022-01388-8","volume":"24","author":"C Ding","year":"2023","unstructured":"Ding C, Shrestha R, Zhu X, Geller AE, Wu S, Woeste MR, et al. Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis. Nat Immunol. 2023;24(2):239\u201354.","journal-title":"Nat Immunol"},{"issue":"3","key":"2658_CR218","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41565-023-01553-6","volume":"19","author":"G Liu","year":"2024","unstructured":"Liu G, Ma N, Cheng K, Feng Q, Ma X, Yue Y, et al. Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity. Nat Nanotechnol. 2024;19(3):387\u201398.","journal-title":"Nat Nanotechnol"},{"issue":"3","key":"2658_CR219","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41590-023-01428-x","volume":"24","author":"T Wang","year":"2023","unstructured":"Wang T, Zhang J, Wang Y, Li Y, Wang L, Yu Y, et al. Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs. Nat Immunol. 2023;24(3):423\u201338.","journal-title":"Nat Immunol"},{"issue":"5","key":"2658_CR220","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s41590-024-01819-8","volume":"25","author":"A Broquet","year":"2024","unstructured":"Broquet A, Gourain V, Goronflot T, Le Mabecque V, Sinha D, Ashayeripanah M, et al. Sepsis-trained macrophages promote antitumoral tissue-resident T cells. Nat Immunol. 2024;25(5):802\u201319.","journal-title":"Nat Immunol"},{"issue":"10082","key":"2658_CR221","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1016\/S0140-6736(17)30866-8","volume":"389","author":"L Richeldi","year":"2017","unstructured":"Richeldi L, Collard HR, Jones MG. Idiopathic pulmonary fibrosis. Lancet. 2017;389(10082):1941\u201352.","journal-title":"Lancet"},{"issue":"2","key":"2658_CR222","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1165\/rcmb.2020-0373PS","volume":"64","author":"A Pardo","year":"2021","unstructured":"Pardo A, Selman M. The interplay of the genetic architecture, aging, and environmental factors in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2021;64(2):163\u201372.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2658_CR223","doi-asserted-by":"publisher","first-page":"1444964","DOI":"10.3389\/fimmu.2024.1444964","volume":"15","author":"Z Ge","year":"2024","unstructured":"Ge Z, Chen Y, Ma L, Hu F, Xie L. Macrophage polarization and its impact on idiopathic pulmonary fibrosis. Front Immunol. 2024;15:1444964.","journal-title":"Front Immunol."},{"issue":"1","key":"2658_CR224","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12931-018-0864-2","volume":"19","author":"L Zhang","year":"2018","unstructured":"Zhang L, Wang Y, Wu G, Xiong W, Gu W, Wang CY. Macrophages: friend or foe in idiopathic pulmonary fibrosis? Respir Res. 2018;19(1):170.","journal-title":"Respir Res"},{"issue":"17","key":"2658_CR225","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1016\/j.cell.2024.06.028","volume":"187","author":"A Simats","year":"2024","unstructured":"Simats A, Zhang S, Messerer D, Chong F, Be\u015fkarde\u015f S, Chivukula AS, et al. Innate immune memory after brain injury drives inflammatory cardiac dysfunction. Cell. 2024;187(17):4637-55 e26.","journal-title":"Cell."},{"issue":"95","key":"2658_CR226","doi-asserted-by":"publisher","first-page":"eade3814","DOI":"10.1126\/sciimmunol.ade3814","volume":"9","author":"Y Nakayama","year":"2024","unstructured":"Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, et al. Heart failure promotes multimorbidity through innate immune memory. Sci Immunol. 2024;9(95):eade3814.","journal-title":"Sci Immunol"},{"issue":"14","key":"2658_CR227","doi-asserted-by":"publisher","first-page":"e2308978","DOI":"10.1002\/advs.202308978","volume":"11","author":"YY Kang","year":"2024","unstructured":"Kang YY, Kim DY, Lee SY, Kim HJ, Kim T, Cho JA, et al. Innate immune training initiates efferocytosis to protect against lung injury. Adv Sci (Weinh). 2024;11(14):e2308978.","journal-title":"Adv Sci (Weinh)"},{"key":"2658_CR228","doi-asserted-by":"publisher","first-page":"868343","DOI":"10.3389\/fimmu.2022.868343","volume":"13","author":"SC Funes","year":"2022","unstructured":"Funes SC, Rios M, Fern\u00e1ndez-Fierro A, Di Genaro MS, Kalergis AM. Trained immunity contribution to autoimmune and inflammatory disorders. Front Immunol. 2022;13:868343.","journal-title":"Front Immunol"},{"issue":"8","key":"2658_CR229","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","volume":"201","author":"ED Crouser","year":"2020","unstructured":"Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, et al. Diagnosis and detection of sarcoidosis. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2020;201(8):e26\u201351.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2658_CR230","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1165\/rcmb.2018-0053OC","volume":"60","author":"LW Locke","year":"2019","unstructured":"Locke LW, Crouser ED, White P, Julian MW, Caceres EG, Papp AC, et al. IL-13-regulated macrophage polarization during granuloma formation in an in vitro human sarcoidosis model. Am J Respir Cell Mol Biol. 2019;60(1):84\u201395.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"2658_CR231","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.immuni.2023.01.014","volume":"56","author":"T Krausgruber","year":"2023","unstructured":"Krausgruber T, Redl A, Barreca D, Doberer K, Romanovskaia D, Dobnikar L, et al. Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation. Immunity. 2023;56(2):289-306 e7.","journal-title":"Immunity."},{"issue":"1","key":"2658_CR232","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1038\/s41467-022-30615-x","volume":"13","author":"W Damsky","year":"2022","unstructured":"Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, et al. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nat Commun. 2022;13(1):3140.","journal-title":"Nat Commun"},{"issue":"6","key":"2658_CR233","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.it.2024.04.013","volume":"45","author":"M Robert","year":"2024","unstructured":"Robert M, Yatim N, Sacr\u00e9 K, Duffy D. Sarcoidosis immunopathogenesis - a new concept of maladaptive trained immunity. Trends Immunol. 2024;45(6):406\u201318.","journal-title":"Trends Immunol"},{"key":"2658_CR234","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12995-016-0135-4","volume":"11","author":"S Stopin\u0161ek","year":"2016","unstructured":"Stopin\u0161ek S, Ihan A, Salobir B, Ter\u010delj M, Sim\u010di\u010d S. Fungal cell wall agents and bacterial lipopolysaccharide in organic dust as possible risk factors for pulmonary sarcoidosis. J Occup Med Toxicol. 2016;11:46.","journal-title":"J Occup Med Toxicol."},{"issue":"1","key":"2658_CR235","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1365-2249.2011.04456.x","volume":"166","author":"M Ter\u010delj","year":"2011","unstructured":"Ter\u010delj M, Stopin\u0161ek S, Ihan A, Salobir B, Sim\u010di\u010d S, Wraber B, et al. In vitro and in vivo reactivity to fungal cell wall agents in sarcoidosis. Clin Exp Immunol. 2011;166(1):87\u201393.","journal-title":"Clin Exp Immunol"},{"key":"2658_CR236","doi-asserted-by":"publisher","first-page":"101333","DOI":"10.1016\/j.smim.2019.101333","volume":"46","author":"T Boonpiyathad","year":"2019","unstructured":"Boonpiyathad T, S\u00f6zener ZC, Satitsuksanoa P, Akdis CA. Immunologic mechanisms in asthma. Semin Immunol. 2019;46:101333.","journal-title":"Semin Immunol"},{"issue":"5","key":"2658_CR237","doi-asserted-by":"publisher","first-page":"201","DOI":"10.23822\/EurAnnACI.1764-1489.177","volume":"53","author":"FS Regateiro","year":"2021","unstructured":"Regateiro FS, Botelho Alves P, Moura AL, Azevedo JP, Regateiro DT. The diverse roles of T cell subsets in asthma. Eur Ann Allergy Clin Immunol. 2021;53(5):201\u20138.","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"2658_CR238","doi-asserted-by":"publisher","first-page":"977235","DOI":"10.3389\/fimmu.2022.977235","volume":"13","author":"H Li","year":"2022","unstructured":"Li H, Ma L, Li W, Zheng B, Wang J, Chen S, et al. Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice. Front Immunol. 2022;13:977235.","journal-title":"Front Immunol"},{"issue":"2","key":"2658_CR239","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/s41423-020-00621-4","volume":"18","author":"PC Chen","year":"2021","unstructured":"Chen PC, Shao YT, Hsieh MH, Kao HF, Kuo WS, Wang SM, et al. Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity. Cell Mol Immunol. 2021;18(2):472\u201383.","journal-title":"Cell Mol Immunol"},{"issue":"7","key":"2658_CR240","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1111\/all.15692","volume":"78","author":"H Movassagh","year":"2023","unstructured":"Movassagh H, Prunicki M, Kaushik A, Zhou X, Dunham D, Smith EM, et al. Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma. Allergy. 2023;78(7):1922\u201333.","journal-title":"Allergy"},{"issue":"6","key":"2658_CR241","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/resp.14721","volume":"29","author":"MA Paraskeva","year":"2024","unstructured":"Paraskeva MA, Snell GI. Advances in lung transplantation: 60 years on. Respirology. 2024;29(6):458\u201370.","journal-title":"Respirology"},{"issue":"10","key":"2658_CR242","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.healun.2018.07.020","volume":"37","author":"DC Chambers","year":"2018","unstructured":"Chambers DC, Cherikh WS, Goldfarb SB, Hayes D Jr., Kucheryavaya AY, Toll AE, et al. The international thoracic organ transplant registry of the International Society for Heart and Lung Transplantation: thirty-fifth adult lung and heart-lung transplant report-2018; focus theme: multiorgan transplantation. J Heart Lung Transplant. 2018;37(10):1169\u201383.","journal-title":"J Heart Lung Transplant"},{"issue":"10","key":"2658_CR243","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1097\/TP.0000000000004978","volume":"108","author":"MC Owen","year":"2024","unstructured":"Owen MC, Kopecky BJ. Targeting macrophages in organ transplantation: a step toward personalized medicine. Transplantation. 2024;108(10):2045\u201356.","journal-title":"Transplantation"},{"key":"2658_CR244","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.eng.2021.10.015","volume":"10","author":"L Tan","year":"2022","unstructured":"Tan L, Guo Y, Feng C, Hou Y, Xie X, Zhao Y. The dual regulatory roles of macrophages in acute allogeneic organ graft rejection. Engineering. 2022;10:21\u20139.","journal-title":"Engineering."},{"issue":"5","key":"2658_CR245","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.immuni.2018.09.008","volume":"49","author":"MS Braza","year":"2018","unstructured":"Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, P\u00e9rez-Medina C, et al. Inhibiting inflammation with myeloid cell-specific Nanobiologics promotes organ transplant acceptance. Immunity. 2018;49(5):819-28 e6.","journal-title":"Immunity."},{"issue":"6495","key":"2658_CR246","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1126\/science.aax4040","volume":"368","author":"H Dai","year":"2020","unstructured":"Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science. 2020;368(6495):1122\u20137.","journal-title":"Science"},{"key":"2658_CR247","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061333","author":"TF Chen-Yoshikawa","year":"2021","unstructured":"Chen-Yoshikawa TF. Ischemia-reperfusion injury in lung transplantation. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10061333.","journal-title":"Cells"},{"key":"2658_CR248","doi-asserted-by":"publisher","first-page":"1292625","DOI":"10.3389\/fimmu.2023.1292625","volume":"14","author":"A Elalouf","year":"2023","unstructured":"Elalouf A, Elalouf H, Rosenfeld A. Modulatory immune responses in fungal infection associated with organ transplant - advancements, management, and challenges. Front Immunol. 2023;14:1292625.","journal-title":"Front Immunol."},{"issue":"1","key":"2658_CR249","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41392-023-01377-9","volume":"8","author":"Q Li","year":"2023","unstructured":"Li Q, Lan P. Activation of immune signals during organ transplantation. Signal Transduct Target Ther. 2023;8(1):110.","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"2658_CR250","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00011-023-01844-7","volume":"73","author":"Q Li","year":"2024","unstructured":"Li Q, Nie H. Advances in lung ischemia\/reperfusion injury: unraveling the role of innate immunity. Inflamm Res. 2024;73(3):393\u2013405.","journal-title":"Inflamm Res"},{"key":"2658_CR251","doi-asserted-by":"publisher","first-page":"583042","DOI":"10.3389\/fimmu.2020.583042","volume":"11","author":"EY Bissonnette","year":"2020","unstructured":"Bissonnette EY, Lauzon-Joset JF, Debley JS, Ziegler SF. Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis. Front Immunol. 2020;11:583042.","journal-title":"Front Immunol"},{"issue":"1\u20132","key":"2658_CR252","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","volume":"172","author":"E Kaufmann","year":"2018","unstructured":"Kaufmann E, Sanz J, Dunn JL, Khan N, Mendon\u00e7a LE, Pacis A, et al. BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018;172(1\u20132):176-90.e19.","journal-title":"Cell"},{"key":"2658_CR253","doi-asserted-by":"publisher","first-page":"107009","DOI":"10.1016\/j.micpath.2024.107009","volume":"197","author":"J Xu","year":"2024","unstructured":"Xu J, He W, Xiao N, Xie L. Repetitive Acinetobacter baumannii pneumonia induces infection tolerance in mice. Microb Pathog. 2024;197:107009.","journal-title":"Microb Pathog"},{"issue":"7918","key":"2658_CR254","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41586-022-04919-3","volume":"607","author":"S Naik","year":"2022","unstructured":"Naik S, Fuchs E. Inflammatory memory and tissue adaptation in sickness and in health. Nature. 2022;607(7918):249\u201355.","journal-title":"Nature"},{"issue":"6","key":"2658_CR255","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41578-021-00413-w","volume":"7","author":"MMT van Leent","year":"2022","unstructured":"van Leent MMT, Priem B, Schrijver DP, de Dreu A, Hofstraat SRJ, Zwolsman R, et al. Regulating trained immunity with nanomedicine. Nat Rev Mater. 2022;7(6):465\u201381.","journal-title":"Nat Rev Mater"},{"issue":"9","key":"2658_CR256","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41551-023-01050-0","volume":"7","author":"DP Schrijver","year":"2023","unstructured":"Schrijver DP, R\u00f6ring RJ, Deckers J, de Dreu A, Toner YC, Prevot G, et al. Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells. Nat Biomed Eng. 2023;7(9):1097\u2013112.","journal-title":"Nat Biomed Eng"},{"issue":"1","key":"2658_CR257","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41392-024-02039-0","volume":"9","author":"W Dai","year":"2024","unstructured":"Dai W, Qiao X, Fang Y, Guo R, Bai P, Liu S, et al. Epigenetics-targeted drugs: current paradigms and future challenges. Signal Transduct Target Ther. 2024;9(1):332.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2658_CR258","doi-asserted-by":"publisher","first-page":"2544683","DOI":"10.1080\/10717544.2025.2544683","volume":"32","author":"Y Gao","year":"2025","unstructured":"Gao Y, Wang W, Yue X, Wang G, Zhang K, Wu C, et al. Inhalable nanoparticle-based delivery systems for the treatment of pulmonary infections: status quo and barrier-overcoming strategies. Drug Deliv. 2025;32(1):2544683.","journal-title":"Drug Deliv"},{"issue":"12","key":"2658_CR259","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/s41578-023-00581-x","volume":"8","author":"PJ Gawne","year":"2023","unstructured":"Gawne PJ, Ferreira M, Papaluca M, Grimm J, Decuzzi P. New opportunities and old challenges in the clinical translation of nanotheranostics. Nat Rev Mater. 2023;8(12):783\u201398.","journal-title":"Nat Rev Mater"},{"issue":"11","key":"2658_CR260","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/s41565-024-01754-7","volume":"19","author":"P Joyce","year":"2024","unstructured":"Joyce P, Allen CJ, Alonso MJ, Ashford M, Bradbury MS, Germain M, et al. A translational framework to DELIVER nanomedicines to the clinic. Nat Nanotechnol. 2024;19(11):1597\u2013611.","journal-title":"Nat Nanotechnol"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-02658-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02658-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02658-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:03:29Z","timestamp":1770285809000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-026-02658-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":260,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2658"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-02658-w","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"24 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}