{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:34:00Z","timestamp":1791383640476,"version":"4.3.3"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Grants from the National Natural Science Foundation of China","award":["82200635"],"award-info":[{"award-number":["82200635"]}]},{"name":"Grants from the National Natural Science Foundation of China","award":["82270606"],"award-info":[{"award-number":["82270606"]}]},{"name":"Grants from the National Natural Science Foundation of China","award":["82370578"],"award-info":[{"award-number":["82370578"]}]},{"name":"the Youth Beijing Scholar","award":["No. 035"],"award-info":[{"award-number":["No. 035"]}]},{"name":"Natural Science Foundation of Beijing Municipality","award":["No. 7232034"],"award-info":[{"award-number":["No. 7232034"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-02662-0","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:15:20Z","timestamp":1768482920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lactate attenuates hepatic ischemia-reperfusion injury by reducing intrahepatic inflammation and suppressing hepatocyte-neutrophil interaction via the IL-33\/ST2 pathway"],"prefix":"10.1186","volume":"24","author":[{"given":"Peiyang","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"6","key":"2662_CR1","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.jcmgh.2023.03.003","volume":"15","author":"J Liu","year":"2023","unstructured":"Liu J, Man K. Mechanistic insight and clinical implications of Ischemia\/Reperfusion injury post liver transplantation. Cell Mol Gastroenterol Hepatol. 2023;15(6):1463\u201374.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2662_CR2","doi-asserted-by":"publisher","first-page":"103258","DOI":"10.1016\/j.redox.2024.103258","volume":"75","author":"J George","year":"2024","unstructured":"George J, Lu Y, Tsuchishima M, Tsutsumi M. Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: the role of oxidative stress and therapeutic approaches. Redox Biol. 2024;75:103258.","journal-title":"Redox Biol"},{"issue":"4","key":"2662_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41575-021-00549-8","volume":"19","author":"H Hirao","year":"2022","unstructured":"Hirao H, Nakamura K, Kupiec-Weglinski JW. Liver ischaemia-reperfusion injury: a new Understanding of the role of innate immunity. Nat Rev Gastroenterol Hepatol. 2022;19(4):239\u201356.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"2662_CR4","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41575-020-00411-3","volume":"18","author":"J Gracia-Sancho","year":"2021","unstructured":"Gracia-Sancho J, Caparros E, Fernandez-Iglesias A, Frances R. Role of liver sinusoidal endothelial cells in liver diseases. Nat Rev Gastroenterol Hepatol. 2021;18(6):411\u201331.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"2662_CR5","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1053\/j.gastro.2014.03.014","volume":"146","author":"R Hoque","year":"2014","unstructured":"Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ. Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology. 2014;146(7):1763\u201374.","journal-title":"Gastroenterology"},{"issue":"1","key":"2662_CR6","doi-asserted-by":"publisher","first-page":"7113","DOI":"10.1038\/s41467-024-51169-0","volume":"15","author":"T Nicola","year":"2024","unstructured":"Nicola T, Wenger N, Xu X, Evans M, Qiao L, Rezonzew G, Yang Y, Jilling T, Margaroli C, Genschmer K, et al. A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation. Nat Commun. 2024;15(1):7113.","journal-title":"Nat Commun"},{"issue":"1","key":"2662_CR7","doi-asserted-by":"publisher","first-page":"2127456","DOI":"10.1080\/19490976.2022.2127456","volume":"14","author":"H Li","year":"2022","unstructured":"Li H, Xie J, Guo X, Yang G, Cai B, Liu J, Yue M, Tang Y, Wang G, Chen S, et al. Bifidobacterium spp. And their metabolite lactate protect against acute pancreatitis via Inhibition of pancreatic And systemic inflammatory responses. Gut Microbes. 2022;14(1):2127456.","journal-title":"Gut Microbes"},{"issue":"11","key":"2662_CR8","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","volume":"131","author":"N Wang","year":"2022","unstructured":"Wang N, Wang W, Wang X, Mang G, Chen J, Yan X, Tong Z, Yang Q, Wang M, Chen L, et al. Histone lactylation boosts reparative gene activation Post-Myocardial infarction. Circ Res. 2022;131(11):893\u2013908.","journal-title":"Circ Res"},{"issue":"2","key":"2662_CR9","doi-asserted-by":"publisher","first-page":"113746","DOI":"10.1016\/j.celrep.2024.113746","volume":"43","author":"W Shi","year":"2024","unstructured":"Shi W, Cassmann TJ, Bhagwate AV, Hitosugi T, Ip WKE. Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation. Cell Rep. 2024;43(2):113746.","journal-title":"Cell Rep"},{"key":"2662_CR10","doi-asserted-by":"crossref","unstructured":"Jin H, Zhang C, Sun C, Zhao X, Tian D, Shi W, Tian Y, Liu K, Sun G, Xu H et al. OX40 expression in neutrophils promotes hepatic ischemia\/reperfusion injury. JCI Insight. 2019;4(21):e129736.","DOI":"10.1172\/jci.insight.129736"},{"key":"2662_CR11","doi-asserted-by":"publisher","first-page":"106632","DOI":"10.1016\/j.intimp.2020.106632","volume":"85","author":"W Shi","year":"2020","unstructured":"Shi W, Wang Y, Zhang C, Jin H, Zeng Z, Wei L, Tian Y, Zhang D, Sun G. Isolation and purification of immune cells from the liver. Int Immunopharmacol. 2020;85:106632.","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"2662_CR12","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.7150\/thno.82607","volume":"13","author":"S Du","year":"2023","unstructured":"Du S, Zhang X, Jia Y, Peng P, Kong Q, Jiang S, Li Y, Li C, Ding Z, Liu L. Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia\/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes. Theranostics. 2023;13(11):3856\u201371.","journal-title":"Theranostics"},{"issue":"4","key":"2662_CR13","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"8","key":"2662_CR14","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41588-022-01134-8","volume":"54","author":"WL Hwang","year":"2022","unstructured":"Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, et al. Single-nucleus and Spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022;54(8):1178\u201391.","journal-title":"Nat Genet"},{"issue":"7","key":"2662_CR15","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.7150\/thno.94537","volume":"14","author":"C Zhang","year":"2024","unstructured":"Zhang C, Liu Y, Jiang J, Chen C, Duan Z, Su H, Wang S, Tian B, Shi Y, Xiang R, et al. Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis. Theranostics. 2024;14(7):2757\u201376.","journal-title":"Theranostics"},{"issue":"6","key":"2662_CR16","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.celrep.2018.10.047","volume":"25","author":"MP Kumar","year":"2018","unstructured":"Kumar MP, Du J, Lagoudas G, Jiao Y, Sawyer A, Drummond DC, Lauffenburger DA, Raue A. Analysis of Single-Cell RNA-Seq identifies Cell-Cell communication associated with tumor characteristics. Cell Rep. 2018;25(6):1458\u2013e14681454.","journal-title":"Cell Rep"},{"issue":"1","key":"2662_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/labinvest.2017.90","volume":"98","author":"THC Oliveira","year":"2018","unstructured":"Oliveira THC, Marques PE, Proost P, Teixeira MMM. Neutrophils: a cornerstone of liver ischemia and reperfusion injury. Lab Invest. 2018;98(1):51\u201362.","journal-title":"Lab Invest"},{"issue":"4","key":"2662_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1159\/000347132","volume":"5","author":"K Pittman","year":"2013","unstructured":"Pittman K, Kubes P. Damage-associated molecular patterns control neutrophil recruitment. J Innate Immun. 2013;5(4):315\u201323.","journal-title":"J Innate Immun"},{"key":"2662_CR19","doi-asserted-by":"crossref","unstructured":"Kaltenmeier C, Wang R, Popp B, Geller D, Tohme S, Yazdani HO. Role of Immuno-Inflammatory signals in liver Ischemia-Reperfusion injury. Cells. 2022;11(14):2222.","DOI":"10.3390\/cells11142222"},{"issue":"2","key":"2662_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nri2692","volume":"10","author":"FY Liew","year":"2010","unstructured":"Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol. 2010;10(2):103\u201310.","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"2662_CR21","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nri.2016.95","volume":"16","author":"FY Liew","year":"2016","unstructured":"Liew FY, Girard JP, Turnquist HR. Interleukin-33 in health and disease. Nat Rev Immunol. 2016;16(11):676\u201389.","journal-title":"Nat Rev Immunol"},{"key":"2662_CR22","doi-asserted-by":"crossref","unstructured":"Yazdani HO, Chen HW, Tohme S, Tai S, van der Windt DJ, Loughran P, Rosborough BR, Sud V, Beer-Stolz D, Turnquist HR et al. IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation. J Hepatol. 2018;68(1):130\u2013139.","DOI":"10.1016\/j.jhep.2017.09.010"},{"issue":"6","key":"2662_CR23","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.jhep.2019.12.017","volume":"72","author":"F Artru","year":"2020","unstructured":"Artru F, Bou Saleh M, Maggiotto F, Lassailly G, Ningarhari M, Demaret J, Ntandja-Wandji LC, Pais de Barros JP, Labreuche J, Drumez E, et al. IL-33\/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis. J Hepatol. 2020;72(6):1052\u201361.","journal-title":"J Hepatol"},{"issue":"1","key":"2662_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/iid3.4","volume":"1","author":"K Anbazhagan","year":"2013","unstructured":"Anbazhagan K, Rabbind Singh A, Isabelle P, Stella I, Celine AD, Bissac E, Bertrand B, Remy N, Naomi T, Vincent F, et al. Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways. Immun Inflamm Dis. 2013;1(1):26\u201336.","journal-title":"Immun Inflamm Dis"},{"key":"2662_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3389\/fncel.2017.00335","volume":"11","author":"B Li","year":"2017","unstructured":"Li B, Jia S, Yue T, Yang L, Huang C, Verkhratsky A, Peng L. Biphasic regulation of Caveolin-1 gene expression by Fluoxetine in astrocytes: opposite effects of PI3K\/AKT and MAPK\/ERK signaling pathways on c-fos. Front Cell Neurosci. 2017;11:335.","journal-title":"Front Cell Neurosci"},{"key":"2662_CR26","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.2147\/OTT.S251295","volume":"13","author":"F Gao","year":"2020","unstructured":"Gao F, Zhou L, Li M, Liu W, Yang S, Li W. Inhibition of ERKs\/Akt-Mediated c-Fos expression is required for Piperlongumine-Induced Cyclin D1 downregulation and tumor suppression in colorectal cancer cells. Onco Targets Ther. 2020;13:5591\u2013603.","journal-title":"Onco Targets Ther"},{"issue":"10","key":"2662_CR27","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1038\/s42255-024-01134-4","volume":"6","author":"S Das","year":"2024","unstructured":"Das S, Finney AC, Anand SK, Rohilla S, Liu Y, Pandey N, Ghrayeb A, Kumar D, Nunez K, Liu Z, et al. Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis. Nat Metab. 2024;6(10):1939\u201362.","journal-title":"Nat Metab"},{"issue":"2","key":"2662_CR28","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jhep.2018.03.016","volume":"69","author":"R Ferriero","year":"2018","unstructured":"Ferriero R, Nusco E, De Cegli R, Carissimo A, Manco G, Brunetti-Pierri N. Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure. J Hepatol. 2018;69(2):325\u201335.","journal-title":"J Hepatol"},{"key":"2662_CR29","doi-asserted-by":"publisher","first-page":"1061544","DOI":"10.3389\/fimmu.2022.1061544","volume":"13","author":"CS Chowdhury","year":"2022","unstructured":"Chowdhury CS, Wareham E, Xu J, Kumar S, Kofron M, Lakshmikanthan S, Chrzanowska M, Filippi MD. Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo. Front Immunol. 2022;13:1061544.","journal-title":"Front Immunol"},{"issue":"24","key":"2662_CR30","doi-asserted-by":"publisher","first-page":"e2200196","DOI":"10.1002\/mnfr.202200196","volume":"66","author":"Y Yan","year":"2022","unstructured":"Yan Y, Li X, Yang Q, Zhang H, Hettinga K, Li H, Chen W. Dietary d-Lactate intake facilitates inflammatory resolution by modulating M1 macrophage polarization. Mol Nutr Food Res. 2022;66(24):e2200196.","journal-title":"Mol Nutr Food Res"},{"key":"2662_CR31","doi-asserted-by":"publisher","first-page":"155615","DOI":"10.1016\/j.phymed.2024.155615","volume":"129","author":"G Feng","year":"2024","unstructured":"Feng G, Zhang L, Bao W, Ni J, Wang Y, Huang Y, Lyv J, Cao X, Chen T, You K, et al. Gentisic acid prevents colorectal cancer metastasis via blocking GPR81-mediated DEPDC5 degradation. Phytomedicine. 2024;129:155615.","journal-title":"Phytomedicine"},{"issue":"6","key":"2662_CR32","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.chom.2018.11.002","volume":"24","author":"YS Lee","year":"2018","unstructured":"Lee YS, Kim TY, Kim Y, Lee SH, Kim S, Kang SW, Yang JY, Baek IJ, Sung YH, Park YY, et al. Microbiota-Derived lactate accelerates intestinal Stem-Cell-Mediated epithelial development. Cell Host Microbe. 2018;24(6):833\u201346. e836.","journal-title":"Cell Host Microbe"},{"issue":"1","key":"2662_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","volume":"29","author":"K Yang","year":"2022","unstructured":"Yang K, Fan M, Wang X, Xu J, Wang Y, Tu F, Gill PS, Ha T, Liu L, Williams DL, et al. Lactate promotes macrophage HMGB1 lactylation, acetylation, and Exosomal release in polymicrobial sepsis. Cell Death Differ. 2022;29(1):133\u201346.","journal-title":"Cell Death Differ"},{"issue":"10","key":"2662_CR34","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/bjs.7176","volume":"97","author":"R Bahde","year":"2010","unstructured":"Bahde R, Spiegel HU. Hepatic ischaemia-reperfusion injury from bench to bedside. Br J Surg. 2010;97(10):1461\u201375.","journal-title":"Br J Surg"},{"issue":"5","key":"2662_CR35","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.jhep.2013.06.017","volume":"59","author":"C Peralta","year":"2013","unstructured":"Peralta C, Jimenez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu. J Hepatol. 2013;59(5):1094\u2013106.","journal-title":"J Hepatol"},{"issue":"2","key":"2662_CR36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1053\/jhep.2000.9323","volume":"32","author":"AB Lentsch","year":"2000","unstructured":"Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia\/reperfusion injury. Hepatology. 2000;32(2):169\u201373.","journal-title":"Hepatology"},{"issue":"1","key":"2662_CR37","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","volume":"7","author":"X Li","year":"2022","unstructured":"Li X, Yang Y, Zhang B, Lin X, Fu X, An Y, Zou Y, Wang JX, Wang Z, Yu T. Lactate metabolism in human health and disease. Signal Transduct Target Ther. 2022;7(1):305.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2662_CR38","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12964-024-01624-8","volume":"22","author":"Y Fang","year":"2024","unstructured":"Fang Y, Li Z, Yang L, Li W, Wang Y, Kong Z, Miao J, Chen Y, Bian Y, Zeng L. Emerging roles of lactate in acute and chronic inflammation. Cell Commun Signal. 2024;22(1):276.","journal-title":"Cell Commun Signal"},{"issue":"7","key":"2662_CR39","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","volume":"2","author":"JD Rabinowitz","year":"2020","unstructured":"Rabinowitz JD, Enerback S. Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020;2(7):566\u201371.","journal-title":"Nat Metab"},{"issue":"3","key":"2662_CR40","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.chom.2025.02.003","volume":"33","author":"AD Wise","year":"2025","unstructured":"Wise AD, TenBarge EG, Mendonca JDC, Mennen EC, McDaniel SR, Reber CP, Holder BE, Bunch ML, Belevska E, Marshall MG, et al. Mitochondria sense bacterial lactate and drive release of neutrophil extracellular traps. Cell Host Microbe. 2025;33(3):341\u201357. e349.","journal-title":"Cell Host Microbe"},{"issue":"1","key":"2662_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/08830185.2021.1974856","volume":"41","author":"Y Luo","year":"2022","unstructured":"Luo Y, Li L, Chen X, Gou H, Yan K, Xu Y. Effects of lactate in immunosuppression and inflammation: progress and prospects. Int Rev Immunol. 2022;41(1):19\u201329.","journal-title":"Int Rev Immunol"},{"issue":"1","key":"2662_CR42","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s00018-024-05427-5","volume":"81","author":"Y Li","year":"2024","unstructured":"Li Y, Min X, Zhang X, Cao X, Kong Q, Mao Q, Cheng H, Gou L, Li Y, Li C, et al. HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cells to facilitate renal functional recovery from kidney ischemia\/reperfusion injury. Cell Mol Life Sci. 2024;81(1):404.","journal-title":"Cell Mol Life Sci"},{"key":"2662_CR43","doi-asserted-by":"publisher","first-page":"174959","DOI":"10.1016\/j.ejphar.2022.174959","volume":"924","author":"G Wu","year":"2022","unstructured":"Wu G, Dai Y, Yan Y, Zheng X, Zhang H, Li H, Chen W. The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of Metformin on experimental NAFLDs. Eur J Pharmacol. 2022;924:174959.","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"2662_CR44","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","volume":"35","author":"H Rho","year":"2023","unstructured":"Rho H, Terry AR, Chronis C, Hay N. Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis. Cell Metab. 2023;35(8):1406\u2013e14231408.","journal-title":"Cell Metab"},{"issue":"6","key":"2662_CR45","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1097\/00007890-199306000-00011","volume":"55","author":"S Suzuki","year":"1993","unstructured":"Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation. 1993;55(6):1265\u201372.","journal-title":"Transplantation"},{"key":"2662_CR46","doi-asserted-by":"publisher","first-page":"744927","DOI":"10.3389\/fimmu.2021.744927","volume":"12","author":"L Barbier","year":"2021","unstructured":"Barbier L, Robin A, Sindayigaya R, Ducousso H, Dujardin F, Thierry A, Hauet T, Girard JP, Pellerin L, Gombert JM, et al. Endogenous Interleukin-33 acts as an alarmin in liver ischemia-Reperfusion and is associated with injury after human liver transplantation. Front Immunol. 2021;12:744927.","journal-title":"Front Immunol"},{"issue":"4","key":"2662_CR47","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/hep.25768","volume":"56","author":"N Sakai","year":"2012","unstructured":"Sakai N, Van Sweringen HL, Quillin RC, Schuster R, Blanchard J, Burns JM, Tevar AD, Edwards MJ, Lentsch AB. Interleukin-33 is hepatoprotective during liver ischemia\/reperfusion in mice. Hepatology. 2012;56(4):1468\u201378.","journal-title":"Hepatology"},{"issue":"4","key":"2662_CR48","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.bbrc.2006.10.166","volume":"351","author":"H Yin","year":"2006","unstructured":"Yin H, Huang BJ, Yang H, Huang YF, Xiong P, Zheng F, Chen XP, Chen YF, Gong FL. Pretreatment with soluble ST2 reduces warm hepatic ischemia\/reperfusion injury. Biochem Biophys Res Commun. 2006;351(4):940\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"2662_CR49","doi-asserted-by":"crossref","unstructured":"Raphael HE, Hassan GF, Osorio OA, Cohen LS, Payne MD, Katz-Kiriakos E, Tata I, Hicks J, Byers DE, Zhang B et al. Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease. JCI Insight. 2024;9(5):e174786.","DOI":"10.1172\/jci.insight.174786"},{"issue":"1","key":"2662_CR50","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41598-020-80111-9","volume":"11","author":"BGC Griffith","year":"2021","unstructured":"Griffith BGC, Upstill-Goddard R, Brunton H, Grimes GR, Biankin AV, Serrels B, Byron A, Frame MC. FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs. Sci Rep. 2021;11(1):229.","journal-title":"Sci Rep"},{"issue":"1","key":"2662_CR51","doi-asserted-by":"publisher","first-page":"e100159","DOI":"10.1136\/egastro-2024-100159","volume":"3","author":"AA Roca Suarez","year":"2025","unstructured":"Roca Suarez AA, Juhling F, Moehlin J, Mailly L, Virzi A, Brignon N, Durand SC, Oudot MA, Schaeffer E, Martin R, et al. Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease. eGastroenterology. 2025;3(1):e100159.","journal-title":"eGastroenterology"},{"key":"2662_CR52","doi-asserted-by":"publisher","first-page":"587913","DOI":"10.3389\/fimmu.2020.587913","volume":"11","author":"K Yang","year":"2020","unstructured":"Yang K, Xu J, Fan M, Tu F, Wang X, Ha T, Williams DL, Li C. Lactate suppresses macrophage Pro-Inflammatory response to LPS stimulation by Inhibition of YAP and NF-kappaB activation via GPR81-Mediated signaling. Front Immunol. 2020;11:587913.","journal-title":"Front Immunol"},{"issue":"2","key":"2662_CR53","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1021\/acs.jafc.3c05049","volume":"72","author":"J Qian","year":"2024","unstructured":"Qian J, Li X, Yin Z, Dai Y, Zhang H, Li H, Peng C, Chen W. Yogurt alleviates Imiquimod-Induced psoriasis by activating the Lactate\/GPR81 signaling axis in mice. J Agric Food Chem. 2024;72(2):1055\u201366.","journal-title":"J Agric Food Chem"},{"issue":"12","key":"2662_CR54","doi-asserted-by":"publisher","first-page":"8938","DOI":"10.1002\/jcp.29739","volume":"235","author":"J Hu","year":"2020","unstructured":"Hu J, Cai M, Liu Y, Liu B, Xue X, Ji R, Bian X, Lou S. The roles of GRP81 as a metabolic sensor and inflammatory mediator. J Cell Physiol. 2020;235(12):8938\u201350.","journal-title":"J Cell Physiol"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-02662-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02662-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02662-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:03:21Z","timestamp":1770836601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-026-02662-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2662"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-02662-0","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"21 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures conformed to ethical standards and were approved by the Institutional Animal Care and Ethics Committee of Beijing Chao-Yang Hospital (Approval No. 24-2033).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"108"}}