{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:54:33Z","timestamp":1778817273625,"version":"3.51.4"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371438"],"award-info":[{"award-number":["82371438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371438"],"award-info":[{"award-number":["82371438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024B1515230001"],"award-info":[{"award-number":["2024B1515230001"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024B1515230001"],"award-info":[{"award-number":["2024B1515230001"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"nnovative Team Project of General Universities in Guangdong Province","award":["2024KCXTD034"],"award-info":[{"award-number":["2024KCXTD034"]}]},{"name":"nnovative Team Project of General Universities in Guangdong Province","award":["2024KCXTD034"],"award-info":[{"award-number":["2024KCXTD034"]}]},{"name":"Affiliated Hospital of Guangdong Medical University High Level talent research Launch project","award":["GCC2022001"],"award-info":[{"award-number":["GCC2022001"]}]},{"name":"Affiliated Hospital of Guangdong Medical University High Level talent research Launch project","award":["GCC2022001"],"award-info":[{"award-number":["GCC2022001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-02787-2","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:18:34Z","timestamp":1773051514000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["De-2-hydroxyisobutyrylation of clusterin modulates neuropathology and memory deficits in an Alzheimer\u2019s disease mouse model"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaoping","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyue","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lv","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sifan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2787_CR1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/978-3-031-31986-0_65","volume":"1425","author":"N Paraskevopoulos","year":"2023","unstructured":"Paraskevopoulos N. Personalized music playlists and headphones in people with dementia: A literature review. Adv Exp Med Biol. 2023;1425:665\u201366.","journal-title":"Adv Exp Med Biol"},{"key":"2787_CR2","doi-asserted-by":"crossref","unstructured":"2024 Alzheimer\u2019s disease facts and figures. Alzheimers Dement. 2024;20:3708\u2009\u2013\u2009821.","DOI":"10.1002\/alz.13809"},{"key":"2787_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack Jr","year":"2018","unstructured":"Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, et al. NIA-AA research framework: Toward a biological definition of Alzheimer\u2019s disease. Alzheimers Dement. 2018;14:535\u201362.","journal-title":"Alzheimers Dement"},{"key":"2787_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40035-024-00432-x","volume":"13","author":"E Liu","year":"2024","unstructured":"Liu E, Zhang Y, Wang JZ. Updates in Alzheimer\u2019s disease: from basic research to diagnosis and therapies. Transl Neurodegener. 2024;13:45.","journal-title":"Transl Neurodegener"},{"key":"2787_CR5","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.14336\/AD.2023.0727","volume":"15","author":"Q Deng","year":"2024","unstructured":"Deng Q, Wu C, Parker E, Liu TC, Duan R, Yang L. Microglia and astrocytes in Alzheimer\u2019s disease: Significance and summary of recent advances. Aging Dis. 2024;15:1537\u201364.","journal-title":"Aging Dis"},{"key":"2787_CR6","doi-asserted-by":"publisher","first-page":"101208","DOI":"10.1016\/j.arr.2020.101208","volume":"65","author":"A John","year":"2021","unstructured":"John A, Reddy PH. Synaptic basis of Alzheimer\u2019s disease: Focus on synaptic amyloid beta, P-tau and mitochondria. Ageing Res Rev. 2021;65:101208.","journal-title":"Ageing Res Rev"},{"key":"2787_CR7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.tins.2015.08.006","volume":"38","author":"SD Mhatre","year":"2015","unstructured":"Mhatre SD, Tsai CA, Rubin AJ, James ML, Andreasson KI. Microglial malfunction: the third rail in the development of Alzheimer\u2019s disease. Trends Neurosci. 2015;38:621\u201336.","journal-title":"Trends Neurosci"},{"key":"2787_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41577-024-01104-7","volume":"25","author":"MT Heneka","year":"2025","unstructured":"Heneka MT, van der Flier WM, Jessen F, Hoozemanns J, Thal DR, Boche D, Brosseron F, Teunissen C, Zetterberg H, Jacobs AH, et al. Neuroinflammation in Alzheimer disease. Nat Rev Immunol. 2025;25:321\u201352.","journal-title":"Nat Rev Immunol"},{"key":"2787_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nchembio.1497","volume":"10","author":"L Dai","year":"2014","unstructured":"Dai L, Peng C, Montellier E, Lu Z, Chen Y, Ishii H, Debernardi A, Buchou T, Rousseaux S, Jin F, et al. Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. Nat Chem Biol. 2014;10:365\u201370.","journal-title":"Nat Chem Biol"},{"key":"2787_CR10","doi-asserted-by":"publisher","first-page":"e01129","DOI":"10.1128\/mSystems.01129-20","volume":"6","author":"H Zheng","year":"2021","unstructured":"Zheng H, Song N, Zhou X, Mei H, Li D, Li X, Liu W. Proteome-Wide Analysis of Lysine 2-Hydroxyisobutyrylation in Candida albicans. mSystems. 2021;6:e01129\u201320.","journal-title":"mSystems"},{"key":"2787_CR11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nrm.2016.140","volume":"18","author":"BR Sabari","year":"2017","unstructured":"Sabari BR, Zhang D, Allis CD, Zhao Y. Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol. 2017;18:90\u2013101.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2787_CR12","first-page":"e9651","volume":"12","author":"S Huang","year":"2020","unstructured":"Huang S, Tang D, Dai Y. Metabolic functions of lysine 2-hydroxyisobutyrylation. Cureus. 2020;12:e9651.","journal-title":"Cureus"},{"key":"2787_CR13","doi-asserted-by":"crossref","unstructured":"Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y et al. p300-Mediated Lysine 2-hydroxyisobutyrylation regulates glycolysis. Mol Cell. 2018;70:663\u2009\u2013\u200978.e6.","DOI":"10.1016\/j.molcel.2018.04.011"},{"key":"2787_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41422-023-00793-4","volume":"33","author":"L Liao","year":"2023","unstructured":"Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, et al. Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner. Cell Res. 2023;33:355\u201371.","journal-title":"Cell Res"},{"key":"2787_CR15","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/s41419-022-05516-y","volume":"13","author":"J Ni","year":"2022","unstructured":"Ni J, Zhang H, Wang X, Liu Z, Nie T, Li L, Su J, Zhu Y, Ma C, Huang Y, et al. Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy. Cell Death Dis. 2022;13:1073.","journal-title":"Cell Death Dis"},{"issue":"Pt 2","key":"2787_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1042\/bj3440375","volume":"344","author":"M Calero","year":"1999","unstructured":"Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999;344(Pt 2):375\u201383.","journal-title":"Biochem J"},{"key":"2787_CR17","doi-asserted-by":"publisher","first-page":"5380","DOI":"10.1021\/bi00474a025","volume":"29","author":"HV de Silva","year":"1990","unstructured":"de Silva HV, Harmony JA, Stuart WD, Gil CM, Robbins J. Apolipoprotein J: structure and tissue distribution. Biochemistry. 1990;29:5380\u20139.","journal-title":"Biochemistry"},{"key":"2787_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/ar.1092400306","volume":"240","author":"L Hermo","year":"1994","unstructured":"Hermo L, Barin K, Oko R. Developmental expression of sulfated glycoprotein-2 in the epididymis of the rat. Anat Rec. 1994;240:327\u201344.","journal-title":"Anat Rec"},{"key":"2787_CR19","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1007\/s00018-011-0684-8","volume":"68","author":"AR Wyatt","year":"2011","unstructured":"Wyatt AR, Yerbury JJ, Berghofer P, Greguric I, Katsifis A, Dobson CM, Wilson MR. Clusterin facilitates in vivo clearance of extracellular misfolded proteins. Cell Mol Life Sci. 2011;68:3919\u201331.","journal-title":"Cell Mol Life Sci"},{"key":"2787_CR20","doi-asserted-by":"publisher","first-page":"11030","DOI":"10.1016\/S0021-9258(18)99123-4","volume":"266","author":"DE Jenne","year":"1991","unstructured":"Jenne DE, Lowin B, Peitsch MC, B\u00f6ttcher A, Schmitz G, Tschopp J. Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma. J Biol Chem. 1991;266:11030\u20136.","journal-title":"J Biol Chem"},{"key":"2787_CR21","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fnins.2019.00164","volume":"13","author":"EM Foster","year":"2019","unstructured":"Foster EM, Dangla-Valls A, Lovestone S, Ribe EM, Buckley NJ. Clusterin in Alzheimer\u2019s disease: mechanisms, genetics, and lessons from other pathologies. Front Neurosci. 2019;13:164.","journal-title":"Front Neurosci"},{"key":"2787_CR22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/ng.440","volume":"41","author":"D Harold","year":"2009","unstructured":"Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease. Nat Genet. 2009;41:1088\u201393.","journal-title":"Nat Genet"},{"key":"2787_CR23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/bpa.12392","volume":"27","author":"JS Miners","year":"2017","unstructured":"Miners JS, Clarke P, Love S. Clusterin levels are increased in Alzheimer\u2019s disease and influence the regional distribution of A\u03b2. Brain Pathol (Zurich Switzerland). 2017;27:305\u201313.","journal-title":"Brain Pathol (Zurich Switzerland)"},{"key":"2787_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fneur.2019.00187","volume":"10","author":"J Camacho","year":"2019","unstructured":"Camacho J, Molin\u00e9 T, Bonaterra-Pastra A, Ram\u00f3n YCS, Mart\u00ednez-S\u00e1ez E, Hern\u00e1ndez-Guillamon M. Brain ApoA-I, ApoJ and ApoE immunodetection in cerebral amyloid angiopathy. Front Neurol. 2019;10:187.","journal-title":"Front Neurol"},{"key":"2787_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0006-8993(95)00482-6","volume":"685","author":"E Kida","year":"1995","unstructured":"Kida E, Choi-Miura NH, Wisniewski KE. Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer\u2019s disease and Down\u2019s syndrome brain. Brain Res. 1995;685:211\u20136.","journal-title":"Brain Res"},{"key":"2787_CR26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nsmb.2191","volume":"19","author":"P Narayan","year":"2011","unstructured":"Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D. The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-\u03b2(1\u201340) peptide. Nat Struct Mol Bio. 2011;19:79\u201383.","journal-title":"Nat Struct Mol Bio"},{"key":"2787_CR27","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41392-022-01157-x","volume":"7","author":"X Liu","year":"2022","unstructured":"Liu X, Che R, Liang W, Zhang Y, Wu L, Han C, Lu H, Song W, Wu Y, Wang Z. Clusterin transduces Alzheimer-risk signals to amyloidogenesis. Signal Transduct Target Ther. 2022;7:325.","journal-title":"Signal Transduct Target Ther"},{"key":"2787_CR28","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1099\/vir.0.007211-0","volume":"90","author":"FT Liao","year":"2009","unstructured":"Liao FT, Lee YJ, Ko JL, Tsai CC, Tseng CJ, Sheu GT. Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells. J Gen Virol. 2009;90:1124\u201334.","journal-title":"J Gen Virol"},{"key":"2787_CR29","doi-asserted-by":"publisher","first-page":"4138","DOI":"10.1158\/0008-5472.CAN-06-3032","volume":"67","author":"DM Hellebrekers","year":"2007","unstructured":"Hellebrekers DM, Melotte V, Vir\u00e9 E, Langenkamp E, Molema G, Fuks F, Herman JG, Van Criekinge W, Griffioen AW, van Engeland M. Identification of epigenetically silenced genes in tumor endothelial cells. Cancer Res. 2007;67:4138\u201348.","journal-title":"Cancer Res"},{"key":"2787_CR30","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.bbadis.2015.04.021","volume":"1852","author":"M Deb","year":"2015","unstructured":"Deb M, Sengupta D, Rath SK, Kar S, Parbin S, Shilpi A, Pradhan N, Bhutia SK, Roy S, Patra SK. Clusterin gene is predominantly regulated by histone modifications in human colon cancer and ectopic expression of the nuclear isoform induces cell death. Biochim Biophys Acta. 2015;1852:1630\u201345.","journal-title":"Biochim Biophys Acta"},{"key":"2787_CR31","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1038\/nprot.2013.155","volume":"8","author":"M Leger","year":"2013","unstructured":"Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, Freret T. Object recognition test in mice. Nat Protoc. 2013;8:2531\u20137.","journal-title":"Nat Protoc"},{"key":"2787_CR32","doi-asserted-by":"publisher","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","volume":"31","author":"GR Barker","year":"2011","unstructured":"Barker GR, Warburton EC. When is the hippocampus involved in recognition memory? J Neurosci. 2011;31:10721\u201331.","journal-title":"J Neurosci"},{"key":"2787_CR33","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"CV Vorhees","year":"2006","unstructured":"Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 2006;1:848\u201358.","journal-title":"Nat Protoc"},{"key":"2787_CR34","doi-asserted-by":"publisher","first-page":"102942","DOI":"10.1016\/j.isci.2021.102942","volume":"24","author":"L Zhang","year":"2021","unstructured":"Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, et al. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer\u2019s disease pathology. iScience. 2021;24:102942.","journal-title":"iScience"},{"key":"2787_CR35","first-page":"3987","volume":"6","author":"Y Sun","year":"2021","unstructured":"Sun Y, Chi X, Meng H, Ma M, Wang J, Feng Z, Quan Q, Liu G, Wang Y, Xie Y, et al. Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo. Bioact Mater. 2021;6:3987\u201398.","journal-title":"Bioact Mater"},{"key":"2787_CR36","doi-asserted-by":"publisher","first-page":"154108","DOI":"10.1016\/j.phymed.2022.154108","volume":"101","author":"Q Yue","year":"2022","unstructured":"Yue Q, Xu Y, Lin L, Hoi MPM. Canthin-6-one (CO) from Picrasma quassioides (D.Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption. Phytomedicine. 2022;101:154108.","journal-title":"Phytomedicine"},{"key":"2787_CR37","doi-asserted-by":"publisher","first-page":"8658","DOI":"10.3390\/ijms23158658","volume":"23","author":"M I EL-D, Manai","year":"2022","unstructured":"I EL-D, Manai M, Neili NE, Marzouki S, Sahraoui G, Ben Achour W, Zouaghi S, BenAhmed M, Doghri R, Srairi-Abid N. Dual mechanism of action of curcumin in experimental models of multiple sclerosis. Int J Mol Sci. 2022;23:8658.","journal-title":"Int J Mol Sci"},{"key":"2787_CR38","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuroscience.2023.08.036","volume":"530","author":"X Wang","year":"2023","unstructured":"Wang X, Su M, Wang L, Zhou Y, Li N, Yang B. NEDD4 like E3 ubiquitin protein ligase represses astrocyte activation and aggravates neuroinflammation in mice with depression via paired box 6 ubiquitination. Neuroscience. 2023;530:144\u201357.","journal-title":"Neuroscience"},{"key":"2787_CR39","first-page":"352","volume":"64","author":"ML Schmidt","year":"1991","unstructured":"Schmidt ML, Lee VM, Trojanowski JQ. Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer\u2019s disease senile plaque neurites and neuropil threads. Lab Invest. 1991;64:352\u20137.","journal-title":"Lab Invest"},{"key":"2787_CR40","doi-asserted-by":"crossref","unstructured":"Huang H, Sabari BR, Garcia BA, Allis CD, Zhao Y. SnapShot: histone modifications. Cell. 2014;159:458\u2009\u2013\u200958.e1.","DOI":"10.1016\/j.cell.2014.09.037"},{"key":"2787_CR41","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrm3546","volume":"14","author":"Y Shiloh","year":"2013","unstructured":"Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol cell Biol. 2013;14:197\u2013210.","journal-title":"Nat Rev Mol cell Biol"},{"key":"2787_CR42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","volume":"363","author":"MA Glozak","year":"2005","unstructured":"Glozak MA, Sengupta N, Zhang X, Seto E. Acetylation and deacetylation of non-histone proteins. Gene. 2005;363:15\u201323.","journal-title":"Gene"},{"key":"2787_CR43","doi-asserted-by":"publisher","first-page":"111062","DOI":"10.1016\/j.celrep.2022.111062","volume":"40","author":"N Bai","year":"2022","unstructured":"Bai N, Li N, Cheng R, Guan Y, Zhao X, Song Z, Xu H, Yi F, Jiang B, Li X, et al. Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP\/PS1 transgenic mice. Cell Rep. 2022;40:111062.","journal-title":"Cell Rep"},{"key":"2787_CR44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41467-021-27572-2","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y, Tapias V, Acosta D, Xu H, Chen H, Bhawal R, Anderson ET, Ivanova E, Lin H, Sagdullaev BT, et al. Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer\u2019s disease. Nat Commun. 2022;13:159.","journal-title":"Nat Commun"},{"key":"2787_CR45","doi-asserted-by":"crossref","unstructured":"Pan RY, He L, Zhang J, Liu X, Liao Y, Gao J, Liao Y, Yan Y, Li Q, Zhou X et al. Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer\u2019s disease. Cell Metab. 2022;34:634\u2009\u2013\u200948.e6.","DOI":"10.1016\/j.cmet.2022.02.013"},{"key":"2787_CR46","doi-asserted-by":"publisher","first-page":"e14368","DOI":"10.1111\/acel.14368","volume":"24","author":"W Han","year":"2025","unstructured":"Han W, Zhang B, Zhao W, Zhao W, He J, Qiu X, Zhang L, Wang X, Wang Y, Lu H, et al. Ketogenic \u03b2-hydroxybutyrate regulates \u03b2-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer\u2019s mice. Aging Cell. 2025;24:e14368.","journal-title":"Aging Cell"},{"key":"2787_CR47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/cr.2017.149","volume":"28","author":"H Huang","year":"2018","unstructured":"Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, et al. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 2018;28:111\u201325.","journal-title":"Cell Res"},{"key":"2787_CR48","doi-asserted-by":"publisher","first-page":"8782","DOI":"10.1073\/pnas.1700796114","volume":"114","author":"J Huang","year":"2017","unstructured":"Huang J, Luo Z, Ying W, Cao Q, Huang H, Dong J, Wu Q, Zhao Y, Qian X, Dai J. 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2017;114:8782\u201387.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2787_CR49","doi-asserted-by":"publisher","first-page":"qzae019","DOI":"10.1093\/gpbjnl\/qzae019","volume":"22","author":"B Hao","year":"2024","unstructured":"Hao B, Chen K, Zhai L, Liu M, Liu B, Tan M. Substrate and functional diversity of protein lysine post-translational modifications. Genomics Proteom Bioinf. 2024;22:qzae019.","journal-title":"Genomics Proteom Bioinf"},{"key":"2787_CR50","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41392-022-01245-y","volume":"7","author":"S Shang","year":"2022","unstructured":"Shang S, Liu J, Hua F. Protein acylation: mechanisms, biological functions and therapeutic targets. Signal Transduct Target Ther. 2022;7:396.","journal-title":"Signal Transduct Target Ther"},{"key":"2787_CR51","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1096\/fj.06-7986com","volume":"21","author":"JJ Yerbury","year":"2007","unstructured":"Yerbury JJ, Poon S, Meehan S, Thompson B, Kumita JR, Dobson CM, Wilson MR. The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J. 2007;21:2312\u201322.","journal-title":"FASEB J"},{"key":"2787_CR52","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/bpa.12660","volume":"29","author":"SB Oh","year":"2019","unstructured":"Oh SB, Kim MS, Park S, Son H, Kim SY, Kim MS, Jo DG, Tak E, Lee JY. Clusterin contributes to early stage of Alzheimer\u2019s disease pathogenesis. Brain Pathol. 2019;29:217\u201331.","journal-title":"Brain Pathol"},{"key":"2787_CR53","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1007\/s12035-022-02973-6","volume":"59","author":"YM Kim","year":"2022","unstructured":"Kim YM, Park S, Choi SY, Oh SB, Jung M, Pack CG, Hwang JJ, Tak E, Lee JY. Clusterin binding modulates the aggregation and neurotoxicity of Amyloid-\u03b2(1\u201342). Mol Neurobiol. 2022;59:6228\u201344.","journal-title":"Mol Neurobiol"},{"key":"2787_CR54","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.1038\/ncomms6775","volume":"5","author":"F Zhang","year":"2014","unstructured":"Zhang F, Kumano M, Beraldi E, Fazli L, Du C, Moore S, Sorensen P, Zoubeidi A, Gleave ME. Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival. Nat Commun. 2014;5:5775.","journal-title":"Nat Commun"},{"key":"2787_CR55","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1750-1326-7-52","volume":"7","author":"L Chami","year":"2012","unstructured":"Chami L, Checler F. BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and \u03b2-amyloid production in Alzheimer\u2019s disease. Mol Neurodegener. 2012;7:52.","journal-title":"Mol Neurodegener"},{"key":"2787_CR56","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/j.1471-4159.2008.05858.x","volume":"108","author":"M Guglielmotto","year":"2009","unstructured":"Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, et al. The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. J Neurochem. 2009;108:1045\u201356.","journal-title":"J Neurochem"},{"key":"2787_CR57","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuron.2008.10.047","volume":"60","author":"T O\u2019Connor","year":"2008","unstructured":"O\u2019Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008;60:988\u20131009.","journal-title":"Neuron"},{"key":"2787_CR58","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.bbadis.2012.01.009","volume":"1822","author":"F Mouton-Liger","year":"2012","unstructured":"Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J. Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2\u03b1 pathway. Biochim Biophys Acta. 2012;1822:885\u201396.","journal-title":"Biochim Biophys Acta"},{"key":"2787_CR59","doi-asserted-by":"publisher","first-page":"3087475","DOI":"10.1155\/2018\/3087475","volume":"2018","author":"F Alasmari","year":"2018","unstructured":"Alasmari F, Alshammari MA, Alasmari AF, Alanazi WA, Alhazzani K. Neuroinflammatory cytokines induce amyloid beta neurotoxicity through modulating amyloid precursor protein levels\/metabolism. Biomed Res Int. 2018;2018:3087475.","journal-title":"Biomed Res Int"},{"key":"2787_CR60","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13024-020-00416-1","volume":"15","author":"AM Wojtas","year":"2020","unstructured":"Wojtas AM, Sens JP, Kang SS, Baker KE, Berry TJ, Kurti A, Daughrity L, Jansen-West KR, Dickson DW, Petrucelli L, et al. Astrocyte-derived clusterin suppresses amyloid formation in vivo. Mol Neurodegener. 2020;15:71.","journal-title":"Mol Neurodegener"},{"key":"2787_CR61","doi-asserted-by":"publisher","first-page":"e16275","DOI":"10.1111\/jnc.16275","volume":"169","author":"W Tsering","year":"2025","unstructured":"Tsering W, de la Rosa A, Ruan IY, Philips JL, Bathe T, Villareal JA, Prokop S. Preferential clustering of microglia and astrocytes around neuritic plaques during progression of Alzheimer\u2019s disease neuropathological changes. J Neurochem. 2025;169:e16275.","journal-title":"J Neurochem"},{"key":"2787_CR62","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/s41593-024-01664-w","volume":"27","author":"Y Huang","year":"2024","unstructured":"Huang Y, Wang M, Ni H, Zhang J, Li A, Hu B, Junqueira Alves C, Wahane S, Rios de Anda M, Ho L, et al. Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer\u2019s disease. Nat Neurosci. 2024;27:1489\u2013504.","journal-title":"Nat Neurosci"},{"key":"2787_CR63","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1038\/s44321-024-00162-7","volume":"16","author":"P Preman","year":"2024","unstructured":"Preman P, Moechars D, Fertan E, Wolfs L, Serneels L, Shah D, Lamote J, Poovathingal S, Snellinx A, Mancuso R, et al. APOE from astrocytes restores Alzheimer\u2019s A\u03b2-pathology and DAM-like responses in APOE deficient microglia. EMBO Mol Med. 2024;16:3113\u201341.","journal-title":"EMBO Mol Med"},{"key":"2787_CR64","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.neuroscience.2017.03.059","volume":"352","author":"YS Batarseh","year":"2017","unstructured":"Batarseh YS, Mohamed LA, Al Rihani SB, Mousa YM, Siddique AB, El Sayed KA, Kaddoumi A. Oleocanthal ameliorates amyloid-\u03b2 oligomers\u2019 toxicity on astrocytes and neuronal cells: In vitro studies. Neuroscience. 2017;352:204\u201315.","journal-title":"Neuroscience"},{"key":"2787_CR65","doi-asserted-by":"publisher","first-page":"103428","DOI":"10.1016\/j.redox.2024.103428","volume":"78","author":"RX Dou","year":"2024","unstructured":"Dou RX, Zhang YM, Hu XJ, Gao FL, Zhang LL, Liang YH, Zhang YY, Yao YP, Yin L, Zhang Y, et al. A\u03b2(1\u201342) promotes microglial activation and apoptosis in the progression of AD by binding to TLR4. Redox Biol. 2024;78:103428.","journal-title":"Redox Biol"},{"key":"2787_CR66","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/cells13010079","volume":"13","author":"Y Ma","year":"2023","unstructured":"Ma Y, Wang W, Liu S, Qiao X, Xing Y, Zhou Q, Zhang Z. Epigenetic Regulation of Neuroinflammation in Alzheimer\u2019s Disease. Cells. 2023;13:79.","journal-title":"Cells"},{"key":"2787_CR67","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.3390\/biom12101452","volume":"12","author":"MM Fareed","year":"2022","unstructured":"Fareed MM, Qasmi M, Aziz S, V\u00f6lker E, F\u00f6rster CY, Shityakov S. The role of clusterin transporter in the pathogenesis of Alzheimer\u2019s Disease at the Blood-Brain Barrier interface: A systematic review. Biomolecules. 2022;12:1452.","journal-title":"Biomolecules"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-02787-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02787-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02787-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:01:36Z","timestamp":1776258096000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-026-02787-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2787"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-02787-2","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"27 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Ethics Committee for Animal Experiments of Guangdong Medical University (GDMU2023-000108), and mice were cared under standard conditions according to institutional guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"229"}}