{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:58:20Z","timestamp":1790488700136,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Associazione Italiana per la Ricerca contro il Cancro","award":["Project Code: 22963"],"award-info":[{"award-number":["Project Code: 22963"]}]},{"name":"PNRR M4C2I1.3","award":["Heal Italia project PE00000019 CUP B43D22000710006"],"award-info":[{"award-number":["Heal Italia project PE00000019 CUP B43D22000710006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-02789-0","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:36:38Z","timestamp":1773066998000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Orphan Nuclear Receptors expression and function in breast cancer cells: oncogenic action of the NR2F6 receptor"],"prefix":"10.1186","volume":"24","author":[{"given":"Maria Azzurra","family":"Caricasulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Paroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Vincenzo","family":"Cavallaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Foglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Remoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guarrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineko","family":"Terao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Garattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2789_CR1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","volume":"83","author":"DJ Mangelsdorf","year":"1995","unstructured":"Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Sch\u00fctz G, Umesono K, et al. The nuclear receptor superfamily: The second decade. Cell. 1995;83:835\u20139. https:\/\/doi.org\/10.1016\/0092-8674(95)90199-X.","journal-title":"Cell"},{"key":"2789_CR2","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1210\/me.2005-0046","volume":"19","author":"RM Evans","year":"2005","unstructured":"Evans RM. The Nuclear Receptor Superfamily: A Rosetta Stone for Physiology. Mol Endocrinol. 2005;19:1429\u201338. https:\/\/doi.org\/10.1210\/me.2005-0046.","journal-title":"Mol Endocrinol"},{"key":"2789_CR3","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1124\/pr.58.4.10","volume":"58","author":"G Benoit","year":"2006","unstructured":"Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, et al. International Union of Pharmacology. LXVI. Orphan Nuclear Receptors. Pharmacol Rev. 2006;58:798\u2013836. https:\/\/doi.org\/10.1124\/pr.58.4.10.","journal-title":"Pharmacol Rev"},{"key":"2789_CR4","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1096\/fasebj.5.9.1860615","volume":"5","author":"W Wahli","year":"1991","unstructured":"Wahli W, Martinez E. Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression. FASEB J. 1991;5:2243\u20139. https:\/\/doi.org\/10.1096\/fasebj.5.9.1860615.","journal-title":"FASEB J"},{"key":"2789_CR5","doi-asserted-by":"publisher","first-page":"T13","DOI":"10.1530\/JME-22-0097","volume":"69","author":"M Petkovich","year":"2022","unstructured":"Petkovich M, Chambon P. Retinoic acid receptors at 35 years. J Mol Endocrinol. 2022;69:T13\u201324. https:\/\/doi.org\/10.1530\/JME-22-0097.","journal-title":"J Mol Endocrinol"},{"key":"2789_CR6","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ctrv.2014.01.001","volume":"40","author":"E Garattini","year":"2014","unstructured":"Garattini E, Bolis M, Garattini SK, Fratelli M, Centritto F, Paroni G, et al. Retinoids and breast cancer: From basic studies to the clinic and back again. Cancer Treat Rev Elsevier. 2014;40:739\u201349. https:\/\/doi.org\/10.1016\/j.ctrv.2014.01.001.","journal-title":"Cancer Treat Rev Elsevier"},{"key":"2789_CR7","doi-asserted-by":"publisher","first-page":"42661","DOI":"10.18632\/oncotarget.7410","volume":"7","author":"E Garattini","year":"2016","unstructured":"Garattini E, Bolis M, Gianni\u2019 M, Paroni G, Fratelli M, Terao M. Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer. Oncotarget Impact Journals. 2016;7:42661\u201382. https:\/\/doi.org\/10.18632\/oncotarget.7410.","journal-title":"Oncotarget Impact Journals"},{"key":"2789_CR8","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.cell.2023.01.040","volume":"186","author":"E Nolan","year":"2023","unstructured":"Nolan E, Lindeman GJ, Visvader JE. Deciphering breast cancer: from biology to the clinic. Cell. 2023;186:1708\u201328. https:\/\/doi.org\/10.1016\/j.cell.2023.01.040.","journal-title":"Cell"},{"key":"2789_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-physiol-030212-183758","volume":"76","author":"SH Baek","year":"2014","unstructured":"Baek SH, Kim KI. Emerging Roles of Orphan Nuclear Receptors in Cancer. Annu Rev Physiol. 2014;76:177\u201395. https:\/\/doi.org\/10.1146\/annurev-physiol-030212-183758.","journal-title":"Annu Rev Physiol"},{"key":"2789_CR10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1210\/me.2013-1291","volume":"28","author":"S Safe","year":"2014","unstructured":"Safe S, Jin U-H, Hedrick E, Reeder A, Lee S-O, Minireview. Role Of Orphan Nuclear Receptors in Cancer and Potential as Drug Targets. Mol Endocrinol. 2014;28:157\u201372. https:\/\/doi.org\/10.1210\/me.2013-1291.","journal-title":"Mol Endocrinol"},{"key":"2789_CR11","doi-asserted-by":"publisher","first-page":"175883591983954","DOI":"10.1177\/1758835919839543","volume":"11","author":"F Ricci","year":"2019","unstructured":"Ricci F, Brunelli L, Affatato R, Chil\u00e0 R, Verza M, Indraccolo S, et al. Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenografts. Ther Adv Med Oncol. 2019;11:1758835919839543. https:\/\/doi.org\/10.1177\/1758835919839543.","journal-title":"Ther Adv Med Oncol"},{"key":"2789_CR12","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4161\/cam.36224","volume":"8","author":"JEN Jonkman","year":"2014","unstructured":"Jonkman JEN, Cathcart JA, Xu F, Bartolini ME, Amon JE, Stevens KM, et al. An introduction to the wound healing assay using live-cell microscopy. Cell Adhes Migr. 2014;8:440\u201351. https:\/\/doi.org\/10.4161\/cam.36224.","journal-title":"Cell Adhes Migr"},{"key":"2789_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1385\/1-59259-869-2:039","volume-title":"Chemosensitivity Vol 1 Vitro Assays [Internet]","author":"W Voigt","year":"2005","unstructured":"Voigt W, Sulforhodamine B. Assay and Chemosensitivity. In: Blumenthal RD, editor. Chemosensitivity Vol 1 Vitro Assays [Internet]. Totowa, NJ: Humana; 2005. pp. 39\u201348. [cited 2020 Jan 16]. https:\/\/doi.org\/10.1385\/1-59259-869-2:039."},{"key":"2789_CR14","doi-asserted-by":"publisher","unstructured":"Morabito A, De Simone G, Ferrario M, Falcetta F, Pastorelli R, Brunelli L. Metabolites. 2022;13:13. https:\/\/doi.org\/10.3390\/metabo13010013","DOI":"10.3390\/metabo13010013"},{"key":"2789_CR15","doi-asserted-by":"publisher","first-page":"950","DOI":"10.15252\/emmm.201404670","volume":"7","author":"F Centritto","year":"2015","unstructured":"Centritto F, Paroni G, Bolis M, Garattini SK, Kurosaki M, Barzago MM, et al. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RAR\u03b1 expression. EMBO Mol Med. 2015;7:950\u201372. https:\/\/doi.org\/10.15252\/emmm.201404670.","journal-title":"EMBO Mol Med"},{"key":"2789_CR16","doi-asserted-by":"publisher","first-page":"5734","DOI":"10.1111\/bph.70215","volume":"182","author":"M Posta","year":"2025","unstructured":"Posta M, Gy\u0151rffy B. Pathway-level mutational signatures predict breast cancer outcomes and reveal therapeutic targets. Br J Pharmacol. 2025;182:5734\u201347. https:\/\/doi.org\/10.1111\/bph.70215.","journal-title":"Br J Pharmacol"},{"key":"2789_CR17","doi-asserted-by":"publisher","first-page":"eadf6621","DOI":"10.1126\/sciadv.adf6621","volume":"9","author":"H Kim","year":"2023","unstructured":"Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, et al. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Sci Adv Am Association Advancement Sci. 2023;9:eadf6621. https:\/\/doi.org\/10.1126\/sciadv.adf6621.","journal-title":"Sci Adv Am Association Advancement Sci"},{"key":"2789_CR18","doi-asserted-by":"publisher","first-page":"qiae260","DOI":"10.1093\/jleuko\/qiae260","volume":"117","author":"H Miftah","year":"2025","unstructured":"Miftah H, Benthami H, Badou A. Insights into the emerging immune checkpoint NR2F6 in cancer immunity. J Leukoc Biol. 2025;117:qiae260. https:\/\/doi.org\/10.1093\/jleuko\/qiae260.","journal-title":"J Leukoc Biol"},{"key":"2789_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1146\/annurev-biochem-060815-014830","volume":"85","author":"K Newton","year":"2016","unstructured":"Newton K, Manning G. Necroptosis and Inflammation. Annu Rev Biochem. 2016;85:743\u201363. https:\/\/doi.org\/10.1146\/annurev-biochem-060815-014830.","journal-title":"Annu Rev Biochem"},{"key":"2789_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3390\/cells11030563","volume":"11","author":"Q Hao","year":"2022","unstructured":"Hao Q, Shetty S, Tucker TA, Idell S, Tang H. Interferon-\u03b3 Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL. Cells. 2022;11:563. https:\/\/doi.org\/10.3390\/cells11030563.","journal-title":"Cells"},{"key":"2789_CR21","doi-asserted-by":"publisher","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","volume":"273","author":"RU J\u00e4nicke","year":"1998","unstructured":"J\u00e4nicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis. J Biol Chem. 1998;273:9357\u201360. https:\/\/doi.org\/10.1074\/jbc.273.16.9357.","journal-title":"J Biol Chem"},{"key":"2789_CR22","doi-asserted-by":"publisher","first-page":"36916","DOI":"10.1074\/jbc.M301598200","volume":"278","author":"H Sakurai","year":"2003","unstructured":"Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, et al. Tumor Necrosis Factor-\u03b1-induced IKK Phosphorylation of NF-\u03baB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway. J Biol Chem. 2003;278:36916\u201323. https:\/\/doi.org\/10.1074\/jbc.M301598200.","journal-title":"J Biol Chem"},{"key":"2789_CR23","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41580-023-00623-w","volume":"24","author":"J Clucas","year":"2023","unstructured":"Clucas J, Meier P. Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death. Nat Rev Mol Cell Biol. 2023;24:835\u201352. https:\/\/doi.org\/10.1038\/s41580-023-00623-w.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2789_CR24","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1073\/pnas.0530291100","volume":"100","author":"M Al-Hajj","year":"2003","unstructured":"Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci. 2003;100:3983\u20138. https:\/\/doi.org\/10.1073\/pnas.0530291100.","journal-title":"Proc Natl Acad Sci"},{"key":"2789_CR25","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.3390\/jcm9051502","volume":"9","author":"M Giordano","year":"2020","unstructured":"Giordano M, Cavallaro U. Different Shades of L1CAM in the Pathophysiology of Cancer Stem Cells. J Clin Med. 2020;9:1502. https:\/\/doi.org\/10.3390\/jcm9051502.","journal-title":"J Clin Med"},{"key":"2789_CR26","doi-asserted-by":"publisher","first-page":"176754","DOI":"10.1016\/j.ejphar.2024.176754","volume":"977","author":"H Bai","year":"2024","unstructured":"Bai H, Xian N, Zhao F, Zhou Y, Qin S. The dual role of SUSD2 in cancer development. Eur J Pharmacol. 2024;977:176754. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176754.","journal-title":"Eur J Pharmacol"},{"key":"2789_CR27","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1182\/blood-2010-02-270777","volume":"116","author":"F Gieseke","year":"2010","unstructured":"Gieseke F, B\u00f6hringer J, Bussolari R, Dominici M, Handgretinger R, M\u00fcller I. Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood. 2010;116:3770\u20139. https:\/\/doi.org\/10.1182\/blood-2010-02-270777.","journal-title":"Blood"},{"key":"2789_CR28","doi-asserted-by":"publisher","unstructured":"Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K et al. S100A11, an Dual Mediator for Growth Regulation of Human Keratinocytes. Omary MB, editor. Mol Biol Cell. 2008;19:78\u201385. https:\/\/doi.org\/10.1091\/mbc.e07-07-0682","DOI":"10.1091\/mbc.e07-07-0682"},{"key":"2789_CR29","doi-asserted-by":"publisher","first-page":"8218","DOI":"10.1038\/ncomms9218","volume":"6","author":"A Chaumet","year":"2015","unstructured":"Chaumet A, Wright GD, Seet SH, Tham KM, Gounko NV, Bard F. Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. Nat Commun. 2015;6:8218. https:\/\/doi.org\/10.1038\/ncomms9218.","journal-title":"Nat Commun"},{"key":"2789_CR30","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3390\/cancers13020306","volume":"13","author":"V H\u00f6ffken","year":"2021","unstructured":"H\u00f6ffken V, Hermann A, Pavenst\u00e4dt H, Kremerskothen JWWC, Proteins. Important Regulators of Hippo Signaling in Cancer. Cancers MDPI AG. 2021;13:306. https:\/\/doi.org\/10.3390\/cancers13020306.","journal-title":"Cancers MDPI AG"},{"key":"2789_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06373-z","author":"Y Shuai","year":"2024","unstructured":"Shuai Y, Zhang H, Liu C, Wang J, Jiang Y, Sun J, et al. CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression. Cell Death Dis [Internet] Springer Sci Bus Media LLC. 2024. https:\/\/doi.org\/10.1038\/s41419-023-06373-z. [cited 2025 July 22];15.","journal-title":"Cell Death Dis [Internet] Springer Sci Bus Media LLC"},{"key":"2789_CR32","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1083\/jcb.200705108","volume":"179","author":"K Oishi","year":"2007","unstructured":"Oishi K, Okano H, Sawa H. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J Cell Biol Rockefeller Univ Press. 2007;179:1149\u201362. https:\/\/doi.org\/10.1083\/jcb.200705108.","journal-title":"J Cell Biol Rockefeller Univ Press"},{"key":"2789_CR33","doi-asserted-by":"publisher","first-page":"110997","DOI":"10.1016\/j.cellsig.2023.110997","volume":"114","author":"H Shi","year":"2024","unstructured":"Shi H, Luo J, Ye L, Duan C, Zhang M, Ran H, et al. SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK\/PI3K\/AKT signaling pathway. Cell Signal. 2024;114:110997. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110997.","journal-title":"Cell Signal"},{"key":"2789_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06843-2","author":"Z Huang","year":"2025","unstructured":"Huang Z, Zhu J, Zhou YL, Shi J. The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implications. J Transl Med [Internet] Springer Sci Bus Media LLC. 2025. https:\/\/doi.org\/10.1186\/s12967-025-06843-2. [cited 2025 July 22];23.","journal-title":"J Transl Med [Internet] Springer Sci Bus Media LLC"},{"key":"2789_CR35","doi-asserted-by":"publisher","first-page":"6074","DOI":"10.3390\/ijms21176074","volume":"21","author":"MJ O\u2019Sullivan","year":"2020","unstructured":"O\u2019Sullivan MJ, Lindsay AJ. The Endosomal Recycling Pathway\u2014At the Crossroads of the Cell. Int J Mol Sci. 2020;21:6074. https:\/\/doi.org\/10.3390\/ijms21176074.","journal-title":"Int J Mol Sci"},{"key":"2789_CR36","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1042\/BST20150269","volume":"44","author":"LP Wilhelm","year":"2016","unstructured":"Wilhelm LP, Tomasetto C, Alpy F. Touch\u00e9! STARD3 and STARD3NL tether the ER to endosomes. Biochem Soc Trans. 2016;44:493\u20138. https:\/\/doi.org\/10.1042\/BST20150269.","journal-title":"Biochem Soc Trans"},{"key":"2789_CR37","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1194\/jlr.R085324","volume":"59","author":"K Hanada","year":"2018","unstructured":"Hanada K. Lipid transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites. J Lipid Res. 2018;59:1341\u201366. https:\/\/doi.org\/10.1194\/jlr.R085324.","journal-title":"J Lipid Res"},{"key":"2789_CR38","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1210\/me.2012-1265","volume":"27","author":"GEO Muscat","year":"2013","unstructured":"Muscat GEO, Eriksson NA, Byth K, Loi S, Graham D, Jindal S, et al. Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Mol Endocrinol. 2013;27:350\u201365. https:\/\/doi.org\/10.1210\/me.2012-1265.","journal-title":"Mol Endocrinol"},{"key":"2789_CR39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.imlet.2016.03.007","volume":"178","author":"V Klepsch","year":"2016","unstructured":"Klepsch V, Hermann-Kleiter N, Baier G, Beyond. CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy. Immunol Lett. 2016;178:31\u20136. https:\/\/doi.org\/10.1016\/j.imlet.2016.03.007.","journal-title":"Immunol Lett"},{"key":"2789_CR40","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.3390\/cancers13112600","volume":"13","author":"V Klepsch","year":"2021","unstructured":"Klepsch V, Siegmund K, Baier G. Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6. Cancers. Multidisciplinary Digit Publishing Inst. 2021;13:2600. https:\/\/doi.org\/10.3390\/cancers13112600.","journal-title":"Multidisciplinary Digit Publishing Inst"},{"key":"2789_CR41","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/leu.2011.137","volume":"25","author":"CV Ichim","year":"2011","unstructured":"Ichim CV, Atkins HL, Iscove NN, Wells RA. Identification of a role for the nuclear receptor EAR-2 in the maintenance of clonogenic status within the leukemia cell hierarchy. Leuk Nat Publishing Group. 2011;25:1687\u201396. https:\/\/doi.org\/10.1038\/leu.2011.137.","journal-title":"Leuk Nat Publishing Group"},{"key":"2789_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.canlet.2011.05.025","volume":"309","author":"X Li","year":"2011","unstructured":"Li X, Jiao S, Sun H, Xue J, Zhao W, Fan L, et al. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. Cancer Lett. 2011;309:137\u201344. https:\/\/doi.org\/10.1016\/j.canlet.2011.05.025.","journal-title":"Cancer Lett"},{"key":"2789_CR43","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/ijc.32293","volume":"145","author":"H Li","year":"2019","unstructured":"Li H, Zhang W, Niu C, Lin C, Wu X, Jian Y, et al. Nuclear orphan receptor NR2F6 confers cisplatin resistance in epithelial ovarian cancer cells by activating the Notch3 signaling pathway. Int J Cancer. 2019;145:1921\u201334. https:\/\/doi.org\/10.1002\/ijc.32293.","journal-title":"Int J Cancer"},{"key":"2789_CR44","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1530\/ERC-19-0229","volume":"27","author":"J Zhang","year":"2020","unstructured":"Zhang J, Meng H, Zhang M, Zhang C, Huang M, Yan C, et al. Regulation of docetaxel chemosensitivity by NR2F6 in breast cancer. Endocr Relat Cancer Bioscientifica Ltd. 2020;27:309\u201323. https:\/\/doi.org\/10.1530\/ERC-19-0229.","journal-title":"Endocr Relat Cancer Bioscientifica Ltd"},{"key":"2789_CR45","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1210\/me.2010-0040","volume":"24","author":"S Holbeck","year":"2010","unstructured":"Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED. Expression Profiling of Nuclear Receptors in the NCI60 Cancer Cell Panel Reveals Receptor-Drug and Receptor-Gene Interactions. Mol Endocrinol. 2010;24:1287\u201396. https:\/\/doi.org\/10.1210\/me.2010-0040.","journal-title":"Mol Endocrinol"},{"key":"2789_CR46","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41419-025-07407-4","volume":"16","author":"J Woelk","year":"2025","unstructured":"Woelk J, Hornsteiner F, Aschauer-Wallner S, Stoitzner P, Baier G, Hermann-Kleiter N. Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6. Cell Death Dis. 2025;16:77. https:\/\/doi.org\/10.1038\/s41419-025-07407-4.","journal-title":"Cell Death Dis"},{"key":"2789_CR47","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1478-811X-12-38","volume":"12","author":"N Hermann-Kleiter","year":"2014","unstructured":"Hermann-Kleiter N, Baier G. Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4\u2009+\u2009T cell effector functions. Cell Commun Signal CCS. 2014;12:38. https:\/\/doi.org\/10.1186\/1478-811X-12-38.","journal-title":"Cell Commun Signal CCS"},{"key":"2789_CR48","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/s41467-018-04004-2","volume":"9","author":"V Klepsch","year":"2018","unstructured":"Klepsch V, Hermann-Kleiter N, Do-Dinh P, Jakic B, Offermann A, Efremova M, et al. Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1\/PD-1 cancer immune checkpoint blockade. Nat Commun. 2018;9:1538. https:\/\/doi.org\/10.1038\/s41467-018-04004-2.","journal-title":"Nat Commun"},{"key":"2789_CR49","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1016\/j.celrep.2015.08.035","volume":"12","author":"N Hermann-Kleiter","year":"2015","unstructured":"Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, et al. The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance. Cell Rep Elsevier. 2015;12:2072\u201385. https:\/\/doi.org\/10.1016\/j.celrep.2015.08.035.","journal-title":"Cell Rep Elsevier"},{"key":"2789_CR50","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.jaut.2012.07.007","volume":"39","author":"N Hermann-Kleiter","year":"2012","unstructured":"Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, M\u00fcller M, Roth L, et al. Nuclear orphan receptor NR2F6 directly antagonizes NFAT and ROR\u03b3t binding to the Il17a promoter. J Autoimmun. 2012;39:428\u201340. https:\/\/doi.org\/10.1016\/j.jaut.2012.07.007.","journal-title":"J Autoimmun"},{"key":"2789_CR51","doi-asserted-by":"publisher","first-page":"951","DOI":"10.3390\/futurepharmacol3040058","volume":"3","author":"MCI de S\u00e1","year":"2023","unstructured":"de S\u00e1 MCI, Castor MGM. Therapeutic Use of Palmitoylethanolamide as an Anti-Inflammatory and Immunomodulator. Future Pharmacol Multidisciplinary Digit Publishing Inst. 2023;3:951\u201377. https:\/\/doi.org\/10.3390\/futurepharmacol3040058.","journal-title":"Future Pharmacol Multidisciplinary Digit Publishing Inst"}],"updated-by":[{"DOI":"10.1186\/s12964-026-03226-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000}}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-02789-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02789-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02789-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:32:03Z","timestamp":1790487123000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-026-02789-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2789"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-02789-0","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"5 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: the authors would like to update figure 3 which was mistakenly processed by the production team.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12964-026-03226-y","URL":"https:\/\/doi.org\/10.1186\/s12964-026-03226-y","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"233"}}