{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:37:01Z","timestamp":1777333021930,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"crossref","award":["2025A03J4454"],"award-info":[{"award-number":["2025A03J4454"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"crossref","award":["2023A03J0859"],"award-info":[{"award-number":["2023A03J0859"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-02794-3","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:23:52Z","timestamp":1773876232000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of CA12 drive proliferation and fibrosis in type i congenital pulmonary airway malformation via promoting abnormal activation of SHH signaling"],"prefix":"10.1186","volume":"24","author":[{"given":"Zefeng","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan Sai Hou","family":"Alexandre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"issue":"3","key":"2794_CR1","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/ppul.25785","volume":"57","author":"W Xu","year":"2022","unstructured":"Xu W, Gao Y, Li W, Chen Z, Li Q, Li R, Liu H, Dai L. A national descriptive epidemiologic analysis on congenital pulmonary airway malformation in China, 2010\u20132019. Pediatr Pulmonol. 2022;57(3):674\u201381. https:\/\/doi.org\/10.1002\/ppul.25785.","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"2794_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00383-016-3991-1","volume":"33","author":"CT Lau","year":"2017","unstructured":"Lau CT, Kan A, Shek N, Tam P, Wong KK. Is congenital pulmonary airway malformation really a rare disease? Result of a prospective registry with universal antenatal screening program. Pediatr Surg Int. 2017;33(1):105\u20138. https:\/\/doi.org\/10.1007\/s00383-016-3991-1.","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"2794_CR3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.62347\/qktk5963","volume":"16","author":"J Liao","year":"2024","unstructured":"Liao J, Lin M, Zeng J, Wang F, Tang J, Yang Q, Huang D, Lin Z, Liang J, Li L. Prognosis of infants with congenital pulmonary airway malformations after surgery: a short and mid-term evaluation. Am J Transl Res. 2024;16(1):208\u201315. https:\/\/doi.org\/10.62347\/qktk5963.","journal-title":"Am J Transl Res"},{"key":"2794_CR4","doi-asserted-by":"publisher","unstructured":"Stocker JT, Madewell JE, Drake RM. Congenital cystic adenomatoid malformation of the lung. Classification and morphologic spectrum, Hum Pathol.1977;8(2):155\u2009\u2013\u200971. https:\/\/doi.org\/10.1016\/s0046-8177(77)80078-6.","DOI":"10.1016\/s0046-8177(77)80078-6"},{"key":"2794_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.humpath.2020.07.015","volume":"103","author":"SM Hermelijn","year":"2020","unstructured":"Hermelijn SM, Wolf JL, Dorine den Toom T, Wijnen RMH, Rottier RJ, Schnater JM., and von der Th\u00fcsen J H. Early KRAS oncogenic driver mutations in nonmucinous tissue of congenital pulmonary airway malformations as an indicator of potential malignant behavior. Hum Pathol. 2020;103:95\u2013106. https:\/\/doi.org\/10.1016\/j.humpath.2020.07.015.","journal-title":"Hum Pathol"},{"issue":"2","key":"2794_CR6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/ajcp\/aqaa245","volume":"156","author":"XF de Cordova","year":"2021","unstructured":"de Cordova XF, Wang H, Mehrad M, Eisenberg R, Johnson J, Wei Q, Borinstein S, Danko ME, Liang J. Mucinous Adenocarcinoma With Intrapulmonary Metastasis Harboring KRAS and GNAS Mutations Arising in Congenital Pulmonary Airway Malformation. Am J Clin Pathol. 2021;156(2):313\u20139. https:\/\/doi.org\/10.1093\/ajcp\/aqaa245.","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"2794_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12931-023-02436-z","volume":"24","author":"Z Tan","year":"2023","unstructured":"Tan Z, Li F, Chen Q, Chen H, Xue Z, Zhang J, Gao Y, Liang L, Huang T, Zhang S, Li J, Shu Q, Yu L. Integrated bulk and single-cell RNA-sequencing reveals SPOCK2 as a novel biomarker gene in the development of congenital pulmonary airway malformation. Respir Res. 2023;24(1):127. https:\/\/doi.org\/10.1186\/s12931-023-02436-z.","journal-title":"Respir Res"},{"key":"2794_CR8","doi-asserted-by":"publisher","first-page":"6428579","DOI":"10.1155\/2023\/6428579","volume":"2023","author":"J Zeng","year":"2023","unstructured":"Zeng J, Zhang X, Yang Q, Peng J, Wang F, Tang J, Xu Y, Huang D, Liang J, Li L. The Role of the miR-548au-3p\/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations. Oxid Med Cell Longev. 2023;2023:6428579. https:\/\/doi.org\/10.1155\/2023\/6428579.","journal-title":"Oxid Med Cell Longev"},{"key":"2794_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/ijms23084342","volume":"23","author":"A Aspatwar","year":"2022","unstructured":"Aspatwar A, Syrj\u00e4nen L, Parkkila S. Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish. Int J Mol Sci. 2022;23:8. https:\/\/doi.org\/10.3390\/ijms23084342.","journal-title":"Int J Mol Sci"},{"key":"2794_CR10","doi-asserted-by":"publisher","first-page":"595969","DOI":"10.3389\/fcell.2020.595969","volume":"8","author":"X Zhao","year":"2020","unstructured":"Zhao X, Shen P, Li H, Yang Y, Guo J, Chen S, Ma Y, Sheng J, Shen S, Liu G, Fang X. Carbonic Anhydrase 12 Protects Endplate Cartilage From Degeneration Regulated by IGF-1\/PI3K\/CREB Signaling Pathway. Front Cell Dev Biol. 2020;8:595969. https:\/\/doi.org\/10.3389\/fcell.2020.595969.","journal-title":"Front Cell Dev Biol"},{"key":"2794_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/ijms26020496","volume":"26","author":"N Azuma","year":"2025","unstructured":"Azuma N, Tadokoro K, Yamada M, Nakafuku M. Sonic Hedgehog Determines Early Retinal Development and Adjusts Eyeball Architecture. Int J Mol Sci. 2025;26:2. https:\/\/doi.org\/10.3390\/ijms26020496.","journal-title":"Int J Mol Sci"},{"key":"2794_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jdb5010003","volume":"5","author":"H Fernandes-Silva","year":"2017","unstructured":"Fernandes-Silva H, Correia-Pinto J, Moura RS. Canonical Sonic Hedgehog Signaling in Early Lung Development. J Dev Biol. 2017;5:1. https:\/\/doi.org\/10.3390\/jdb5010003.","journal-title":"J Dev Biol"},{"key":"2794_CR13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.tcb.2019.02.005","volume":"29","author":"ET Hall","year":"2019","unstructured":"Hall ET, Cleverdon ER, Ogden SK. Dispatching Sonic Hedgehog: Molecular Mechanisms Controlling Deployment. Trends Cell Biol. 2019;29:5, 385\u201395. https:\/\/doi.org\/10.1016\/j.tcb.2019.02.005.","journal-title":"Trends Cell Biol"},{"key":"2794_CR14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1750-1172-8-130","volume":"8","author":"G Lezmi","year":"2013","unstructured":"Lezmi G, Verkarre V, Khen-Dunlop N, Vibhushan S, Hadchouel A, Rambaud C, Copin MC, Rittie JL, Benachi A, Fournet JC, Delacourt C. FGF10 Signaling differences between type I pleuropulmonary blastoma and congenital cystic adenomatoid malformation. Orphanet J Rare Dis. 2013;8:130. https:\/\/doi.org\/10.1186\/1750-1172-8-130.","journal-title":"Orphanet J Rare Dis"},{"key":"2794_CR15","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1111\/febs.15669","volume":"288","author":"J Hou","year":"2021","unstructured":"Hou J, Ji J, Chen X, Cao H, Tan Y, Cui Y, Xiang Z, Han X. Alveolar epithelial cell-derived Sonic hedgehog promotes pulmonary fibrosis through OPN-dependent alternative macrophage activation. Febs j. 2021;288:11, 3530\u201346. https:\/\/doi.org\/10.1111\/febs.15669.","journal-title":"Febs j"},{"key":"2794_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/jdb7030014","volume":"7","author":"C Wang","year":"2019","unstructured":"Wang C, Cassandras M, Peng T. The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance. J Dev Biol. 2019;7:3. https:\/\/doi.org\/10.3390\/jdb7030014.","journal-title":"J Dev Biol"},{"issue":"1","key":"2794_CR17","doi-asserted-by":"publisher","first-page":"2247181","DOI":"10.1080\/14756366.2023.2247181","volume":"38","author":"HJ Kim","year":"2023","unstructured":"Kim HJ, Hong JH. Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells. J Enzyme Inhib Med Chem. 2023;38(1):2247181. https:\/\/doi.org\/10.1080\/14756366.2023.2247181.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2794_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1113\/jp271378","volume":"593","author":"JH Hong","year":"2015","unstructured":"Hong JH, Muhammad E, Zheng C, Hershkovitz E, Alkrinawi S, Loewenthal N, Parvari R, Muallem S. Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation. J Physiol. 2015;593:24. https:\/\/doi.org\/10.1113\/jp271378.","journal-title":"J Physiol"},{"issue":"5","key":"2794_CR19","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1007\/s00432-020-03447-9","volume":"147","author":"Y Du","year":"2021","unstructured":"Du Y, Xin Z, Liu T, Xu P, Mao F, Yao J. Overexpressed CA12 has prognostic value in pancreatic cancer and promotes tumor cell apoptosis via NF-\u03baB signaling. J Cancer Res Clin Oncol. 2021;147(5):1557\u201364. https:\/\/doi.org\/10.1007\/s00432-020-03447-9.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"2794_CR20","doi-asserted-by":"publisher","first-page":"420","DOI":"10.4149\/neo_2018_180819N624","volume":"66","author":"Y Li","year":"2019","unstructured":"Li Y, Lei B, Zou J, Wang W, Chen A, Zhang J, Fu Y, Li Z. High expression of carbonic anhydrase 12 (CA12) is associated with good prognosis in breast cancer. Neoplasma. 2019;66(3):420\u20136. https:\/\/doi.org\/10.4149\/neo_2018_180819N624.","journal-title":"Neoplasma"},{"key":"2794_CR21","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/ijc.25491","volume":"128","author":"MI Ilie","year":"2011","unstructured":"Ilie MI, Hofman V, Ortholan C, Ammadi RE, Bonnetaud C, Havet K, Venissac N, Mouroux J, Mazure NM, Pouyss\u00e9gur J, Hofman P. Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis. Int J Cancer. 2011;128:7, 1614\u201323. https:\/\/doi.org\/10.1002\/ijc.25491.","journal-title":"Int J Cancer"},{"issue":"1","key":"2794_CR22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13046-024-03012-z","volume":"43","author":"C Deben","year":"2024","unstructured":"Deben C, Boullosa LF, Fortes FR, De La Hoz EC, Le Compte M, Seghers S, Peeters M, Vanlanduit S, Lin A, Dijkstra KK, Van Schil P, Hendriks JMH, Prenen H, Roeyen G, Lardon F, Smits E. Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition. J Exp Clin Cancer Res. 2024;43(1):88. https:\/\/doi.org\/10.1186\/s13046-024-03012-z.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"2794_CR23","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1186\/s13018-024-05262-1","volume":"19","author":"G Deng","year":"2024","unstructured":"Deng G, Xu Y, Li Z, Zeng G. WTAP mediates IL-1\u03b2-induced chondrocyte injury by enhancing CA12 mRNA stability depending on m6A modification. J Orthop Surg Res. 2024;19(1):826. https:\/\/doi.org\/10.1186\/s13018-024-05262-1.","journal-title":"J Orthop Surg Res"},{"key":"2794_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.matbio.2018.08.003","volume":"77","author":"H Pan","year":"2019","unstructured":"Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1\u03b1 signaling in nucleus pulposus cells. Matrix Biol. 2019;77:23\u201340. https:\/\/doi.org\/10.1016\/j.matbio.2018.08.003.","journal-title":"Matrix Biol"},{"key":"2794_CR25","doi-asserted-by":"publisher","unstructured":"Jiang Y, Luo Y, Tang Y, Moats R, Warburton D, Zhou S, Lou J, Pryhuber G S, Shi W, Wang LL. Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. Sci Rep. 2019;9(1):5296. https:\/\/doi.org\/10.1038\/s41598-019-41777-y.","DOI":"10.1038\/s41598-019-41777-y"},{"key":"2794_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.kint.2019.08.023","volume":"97","author":"KS Kamel","year":"2020","unstructured":"Kamel KS, Oh MS, Halperin ML. L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. Kidney Int. 2020;97:1, 75\u201388. https:\/\/doi.org\/10.1016\/j.kint.2019.08.023.","journal-title":"Kidney Int"},{"key":"2794_CR27","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41584-021-00621-2","volume":"17","author":"ES Silagi","year":"2021","unstructured":"Silagi ES, Schipani E, Shapiro IM, Risbud MV. The role of HIF proteins in maintaining the metabolic health of the intervertebral disc. Nat Rev Rheumatol. 2021;17:7, 426\u201339. https:\/\/doi.org\/10.1038\/s41584-021-00621-2.","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"2794_CR28","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/labinvest.2016.32","volume":"96","author":"S Chen","year":"2016","unstructured":"Chen S, Fang XQ, Wang Q, Wang SW, Hu ZJ, Zhou ZJ, Xu WB, Wang JY, Qin A, Fan SW. PHD\/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. Lab Invest. 2016;96(5):561\u20139. https:\/\/doi.org\/10.1038\/labinvest.2016.32.","journal-title":"Lab Invest"},{"issue":"5","key":"2794_CR29","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/s41401-023-01219-y","volume":"45","author":"LB Li","year":"2024","unstructured":"Li LB, Yang LX, Liu L, Liu FR, Li AH, Zhu YL, Wen H, Xue X, Tian ZX, Sun H, Li PC, Zhao XG. Targeted inhibition of the HNF1A\/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer. Acta Pharmacol Sin. 2024;45(5):1060\u201376. https:\/\/doi.org\/10.1038\/s41401-023-01219-y.","journal-title":"Acta Pharmacol Sin"},{"key":"2794_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2019.01.002","volume":"365","author":"M Zhang","year":"2019","unstructured":"Zhang M, Tan S, Yu D, Zhao Z, Zhang B, Zhang P, Lv C, Zhou Q, Cao Z. Triptonide inhibits lung cancer cell tumorigenicity by selectively attenuating the Shh-Gli1 signaling pathway. Toxicol Appl Pharmacol. 2019;365:1\u20138. https:\/\/doi.org\/10.1016\/j.taap.2019.01.002.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"2794_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00262-022-03215-3","volume":"72","author":"L Longhitano","year":"2023","unstructured":"Longhitano L, Vicario N, Forte S, Giallongo C, Broggi G, Caltabiano R, Barbagallo GM, V, Altieri R, Raciti G, Di Rosa M, Caruso M, Parenti R, Liso A, Busi F, Lolicato M, Mione MC, Li Volti G, Tibullo D. Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. Cancer Immunol Immunother. 2023;72(1):1\u201320. https:\/\/doi.org\/10.1007\/s00262-022-03215-3.","journal-title":"Cancer Immunol Immunother"},{"issue":"5","key":"2794_CR32","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.7150\/ijbs.91492","volume":"20","author":"X Yu","year":"2024","unstructured":"Yu X, Yang J, Xu J, Pan H, Wang W, Yu X, Shi S. Histone lactylation: from tumor lactate metabolism to epigenetic regulation. Int J Biol Sci. 2024;20(5):1833\u201354. https:\/\/doi.org\/10.7150\/ijbs.91492.","journal-title":"Int J Biol Sci"},{"key":"2794_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11658-024-00541-5","volume":"29","author":"J Wang","year":"2024","unstructured":"Wang J, Wang Z, Wang Q, Li X, Guo Y. Ubiquitous protein lactylation in health and diseases. Cell Mol Biol Lett. 2024;29:1. https:\/\/doi.org\/10.1186\/s11658-024-00541-5.","journal-title":"Cell Mol Biol Lett"},{"issue":"4","key":"2794_CR34","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1165\/rcmb.2014-0108OC","volume":"52","author":"B Hu","year":"2015","unstructured":"Hu B, Liu J, Wu Z, Liu T, Ullenbruch MR, Ding L, Henke CA, Bitterman PB, Phan SH. Reemergence of hedgehog mediates epithelial-mesenchymal crosstalk in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2015;52(4):418\u201328. https:\/\/doi.org\/10.1165\/rcmb.2014-0108OC.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"11","key":"2794_CR35","doi-asserted-by":"publisher","first-page":"L978","DOI":"10.1152\/ajplung.00184.2012","volume":"303","author":"AL Bola\u00f1os","year":"2012","unstructured":"Bola\u00f1os AL, Milla CM, Lira JC, Ram\u00edrez R, Checa M, Barrera L, Garc\u00eda-Alvarez J, Carbajal V, Becerril C, Gaxiola M, Pardo A, Selman M. Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2012;303(11):L978\u201390. https:\/\/doi.org\/10.1152\/ajplung.00184.2012.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2794_CR36","doi-asserted-by":"publisher","unstructured":"Andersen AP, Sams\u00f8e-Petersen J, Oernbo EK, Boedtkjer E. The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms, 2018;142(12):2529\u201342. https:\/\/doi.org\/10.1002\/ijc.31276.","DOI":"10.1002\/ijc.31276"},{"key":"2794_CR37","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.devcel.2020.06.018","volume":"54","author":"F Li","year":"2020","unstructured":"Li F, Simon MC. Cancer Cells Don\u2019t Live Alone: Metabolic Communication within Tumor Microenvironments. Dev Cell. 2020;54:2, 183\u201395. https:\/\/doi.org\/10.1016\/j.devcel.2020.06.018.","journal-title":"Dev Cell"},{"key":"2794_CR38","doi-asserted-by":"publisher","first-page":"121219","DOI":"10.1016\/j.lfs.2022.121219","volume":"312","author":"RA Di Mattia","year":"2023","unstructured":"Di Mattia RA, Diaz-Zegarra LA, Blanco PG, Valverde CA, Gonano LA, Jaquenod De Giusti C, Portiansky EL, Vila-Petroff MG, Aiello EA, Orlowski A. The specific inhibition of the cardiac electrogenic sodium\/bicarbonate cotransporter leads to cardiac hypertrophy. Life Sci. 2023;312:121219. https:\/\/doi.org\/10.1016\/j.lfs.2022.121219.","journal-title":"Life Sci"},{"issue":"12","key":"2794_CR39","doi-asserted-by":"publisher","first-page":"F1765","DOI":"10.1152\/ajprenal.00096.2013","volume":"305","author":"A Orlowski","year":"2013","unstructured":"Orlowski A, Vargas LA, Aiello EA, \u00c1lvarez BV. Elevated carbon dioxide upregulates NBCn1 Na+\/HCO3(-) cotransporter in human embryonic kidney cells. Am J Physiol Ren Physiol. 2013;305(12):F1765\u201374. https:\/\/doi.org\/10.1152\/ajprenal.00096.2013.","journal-title":"Am J Physiol Ren Physiol"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-02794-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02794-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-02794-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:57:06Z","timestamp":1777330626000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-026-02794-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2794"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-02794-3","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"1 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Women and Children\u2019s Medical Center Affiliated to Guangzhou Medical University Ethics Committee (No. [2025]101B00). Written informed consent was obtained from the patients and their parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"255"}}