{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:40:35Z","timestamp":1792525235643,"version":"4.5.0"},"reference-count":224,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Department of Science and Technology of Jilin Province","award":["YDZJ202102CXJD011"],"award-info":[{"award-number":["YDZJ202102CXJD011"]}]},{"name":"Jilin Provincial Health Commission","award":["2021LC016"],"award-info":[{"award-number":["2021LC016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-03073-x","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:07:49Z","timestamp":1784869669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circadian clock and its potential as a therapy for ischemic heart disease"],"prefix":"10.1186","volume":"24","author":[{"given":"Yiran","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-6806","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"3073_CR1","doi-asserted-by":"crossref","unstructured":"Mure LS, Le HD, Benegiamo G, Chang MW, Rios L, Jillani N, Ngotho M, Kariuki T, Dkhissi-Benyahya O, Cooper HM, Panda S. Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. 2018;359(6381):eaao0318.","DOI":"10.1126\/science.aao0318"},{"key":"3073_CR2","doi-asserted-by":"crossref","unstructured":"Delb\u00e8s AS, Qui\u00f1ones M, Gobet C, Castel J, Denis RG, Berthelet J, Weger BD, Challet E, Charpagne A, Metairon S, Piccand J. Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior. 2023;9(20):eadf2982\u201323.","DOI":"10.1126\/sciadv.adf2982"},{"key":"3073_CR3","doi-asserted-by":"crossref","unstructured":"Liu Z, Liu W, Wu Q, Xie Z, Qi K, Zhang S, Wu J, Wang P. Dual roles of pear EARLY FLOWERING 4 -like genes in regulating flowering and leaf senescence. 2024;24(1):1117.","DOI":"10.1186\/s12870-024-05850-7"},{"key":"3073_CR4","doi-asserted-by":"crossref","unstructured":"Xu Y, Xiao W. NAD+: An Old but Promising Therapeutic Agent for Skeletal Muscle Ageing. 2023:102106.","DOI":"10.1016\/j.arr.2023.102106"},{"key":"3073_CR5","doi-asserted-by":"crossref","unstructured":"Speksnijder EM, Bisschop PH, Siegelaar SE, Stenvers DJ, Kalsbeek A. Circadian desynchrony and glucose metabolism. 2024;76(4)e12956.","DOI":"10.1111\/jpi.12956"},{"key":"3073_CR6","doi-asserted-by":"crossref","unstructured":"Reynders M, Willems S, Marschner JA, Wein T, Merk D, Thorn\u2010Seshold O. A High-Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor ROR\u03b3. 2024;63(49):e202410139.","DOI":"10.1002\/anie.202410139"},{"key":"3073_CR7","doi-asserted-by":"crossref","unstructured":"Wei J, Wu H, Zheng Y, Weng B, Xiao Y, Benedict C, Wang N, Luo XH, Tan X. Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases. 2025;77(4):e70067.","DOI":"10.1111\/jpi.70067"},{"key":"3073_CR8","doi-asserted-by":"crossref","unstructured":"Schrader LA, Ronnekleiv-Kelly SM, Hogenesch JB, Bradfield CA, Malecki KM. Circadian disruption, clock genes, and metabolic health. 2024;134(14):e170998.","DOI":"10.1172\/JCI170998"},{"key":"3073_CR9","doi-asserted-by":"crossref","unstructured":"Xin M, Bi F, Wang C, Huang Y, Xu Y, Liang S, Cai T, Xu X, Dong L, Li T, Wang X. The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system. 2024;69(0):495\u2013514.","DOI":"10.1016\/j.jare.2024.04.005"},{"key":"3073_CR10","doi-asserted-by":"crossref","unstructured":"Zeng Q, Oliva VM, Moro M\u00c1, Scheiermann C. Circadian Effects on Vascular Immunopathologies. 2024;134(6):791\u2013809.","DOI":"10.1161\/CIRCRESAHA.123.323619"},{"key":"3073_CR11","doi-asserted-by":"crossref","unstructured":"Delisle BP, Prabhat A, Burgess DE, Ono M, Esser KA, Schroder EA, Circadian Regulation of Cardiac Arrhythmias and Electrophysiology. 2024;134(6):659\u201374.","DOI":"10.1161\/CIRCRESAHA.123.323513"},{"key":"3073_CR12","doi-asserted-by":"crossref","unstructured":"Festus ID, Spilberg J, Young ME, Cain S, Khoshnevis S, Smolensky MH, Zaheer F, Descalzi G, Martino TA. Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health. 2024;35(7):607\u201323.","DOI":"10.1016\/j.tem.2024.02.011"},{"key":"3073_CR13","doi-asserted-by":"crossref","unstructured":"Rabinovich-Nikitin I, Kirshenbaum E, Kirshenbaum LA. Autophagy, Clock Genes, and Cardiovascular Disease. Can J Cardiol. 2023;39(12):1772\u201380.","DOI":"10.1016\/j.cjca.2023.08.022"},{"key":"3073_CR14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-031521-033828","author":"E Nyamugenda","year":"2024","unstructured":"Nyamugenda E, Rosensweig C, Allada R. Circadian clocks, daily stress, and neurodegenerative disease. Annu Rev Pathol Mech Dis. 2025(1):355\u201374. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-031521-033828.","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"6","key":"3073_CR15","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1161\/CIRCRESAHA.123.323619","volume":"134","author":"Q Zeng","year":"2024","unstructured":"Zeng Q, Oliva V, Moro M, Scheiermann C. Circadian effects on vascular immunopathologies. Circ Res. 2024;134(6):791\u2013809.","journal-title":"Circ Res"},{"key":"3073_CR16","doi-asserted-by":"crossref","unstructured":"Jiang Q, Ding Y, Li F, Fayyaz AI, Duan H, Geng X. Modulation of NLRP3 inflammasome-related-inflammation via RIPK1\/RIPK3-DRP1 or HIF-1\u03b1 signaling by phenothiazine in hypothermic and normothermic neuroprotection after acute ischemic stroke. Redox Biol. 2024;73(0):103169.","DOI":"10.1016\/j.redox.2024.103169"},{"key":"3073_CR17","doi-asserted-by":"crossref","unstructured":"Eckle T, Ko\u0308hler D, Lehmann R, El Kasmi KC, Eltzschig HK. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation. 2008;118(2):166\u201375.","DOI":"10.1161\/CIRCULATIONAHA.107.758516"},{"key":"3073_CR18","doi-asserted-by":"crossref","unstructured":"Bartman CM, Eckle T. Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease. Curr Pharm Des. 2019;25(10):1075\u201390.","DOI":"10.2174\/1381612825666190516081612"},{"key":"3073_CR19","doi-asserted-by":"crossref","unstructured":"Wallach T, Kramer A. Chemical chronobiology: Toward drugs manipulating time, FEBS Lett. 2015;589(14):1530\u20138.","DOI":"10.1016\/j.febslet.2015.04.059"},{"key":"3073_CR20","doi-asserted-by":"crossref","unstructured":"Levi F, Schibler U. Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol. 2007;47(0):593\u2013628.","DOI":"10.1146\/annurev.pharmtox.47.120505.105208"},{"key":"3073_CR21","doi-asserted-by":"crossref","unstructured":"Hirota T, Kay SA. High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. 2009; Chem Biol. 16(9):921\u20137.","DOI":"10.1016\/j.chembiol.2009.09.002"},{"key":"3073_CR22","doi-asserted-by":"crossref","unstructured":"Okamura H, Doi M, Fustin JM, Yamaguchi Y, Matsuo M. Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences. 2010;62(9-10):876\u201384.","DOI":"10.1016\/j.addr.2010.06.004"},{"key":"3073_CR23","doi-asserted-by":"crossref","unstructured":"An Y, Yuan B, Xie P, Gu Y, Liu Z, Wang T, Li Z, Xu Y, Liu Y. Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction. 2022;13(1):3991.","DOI":"10.1038\/s41467-022-31715-4"},{"key":"3073_CR24","doi-asserted-by":"crossref","unstructured":"Francisco JC, Virshup DM. Hierarchical and scaffolded phosphorylation of two degrons controls PER2 stability. 2024;300(6):107391.","DOI":"10.1016\/j.jbc.2024.107391"},{"key":"3073_CR25","doi-asserted-by":"crossref","unstructured":"Narasimamurthy R, Virshup DM. The phosphorylation switch that regulates ticking of the circadian clock. 2021;81(6):1133\u201346.","DOI":"10.1016\/j.molcel.2021.01.006"},{"key":"3073_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042373","author":"S Confino","year":"2022","unstructured":"Confino S, Dor T, Tovin A, Wexler Y, Ben-Moshe Livne Z, Kolker M, et al. A Zebrafish model for a rare genetic disease reveals a conserved role for FBXL3 in the circadian clock system. Int J Mol Sci. 2022;23(4):2373. https:\/\/doi.org\/10.3390\/ijms23042373.","journal-title":"Int J Mol Sci"},{"key":"3073_CR27","doi-asserted-by":"crossref","unstructured":"Ukai-Tadenuma M, Yamada RG, Xu H, Ripperger JA, Liu AC, Ueda HR. Delay in feedback repression by cryptochrome 1 is required for circadian clock function. 2011;144(2):268\u201381.","DOI":"10.1016\/j.cell.2010.12.019"},{"key":"3073_CR28","doi-asserted-by":"crossref","unstructured":"Turkowska E, Pietruszka D, Skwarlo-Sonta K. Thymic E4bp4 gene transcription is up-regulated in the chicken during experimental peritonitis modified by the season-related lighting conditions. 2016;65(0):309\u201313.","DOI":"10.1016\/j.dci.2016.08.002"},{"issue":"6","key":"3073_CR29","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1007\/s00018-020-03713-6","volume":"78","author":"S Soni","year":"2021","unstructured":"Soni S, Basu P, Singaravel M, Sharma R, Pandi-Perumal S, Cardinali D, et al. Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1. Cell Mol Life Sci. 2021;78(6):2503\u201315.","journal-title":"Cell Mol Life Sci"},{"key":"3073_CR30","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.addr.2010.06.004","volume":"62","author":"H Okamura","year":"2010","unstructured":"Okamura H, Doi M, Fustin J, Yamaguchi Y, Matsuo M. Mammalian circadian clock system: molecular mechanisms for pharmaceutical and medical sciences. Adv Drug Deliv Rev. 2010;62:876\u201384.","journal-title":"Adv Drug Deliv Rev"},{"key":"3073_CR31","doi-asserted-by":"crossref","unstructured":"Preitner N, Damiola F, Zakany J, Duboule D, Albrecht U, Schibler U. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. 2002;110(2):251\u201360.","DOI":"10.1016\/S0092-8674(02)00825-5"},{"issue":"5927","key":"3073_CR32","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1126\/science.1171641","volume":"324","author":"K Ramsey","year":"2009","unstructured":"Ramsey K, Yoshino J, Brace C, Abrassart D, Kobayashi Y, Marcheva B, et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009;324(5927):651\u20134.","journal-title":"Science"},{"issue":"5927","key":"3073_CR33","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1126\/science.1170803","volume":"324","author":"Y Nakahata","year":"2009","unstructured":"Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science. 2009;324(5927):654\u20137.","journal-title":"Science"},{"issue":"2","key":"3073_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","volume":"134","author":"Y Nakahata","year":"2008","unstructured":"Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008;134(2):329\u201340.","journal-title":"Cell"},{"key":"3073_CR35","doi-asserted-by":"crossref","unstructured":"Um JH, Yang S, Yamazaki S, Kang H, Viollet B, Foretz M, Chung JH. Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2. 2007;282(29):20794\u20138.","DOI":"10.1074\/jbc.C700070200"},{"key":"3073_CR36","doi-asserted-by":"crossref","unstructured":"Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR. NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus. 2018;7(0):e31656.","DOI":"10.7554\/eLife.31656"},{"key":"3073_CR37","doi-asserted-by":"crossref","unstructured":"Bellet MM, Zocchi L, Sassone-Corsi P. The RelB subunit of NF\u03baB acts as a negative regulator of circadian gene expression. 2012;11(17):3304\u201311.","DOI":"10.4161\/cc.21669"},{"key":"3073_CR38","doi-asserted-by":"crossref","unstructured":"Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP. Core circadian protein CLOCK is a positive regulator of NF-\u03baB-mediated transcription. 2012;109(37):E2457\u201365.","DOI":"10.1073\/pnas.1206274109"},{"issue":"12","key":"3073_CR39","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1016\/j.jmb.2020.02.002","volume":"432","author":"A Morris","year":"2020","unstructured":"Morris A, Stanton D, Roman D, Liu A. Systems level understanding of circadian integration with cell physiology. J Mol Biol. 2020;432(12):3547\u201364.","journal-title":"J Mol Biol"},{"issue":"5","key":"3073_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007369","volume":"14","author":"C Ramanathan","year":"2018","unstructured":"Ramanathan C, Kathale N, Liu D, Lee C, Freeman D, Hogenesch J, et al. mTOR signaling regulates central and peripheral circadian clock function. PLoS Genet. 2018;14(5):e1007369.","journal-title":"PLoS Genet"},{"key":"3073_CR41","doi-asserted-by":"crossref","unstructured":"Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals: implications for biology and medicine. 2014;111(45):162192\u20134.","DOI":"10.1073\/pnas.1408886111"},{"key":"3073_CR42","unstructured":"Devarajan K, Fidino M, Farris ZJ, Adalsteinsson SA, Andrade-Ponce G, Angstmann JL, Anthonysamy W, Aquino J, Asefa A, Avila B, Bailey LL, et al. When the wild things are: Defining mammalian diel activity and plasticity. 2025;11(9):eado3843."},{"key":"3073_CR43","doi-asserted-by":"crossref","unstructured":"Molcan L, Babarikova K, Cvikova D, Kincelova N, Kubincova L, Mauer Sutovska H. Artificial light at night suppresses the day-night cardiovascular variability: evidence from humans and rats. 2024;476(3):295\u2013306.","DOI":"10.1007\/s00424-023-02901-0"},{"key":"3073_CR44","doi-asserted-by":"crossref","unstructured":"FFelten M, Ferencik S, Teixeira Alves LG, Letsiou E, Lienau J, M\u00fcller-Redetzky HC, Langenhagen AK, Vo\u00df A, Dietert K, Kershaw O, Gruber AD. Ventilator-induced Lung Injury Is Modulated by the Circadian Clock. 2022;207(11):1464\u201374.","DOI":"10.1164\/rccm.202202-0320OC"},{"key":"3073_CR45","doi-asserted-by":"crossref","unstructured":"Liao BY, Weng MP, Chang TY, Chang AY, Ching YH, Wu CH. Degeneration of the Olfactory System in a Murid Rodent that Evolved Diurnalism. 2024;41(3):msae037.","DOI":"10.1093\/molbev\/msae037"},{"key":"3073_CR46","doi-asserted-by":"crossref","unstructured":"Semenza GL. Hypoxia-inducible factor 1 and cardiovascular disease. Annu Rev Physiol. 2013;76(0):39\u201356.","DOI":"10.1146\/annurev-physiol-021113-170322"},{"issue":"1","key":"3073_CR47","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.cmet.2016.09.009","volume":"25","author":"Y Wu","year":"2017","unstructured":"Wu Y, Tang D, Liu N, Xiong W, Huang H, Li Y, et al. Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals. Cell Metab. 2017;25(1):73\u201385.","journal-title":"Cell Metab"},{"key":"3073_CR48","doi-asserted-by":"crossref","unstructured":"Moreno-Dom\u00ednguez A, Colinas O, Arias-Mayenco I, Cabeza JM, L\u00f3pez-Ogayar JL, Chandel NS, Weissmann N, Sommer N, Pascual A, L\u00f3pez-Barneo J. Hif1\u03b1-dependent mitochondrial acute O(2) sensing and signaling to myocyte Ca(2+) channels mediate arterial hypoxic vasodilation. Nat Commun. 2024;15(1):6649.","DOI":"10.1038\/s41467-024-51023-3"},{"key":"3073_CR49","doi-asserted-by":"crossref","unstructured":"Adamovich Y, Ladeuix B, Golik M, Koeners MP, Asher G. Gad, Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1\u03b1. Cell Metab. 2016;25(1):93\u2013101.","DOI":"10.1016\/j.cmet.2016.09.014"},{"key":"3073_CR50","doi-asserted-by":"crossref","unstructured":"Peek CB, Levine DC, Cedernaes J, Taguchi A, Kobayashi Y, Tsai SJ, Bonar NA, McNulty MR, Ramsey KM, Bass J. Circadian Clock Interaction with HIF1\u03b1 Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metab. 2016;25(1):86\u201392.","DOI":"10.1016\/j.cmet.2016.09.010"},{"key":"3073_CR51","doi-asserted-by":"crossref","unstructured":"Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F. Hypoxia as a therapy for mitochondrial disease. Science. 2016;352(6281):54\u201361.","DOI":"10.1126\/science.aad9642"},{"key":"3073_CR52","doi-asserted-by":"crossref","unstructured":"Seneviratna A, Lim GH, Devi A, Carvalho LP, Chua T, Koh TH, Tan HC, Foo D, Tong KL, Ong HY, Richards AM. Circadian Dependence of Infarct Size and Acute Heart Failure in ST Elevation Myocardial Infarction. PLoS One. 2015;10(6):e0128526.","DOI":"10.1371\/journal.pone.0128526"},{"key":"3073_CR53","doi-asserted-by":"crossref","unstructured":"Eltzschig HK, Bonney SK, Eckle T. Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med. 2013;19(6):345\u201354.","DOI":"10.1016\/j.molmed.2013.02.005"},{"key":"3073_CR54","doi-asserted-by":"crossref","unstructured":"Dimova EY, Jakupovic M, Kubaichuk K, Mennerich D, Chi TF, Tamanini F, Oklejewicz M, H\u00e4nig J, Byts N, M\u00e4kel\u00e4 KA, Herzig KH. The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1\u03b1. iScience. 2019;13(0):284\u2013304.","DOI":"10.1016\/j.isci.2019.02.027"},{"key":"3073_CR55","doi-asserted-by":"crossref","unstructured":"Hogenesch JB, Gu YZ, Jain S, Bradfield CA. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998;95(10):5474\u20139.","DOI":"10.1073\/pnas.95.10.5474"},{"key":"3073_CR56","doi-asserted-by":"crossref","unstructured":"Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer. 2014;14(6):430\u20139.","DOI":"10.1038\/nrc3726"},{"key":"3073_CR57","doi-asserted-by":"crossref","unstructured":"Zieseniss A, Hesse AR, Jatho A, Krull S, H\u00f6lscher M, Vogel S, Katschinski DM. Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia. Cell Physiol Biochem. 2015;36(3):843\u201351.","DOI":"10.1159\/000430260"},{"key":"3073_CR58","doi-asserted-by":"crossref","unstructured":"Kim JW, Tchernyshyov I, Semenza GL, Dang CV, HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3(3):177\u201385.","DOI":"10.1016\/j.cmet.2006.02.002"},{"key":"3073_CR59","doi-asserted-by":"crossref","unstructured":"Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta. 2010;1813(7):1263\u20138.","DOI":"10.1016\/j.bbamcr.2010.08.006"},{"key":"3073_CR60","doi-asserted-by":"crossref","unstructured":"Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell. 2007;129(1):111\u201322.","DOI":"10.1016\/j.cell.2007.01.047"},{"key":"3073_CR61","doi-asserted-by":"crossref","unstructured":"Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E, Perriard JC. Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab. 2009;9(6):512\u201324.","DOI":"10.1016\/j.cmet.2009.05.005"},{"key":"3073_CR62","doi-asserted-by":"crossref","unstructured":"Resar JR, Roguin A, Voner J, Nasir K, Hennebry TA, Miller JM, Ingersoll R, Kasch LM, Semenza GL. Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. Chest. 2005;128(2):787\u201391.","DOI":"10.1378\/chest.128.2.787"},{"key":"3073_CR63","doi-asserted-by":"crossref","unstructured":"Zhang X, Gao YP, Dong WS, Li K, Hu YX, Ye YJ, Hu C. FNDC4 alleviates cardiac ischemia\/reperfusion injury through facilitating HIF1\u03b1-dependent cardiomyocyte survival and angiogenesis in male mice. Nat Commun. 2024;15(1):9667.","DOI":"10.1038\/s41467-024-53564-z"},{"key":"3073_CR64","doi-asserted-by":"crossref","unstructured":"Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, et al. Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M. Nat Commun. 2019;10(1):2824.","DOI":"10.1038\/s41467-019-10859-w"},{"key":"3073_CR65","doi-asserted-by":"crossref","unstructured":"Li X, He Y, Wang D, Momeni MR. Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk. Clin Exp Med. 2024;25(1):6.","DOI":"10.1007\/s10238-024-01514-w"},{"key":"3073_CR66","doi-asserted-by":"crossref","unstructured":"Lal H, Verma SK, Wang Y, Xie M, Young ME. Circadian Rhythms in Cardiovascular Metabolism, Circ Res. 2024;134(6):635\u201358.","DOI":"10.1161\/CIRCRESAHA.123.323520"},{"key":"3073_CR67","doi-asserted-by":"crossref","unstructured":"Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, Liu W, Li G, Lu D, Meng G, Hu L. Circadian nuclear receptor Rev-erb\u03b1 is expressed by platelets and potentiates platelet activation and thrombus formation. Eur Heart J. 2022;43(24):2317\u201334.","DOI":"10.1093\/eurheartj\/ehac109"},{"key":"3073_CR68","doi-asserted-by":"crossref","unstructured":"Wu J, Jing X, Du Q, Sun X, Holgersson K, Gao J, He X, Hosaka K, Zhao C, Tao W, FitzGerald GA. Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-\u03b2-myoCAF-Dependent Mechanism. Adv Sci (Weinh). 2023;10(24):e2301505.","DOI":"10.1002\/advs.202301505"},{"key":"3073_CR69","doi-asserted-by":"crossref","unstructured":"Maximilian BL. Pathobiology of myocardial and cardiomyocyte injury in ischemic heart disease: Perspective from seventy years of cell injury research. Exp Mol Pathol. 2024;140(0):104944.","DOI":"10.1016\/j.yexmp.2024.104944"},{"key":"3073_CR70","doi-asserted-by":"crossref","unstructured":"Boden WE, De Caterina R, Kaski JC, Bairey Merz N, Berry C, Marzilli M, Pepine CJ, Barbato E, Stefanini G, Prescott E, Steg PG. Myocardial ischaemic syndromes: a new nomenclature to harmonize evolving international clinical practice guidelines. Eur Heart J. 2024; 45(36): 3701\u20133706.","DOI":"10.1093\/eurheartj\/ehae278"},{"key":"3073_CR71","doi-asserted-by":"crossref","unstructured":"Boden WE, De Caterina R, Kaski JC, Bairey Merz N, Berry C, Marzilli M, Pepine CJ, Barbato E, Stefanini G, Prescott E, Steg PG. Myocardial Ischemic Syndromes: A New Nomenclature to Harmonize Evolving International Clinical Practice Guidelines. Circulation. 2024; 150(20): 1631\u20131637.","DOI":"10.1161\/CIRCULATIONAHA.123.065656"},{"issue":"3","key":"3073_CR72","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1161\/CIRCRESAHA.109.209346","volume":"106","author":"D Durgan","year":"2010","unstructured":"Durgan D, Pulinilkunnil T, Villegas-Montoya C, Garvey M, Frangogiannis N, Michael L, et al. Short communication: ischemia\/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res. 2010;106(3):546\u201350.","journal-title":"Circ Res"},{"issue":"7","key":"3073_CR73","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1111\/jcmm.17223","volume":"26","author":"P Ye","year":"2022","unstructured":"Ye P, Li W, Huang X, Zhao S, Chen W, Xia Y, et al. BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1\/PGC-1\u03b1 axis. J Cell Mol Med. 2022;26(7):1994\u20132009.","journal-title":"J Cell Mol Med"},{"issue":"6","key":"3073_CR74","doi-asserted-by":"publisher","first-page":"727","DOI":"10.5603\/CJ.a2018.0142","volume":"26","author":"B Krasi\u0144ska","year":"2019","unstructured":"Krasi\u0144ska B, Paluszkiewicz L, Miciak-Lawicka E, Krasi\u0144ski M, Rzymski P, Tykarski A, et al. The effect of acetylsalicylic acid dosed at bedtime on the anti-aggregation effect in patients with coronary heart disease and arterial hypertension: a randomized, controlled trial. Cardiol J. 2019;26(6):727\u201335.","journal-title":"Cardiol J"},{"issue":"24","key":"3073_CR75","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1093\/eurheartj\/ehac109","volume":"43","author":"J Shi","year":"2022","unstructured":"Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, et al. Circadian nuclear receptor Rev-erb\u03b1 is expressed by platelets and potentiates platelet activation and thrombus formation. Eur Heart J. 2022;43(24):2317\u201334.","journal-title":"Eur Heart J"},{"key":"3073_CR76","doi-asserted-by":"crossref","unstructured":"West AC, Smith L, Ray DW, Loudon AS, Brown TM, Bechtold DA. Misalignment with the external light environment drives metabolic and cardiac dysfunction. Nat Commun. 2017;8(1):417.","DOI":"10.1038\/s41467-017-00462-2"},{"key":"3073_CR77","doi-asserted-by":"crossref","unstructured":"Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012;483(7387):96\u20139.","DOI":"10.1038\/nature10852"},{"key":"3073_CR78","doi-asserted-by":"crossref","unstructured":"Schroder EA, Lefta M, Zhang X, Bartos DC, Feng HZ, Zhao Y, Patwardhan A, Jin JP, Esser KA, Delisle BP. The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility. Am J Physiol Cell Physiol. 2013;304(10):C954\u201365.","DOI":"10.1152\/ajpcell.00383.2012"},{"key":"3073_CR79","doi-asserted-by":"crossref","unstructured":"Schroder EA, Burgess DE, Zhang X, Lefta M, Smith JL, Patwardhan A, Bartos DC, Elayi CS, Esser KA, Delisle BP. The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization. Heart Rhythm. 2015;12(6):1306\u201314.","DOI":"10.1016\/j.hrthm.2015.02.019"},{"key":"3073_CR80","doi-asserted-by":"crossref","unstructured":"Yu Z, Liu Z, Jiao L, Zhang S, Nie L, Wang Y, Zhou L, Wang Y, Liu Z, Liu Z, Xu X. Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia. Front Cardiovasc Med. 2022;9(0):937608.","DOI":"10.3389\/fcvm.2022.937608"},{"key":"3073_CR81","doi-asserted-by":"crossref","unstructured":"Podobed P, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze EV, Ratcliffe WF, Mackay A, Simpson J, Wright DC, Kirby GM, Young ME. The day\/night proteome in the murine heart. Am J Physiol Regul Integr Comp Physiol. 2014;307(2):R1213\u20137.","DOI":"10.1152\/ajpregu.00011.2014"},{"key":"3073_CR82","doi-asserted-by":"crossref","unstructured":"Ko ML, Shi L, Grushin K, Nigussie F, Ko GY. Circadian profiles in the embryonic chick heart: L-type voltage-gated calcium channels and signaling pathways. Chronobiol Int. 2010;27(9-10):1673\u201396.","DOI":"10.3109\/07420528.2010.514631"},{"key":"3073_CR83","doi-asserted-by":"crossref","unstructured":"Chen Y, Zhu D, Yuan J, Han Z, Wang Y, Qian Z, Hou X, Wu T, Zou J. CLOCK-BMAL1 regulate the cardiac L-type calcium channel subunit CACNA1C through PI3K-Akt signaling pathway. Can J Physiol Pharmacol. 2016;94(9):1023\u201332.","DOI":"10.1139\/cjpp-2015-0398"},{"key":"3073_CR84","doi-asserted-by":"crossref","unstructured":"Collins HE, Turrell HE, Samani NJ, Rodrigo GC. Diurnal variation in excitation-contraction coupling is lost in the adult spontaneously hypertensive rat heart. J Hypertens. 2013;31(6):1214\u201323.","DOI":"10.1097\/HJH.0b013e328360ae4b"},{"key":"3073_CR85","doi-asserted-by":"crossref","unstructured":"Dillier R, Zuber M, Arand P, Erne S, Erne P. Assessment of systolic and diastolic function in heart failure using ambulatory monitoring with acoustic cardiography. Ann Med. 2011;43(5):403\u201311.","DOI":"10.3109\/07853890.2010.550309"},{"key":"3073_CR86","doi-asserted-by":"crossref","unstructured":"Che Y, Shimizu Y, Hayashi T, Suzuki J, Pu Z, Tsuzuki K, Narita S, Shibata R, Murohara T. Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway. 2024;14(1):10777.","DOI":"10.1038\/s41598-024-61710-2"},{"key":"3073_CR87","doi-asserted-by":"crossref","unstructured":"Shafer BM, Kogan SA, McHill AW. Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure. Curr Hypertens Rep. 2023;26(1):31\u201342.","DOI":"10.1007\/s11906-023-01274-0"},{"key":"3073_CR88","doi-asserted-by":"crossref","unstructured":"Festus ID, Spilberg J, Young ME, Cain S, Khoshnevis S, Smolensky MH, Zaheer F, Descalzi G, Martino TA. Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health. Trends Endocrinol Metab. 2024;35(7):607\u201323.","DOI":"10.1016\/j.tem.2024.02.011"},{"key":"3073_CR89","doi-asserted-by":"crossref","unstructured":"Ayala DE, Ucieda R, Hermida RC. Chronotherapy with low-dose aspirin for prevention of complications in pregnancy. Chronobiol Int. 2012;30(0):260\u201379.","DOI":"10.3109\/07420528.2012.717455"},{"key":"3073_CR90","doi-asserted-by":"crossref","unstructured":"Pritha D, Anita LT, Sex and circadian regulation of metabolic demands in the rat kidney: A modeling analysis. PLoS One. 2024;19(7):e0293419.","DOI":"10.1371\/journal.pone.0293419"},{"key":"3073_CR91","doi-asserted-by":"crossref","unstructured":"Anea CB, Zhang M, Stepp DW, Simkins GB, Reed G, Fulton DJ, Rudic RD. Vascular disease in mice with a dysfunctional circadian clock. Circulation. 2009;119(11):1510\u20137.","DOI":"10.1161\/CIRCULATIONAHA.108.827477"},{"key":"3073_CR92","doi-asserted-by":"crossref","unstructured":"Xie Z, Su W, Liu S, Zhao G, Esser K, Schroder EA, Lefta M, Stauss HM, Guo Z, Gong MC. Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation. J Clin Invest. 2014;125(1):324\u201336.","DOI":"10.1172\/JCI76881"},{"key":"3073_CR93","doi-asserted-by":"crossref","unstructured":"Lin C, Xu L, Tang X, Li X, Lu C, Cheng Q, Jiang J, Shen Y, Yan D, Qian R, Fu W. Clock Gene Bmal1 Disruption in Vascular Smooth Muscle Cells Worsens Carotid Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol. 2022;42(5):565\u201379.","DOI":"10.1161\/ATVBAHA.121.316480"},{"key":"3073_CR94","doi-asserted-by":"crossref","unstructured":"Alkan I, Durkut B, Ucak M, Bozkurt M, Canat HL, Celik-Ozenci C. Uncovering the Penile Clock: Expression of Molecular Clock Proteins in Human Penile Cavernous Tissue. World J Mens Health. 2024;42(4):797\u2013809.","DOI":"10.5534\/wjmh.230136"},{"key":"3073_CR95","doi-asserted-by":"crossref","unstructured":"Lin C, Tang X, Zhu Z, Liao X, Zhao R, Fu W, Chen B, Jiang J, Qian R, Guo D. The rhythmic expression of clock genes attenuated in human plaque-derived vascular smooth muscle cells. Lipids Health Dis. 2014;13(0):14.","DOI":"10.1186\/1476-511X-13-14"},{"key":"3073_CR96","doi-asserted-by":"crossref","unstructured":"Timea T, Anne Caroline M, Silvia T, Michal T. Circadian control of polycyclic aromatic hydrocarbon-induced dysregulation of endothelial tight junctions and mitochondrial bioenergetics. Sci Total Environ. 2024;952(0):175886.","DOI":"10.1016\/j.scitotenv.2024.175886"},{"key":"3073_CR97","doi-asserted-by":"crossref","unstructured":"Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A. Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013;341(6153):1483\u20138.","DOI":"10.1126\/science.1240636"},{"key":"3073_CR98","doi-asserted-by":"crossref","unstructured":"Lempesis IG. Illuminating the metabolic effects of circadian misalignment. Nat Rev Endocrinol. 2025;21(4):202.","DOI":"10.1038\/s41574-024-01085-6"},{"key":"3073_CR99","doi-asserted-by":"crossref","unstructured":"Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med. 2012;18(12):1768\u201377.","DOI":"10.1038\/nm.2979"},{"issue":"5724","key":"3073_CR100","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1126\/science.1108750","volume":"308","author":"FW Turek","year":"2005","unstructured":"Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005;308(5724):1043\u20135.","journal-title":"Science"},{"key":"3073_CR101","doi-asserted-by":"crossref","unstructured":"Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, FitzGerald GA. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004;2(11):e377.","DOI":"10.1371\/journal.pbio.0020377"},{"key":"3073_CR102","doi-asserted-by":"crossref","unstructured":"Young ME. The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function. Am J Physiol Heart Circ Physiol. 2005;290(1):H1\u201316.","DOI":"10.1152\/ajpheart.00582.2005"},{"key":"3073_CR103","doi-asserted-by":"crossref","unstructured":"Zvonic S, Ptitsyn AA, Conrad SA, Scott LK, Floyd ZE, Kilroy G, Wu X, Goh BC, Mynatt RL, Gimble JM. Characterization of peripheral circadian clocks in adipose tissues. Diabetes. 2006;55(4):962\u201370.","DOI":"10.2337\/diabetes.55.04.06.db05-0873"},{"key":"3073_CR104","doi-asserted-by":"crossref","unstructured":"Matsumura S, Signoretti C, Fatehi S, Tumenbayar BI, D\u2019Addario C, Nimmer E, Thomas C, Viswanathan T, Wolf A, Garcia V, Rocic P. Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats. J Biol Chem. 2024;300(7):107460.","DOI":"10.1016\/j.jbc.2024.107460"},{"key":"3073_CR105","doi-asserted-by":"crossref","unstructured":"Speksnijder EM, Bisschop PH, Siegelaar SE, Stenvers DJ, Kalsbeek A. Circadian desynchrony and glucose metabolism. J Pineal Res. 2024;76(4):e12956.","DOI":"10.1111\/jpi.12956"},{"key":"3073_CR106","doi-asserted-by":"crossref","unstructured":"Knutson KL, Spiegel K, Penev P, Van Cauter E. The metabolic consequences of sleep deprivation, Sleep Med Rev. 2007;11(3):117\u201329.","DOI":"10.1016\/j.smrv.2007.01.002"},{"key":"3073_CR107","doi-asserted-by":"crossref","unstructured":"Buxton OM, Cain SW, O\u2019Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med. 2012;4(129):129ra43.","DOI":"10.1126\/scitranslmed.3003200"},{"key":"3073_CR108","doi-asserted-by":"crossref","unstructured":"Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010;466(7306):627\u201331.","DOI":"10.1038\/nature09253"},{"key":"3073_CR109","doi-asserted-by":"crossref","unstructured":"Lamia KA, Storch KF, Weitz CJ. Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A. 2008;105(39):15172\u20137.","DOI":"10.1073\/pnas.0806717105"},{"key":"3073_CR110","doi-asserted-by":"crossref","unstructured":"Doi R, Oishi K, Ishida N. CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J Biol Chem. 2010;285(29):22114\u201321.","DOI":"10.1074\/jbc.M110.110361"},{"key":"3073_CR111","doi-asserted-by":"crossref","unstructured":"Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010;16(10):1152\u20136.","DOI":"10.1038\/nm.2214"},{"key":"3073_CR112","doi-asserted-by":"crossref","unstructured":"Tan JT, Cheney CV, Bamhare NE, Hossin T, Bilu C, Sandeman L, Nankivell VA, Solly EL, Kronfeld-Schor N, Bursill CA. Female Psammomys obesus Are Protected from Circadian Disruption-Induced Glucose Intolerance, Cardiac Fibrosis and Adipocyte Dysfunction. Int J Mol Sci. 2024;25(13):7265.","DOI":"10.3390\/ijms25137265"},{"key":"3073_CR113","doi-asserted-by":"crossref","unstructured":"Luna-Marco C, Devos D, Cacace J, Fernandez-Reyes M, D\u00edaz-Pozo P, Salazar JD, Sol\u00e1 E, Morillas C, Rocha M, V\u00edctor VM, Rovira-Llopis S. Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte-endothelial interactions. Diabetologia. 2024;67(10):2316\u201328.","DOI":"10.1007\/s00125-024-06219-z"},{"key":"3073_CR114","doi-asserted-by":"crossref","unstructured":"Bass J. Circadian topology of metabolism.Nature. 2012;491(7424):348\u201356.","DOI":"10.1038\/nature11704"},{"key":"3073_CR115","doi-asserted-by":"crossref","unstructured":"Mortimer T, Smith JG, Mu\u00f1oz-C\u00e1noves P, Benitah SA. Circadian clock communication during homeostasis and ageing. Nat Rev Mol Cell Biol. 2025;26(4):314\u201331.","DOI":"10.1038\/s41580-024-00802-3"},{"key":"3073_CR116","doi-asserted-by":"crossref","unstructured":"Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res. 2008;102(5):607\u201314.","DOI":"10.1161\/CIRCRESAHA.107.162230"},{"key":"3073_CR117","doi-asserted-by":"crossref","unstructured":"Blacher E, Tsai C, Litichevskiy L, Shipony Z, Iweka CA, Schneider KM, Chuluun B, Heller HC, Menon V, Thaiss CA, Andreasson KI.,Aging disrupts circadian gene regulation and function in macrophages. Nat Immunol. 2021;23(2):229\u201336.","DOI":"10.1038\/s41590-021-01083-0"},{"key":"3073_CR118","doi-asserted-by":"crossref","unstructured":"Alibhai FJ, Reitz CJ, Peppler WT, Basu P, Sheppard P, Choleris E, Bakovic M, Martino TA. Female Clock\u039419\/\u039419 mice are protected from the development of age-dependent cardiomyopathy, Cardiovasc Res. 2017;114(2):259\u201371.","DOI":"10.1093\/cvr\/cvx185"},{"key":"3073_CR119","doi-asserted-by":"crossref","unstructured":"Wang C, Lutes LK, Barnoud C, Scheiermann C. The circadian immune system. Sci Immunol. 2022;7(72):eabm2465.","DOI":"10.1126\/sciimmunol.abm2465"},{"key":"3073_CR120","doi-asserted-by":"crossref","unstructured":"Scheiermann C, Kunisaki Y, Frenette PS. Circadian control of the immune system. Nat Rev Immunol. 2013;13(3):190\u20138.","DOI":"10.1038\/nri3386"},{"key":"3073_CR121","doi-asserted-by":"crossref","unstructured":"Lange T, Dimitrov S, Born J. Effects of sleep and circadian rhythm on the human immune system. Ann N Y Acad Sci. 2010;1193(0):48\u201359.","DOI":"10.1111\/j.1749-6632.2009.05300.x"},{"key":"3073_CR122","doi-asserted-by":"crossref","unstructured":"Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, et al. Circadian clock protein BMAL1 regulates IL-1\u03b2 in macrophages via NRF2. Proc Natl Acad Sci U S A. 2018;115(36):E8460\u20138.","DOI":"10.1073\/pnas.1800431115"},{"key":"3073_CR123","doi-asserted-by":"crossref","unstructured":"Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, et al. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity. 2017;46(1):120\u201332.","DOI":"10.1016\/j.immuni.2016.12.011"},{"key":"3073_CR124","doi-asserted-by":"crossref","unstructured":"Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Muehlstaedt M, Boehncke WH, Weber J, Circadian clocks guide dendritic cells into skin lymphatics. Nat Immunol. 2021;22(11):1375\u201381.","DOI":"10.1038\/s41590-021-01040-x"},{"key":"3073_CR125","doi-asserted-by":"crossref","unstructured":"Pu H, Bailey LC, Bauer LG, Voronkov M, Baxter M, Huber KV, Khorasanizadeh S, Ray D, Rastinejad F. Pharmacological targeting of BMAL1 modulates circadian and immune pathways. Nat Chem Biol. 2025;21(5):736\u201345.","DOI":"10.1038\/s41589-025-01863-x"},{"key":"3073_CR126","doi-asserted-by":"crossref","unstructured":"Gao Y, Meng D, Sun N, Zhu Z, Zhao R, Lu C, Chen S, Hua L, Qian R. Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells. Biochem Biophys Res Commun. 2013;443(2):586\u201391.","DOI":"10.1016\/j.bbrc.2013.12.022"},{"key":"3073_CR127","doi-asserted-by":"crossref","unstructured":"Pan X, Jiang XC, Hussain MM. Impaired cholesterol metabolism and enhanced atherosclerosis in clock mutant mice. Circulation. 2013;128(16):1758\u201369.","DOI":"10.1161\/CIRCULATIONAHA.113.002885"},{"key":"3073_CR128","doi-asserted-by":"crossref","unstructured":"Pourcet B, Duez H. Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine. Front Immunol. 2020;11(0):1630.","DOI":"10.3389\/fimmu.2020.01630"},{"key":"3073_CR129","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.954238","volume":"9","author":"K Kadier","year":"2022","unstructured":"Kadier K, Qin L, Ainiwaer A, Rehemuding R, Dilixiati D, Du Y, et al. Association of sleep-related disorders with cardiovascular disease among adults in the United States: a cross-sectional study based on national health and nutrition examination survey 2005\u20132008. Front Cardiovasc Med. 2022;9(0):954238.","journal-title":"Front Cardiovasc Med"},{"issue":"8","key":"3073_CR130","doi-asserted-by":"publisher","first-page":"e574","DOI":"10.1210\/clinem\/dgad089","volume":"108","author":"X Wang","year":"2023","unstructured":"Wang X, Zhao C, Feng H, Li G, He L, Yang L, et al. Associations of insomnia with insulin resistance traits: a cross-sectional and Mendelian randomization study. J Clin Endocrinol Metab. 2023;108(8):e574\u201382.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3073_CR131","doi-asserted-by":"publisher","first-page":"772","DOI":"10.2337\/dc21-0089","volume":"45","author":"J Liu","year":"2022","unstructured":"Liu J, Richmond R, Bowden J, Barry C, Dashti H, Daghlas I, et al. Assessing the causal role of sleep traits on glycated hemoglobin: a Mendelian randomization study. Diabetes Care. 2022;45(4):772\u201381.","journal-title":"Diabetes Care"},{"issue":"5","key":"3073_CR132","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1159\/000518338","volume":"112","author":"W Wang","year":"2022","unstructured":"Wang W, Huang Z, Huang L, Tan C, Chen W, Roelfsema F, et al. Rotating day and night disturb growth hormone secretion profiles, body energy metabolism, and insulin levels in mice. Neuroendocrinology. 2022;112(5):481\u201392.","journal-title":"Neuroendocrinology"},{"issue":"8","key":"3073_CR133","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s00125-017-4317-0","volume":"60","author":"A Sharma","year":"2017","unstructured":"Sharma A, Laurenti M, Dalla Man C, Varghese R, Cobelli C, Rizza R, et al. Glucose metabolism during rotational shift-work in healthcare workers. Diabetologia. 2017;60(8):1483\u201390.","journal-title":"Diabetologia"},{"key":"3073_CR134","doi-asserted-by":"crossref","unstructured":"Huynh P, Hoffmann JD, Gerhardt T, Kiss MG, Zuraikat FM, Cohen O, Wolfram C, Yates AG, Leunig A, Heiser M, Gaebel L, et al. Myocardial infarction augments sleep to limit cardiac inflammation and damage. Nature. 2024;635(8037):168\u201377.","DOI":"10.1038\/s41586-024-08100-w"},{"issue":"20","key":"3073_CR135","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1016\/j.jacc.2010.11.022","volume":"57","author":"T Martino","year":"2011","unstructured":"Martino T, Tata N, Simpson J, Vanderlaan R, Dawood F, Kabir M, et al. The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. J Am Coll Cardiol. 2011;57(20):2020\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"3073_CR136","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.jacc.2011.12.013","volume":"59","author":"A Demaria","year":"2012","unstructured":"Demaria A, Bax J, Ben-Yehuda O, Feld G, Greenberg B, Hall J, et al. Highlights of the year in JACC 2011. J Am Coll Cardiol. 2012;59(5):503\u201337.","journal-title":"J Am Coll Cardiol"},{"key":"3073_CR137","doi-asserted-by":"crossref","unstructured":"Chen L, Yang G, Zhang J, Ren B, Tang S, Li X, FitzGerald GA. Time-Dependent Hypotensive Effect of Aspirin in Mice. Arterioscler Thromb Vasc Biol. 2018;38(12):2819\u201326.","DOI":"10.1161\/ATVBAHA.118.311296"},{"key":"3073_CR138","doi-asserted-by":"crossref","unstructured":"M. Tami A, T. Nazneen, S. Jeremy A, V. Rachel, D. Fayez, K. M Golam, K. Neelam, C. Carlo, P. Peter, L. Peter P, H. Mansoor, H. Scott, B. Peter H, S.J.J.A.C.C. Michael J, The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy, J Am Coll Cardiol. 2011;57(20):2020\u20138 .","DOI":"10.1016\/j.jacc.2010.11.022"},{"issue":"6","key":"3073_CR139","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.celrep.2019.07.020","volume":"28","author":"Y Oyama","year":"2019","unstructured":"Oyama Y, Bartman C, Bonney S, Lee J, Walker L, Han J, et al. Intense light-mediated circadian cardioprotection via transcriptional reprogramming of the endothelium. Cell Rep. 2019;28(6):1471\u201384.e11.","journal-title":"Cell Rep"},{"issue":"7","key":"3073_CR140","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.molmed.2021.04.007","volume":"27","author":"S Shuff","year":"2021","unstructured":"Shuff S, Oyama Y, Walker L, Eckle T. Circadian angiopoietin-like-4 as a novel therapy in cardiovascular disease. Trends Mol Med. 2021;27(7):627\u20139.","journal-title":"Trends Mol Med"},{"key":"3073_CR141","doi-asserted-by":"crossref","unstructured":"Galaup A, Gomez E, Souktani R, Durand M, Cazes A, Monnot C, Teillon J, Le Jan S, Bouleti C, Briois G, Philippe J, et al. Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.Circulation. 2011;125(1):140\u20139.","DOI":"10.1161\/CIRCULATIONAHA.111.049072"},{"key":"3073_CR142","doi-asserted-by":"crossref","unstructured":"Im Cho D, Kang HJ, Jeon JH, Eom GH, Cho HH, Kim MR, Cho M, Jeong HY, Cho HC, Hong MH, Kim YS. Antiinflammatory activity of ANGPTL4 facilitates macrophage polarization to induce cardiac repair. JCI Insight. 2019;4(16):e125437.","DOI":"10.1172\/jci.insight.125437"},{"issue":"19","key":"3073_CR143","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1073\/pnas.1515296113","volume":"113","author":"D Yuan","year":"2016","unstructured":"Yuan D, Collage R, Huang H, Zhang X, Kautza B, Lewis A, et al. Blue light reduces organ injury from ischemia and reperfusion. Proc Natl Acad Sci U S A. 2016;113(19):5239\u201344.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3073_CR144","doi-asserted-by":"crossref","unstructured":"Yoon J, Heo SJ, Lee H, Sul EG, Han T, Kwon YJ. Assessing the Feasibility and Efficacy of Pre-Sleep Dim Light Therapy for Adults with Insomnia: A Pilot Study. Medicina (Kaunas, Lithuania). 2024;60(4):632.","DOI":"10.3390\/medicina60040632"},{"key":"3073_CR145","doi-asserted-by":"crossref","unstructured":"Chellappa SL, Qian J, Vujovic N, Morris CJ, Nedeltcheva A, Nguyen H, Rahman N, Heng SW, Kelly L, Kerlin-Monteiro K, Srivastav S. Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Sci Adv. 2021; 7(49): eabg9910.","DOI":"10.1126\/sciadv.abg9910"},{"key":"3073_CR146","doi-asserted-by":"crossref","unstructured":"\u00a0Kosmadopoulos A, Kervezee L, Boudreau P, Gonzales-Aste F, Vujovic N, Scheer FA, Boivin DB. Effects of Shift Work on the Eating Behavior of Police Officers on Patrol. Nutrients. 2020;12(4):999.","DOI":"10.3390\/nu12040999"},{"key":"3073_CR147","doi-asserted-by":"crossref","unstructured":"Melkani GC. Time-restricted feeding mediated synchronization of circadian rhythms to sustain cardiovascular health.J Mol Cell Cardiol. 2025;206(0):1\u201310.","DOI":"10.1016\/j.yjmcc.2025.07.007"},{"key":"3073_CR148","doi-asserted-by":"crossref","unstructured":"Palomar-Cros A, Andreeva VA, Fezeu LK, Julia C, Bellicha A, Kesse-Guyot E, Hercberg S, Romaguera D, Kogevinas M, Touvier M, Srour B. Dietary circadian rhythms and cardiovascular disease risk in the prospective NutriNet-Sant\u00e9 cohort. Nat Commun. 2023;14(1):7899.","DOI":"10.1038\/s41467-023-43444-3"},{"key":"3073_CR149","doi-asserted-by":"crossref","unstructured":"Salgado-Delgado R, Angeles-Castellanos M, Saderi N, Buijs RM, Escobar C. Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work.Endocrinology. 2010;151(3):1019\u201329.","DOI":"10.1210\/en.2009-0864"},{"issue":"1","key":"3073_CR150","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2018-000443","volume":"4","author":"P Lewis","year":"2018","unstructured":"Lewis P, Korf H, Kuffer L, Gro\u00df J, Erren T. Exercise time cues (zeitgebers) for human circadian systems can foster health and improve performance: a systematic review. BMJ Open Sport Exerc Med. 2018;4(1):e000443.","journal-title":"BMJ Open Sport Exerc Med"},{"key":"3073_CR151","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13395-016-0082-x","volume":"6","author":"B Harfmann","year":"2016","unstructured":"Harfmann B, Schroder E, Kachman M, Hodge B, Zhang X, Esser K. Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis. Skeletal muscle. 2016;6(0):12.","journal-title":"Skeletal muscle"},{"issue":"4","key":"3073_CR152","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.2337\/dc20-2178","volume":"44","author":"J Qian","year":"2021","unstructured":"Qian J, Walkup M, Chen S, Brubaker P, Bond D, Richey P, et al. Association of objectively measured timing of physical activity bouts with cardiovascular health in type 2 diabetes. Diabetes Care. 2021;44(4):1046\u201354.","journal-title":"Diabetes Care"},{"key":"3073_CR153","doi-asserted-by":"crossref","unstructured":"Gal\u00e1n L\u00f3pez P, Casuso P\u00e9rez R. Metabolic Adaptations to Morning Versus Afternoon Training: A Systematic Review and Meta-analysis. Sports medicine (Auckland, N.Z.). 2023;53(10):19516\u20131.","DOI":"10.1007\/s40279-023-01879-0"},{"key":"3073_CR154","doi-asserted-by":"crossref","unstructured":"Menek MY, Budak M. Effect of exercises according to the circadian rhythm in type 2 diabetes: Parallel-group, single-blind, crossover study. Nutr Metab Cardiovasc Dis. 2022;32(7):1742\u201352.","DOI":"10.1016\/j.numecd.2022.04.017"},{"key":"3073_CR155","doi-asserted-by":"crossref","unstructured":"He C, Wakayama M, Jiang H, Zhao T, Zhang Y, Liu B, Moriyama H. Effects of exercise on mental health in mice with circadian rhythm disruption. J Affect Disord. 2025;389(0):119936.","DOI":"10.1016\/j.jad.2025.119936"},{"key":"3073_CR156","doi-asserted-by":"crossref","unstructured":"Ciorciari AM, Irizarry E, Montaruli A, Lamia KA. Exercise as a Synchronizer: Effects on Circadian Re-Entrainment of Core Body Temperature and Metabolism Following Light-Dark Cycle Inversion in Mice. J Pineal Res. 2025;77(3):e70057.","DOI":"10.1111\/jpi.70057"},{"key":"3073_CR157","doi-asserted-by":"crossref","unstructured":"Liu J, Xiao F, Choubey A, Kumar S U, Wang Y, Hong S, Yang T, Otlu HG, Oturmaz ES, Loro E, Sun Y, et al. Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice. Nat Commun. 2025;16(1):5708.","DOI":"10.1038\/s41467-025-60520-y"},{"key":"3073_CR158","doi-asserted-by":"crossref","unstructured":"Caputo R, Schoonderwoerd RA, Ramkisoensing A, Janse JA, van Diepen HC, Raison S, P\u00e9vet P, Sage-Ciocca D, Deboer T, Challet E, Meijer JH. Physical activity stimulates clock neurons of the day-active rodent Arvicanthis ansorgei. Proc Natl Acad Sci U S A. 2025;122(21):e2424545122.","DOI":"10.1073\/pnas.2424545122"},{"key":"3073_CR159","doi-asserted-by":"crossref","unstructured":"Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004;43(2):192\u20137.","DOI":"10.1161\/01.HYP.0000113293.15186.3b"},{"key":"3073_CR160","doi-asserted-by":"crossref","unstructured":"Grossman E, Laudon M, Yalcin R, Zengil H, Peleg E, Sharabi Y, Kamari Y, Shen-Orr Z, Zisapel N. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med. 2006;119(10):898\u2013902.","DOI":"10.1016\/j.amjmed.2006.02.002"},{"key":"3073_CR161","doi-asserted-by":"crossref","unstructured":"Dwaich KH, Al-Amran FG, Al-Sheibani BI, Al-Aubaidy HA. Melatonin effects on myocardial ischemia-reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery. Int J Cardiol. 2016;221(0):977\u201386.","DOI":"10.1016\/j.ijcard.2016.07.108"},{"key":"3073_CR162","doi-asserted-by":"crossref","unstructured":"Jiao L, Wang Y, Zhang S, Wang Y, Liu Z, Liu Z, Zhou Y, Zhou H, Xu X, Li Z, Liu Z. Melatonin improves cardiac remodeling and brain-heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction. J Pineal Res. 2022;73(4):977\u201386.","DOI":"10.1111\/jpi.12829"},{"key":"3073_CR163","doi-asserted-by":"crossref","unstructured":"He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J. The nuclear melatonin receptor ROR\u03b1 is a novel endogenous defender against myocardial ischemia\/reperfusion injury. J Pineal Res. 2016;60(3):313\u201326.","DOI":"10.1111\/jpi.12312"},{"key":"3073_CR164","doi-asserted-by":"crossref","unstructured":"Yu L, Liang H, Lu Z, Zhao G, Zhai M, Yang Y, Yang J, Yi D, Chen W, Wang X, Duan W. Membrane receptor-dependent Notch1\/Hes1 activation by melatonin protects against myocardial ischemia-reperfusion injury: in vivo and in vitro studies. J Pineal Res. 2015;59(4):420\u201333.","DOI":"10.1111\/jpi.12272"},{"key":"3073_CR165","doi-asserted-by":"crossref","unstructured":"Yu L, Sun Y, Cheng L, Jin Z, Yang Y, Zhai M, Pei H, Wang X, Zhang H, Meng Q, Zhang Y. Melatonin receptor-mediated protection against myocardial ischemia\/reperfusion injury: role of SIRT1. J Pineal Res. 2014;57(2):228\u201338.","DOI":"10.1111\/jpi.12161"},{"key":"3073_CR166","doi-asserted-by":"crossref","unstructured":"Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, Wang N, Liang Z, Li Y, Chen W, Yi D. JAK2\/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia\/reperfusion injury. J Pineal Res. 2013;55(3):275\u201386.","DOI":"10.1111\/jpi.12070"},{"key":"3073_CR167","doi-asserted-by":"crossref","unstructured":"Koop S, Oster H. Eat, sleep, repeat - endocrine regulation of behavioural circadian rhythms. FEBS J. 2021;289(21):6543\u201358.","DOI":"10.1111\/febs.16109"},{"key":"3073_CR168","doi-asserted-by":"crossref","unstructured":"Zhu M, Li X, Guo J, Zhang Z, Guo X, Li Z, Lin J, Li P, Jiang Z, Zhu Y. Orexin A protects against cerebral ischemia-reperfusion injury by enhancing reperfusion in ischemic cortex via HIF-1\u03b1-ET-1\/eNOS pathway. Brain Res Bull. 2024; 218(0): 111105.","DOI":"10.1016\/j.brainresbull.2024.111105"},{"key":"3073_CR169","doi-asserted-by":"crossref","unstructured":"Xiao-Jun Gou, Fang Cen, Zi-Quan Fan, Ying Xu, Hong-Yi Shen, Ming-Mei Zhou.Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment .Int J Genomics.2017; 2017(0) :5179271.","DOI":"10.1155\/2017\/5179271"},{"key":"3073_CR170","doi-asserted-by":"crossref","unstructured":"Gou XJ, Cen F, Fan ZQ, Xu Y, Shen HY, Zhou MM. Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment. Int J Genomics. 2017; 2017(0): 5179271.","DOI":"10.1155\/2017\/5179271"},{"key":"3073_CR171","doi-asserted-by":"crossref","unstructured":"Jiang N, Yao C, Zhang Y, Sun X, Choudhary MI, Liu X. Ginsenoside Rg1 Attenuates Chronic Sleep Deprivation-Induced Hippocampal Mitochondrial Dysfunction and Improves Memory by the AMPK-SIRT3 Pathway. J Agric Food Chem. 2024; 72(4): 2362-73.","DOI":"10.1021\/acs.jafc.3c04618"},{"key":"3073_CR172","doi-asserted-by":"crossref","unstructured":"Lu H, Zhang Y, Ran S, Chen Y, Ye Z, Huang M, Wang P. Ginsenoside Rg1 alleviates sleep deprivation-induced learning and memory impairment by inhibiting excessive neuronal apoptosis in zebrafish. Neuroreport.\u00a02023; 34(11): 566-574.","DOI":"10.1097\/WNR.0000000000001926"},{"key":"3073_CR173","doi-asserted-by":"crossref","unstructured":"Cong L, Zhe S, Liming D, Jingwei L, Pan X, Yinghui L, Lina Q, Xinmin L, Exploring the Effect of Ginsenoside Rh1 in a Sleep Deprivation-Induced Mouse Memory Impairment Model. Phytother Res.\u00a02017;31(5):763\u201370.","DOI":"10.1002\/ptr.5797"},{"key":"3073_CR174","doi-asserted-by":"crossref","unstructured":"Leem KH, Kim SA, Park HJ. Antimania-Like Effect of Panax ginseng Regulating the Glutamatergic Neurotransmission in REM-Sleep Deprivation Rats. Biomed Res Int. 2020;2020(0):3636874.","DOI":"10.1155\/2020\/3636874"},{"key":"3073_CR175","doi-asserted-by":"crossref","unstructured":"Gabriel BM, Alt\u0131nta\u015f A, Smith JA, Sardon-Puig L, Zhang X, Basse AL, Laker RC, Gao H, Liu Z, Dollet L, Treebak JT. Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle. Sci Adv. 2021;7(43):eabi9654.","DOI":"10.1126\/sciadv.abi9654"},{"key":"3073_CR176","doi-asserted-by":"crossref","unstructured":"Tan X, Li L, Wang J, Zhao B, Pan J, Wang L, Liu X, Liu X, Liu Z. Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes. J Agric Food Chem. 2019;67(31):8510\u20139.","DOI":"10.1021\/acs.jafc.9b03368"},{"key":"3073_CR177","doi-asserted-by":"crossref","unstructured":"Miranda J, Portillo MP, Madrid JA, Arias N, Macarulla MT, Garaulet M. Effects of resveratrol on changes induced by high-fat feeding on clock genes in rats. Br J Nutr. 2013;110(8):1421\u20138.","DOI":"10.1017\/S0007114513000755"},{"key":"3073_CR178","doi-asserted-by":"crossref","unstructured":"Ye P, Li W, Huang X, Zhao S, Chen W, Xia Y, Yu W, Rao T, Ning J, Zhou X, Ruan Y. BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1\/PGC-1\u03b1 axis. J Cell Mol Med. 2022; 26(7): 1994-2009.","DOI":"10.1111\/jcmm.17223"},{"key":"3073_CR179","doi-asserted-by":"crossref","unstructured":"Kapar SG, Pino MF, Yi F, Gutierrez-Monreal MA, Esser KA, Sparks LM, Erickson ML. Effects of resveratrol on in vitro circadian clock gene expression in young and older human adipose-derived progenitor cells. Aging (Albany NY) . 2024;16(1):1\u201314 .","DOI":"10.18632\/aging.205292"},{"key":"3073_CR180","doi-asserted-by":"crossref","unstructured":"Kratz EM, So\u0142kiewicz K, Kubis-Kubiak A, Piwowar A. Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators. Int J Mol Sci. 2021;22(2):630.","DOI":"10.3390\/ijms22020630"},{"key":"3073_CR181","doi-asserted-by":"crossref","unstructured":"Li R, Wang G, Liu R, Luo L, Zhang Y, Wan Z. Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet. J Physiol Biochem. 2023;80(1):137\u201347.","DOI":"10.1007\/s13105-023-00990-0"},{"key":"3073_CR182","doi-asserted-by":"crossref","unstructured":"Okada Y, Okada M. Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. Mol Biol Rep. 2019;47(2):1021\u201332.","DOI":"10.1007\/s11033-019-05194-8"},{"key":"3073_CR183","doi-asserted-by":"crossref","unstructured":"Kuhlmann CR, Schaefer CA, Kosok C, Abdallah Y, Walther S, L\u00fcdders DW, Neumann T, Tillmanns H, Sch\u00e4fer C, Piper HM, Erdogan A. Quercetin-induced induction of the NO\/cGMP pathway depends on Ca2+-activated K+ channel-induced hyperpolarization-mediated Ca2+-entry into cultured human endothelial cells. Planta Med. 2005;71(6):520\u20134.","DOI":"10.1055\/s-2005-864152"},{"key":"3073_CR184","doi-asserted-by":"crossref","unstructured":"Lu Z, Li X, Wang M, Zhang X, Zhuang R, Wu F, Li W, Zhu W, Zhang B. Liver-Specific Bmal1 Depletion Reverses the Beneficial Effects of Nobiletin on Liver Cholesterol Homeostasis in Mice Fed with High-Fat Diet.Nutrients. 2023;15(11):2547.","DOI":"10.3390\/nu15112547"},{"key":"3073_CR185","doi-asserted-by":"crossref","unstructured":"He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.Cell Metab. 2016;23(4):610\u201321.","DOI":"10.1016\/j.cmet.2016.03.007"},{"key":"3073_CR186","doi-asserted-by":"crossref","unstructured":"Kim E, Mawatari K, Yoo SH, Chen Z. The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and I\u03baB\u03b1\/NF-\u03baB Signaling in Adipocytes. Nutrients. 2023;15(18):3919.","DOI":"10.3390\/nu15183919"},{"key":"3073_CR187","doi-asserted-by":"crossref","unstructured":"Nohara K, Nemkov T, D\u2019Alessandro A, Yoo SH, Chen Z. Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice.Int J Mol Sci. 2019;20(17):4281.","DOI":"10.3390\/ijms20174281"},{"key":"3073_CR188","doi-asserted-by":"crossref","unstructured":"Nohara K, Mallampalli V, Nemkov T, Wirianto M, Yang J, Ye Y, Sun Y, Han L, Esser KA, Mileykovskaya E, D\u2019Alessandro A. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.Nat Commun. 2019;10(1):3923.","DOI":"10.1038\/s41467-019-11926-y"},{"key":"3073_CR189","doi-asserted-by":"crossref","unstructured":"Qi G, Guo R, Tian H, Li L, Liu H, Mi Y, Liu X., Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes.Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(6):549-62.","DOI":"10.1016\/j.bbalip.2018.02.009"},{"key":"3073_CR190","doi-asserted-by":"crossref","unstructured":"Liu D, Zhao H, Zhang Y, Hu J, Xu H. Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials. Front Pharmacol. 2025;16(0):1572197.","DOI":"10.3389\/fphar.2025.1572197"},{"key":"3073_CR191","doi-asserted-by":"crossref","unstructured":"Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L, Hassan ST, \u0160mejkal K, Malanik M, Sychrova A, et al. Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics. 2019;9(7):1923\u201351.","DOI":"10.7150\/thno.30787"},{"key":"3073_CR192","doi-asserted-by":"crossref","unstructured":"Hirai T, Mitani Y, Kurumisawa K, Nomura K, Wang W, Nakashima KI, Inoue M. Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue. Biochem Pharmacol. 2019;164(0):165\u201376.","DOI":"10.1016\/j.bcp.2019.04.017"},{"key":"3073_CR193","doi-asserted-by":"crossref","unstructured":"Ye C, Zhang Y, Lin S, Chen Y, Wang Z, Feng H, Fang G, Quan S. Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions.Molecules. 2023;28(4):1874.","DOI":"10.3390\/molecules28041874"},{"key":"3073_CR194","doi-asserted-by":"crossref","unstructured":"Zhou Z, Lin Y, Gao L, Yang Z, Wang S, Wu B. Circadian pharmacological effects of berberine on chronic colitis in mice: Role of the clock component Rev-erb\u03b1. Biochem Pharmacol. 2020;172(0):113773.","DOI":"10.1016\/j.bcp.2019.113773"},{"key":"3073_CR195","doi-asserted-by":"crossref","unstructured":"Salehi S, Schallmayer E, Bandomir N, K\u00e4rcher A, G\u00fcth JF, Heitel P. Screening of Chelidonium majus isoquinoline alkaloids reveals berberine and chelidonine as selective ligands for the nuclear receptors ROR\u03b2 and HNF4\u03b1, respectively. Arch Pharm (Weinheim). 2024;357(7):e2300756.","DOI":"10.1002\/ardp.202300756"},{"key":"3073_CR196","doi-asserted-by":"crossref","unstructured":"Helleboid S, Haug C, Lamottke K, Zhou Y, Wei J, Daix S, Cambula L, Rigou G, Hum DW, Walczak R. The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor ROR\u03b1 (NR1F1). J Biomol Screen. 2013;19(3):399\u2013406.","DOI":"10.1177\/1087057113497095"},{"key":"3073_CR197","doi-asserted-by":"crossref","unstructured":"Han C, Wirianto M, Kim E, Burish MJ, Yoo SH, Chen Z. Clock-Modulating Activities of the Anti-Arrhythmic Drug Moricizine. Clocks Sleep. 2021;3(3):351\u201365.","DOI":"10.3390\/clockssleep3030022"},{"key":"3073_CR198","doi-asserted-by":"crossref","unstructured":"Burish MJ, Han C, Mawatari K, Wirianto M, Kim E, Ono K, Parakramaweera R, Chen Z, Yoo SH. The first-line cluster headache medication verapamil alters the circadian period and elicits sex-specific sleep changes in mice. Chronobiol Int. 2021;38(6):839\u201350.","DOI":"10.1080\/07420528.2021.1892127"},{"key":"3073_CR199","doi-asserted-by":"crossref","unstructured":"Alpha A,\u00a0Luo Q, Mathew D, Di R, Bhatwadekar AD. Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. Invest Ophthalmol Vis Sci. 2010;61(6):46.","DOI":"10.1167\/iovs.61.6.46"},{"key":"3073_CR200","doi-asserted-by":"crossref","unstructured":"Shu-Chuan Y, Huey-Lin T, Kun-Ruey S. Circadian-clock system in mouse liver affected by insulin resistance. Chronobiol Int.\u00a02013;30(6):796\u2013810.","DOI":"10.3109\/07420528.2013.766204"},{"key":"3073_CR201","doi-asserted-by":"crossref","unstructured":"Amador A, Wang Y, Banerjee S, Kameneka TM, Solt LA, Burris TP. Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. PLoS One. 2016;11(3):e0151014.","DOI":"10.1371\/journal.pone.0151014"},{"key":"3073_CR202","doi-asserted-by":"crossref","unstructured":"Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature; 2012;485(7396):62\u20138.","DOI":"10.1038\/nature11030"},{"key":"3073_CR203","doi-asserted-by":"crossref","unstructured":"Eckle T, Bertazzo J, Khatua TN, Fatemi Tabatabaei SR, Moori Bakhtiari N, Walker LA, Martino TA. Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure. Circ Res. 2024;134(6):675\u201394.","DOI":"10.1161\/CIRCRESAHA.123.323522"},{"key":"3073_CR204","doi-asserted-by":"crossref","unstructured":"Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS. The nuclear receptor REV-ERB\u03b1 mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A. 2011;109(2):582\u20137.","DOI":"10.1073\/pnas.1106750109"},{"key":"3073_CR205","doi-asserted-by":"crossref","unstructured":"Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erb\u03b1. ACS Chem Biol. 2010;5(10):925\u201332.","DOI":"10.1021\/cb100141y"},{"key":"3073_CR206","doi-asserted-by":"crossref","unstructured":"Kamat PK, Khan MB, Siddiqui S, Hattaway TG, Anas A, Rudic RD, Baban B, Dhandapani KM, Hess DC. Time of day dependent reduction in stroke infarct volume by the Reverb agonist SR9009 in mice. Exp Neurol. 2024;384(0):115067.","DOI":"10.1016\/j.expneurol.2024.115067"},{"key":"3073_CR207","doi-asserted-by":"crossref","unstructured":"Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, Ninni S, Klein C, Ortmans S, Seunes C, Potelle C, et al. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erb\u03b1 antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet. 2018;391(10115):59\u20136.","DOI":"10.1016\/S0140-6736(17)32132-3"},{"key":"3073_CR208","doi-asserted-by":"crossref","unstructured":"Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidovi\u0107 D, Sch\u00fcrer SC, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011;472(7344):491\u20134.","DOI":"10.1038\/nature10075"},{"key":"3073_CR209","doi-asserted-by":"crossref","unstructured":"Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Identification of SR3335 (ML-176): a synthetic ROR\u03b1 selective inverse agonist. ACS Chem Biol. 2010;6(3):218\u201322.","DOI":"10.1021\/cb1002762"},{"key":"3073_CR210","doi-asserted-by":"crossref","unstructured":"E. Tobias, H. Katherine, B. Stephanie, R. Susan, M. Michel, W. Lori A, L. Brian D, H. Jun, B. Christoph H, B. Peter M, K. Douglas J, C. Sean P, E. Holger K, Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012;18(5):774\u201382.","DOI":"10.1038\/nm.2728"},{"key":"3073_CR211","doi-asserted-by":"crossref","unstructured":"Surme S, Ergun C, Gul S, Akyel YK, Gul ZM, Ozcan O, Ipek OS, Akarlar BA, Ozlu N, Taskin AC, Turkay M, et al. TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob\/ob and high fat-diet-induced obese mice. Biochem Pharmacol. 2023;218(0):115896.","DOI":"10.1016\/j.bcp.2023.115896"},{"key":"3073_CR212","doi-asserted-by":"crossref","unstructured":"Hirota T, Lee JW, St. John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle III FJ et al. Identification of small molecule activators of cryptochrome. Science. 2012;337(6098):1094\u20137.","DOI":"10.1126\/science.1223710"},{"key":"3073_CR213","doi-asserted-by":"crossref","unstructured":"Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL. Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents. Bioorg Med Chem Lett. 2016;26(3):757\u201360.","DOI":"10.1016\/j.bmcl.2015.12.102"},{"key":"3073_CR214","doi-asserted-by":"crossref","unstructured":"Cunningham PS, Ahern SA, Smith LC, da Silva Santos CS, Wager TT, Bechtold DA. Targeting of the circadian clock via CK1\u03b4\/\u03b5 to improve glucose homeostasis in obesity. Sci Rep. 2016;6(0):29983.","DOI":"10.1038\/srep29983"},{"key":"3073_CR215","doi-asserted-by":"crossref","unstructured":"Baokun H, Zheng C. Molecular Targets for Small-Molecule Modulators of Circadian Clocks, Curr Drug Metab. 2016;17(5):503\u201312.","DOI":"10.2174\/1389200217666160111124439"},{"key":"3073_CR216","doi-asserted-by":"crossref","unstructured":"Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Ch\u00e8vre R, A-Gonz\u00e1lez N, Kunisaki Y, Zhang D, Van Rooijen N, Silberstein LE, Weber C, et al. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013;153(5):1025\u201335.","DOI":"10.1016\/j.cell.2013.04.040"},{"key":"3073_CR217","doi-asserted-by":"crossref","unstructured":"Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M. Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis. Cell Metab. 2018;28(1):175\u2013182.e5.","DOI":"10.1016\/j.cmet.2018.05.002"},{"key":"3073_CR218","doi-asserted-by":"crossref","unstructured":"Lihong C, Guangrui Y. PPARs Integrate the Mammalian Clock and Energy Metabolism, PPAR Res. 2014;2014(0):653017.","DOI":"10.1155\/2014\/653017"},{"key":"3073_CR219","doi-asserted-by":"crossref","unstructured":"Oren F, Marta G. The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects. Endocr Rev. 2018;39(3):261\u201373.","DOI":"10.1210\/er.2017-00193"},{"key":"3073_CR220","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1042\/BJ20041150","volume":"386","author":"K Oishi","year":"2005","unstructured":"Oishi K, Shirai H, Ishida N. CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice. Biochem J. 2005;386(Pt 3):575\u201381.","journal-title":"Biochem J"},{"issue":"3","key":"3073_CR221","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5551\/jat.12.169","volume":"12","author":"I Inoue","year":"2005","unstructured":"Inoue I, Shinoda Y, Ikeda M, Hayashi K, Kanazawa K, Nomura M, et al. CLOCK\/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element. J Atheroscler Thromb. 2005;12(3):169\u201374.","journal-title":"J Atheroscler Thromb"},{"key":"3073_CR222","doi-asserted-by":"crossref","unstructured":"Canaple L, Rambaud J, Dkhissi-Benyahya O, Rayet B, Tan NS, Michalik L, Delaunay F, Wahli W, Laudet V. Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol (Baltimore, Md.). 2006; 20(8): 1715\u201327.","DOI":"10.1210\/me.2006-0052"},{"issue":"1","key":"3073_CR223","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.cmet.2018.05.002","volume":"28","author":"C Winter","year":"2018","unstructured":"Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, et al. Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis. Cell Metab. 2018;28(1):175-182.e5.","journal-title":"Cell Metab"},{"issue":"2","key":"3073_CR224","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.immuni.2019.01.002","volume":"50","author":"J Adrover","year":"2019","unstructured":"Adrover J, Del Fresno C, Crainiciuc G, Cuartero M, Casanova-Acebes M, Weiss L, et al. A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. Immunity. 2019;50(2):390-402.e10.","journal-title":"Immunity"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-03073-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-03073-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-03073-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:03:13Z","timestamp":1792522993000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-03073-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":224,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3073"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-03073-x","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"30 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable. Our manuscript does not report on or involve any animals. Clinical trial number: not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"569"}}