{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:39:39Z","timestamp":1792636779485,"version":"4.5.0"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Graduate Research and Innovation Projects of Central South University","award":["2020zzts233"],"award-info":[{"award-number":["2020zzts233"]}]},{"name":"National Natural Science Foundation of China","award":["82073096"],"award-info":[{"award-number":["82073096"]}]},{"name":"Key Research and Development Plan of Hunan Province","award":["2024DK2006"],"award-info":[{"award-number":["2024DK2006"]}]},{"name":"Scientific Research Program of FuRong Laboratory","award":["2023SK2085"],"award-info":[{"award-number":["2023SK2085"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Three-dimensional (3D) chromatin structure is crucial for gene regulation and cellular identity, with alterations in this structure being closely associated with tumor development. Although the research of tumor genomics has made significant progress in the past decade, the mechanism of 3D chromatin structure in tumorigenesis is not completely clear. Recent studies have shown that the distortion of chromatin spatial conformation has become one of the core factors driving normal cell carcinogenesis by changing the gene regulatory network. Abnormal high-order chromatin organization leads to abnormal activation of oncogenes or silencing of tumor suppressor genes. This 3D chromatin disorder has been confirmed to be directly related to the phenotypic plasticity of a variety of tumors. Therefore, the dynamic changes of 3D chromatin structure play a key role in the occurrence and development of tumors, especially for malignant tumors with difficult diagnosis and lack of treatment. This article provides an overview of hierarchical alterations in cancer 3D chromatin structure, the mechanisms governing these changes, recent advances in detection technologies, and emerging therapeutic strategies. The unique 3D chromatin variation pattern in cancers may become a new biomarker and provide a theoretical basis for epigenetic therapy targeting chromatin spatial organization. In the future, integrating multi-omics data to develop specific drugs for key nodes of the 3D chromatin and establishing an early diagnosis system based on spatial chromatin characteristics will become an important direction to break through the bottleneck of cancer treatment.<\/jats:p>","DOI":"10.1186\/s12964-026-03097-3","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:15:47Z","timestamp":1785140147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D chromatin structure remodelling in cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"3097_CR1","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","volume":"159","author":"SS Rao","year":"2014","unstructured":"Rao SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell. 2014;159:1665\u201380.","journal-title":"Cell"},{"key":"3097_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41576-019-0195-2","volume":"21","author":"R Kempfer","year":"2020","unstructured":"Kempfer R, Pombo A. Methods for mapping 3D chromosome architecture. Nat Rev Genet. 2020;21:207\u201326.","journal-title":"Nat Rev Genet"},{"key":"3097_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1126\/science.1181369","volume":"326","author":"E Lieberman-Aiden","year":"2009","unstructured":"Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, Telling A, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science. 2009;326:289\u201393.","journal-title":"Science"},{"key":"3097_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.gde.2016.03.008","volume":"36","author":"AL Valton","year":"2016","unstructured":"Valton AL, Dekker J. TAD disruption as oncogenic driver. Curr Opin Genet Dev. 2016;36:34\u201340.","journal-title":"Curr Opin Genet Dev"},{"key":"3097_CR5","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.1016\/j.molcel.2023.07.006","volume":"83","author":"H Zhang","year":"2023","unstructured":"Zhang H, Shi Z, Banigan EJ, Kim Y, Yu H, Bai XC, et al. CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol Cell. 2023;83:2856\u2013e718.","journal-title":"Mol Cell"},{"key":"3097_CR6","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.cell.2019.01.020","volume":"176","author":"EH Finn","year":"2019","unstructured":"Finn EH, Pegoraro G, Brandao HB, Valton AL, Oomen ME, Dekker J, et al. Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization. Cell. 2019;176:1502\u2013e1510.","journal-title":"Cell"},{"key":"3097_CR7","doi-asserted-by":"publisher","first-page":"e25776","DOI":"10.7554\/eLife.25776","volume":"6","author":"AS Hansen","year":"2017","unstructured":"Hansen AS, Pustova I, Cattoglio C, Tjian R, Darzacq X. CTCF and cohesin regulate chromatin loop stability with distinct dynamics. Elife. 2017;6:e25776.","journal-title":"Elife"},{"key":"3097_CR8","first-page":"305","volume":"171","author":"SSP Rao","year":"2017","unstructured":"Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, et al. Cohesin Loss Eliminates All Loop Domains Cell. 2017;171:305\u201320. e24.","journal-title":"Cohesin Loss Eliminates All Loop Domains Cell"},{"key":"3097_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022;12:31\u201346.","journal-title":"Cancer Discov"},{"key":"3097_CR10","doi-asserted-by":"publisher","first-page":"e2200818","DOI":"10.1002\/advs.202200818","volume":"9","author":"Y Du","year":"2022","unstructured":"Du Y, Gu Z, Li Z, Yuan Z, Zhao Y, Zheng X, et al. Dynamic Interplay between Structural Variations and 3D Genome Organization in Pancreatic Cancer. Adv Sci (Weinh). 2022;9:e2200818.","journal-title":"Adv Sci (Weinh)"},{"key":"3097_CR11","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41586-022-05365-x","volume":"611","author":"J Xu","year":"2022","unstructured":"Xu J, Song F, Lyu H, Kobayashi M, Zhang B, Zhao Z, et al. Subtype-specific 3D genome alteration in acute myeloid leukaemia. Nature. 2022;611:387\u201398.","journal-title":"Nature"},{"key":"3097_CR12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12920-018-0437-8","volume":"11","author":"LAE Nagai","year":"2019","unstructured":"Nagai LAE, Park SJ, Nakai K. Analyzing the 3D chromatin organization coordinating with gene expression regulation in B-cell lymphoma. BMC Med Genomics. 2019;11:127.","journal-title":"BMC Med Genomics"},{"key":"3097_CR13","doi-asserted-by":"publisher","first-page":"eadn2830","DOI":"10.1126\/sciadv.adn2830","volume":"11","author":"Q Wang","year":"2025","unstructured":"Wang Q, Wang J, Mathur R, Youngblood MW, Jin Q, Hou Y, et al. Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples. Sci Adv. 2025;11:eadn2830.","journal-title":"Sci Adv"},{"key":"3097_CR14","doi-asserted-by":"publisher","first-page":"115585","DOI":"10.1016\/j.celrep.2025.115585","volume":"44","author":"L Choppavarapu","year":"2025","unstructured":"Choppavarapu L, Fang K, Liu T, Ohihoin AG, Jin VX. Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity informing a looping-mediated therapeutic avenue. Cell Rep. 2025;44:115585.","journal-title":"Cell Rep"},{"key":"3097_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13045-021-01131-0","volume":"14","author":"B Ren","year":"2021","unstructured":"Ren B, Yang J, Wang C, Yang G, Wang H, Chen Y, et al. High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis. J Hematol Oncol. 2021;14:120.","journal-title":"J Hematol Oncol"},{"key":"3097_CR16","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s42003-025-07647-2","volume":"8","author":"X Xu","year":"2025","unstructured":"Xu X, Gan J, Gao Z, Li R, Huang D, Lin L, et al. 3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression. Commun Biol. 2025;8:365.","journal-title":"Commun Biol"},{"key":"3097_CR17","first-page":"20220136","volume":"3","author":"P Li","year":"2023","unstructured":"Li P, Shang X, Jiao Q, Mi Q, Zhu M, Ren Y, et al. Alteration of chromatin high-order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells. Explor (Beijing). 2023;3:20220136.","journal-title":"Explor (Beijing)"},{"key":"3097_CR18","doi-asserted-by":"publisher","first-page":"19331","DOI":"10.1038\/s41598-025-03132-2","volume":"15","author":"K Zhang","year":"2025","unstructured":"Zhang K, Chen M, Chen M, Wang Y, Liu H, Li Y, et al. The 3D genome of plasma cells in multiple myeloma. Sci Rep. 2025;15:19331.","journal-title":"Sci Rep"},{"key":"3097_CR19","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.1038\/s41467-018-06961-0","volume":"9","author":"N Diaz","year":"2018","unstructured":"Diaz N, Kruse K, Erdmann T, Staiger AM, Ott G, Lenz G, et al. Chromatin conformation analysis of primary patient tissue using a low input Hi-C method. Nat Commun. 2018;9:4938.","journal-title":"Nat Commun"},{"key":"3097_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40364-024-00723-5","volume":"13","author":"H Li","year":"2025","unstructured":"Li H, Xing C, Li J, Zhan Y, Luo M, Wang P, et al. Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis. Biomark Res. 2025;13:15.","journal-title":"Biomark Res"},{"key":"3097_CR21","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12864-024-10109-4","volume":"25","author":"W Han","year":"2024","unstructured":"Han W, Shi D, Yang Q, Li X, Zhang J, Peng C, et al. Alteration of chromosome structure impacts gene expressions implicated in pancreatic ductal adenocarcinoma cells. BMC Genomics. 2024;25:206.","journal-title":"BMC Genomics"},{"key":"3097_CR22","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41588-024-01826-3","volume":"56","author":"SG Zhao","year":"2024","unstructured":"Zhao SG, Bootsma M, Zhou S, Shrestha R, Moreno-Rodriguez T, Lundberg A, et al. Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer. Nat Genet. 2024;56:1689\u2013700.","journal-title":"Nat Genet"},{"key":"3097_CR23","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1038\/s43018-024-00823-z","volume":"5","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Lee H, White S, Weimer AK, Monte E, Horning A, et al. Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis. Nat Cancer. 2024;5:1697\u2013712.","journal-title":"Nat Cancer"},{"key":"3097_CR24","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1158\/2159-8290.CD-21-0145","volume":"11","author":"LE Montefiori","year":"2021","unstructured":"Montefiori LE, Bendig S, Gu Z, Chen X, Polonen P, Ma X, et al. Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia. Cancer Discov. 2021;11:2846\u201367.","journal-title":"Cancer Discov"},{"key":"3097_CR25","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1182\/blood.2023022920","volume":"145","author":"P Polonen","year":"2025","unstructured":"Polonen P, Mullighan CG, Teachey DT. Classification and risk stratification in T-lineage acute lymphoblastic leukemia. Blood. 2025;145:1464\u201374.","journal-title":"Blood"},{"key":"3097_CR26","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1038\/s41467-021-24044-5","volume":"12","author":"L Yang","year":"2021","unstructured":"Yang L, Chen F, Zhu H, Chen Y, Dong B, Shi M, et al. 3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia. Nat Commun. 2021;12:3708.","journal-title":"Nat Commun"},{"key":"3097_CR27","doi-asserted-by":"publisher","first-page":"8070","DOI":"10.1038\/s41467-024-52375-6","volume":"15","author":"BS Perlman","year":"2024","unstructured":"Perlman BS, Burget N, Zhou Y, Schwartz GW, Petrovic J, Modrusan Z, et al. Enhancer-promoter hubs organize transcriptional networks promoting oncogenesis and drug resistance. Nat Commun. 2024;15:8070.","journal-title":"Nat Commun"},{"key":"3097_CR28","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00401-011-0922-z","volume":"123","author":"MD Taylor","year":"2012","unstructured":"Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123:465\u201372.","journal-title":"Acta Neuropathol"},{"key":"3097_CR29","doi-asserted-by":"crossref","unstructured":"Wu SC, Diaz EFM, Mileti E, Bihannic L, Smith KS, Rodr\u00edguez-Gonz\u00e1lez FG et al. The 3d Chromatin Landscape of Medulloblastoma. Neurooncology. 2024;26(Suppl 4).","DOI":"10.1093\/neuonc\/noae064.468"},{"key":"3097_CR30","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature13379","volume":"511","author":"PA Northcott","year":"2014","unstructured":"Northcott PA, Lee C, Zichner T, Stutz AM, Erkek S, Kawauchi D, et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 2014;511:428\u201334.","journal-title":"Nature"},{"key":"3097_CR31","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1016\/j.csbj.2022.04.007","volume":"20","author":"Q Yang","year":"2022","unstructured":"Yang Q, Jiang N, Zou H, Fan X, Liu T, Huang X, et al. Alterations in 3D chromatin organization contribute to tumorigenesis of EGFR-amplified glioblastoma. Comput Struct Biotechnol J. 2022;20:1967\u201378.","journal-title":"Comput Struct Biotechnol J"},{"key":"3097_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1158\/2643-3230.BCD-23-0211","volume":"5","author":"R Mulet-Lazaro","year":"2024","unstructured":"Mulet-Lazaro R, Delwel R. Oncogenic Enhancers in Leukemia. Blood Cancer Discov. 2024;5:303\u201317.","journal-title":"Blood Cancer Discov"},{"key":"3097_CR33","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1158\/2159-8290.CD-20-1793","volume":"11","author":"L Smeenk","year":"2021","unstructured":"Smeenk L, Ottema S, Mulet-Lazaro R, Ebert A, Havermans M, Varea AA, et al. Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia. Cancer Discov. 2021;11:2868\u201383.","journal-title":"Cancer Discov"},{"key":"3097_CR34","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cell.2014.02.019","volume":"157","author":"S Groschel","year":"2014","unstructured":"Groschel S, Sanders MA, Hoogenboezem R, de Wit E, Bouwman BAM, Erpelinck C, et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell. 2014;157:369\u201381.","journal-title":"Cell"},{"key":"3097_CR35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1182\/blood-2023-190394","volume":"142","author":"GA Botten","year":"2023","unstructured":"Botten GA, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, et al. Structural variation cooperates with permissive chromatin to control enhancer hijacking-mediated oncogenic transcription. Blood. 2023;142:336\u201351.","journal-title":"Blood"},{"key":"3097_CR36","doi-asserted-by":"publisher","first-page":"eabg4126","DOI":"10.1126\/sciadv.abg4126","volume":"7","author":"J Wang","year":"2021","unstructured":"Wang J, Huang TY, Hou Y, Bartom E, Lu X, Shilatifard A, et al. Epigenomic landscape and 3D genome structure in pediatric high-grade glioma. Sci Adv. 2021;7:eabg4126.","journal-title":"Sci Adv"},{"key":"3097_CR37","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nature22973","volume":"547","author":"PA Northcott","year":"2017","unstructured":"Northcott PA, Buchhalter I, Morrissy AS, Hovestadt V, Weischenfeldt J, Ehrenberger T, et al. The whole-genome landscape of medulloblastoma subtypes. Nature. 2017;547:311\u20137.","journal-title":"Nature"},{"key":"3097_CR38","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41588-020-0602-9","volume":"52","author":"A Kloetgen","year":"2020","unstructured":"Kloetgen A, Thandapani P, Ntziachristos P, Ghebrechristos Y, Nomikou S, Lazaris C, et al. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 2020;52:388\u2013400.","journal-title":"Nat Genet"},{"key":"3097_CR39","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1158\/2159-8290.CD-23-1452","volume":"14","author":"S Kimura","year":"2024","unstructured":"Kimura S, Park CS, Montefiori LE, Iacobucci I, Polonen P, Gao Q, et al. Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2\/STAG2 Rearrangements as Extremely High Risk. Cancer Discov. 2024;14:1838\u201359.","journal-title":"Cancer Discov"},{"key":"3097_CR40","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.ccell.2021.05.007","volume":"39","author":"B Adane","year":"2021","unstructured":"Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, et al. STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Cancer Cell. 2021;39:827\u201344. e10.","journal-title":"Cancer Cell"},{"key":"3097_CR41","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1038\/s41467-023-37544-3","volume":"14","author":"Z Wei","year":"2023","unstructured":"Wei Z, Wang S, Xu Y, Wang W, Soares F, Ahmed M, et al. MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. Nat Commun. 2023;14:1787.","journal-title":"Nat Commun"},{"key":"3097_CR42","doi-asserted-by":"publisher","first-page":"eads4985","DOI":"10.1126\/sciadv.ads4985","volume":"11","author":"H Lyu","year":"2025","unstructured":"Lyu H, Chen X, Cheng Y, Zhang T, Wang P, Wong JH, et al. Pioneer factor GATA6 promotes colorectal cancer through 3D genome regulation. Sci Adv. 2025;11:eads4985.","journal-title":"Sci Adv"},{"key":"3097_CR43","doi-asserted-by":"publisher","first-page":"9814","DOI":"10.1093\/nar\/gkac747","volume":"50","author":"IA Showpnil","year":"2022","unstructured":"Showpnil IA, Selich-Anderson J, Taslim C, Boone MA, Crow JC, Theisen ER, et al. EWS\/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma. Nucleic Acids Res. 2022;50:9814\u201337.","journal-title":"Nucleic Acids Res"},{"key":"3097_CR44","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41586-020-3032-z","volume":"589","author":"MA Willcockson","year":"2021","unstructured":"Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, et al. H1 histones control the epigenetic landscape by local chromatin compaction. Nature. 2021;589:293\u20138.","journal-title":"Nature"},{"key":"3097_CR45","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41586-020-3017-y","volume":"589","author":"N Yusufova","year":"2021","unstructured":"Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, et al. Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature. 2021;589:299\u2013305.","journal-title":"Nature"},{"key":"3097_CR46","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41576-020-00323-7","volume":"22","author":"L Koch","year":"2021","unstructured":"Koch L. Chromatin control by H1 histones. Nat Rev Genet. 2021;22:68\u20139.","journal-title":"Nat Rev Genet"},{"key":"3097_CR47","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.tig.2020.12.006","volume":"37","author":"Y Guo","year":"2021","unstructured":"Guo Y, Zhao S, Wang GG. Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 \u2018Readout\u2019, and Phase Separation-Based Compaction. Trends Genet. 2021;37:547\u201365.","journal-title":"Trends Genet"},{"key":"3097_CR48","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/s41588-018-0338-y","volume":"51","author":"MC Donaldson-Collier","year":"2019","unstructured":"Donaldson-Collier MC, Sungalee S, Zufferey M, Tavernari D, Katanayeva N, Battistello E, et al. EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains. Nat Genet. 2019;51:517\u201328.","journal-title":"Nat Genet"},{"key":"3097_CR49","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/35013100","volume":"405","author":"AC Bell","year":"2000","unstructured":"Bell AC, Felsenfeld G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature. 2000;405:482\u20135.","journal-title":"Nature"},{"key":"3097_CR50","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/35013106","volume":"405","author":"AT Hark","year":"2000","unstructured":"Hark AT, Schoenherr CJ, Katz DJ, Ingram RS, Levorse JM, Tilghman SM. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19\/Igf2 locus. Nature. 2000;405:486\u20139.","journal-title":"Nature"},{"key":"3097_CR51","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature16490","volume":"529","author":"WA Flavahan","year":"2016","unstructured":"Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, et al. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature. 2016;529:110\u20134.","journal-title":"Nature"},{"key":"3097_CR52","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/s41467-019-14098-x","volume":"11","author":"J Achinger-Kawecka","year":"2020","unstructured":"Achinger-Kawecka J, Valdes-Mora F, Luu PL, Giles KA, Caldon CE, Qu W, et al. Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer. Nat Commun. 2020;11:320.","journal-title":"Nat Commun"},{"key":"3097_CR53","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/s41419-021-04291-6","volume":"12","author":"XY Shang","year":"2021","unstructured":"Shang XY, Shi Y, He DD, Wang L, Luo Q, Deng CH, et al. ARID1A deficiency weakens BRG1-RAD21 interaction that jeopardizes chromatin compactness and drives liver cancer cell metastasis. Cell Death Dis. 2021;12:990.","journal-title":"Cell Death Dis"},{"key":"3097_CR54","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41586-021-04246-z","volume":"601","author":"L Xiao","year":"2022","unstructured":"Xiao L, Parolia A, Qiao Y, Bawa P, Eyunni S, Mannan R, et al. Targeting SWI\/SNF ATPases in enhancer-addicted prostate cancer. Nature. 2022;601:434\u20139.","journal-title":"Nature"},{"key":"3097_CR55","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41586-021-03662-5","volume":"595","author":"JH Ahn","year":"2021","unstructured":"Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, et al. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021;595:591\u20135.","journal-title":"Nature"},{"key":"3097_CR56","doi-asserted-by":"crossref","unstructured":"Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F et al. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Mol Cell. 2022;82:833\u2009\u2013\u200951 e11.","DOI":"10.1016\/j.molcel.2022.01.014"},{"key":"3097_CR57","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/cr.2014.35","volume":"24","author":"JF Xiang","year":"2014","unstructured":"Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, et al. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res. 2014;24:513\u201331.","journal-title":"Cell Res"},{"key":"3097_CR58","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nature12210","volume":"498","author":"W Li","year":"2013","unstructured":"Li W, Notani D, Ma Q, Tanasa B, Nunez E, Chen AY, et al. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature. 2013;498:516\u201320.","journal-title":"Nature"},{"key":"3097_CR59","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13059-023-02926-9","volume":"24","author":"M Karimzadeh","year":"2023","unstructured":"Karimzadeh M, Arlidge C, Rostami A, Lupien M, Bratman SV, Hoffman MM. Human papillomavirus integration transforms chromatin to drive oncogenesis. Genome Biol. 2023;24:142.","journal-title":"Genome Biol"},{"key":"3097_CR60","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jgg.2020.05.006","volume":"47","author":"C Cao","year":"2020","unstructured":"Cao C, Hong P, Huang X, Lin D, Cao G, Wang L, et al. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer. J Genet Genomics. 2020;47:437\u201350.","journal-title":"J Genet Genomics"},{"key":"3097_CR61","doi-asserted-by":"publisher","first-page":"785169","DOI":"10.3389\/fcimb.2021.785169","volume":"11","author":"X Xu","year":"2021","unstructured":"Xu X, Han Z, Ruan Y, Liu M, Cao G, Li C, et al. HPV16-LINC00393 Integration Alters Local 3D Genome Architecture in Cervical Cancer Cells. Front Cell Infect Microbiol. 2021;11:785169.","journal-title":"Front Cell Infect Microbiol"},{"key":"3097_CR62","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1093\/nar\/gkad105","volume":"51","author":"R Tian","year":"2023","unstructured":"Tian R, Huang Z, Li L, Yuan J, Zhang Q, Meng L, et al. HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription. Nucleic Acids Res. 2023;51:4237\u201351.","journal-title":"Nucleic Acids Res"},{"key":"3097_CR63","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1126\/science.1067799","volume":"295","author":"J Dekker","year":"2002","unstructured":"Dekker J, Rippe K, Dekker M, Kleckner N. Capturing chromosome conformation. Science. 2002;295:1306\u201311.","journal-title":"Science"},{"key":"3097_CR64","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/ng1891","volume":"38","author":"Z Zhao","year":"2006","unstructured":"Zhao Z, Tavoosidana G, Sjolinder M, Gondor A, Mariano P, Wang S, et al. Circular chromosome conformation capture (4\u00a0C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet. 2006;38:1341\u20137.","journal-title":"Nat Genet"},{"key":"3097_CR65","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1101\/gr.5571506","volume":"16","author":"J Dostie","year":"2006","unstructured":"Dostie J, Richmond TA, Arnaout RA, Selzer RR, Lee WL, Honan TA, et al. Chromosome Conformation Capture Carbon Copy (5\u00a0C): a massively parallel solution for mapping interactions between genomic elements. Genome Res. 2006;16:1299\u2013309.","journal-title":"Genome Res"},{"key":"3097_CR66","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature21411","volume":"543","author":"RA Beagrie","year":"2017","unstructured":"Beagrie RA, Scialdone A, Schueler M, Kraemer DC, Chotalia M, Xie SQ, et al. Complex multi-enhancer contacts captured by genome architecture mapping. Nature. 2017;543:519\u201324.","journal-title":"Nature"},{"key":"3097_CR67","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.cell.2018.05.024","volume":"174","author":"SA Quinodoz","year":"2018","unstructured":"Quinodoz SA, Ollikainen N, Tabak B, Palla A, Schmidt JM, Detmar E, et al. Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. Cell. 2018;174:744\u201357. e24.","journal-title":"Cell"},{"key":"3097_CR68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41587-020-0643-8","volume":"39","author":"Q You","year":"2021","unstructured":"You Q, Cheng AY, Gu X, Harada BT, Yu M, Wu T, et al. Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution. Nat Biotechnol. 2021;39:225\u201335.","journal-title":"Nat Biotechnol"},{"key":"3097_CR69","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.cell.2015.05.048","volume":"162","author":"TH Hsieh","year":"2015","unstructured":"Hsieh TH, Weiner A, Lajoie B, Dekker J, Friedman N, Rando OJ. Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C. Cell. 2015;162:108\u201319.","journal-title":"Cell"},{"key":"3097_CR70","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41588-026-02503-3","volume":"58","author":"N Maziak","year":"2026","unstructured":"Maziak N, Zhang Y, Groll F, Brown HE, Madich A, Kaur Y, et al. Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila. Nat Genet. 2026;58:607\u201317.","journal-title":"Nat Genet"},{"key":"3097_CR71","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature12593","volume":"502","author":"T Nagano","year":"2013","unstructured":"Nagano T, Lubling Y, Stevens TJ, Schoenfelder S, Yaffe E, Dean W, et al. Single-cell Hi-C reveals cell-to-cell variability in chromosome structure. Nature. 2013;502:59\u201364.","journal-title":"Nature"},{"key":"3097_CR72","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature21711","volume":"544","author":"IM Flyamer","year":"2017","unstructured":"Flyamer IM, Gassler J, Imakaev M, Brandao HB, Ulianov SV, Abdennur N, et al. Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition. Nature. 2017;544:110\u20134.","journal-title":"Nature"},{"key":"3097_CR73","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1126\/science.aat5641","volume":"361","author":"L Tan","year":"2018","unstructured":"Tan L, Xing D, Chang CH, Li H, Xie XS. Three-dimensional genome structures of single diploid human cells. Science. 2018;361:924\u20138.","journal-title":"Science"},{"key":"3097_CR74","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1038\/s41587-024-02447-1","volume":"43","author":"L Chang","year":"2025","unstructured":"Chang L, Xie Y, Taylor B, Wang Z, Sun J, Armand EJ, et al. Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues. Nat Biotechnol. 2025;43:1694\u2013707.","journal-title":"Nat Biotechnol"},{"key":"3097_CR75","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1038\/s41588-025-02247-6","volume":"57","author":"H Wu","year":"2025","unstructured":"Wu H, Zhang J, Tan L, Xie XS. Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs. Nat Genet. 2025;57:1777\u201386.","journal-title":"Nat Genet"},{"key":"3097_CR76","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ng1491","volume":"37","author":"S Horike","year":"2005","unstructured":"Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet. 2005;37:31\u201340.","journal-title":"Nat Genet"},{"key":"3097_CR77","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nature08497","volume":"462","author":"MJ Fullwood","year":"2009","unstructured":"Fullwood MJ, Liu MH, Pan YF, Liu J, Xu H, Mohamed YB, et al. An oestrogen-receptor-alpha-bound human chromatin interactome. Nature. 2009;462:58\u201364.","journal-title":"Nature"},{"key":"3097_CR78","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/nmeth.3999","volume":"13","author":"MR Mumbach","year":"2016","unstructured":"Mumbach MR, Rubin AJ, Flynn RA, Dai C, Khavari PA, Greenleaf WJ, et al. HiChIP: efficient and sensitive analysis of protein-directed genome architecture. Nat Methods. 2016;13:919\u201322.","journal-title":"Nat Methods"},{"key":"3097_CR79","doi-asserted-by":"publisher","first-page":"e1010121","DOI":"10.1371\/journal.pgen.1010121","volume":"18","author":"S Sati","year":"2022","unstructured":"Sati S, Jones P, Kim HS, Zhou LA, Rapp-Reyes E, Leung TH. HiCuT: An efficient and low input method to identify protein-directed chromatin interactions. PLoS Genet. 2022;18:e1010121.","journal-title":"PLoS Genet"},{"key":"3097_CR80","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/s41586-019-0949-1","volume":"566","author":"M Zheng","year":"2019","unstructured":"Zheng M, Tian SZ, Capurso D, Kim M, Maurya R, Lee B, et al. Multiplex chromatin interactions with single-molecule precision. Nature. 2019;566:558\u201362.","journal-title":"Nature"},{"key":"3097_CR81","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.1016\/j.cell.2021.10.014","volume":"184","author":"SA Quinodoz","year":"2021","unstructured":"Quinodoz SA, Jachowicz JW, Bhat P, Ollikainen N, Banerjee AK, Goronzy IN, et al. RNA promotes the formation of spatial compartments in the nucleus. Cell. 2021;184:5775\u2013e9030.","journal-title":"Cell"},{"key":"3097_CR82","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41592-019-0407-x","volume":"16","author":"MR Mumbach","year":"2019","unstructured":"Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, et al. HiChIRP reveals RNA-associated chromosome conformation. Nat Methods. 2019;16:489\u201392.","journal-title":"Nat Methods"},{"key":"3097_CR83","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s41586-024-07239-w","volume":"628","author":"X Wen","year":"2024","unstructured":"Wen X, Luo Z, Zhao W, Calandrelli R, Nguyen TC, Wan X, et al. Single-cell multiplex chromatin and RNA interactions in ageing human brain. Nature. 2024;628:648\u201356.","journal-title":"Nature"},{"key":"3097_CR84","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13059-023-02889-x","volume":"24","author":"H Fu","year":"2023","unstructured":"Fu H, Zheng H, Chen X, Weirauch MT, Muglia LJ, Wang L, et al. NOMe-HiC: joint profiling of genetic variant, DNA methylation, chromatin accessibility, and 3D genome in the same DNA molecule. Genome Biol. 2023;24:50.","journal-title":"Genome Biol"},{"key":"3097_CR85","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/s41586-026-10322-z","volume":"653","author":"Y Chen","year":"2026","unstructured":"Chen Y, Liu Z, Xu H, Liu J, Wang M, Chi Y, et al. Gene regulatory landscape dissected by single-cell four-omics sequencing. Nature. 2026;653:942\u201351.","journal-title":"Nature"},{"key":"3097_CR86","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.cell.2020.07.032","volume":"182","author":"JH Su","year":"2020","unstructured":"Su JH, Zheng P, Kinrot SS, Bintu B, Zhuang X. Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin. Cell. 2020;182:1641\u2013e5926.","journal-title":"Cell"},{"key":"3097_CR87","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s41586-020-03126-2","volume":"590","author":"Y Takei","year":"2021","unstructured":"Takei Y, Yun J, Zheng S, Ollikainen N, Pierson N, White J, et al. Integrated spatial genomics reveals global architecture of single nuclei. Nature. 2021;590:344\u201350.","journal-title":"Nature"},{"key":"3097_CR88","first-page":"0865","volume":"8","author":"X Jiang","year":"2025","unstructured":"Jiang X, Wang X, Shen S, Hou S, Yu C. 3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases. Res (Wash D C). 2025;8:0865.","journal-title":"Res (Wash D C)"},{"key":"3097_CR89","doi-asserted-by":"publisher","first-page":"eadr8265","DOI":"10.1126\/sciadv.adr8265","volume":"11","author":"G Schuette","year":"2025","unstructured":"Schuette G, Lao Z, Zhang B, ChromoGen. Diffusion model predicts single-cell chromatin conformations. Sci Adv. 2025;11:eadr8265.","journal-title":"Sci Adv"},{"key":"3097_CR90","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/s41586-025-10014-0","volume":"649","author":"Z Avsec","year":"2026","unstructured":"Avsec Z, Latysheva N, Cheng J, Novati G, Taylor KR, Ward T, et al. Advancing regulatory variant effect prediction with AlphaGenome. Nature. 2026;649:1206\u201318.","journal-title":"Nature"},{"key":"3097_CR91","doi-asserted-by":"publisher","first-page":"398","DOI":"10.5483\/BMBRep.2023-0044","volume":"56","author":"EC Lee","year":"2023","unstructured":"Lee EC, Kim K, Jung WJ, Kim HP. Vorinostat-induced acetylation of RUNX3 reshapes transcriptional profile through long-range enhancer-promoter interactions in natural killer cells. BMB Rep. 2023;56:398\u2013403.","journal-title":"BMB Rep"},{"key":"3097_CR92","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1038\/leu.2008.397","volume":"23","author":"C Flotho","year":"2009","unstructured":"Flotho C, Claus R, Batz C, Schneider M, Sandrock I, Ihde S, et al. The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009;23:1019\u201328.","journal-title":"Leukemia"},{"key":"3097_CR93","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/s41594-023-01181-7","volume":"31","author":"J Achinger-Kawecka","year":"2024","unstructured":"Achinger-Kawecka J, Stirzaker C, Portman N, Campbell E, Chia KM, Du Q, et al. The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer. Nat Struct Mol Biol. 2024;31:498\u2013512.","journal-title":"Nat Struct Mol Biol"},{"key":"3097_CR94","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41556-022-00850-x","volume":"24","author":"J Wang","year":"2022","unstructured":"Wang J, Yu X, Gong W, Liu X, Park KS, Ma A, et al. EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nat Cell Biol. 2022;24:384\u201399.","journal-title":"Nat Cell Biol"},{"key":"3097_CR95","doi-asserted-by":"publisher","unstructured":"Cao T, Liu D, Gao H, Qin C, Zhang W, Lu Z et al. Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2-Selective Small Molecule Inhibitor. Adv Sci (Weinh). 2026:e76025. https:\/\/doi.org\/10.1002\/advs.76025.","DOI":"10.1002\/advs.76025"},{"key":"3097_CR96","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature11606","volume":"492","author":"MT McCabe","year":"2012","unstructured":"McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012;492:108\u201312.","journal-title":"Nature"},{"key":"3097_CR97","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11912-026-01754-x","volume":"28","author":"M Kucukoner","year":"2026","unstructured":"Kucukoner M, Demir T, Alsubaie AM, Alabalik U, Ibrahim AK, Pierobon M, et al. The Role of EZH2 in Malignant Pleural Mesothelioma and Beyond: Current Practice and Future Perspectives. Curr Oncol Rep. 2026;28:65.","journal-title":"Curr Oncol Rep"},{"key":"3097_CR98","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1038\/s41467-019-09500-7","volume":"10","author":"OL Kantidze","year":"2019","unstructured":"Kantidze OL, Luzhin AV, Nizovtseva EV, Safina A, Valieva ME, Golov AK, et al. The anti-cancer drugs curaxins target spatial genome organization. Nat Commun. 2019;10:1441.","journal-title":"Nat Commun"},{"key":"3097_CR99","doi-asserted-by":"publisher","first-page":"117159","DOI":"10.1016\/j.bcp.2025.117159","volume":"241","author":"J Hu","year":"2025","unstructured":"Hu J, Yang J, Zhou R, Chen K, Zhao H, Zhou Y. Discovery of a potent BRD4 PROTAC and evaluation of its bioactivity in breast cancer cell lines. Biochem Pharmacol. 2025;241:117159.","journal-title":"Biochem Pharmacol"},{"key":"3097_CR100","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/ph16020199","volume":"16","author":"DH Chin","year":"2023","unstructured":"Chin DH, Osman I, Porch J, Kim H, Buck KK, Rodriguez J, et al. BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters. Pharmaceuticals (Basel). 2023;16:199.","journal-title":"Pharmaceuticals (Basel)"},{"key":"3097_CR101","doi-asserted-by":"publisher","first-page":"gkaf726","DOI":"10.1093\/nar\/gkaf726","volume":"53","author":"II Pavlova","year":"2025","unstructured":"Pavlova II, Ivanova OM, Iudin MS, Surdina AV, Barinov NA, Bogomiakova ME, et al. G-quadruplexes as potential traps for superenhancer marker BRD4: ligand-sensitive binding and co-separation in vitro. Nucleic Acids Res. 2025;53:gkaf726.","journal-title":"Nucleic Acids Res"},{"key":"3097_CR102","doi-asserted-by":"publisher","first-page":"103784","DOI":"10.1016\/j.dnarep.2024.103784","volume":"144","author":"Q Zhu","year":"2024","unstructured":"Zhu Q, Chen X, Lin Z. Discovery of KPT-6566 as STAG1\/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro. DNA Repair (Amst). 2024;144:103784.","journal-title":"DNA Repair (Amst)"},{"key":"3097_CR103","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1038\/s43018-024-00816-y","volume":"5","author":"B Lu","year":"2024","unstructured":"Lu B, Qiu R, Wei J, Wang L, Zhang Q, Li M, et al. Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer. Nat Cancer. 2024;5:1622\u201340.","journal-title":"Nat Cancer"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-03097-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-03097-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-03097-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:02:20Z","timestamp":1792634540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-03097-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":103,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3097"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-03097-3","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"26 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"571"}}