{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:55:56Z","timestamp":1790646956742,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1304604"],"award-info":[{"award-number":["2022YFA1304604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1204600"],"award-info":[{"award-number":["2023YFF1204600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515012568"],"award-info":[{"award-number":["2026A1515012568"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024B1515020029"],"award-info":[{"award-number":["2024B1515020029"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21626714"],"award-info":[{"award-number":["21626714"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372691"],"award-info":[{"award-number":["82372691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental research funds for the central universities","award":["21626102"],"award-info":[{"award-number":["21626102"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"DOI":"10.1186\/s12964-026-03211-5","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:46:07Z","timestamp":1789040767000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Avobenzone induces intestinal injury by targeting ATG14 and impairing mitophagy"],"prefix":"10.1186","volume":"24","author":[{"given":"Zi-Kang","family":"Gui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Rui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"issue":"3","key":"3211_CR1","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s00204-016-1794-8","volume":"91","author":"P Akbari","year":"2017","unstructured":"Akbari P, Braber S, Varasteh S, Alizadeh A, Garssen J, Fink-Gremmels J. The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins. Arch Toxicol. 2017;91(3):1007\u201329.","journal-title":"Arch Toxicol"},{"key":"3211_CR2","doi-asserted-by":"publisher","first-page":"116337","DOI":"10.1016\/j.ecoenv.2024.116337","volume":"277","author":"M Verma","year":"2024","unstructured":"Verma M, Garg M, Khan AS, Yadav P, Rahman SS, Ali A, Kamthan M. Cadmium modulates intestinal Wnt\/\u03b2-catenin signaling ensuing intestinal barrier disruption and systemic inflammation. Ecotoxicol Environ Saf. 2024;277:116337.","journal-title":"Ecotoxicol Environ Saf"},{"key":"3211_CR3","doi-asserted-by":"publisher","first-page":"122311","DOI":"10.1016\/j.lfs.2023.122311","volume":"336","author":"NS Kiran","year":"2024","unstructured":"Kiran NS, Yashaswini C, Chatterjee A. Noxious ramifications of cosmetic pollutants on gastrointestinal microbiome: A pathway to neurological disorders. Life Sci. 2024;336:122311.","journal-title":"Life Sci"},{"issue":"5","key":"3211_CR4","doi-asserted-by":"publisher","first-page":"354","DOI":"10.4252\/wjsc.v15.i5.354","volume":"15","author":"Z Wang","year":"2023","unstructured":"Wang Z, Qu YJ, Cui M. Modulation of stem cell fate in intestinal homeostasis, injury and repair. World J Stem Cells. 2023;15(5):354\u201368.","journal-title":"World J Stem Cells"},{"issue":"1","key":"3211_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrm3721","volume":"15","author":"N Barker","year":"2014","unstructured":"Barker N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol. 2014;15(1):19\u201333.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"3211_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/15548627.2020.1725377","volume":"17","author":"RQ Yao","year":"2021","unstructured":"Yao RQ, Ren C, Xia ZF, Yao YM. Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. Autophagy. 2021;17(2):385\u2013401.","journal-title":"Autophagy"},{"key":"3211_CR7","doi-asserted-by":"crossref","unstructured":"Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, et al. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife. 2016;5:e10575.","DOI":"10.7554\/eLife.10575"},{"issue":"1","key":"3211_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20081386","volume":"417","author":"MP Murphy","year":"2009","unstructured":"Murphy MP. How mitochondria produce reactive oxygen species. Biochem J. 2009;417(1):1\u201313.","journal-title":"Biochem J"},{"issue":"7548","key":"3211_CR9","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nature14156","volume":"520","author":"AP West","year":"2015","unstructured":"West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520(7548):553\u20137.","journal-title":"Nature"},{"issue":"6","key":"3211_CR10","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194\u2013217.","journal-title":"Cell"},{"issue":"1","key":"3211_CR11","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41467-024-44808-z","volume":"15","author":"L Yang","year":"2024","unstructured":"Yang L, Ruan Z, Lin X, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, et al. NAD(+) dependent UPR(mt) activation underlies intestinal aging caused by mitochondrial DNA mutations. Nat Commun. 2024;15(1):546.","journal-title":"Nat Commun"},{"key":"3211_CR12","doi-asserted-by":"publisher","first-page":"105495","DOI":"10.1016\/j.envint.2020.105495","volume":"137","author":"AT Lebedev","year":"2020","unstructured":"Lebedev AT, Bavcon Kralj M, Polyakova OV, Detenchuk EA, Pokryshkin SA, Treb\u0161e P. Identification of avobenzone by-products formed by various disinfectants in different types of swimming pool waters. Environ Int. 2020;137:105495.","journal-title":"Environ Int"},{"issue":"6","key":"3211_CR13","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1007\/s10646-022-02555-1","volume":"31","author":"Y Ka","year":"2022","unstructured":"Ka Y, Ji K. Waterborne exposure to avobenzone and octinoxate induces thyroid endocrine disruption in wild-type and thr\u03b1a(-\/-) zebrafish larvae. Ecotoxicology. 2022;31(6):948\u201355.","journal-title":"Ecotoxicology"},{"key":"3211_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.watres.2014.09.013","volume":"67","author":"MM Tsui","year":"2014","unstructured":"Tsui MM, Leung HW, Wai TC, Yamashita N, Taniyasu S, Liu W, Lam PK, Murphy MB. Occurrence, distribution and ecological risk assessment of multiple classes of UV filters in surface waters from different countries. Water Res. 2014;67:55\u201365.","journal-title":"Water Res"},{"issue":"6","key":"3211_CR15","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1080\/10408444.2025.2535394","volume":"55","author":"KG Norman","year":"2025","unstructured":"Norman KG, Kaufman LE, D\u2019Ruiz C, Loretz L, Kowcz A, Cohen SM, Scialli AR, Boobis AR, Jacobson-Kram D, Schoeny R, et al. Comprehensive review of avobenzone (butyl methoxydibenzoylmethane) toxicology data and human exposure assessment for personal care products. Crit Rev Toxicol. 2025;55(6):662\u201392.","journal-title":"Crit Rev Toxicol"},{"issue":"3","key":"3211_CR16","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1001\/jama.2019.20747","volume":"323","author":"MK Matta","year":"2020","unstructured":"Matta MK, Florian J, Zusterzeel R, Pilli NR, Patel V, Volpe DA, Yang Y, Oh L, Bashaw E, Zineh I, et al. Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial. JAMA. 2020;323(3):256\u201367.","journal-title":"JAMA"},{"issue":"7","key":"3211_CR17","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1007\/s00204-019-02462-1","volume":"93","author":"S Ahn","year":"2019","unstructured":"Ahn S, An S, Lee M, Lee E, Pyo JJ, Kim JH, Ki MW, Jin SH, Ha J, Noh M. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019;93(7):1903\u201315.","journal-title":"Arch Toxicol"},{"key":"3211_CR18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.reprotox.2018.07.003","volume":"81","author":"C Yang","year":"2018","unstructured":"Yang C, Lim W, Bazer FW, Song G. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol. 2018;81:50\u20137.","journal-title":"Reprod Toxicol"},{"issue":"2","key":"3211_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27\u201331.","journal-title":"J Basic Clin Pharm"},{"key":"3211_CR20","unstructured":"European Chemicals Agency. REACH registrations for 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)propane-1,3-dione - ECHA CHEM. https:\/\/chem.echa.europa.eu\/100.067.779\/dossier-list\/reach\/dossiers\/active. Accessed 30 July 2026."},{"issue":"6","key":"3211_CR21","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.7150\/ijbs.82361","volume":"20","author":"ZJ Huang","year":"2024","unstructured":"Huang ZJ, Li YJ, Yang J, Huang L, Zhao Q, Lu YF, Hu Y, Zhang WX, Liang JZ, Pan J, et al. PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer. Int J Biol Sci. 2024;20(6):2202\u201318.","journal-title":"Int J Biol Sci"},{"issue":"10","key":"3211_CR22","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.jpha.2023.06.005","volume":"13","author":"XL Liang","year":"2023","unstructured":"Liang XL, Ouyang L, Yu NN, Sun ZH, Gui ZK, Niu YL, He QY, Zhang J, Wang Y. Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission. J Pharm Anal. 2023;13(10):1168\u201382.","journal-title":"J Pharm Anal"},{"key":"3211_CR23","doi-asserted-by":"crossref","unstructured":"Rojansky R, Cha MY, Chan DC. Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. Elife. 2016;5:e17896.","DOI":"10.7554\/eLife.17896"},{"issue":"7","key":"3211_CR24","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1016\/j.ymthe.2023.05.015","volume":"31","author":"Y Wang","year":"2023","unstructured":"Wang Y, Chen YY, Gao GB, Zheng YH, Yu NN, Ouyang L, Gao X, Li N, Wen SY, Huang S, et al. Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase. Mol Ther. 2023;31(7):2169\u201387.","journal-title":"Mol Ther"},{"issue":"9","key":"3211_CR25","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.stem.2022.08.002","volume":"29","author":"GW He","year":"2022","unstructured":"He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, et al. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell. 2022;29(9):1333\u2013e13451336.","journal-title":"Cell Stem Cell"},{"issue":"5","key":"3211_CR26","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","volume":"141","author":"T Sato","year":"2011","unstructured":"Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett\u2019s epithelium. Gastroenterology. 2011;141(5):1762\u201372.","journal-title":"Gastroenterology"},{"issue":"51","key":"3211_CR27","doi-asserted-by":"publisher","first-page":"e2518675122","DOI":"10.1073\/pnas.2518675122","volume":"122","author":"Y Wang","year":"2025","unstructured":"Wang Y, Huang ZJ, Yu NN, Liang JZ, Zeng YH, Zhao Q, Zhou YP, Zeng YJ, Sun ZH, Zhang S, et al. MLKL\/retromer axis controls PD-L1 recycling to compromise antitumor immunity during VCP inhibition-induced necroptosis. Proc Natl Acad Sci U S A. 2025;122(51):e2518675122.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3211_CR28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","volume":"20","author":"JA Olzmann","year":"2019","unstructured":"Olzmann JA, Carvalho P. Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol. 2019;20(3):137\u201355.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"3211_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","volume":"12","author":"RJ Youle","year":"2011","unstructured":"Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2011;12(1):9\u201314.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3211_CR30","doi-asserted-by":"publisher","first-page":"e06734","DOI":"10.7554\/eLife.06734","volume":"4","author":"T Zhang","year":"2015","unstructured":"Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, et al. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife. 2015;4:e06734.","journal-title":"Elife"},{"issue":"3","key":"3211_CR31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/cr.2018.16","volume":"28","author":"A Melber","year":"2018","unstructured":"Melber A, Haynes CM. UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication. Cell Res. 2018;28(3):281\u201395.","journal-title":"Cell Res"},{"issue":"7609","key":"3211_CR32","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nature18302","volume":"534","author":"C M\u00fcnch","year":"2016","unstructured":"M\u00fcnch C, Harper JW. Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation. Nature. 2016;534(7609):710\u20133.","journal-title":"Nature"},{"issue":"7165","key":"3211_CR33","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449(7165):1003\u20137.","journal-title":"Nature"},{"issue":"2","key":"3211_CR34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.stem.2013.11.008","volume":"14","author":"C Metcalfe","year":"2014","unstructured":"Metcalfe C, Kljavin NM, Ybarra R, de Sauvage FJ. Lgr5\u2009+\u2009stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell. 2014;14(2):149\u201359.","journal-title":"Cell Stem Cell"},{"key":"3211_CR35","doi-asserted-by":"publisher","first-page":"e07314","DOI":"10.7554\/eLife.07314","volume":"4","author":"C Sidrauski","year":"2015","unstructured":"Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, et al. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015;4:e07314.","journal-title":"Elife"},{"issue":"2","key":"3211_CR36","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274\u201393.","journal-title":"Cell"},{"issue":"6","key":"3211_CR37","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s43587-023-00416-y","volume":"3","author":"JB Mannick","year":"2023","unstructured":"Mannick JB, Lamming DW. Targeting the biology of aging with mTOR inhibitors. Nat Aging. 2023;3(6):642\u201360.","journal-title":"Nat Aging"},{"issue":"1","key":"3211_CR38","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s11658-024-00677-4","volume":"29","author":"J Cheng","year":"2024","unstructured":"Cheng J, Wu H, Cui Y. WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration. Cell Mol Biol Lett. 2024;29(1):158.","journal-title":"Cell Mol Biol Lett"},{"issue":"7","key":"3211_CR39","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41419-021-03993-1","volume":"12","author":"X Gao","year":"2021","unstructured":"Gao X, Jiang Z, Yan X, Liu J, Li F, Liu P, Li J, Wei Y, Sun YE, Zhang Y, Wang C. ATF5, a putative therapeutic target for the mitochondrial DNA 3243A\u2009>\u2009G mutation-related disease. Cell Death Dis. 2021;12(7):701.","journal-title":"Cell Death Dis"},{"issue":"6","key":"3211_CR40","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.cmet.2023.04.012","volume":"35","author":"CL Wang","year":"2023","unstructured":"Wang CL, Ohkubo R, Mu WC, Chen W, Fan JL, Song Z, Maruichi A, Sudmant PH, Pisco AO, Dubal DB, et al. The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging. Cell Metab. 2023;35(6):996\u2013e10081007.","journal-title":"Cell Metab"},{"issue":"12","key":"3211_CR41","doi-asserted-by":"publisher","first-page":"3687","DOI":"10.1084\/jem.20170558","volume":"214","author":"Y Matsuzawa-Ishimoto","year":"2017","unstructured":"Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A, Marinis JM, et al. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J Exp Med. 2017;214(12):3687\u2013705.","journal-title":"J Exp Med"},{"issue":"7219","key":"3211_CR42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nature07416","volume":"456","author":"K Cadwell","year":"2008","unstructured":"Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008;456(7219):259\u201363.","journal-title":"Nature"},{"issue":"3","key":"3211_CR43","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.chom.2023.01.006","volume":"31","author":"M Naama","year":"2023","unstructured":"Naama M, Telpaz S, Awad A, Ben-Simon S, Harshuk-Shabso S, Modilevsky S, Rubin E, Sawaed J, Zelik L, Zigdon M, et al. Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress. Cell Host Microbe. 2023;31(3):433\u2013e446434.","journal-title":"Cell Host Microbe"},{"issue":"7","key":"3211_CR44","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.semcdb.2010.04.002","volume":"21","author":"T Noda","year":"2010","unstructured":"Noda T, Matsunaga K, Taguchi-Atarashi N, Yoshimori T. Regulation of membrane biogenesis in autophagy via PI3P dynamics. Semin Cell Dev Biol. 2010;21(7):671\u20136.","journal-title":"Semin Cell Dev Biol"},{"issue":"9","key":"3211_CR45","doi-asserted-by":"publisher","first-page":"113045","DOI":"10.1016\/j.celrep.2023.113045","volume":"42","author":"X Shi","year":"2023","unstructured":"Shi X, Wu W, Feng Z, Fan P, Shi R, Zhang X. MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy. Cell Rep. 2023;42(9):113045.","journal-title":"Cell Rep"},{"key":"3211_CR46","doi-asserted-by":"publisher","first-page":"155693","DOI":"10.1016\/j.metabol.2023.155693","volume":"148","author":"M Huang","year":"2023","unstructured":"Huang M, Zhang Y, Park J, Chowdhury K, Xu J, Lu A, Wang L, Zhang W, Ekser B, Yu L, Dong XC. ATG14 plays a critical role in hepatic lipid droplet homeostasis. Metabolism. 2023;148:155693.","journal-title":"Metabolism"},{"issue":"1","key":"3211_CR47","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41418-020-00665-z","volume":"28","author":"J Sprangers","year":"2021","unstructured":"Sprangers J, Zaalberg IC, Maurice MM. Organoid-based modeling of intestinal development, regeneration, and repair. Cell Death Differ. 2021;28(1):95\u2013107.","journal-title":"Cell Death Differ"},{"issue":"5","key":"3211_CR48","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1002\/ieam.4449","volume":"17","author":"B Kwon","year":"2021","unstructured":"Kwon B, Choi K. Occurrence of major organic UV filters in aquatic environments and their endocrine disruption potentials: A mini-review. Integr Environ Assess Manag. 2021;17(5):940\u201350.","journal-title":"Integr Environ Assess Manag"},{"key":"3211_CR49","volume-title":"Review of Fate, Exposure, and Effects of Sunscreens in Aquatic Environments and Implications for Sunscreen Usage and Human Health","author":"National Academies of Sciences, Engineering, and Medicine","year":"2022","unstructured":"National Academies of Sciences, Engineering, and Medicine. Review of Fate, Exposure, and Effects of Sunscreens in Aquatic Environments and Implications for Sunscreen Usage and Human Health. Washington, DC: National Academies; 2022."}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-026-03211-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-03211-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-026-03211-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:22Z","timestamp":1790643802000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12964-026-03211-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3211"],"URL":"https:\/\/doi.org\/10.1186\/s12964-026-03211-5","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"24 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Jinan University and conducted in accordance with the approved protocols (IACUC-20231106-03 and IACUC-20241202-02). Human intestinal tissues used for organoid establishment were obtained from surgically resected specimens from patients with colorectal cancer. The use of human tissues was approved by the Institutional Review Board of Jinan University (Approval number: JNUKY-2023-0092). Written informed consent was obtained from all participants prior to tissue collection.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"514"}}