{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:16:30Z","timestamp":1790507790750,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,3]],"date-time":"2014-08-03T00:00:00Z","timestamp":1407024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12967-014-0220-3","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T08:07:01Z","timestamp":1406966821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models"],"prefix":"10.1186","volume":"12","author":[{"given":"Patricia","family":"Mart\u00ednez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Guti\u00e9rrez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Masju\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Alonso de Leci\u00f1ana","family":"Cases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Novillo-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Exuperio","family":"D\u00edez-Tejedor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,3]]},"reference":[{"issue":"1","key":"220_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.pbb.2007.04.015","volume":"87","author":"A Durukan","year":"2007","unstructured":"Durukan A, Tatlisumak T: Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav. 2007, 87 (1): 179-197.","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"220_CR2","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1161\/STROKEAHA.108.541128","volume":"40","author":"M Fisher","year":"2009","unstructured":"Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH: Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009, 40 (6): 2244-2250.","journal-title":"Stroke"},{"key":"220_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/jcbfm.1981.6","volume":"1","author":"A Tamura","year":"1981","unstructured":"Tamura A, Graham DI, McCulloch J, Teasdale GM: Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1981, 1: 53-60.","journal-title":"J Cereb Blood Flow Metab"},{"key":"220_CR4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/j.1365-2125.1992.tb05634.x","volume":"34","author":"I Macrae","year":"1992","unstructured":"Macrae I: New models of focal cerebral ischaemia. Br J Clin Pharmacol. 1992, 34: 302-308.","journal-title":"Br J Clin Pharmacol"},{"key":"220_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1227\/00006123-199207000-00014","volume":"31","author":"SA Menzies","year":"1992","unstructured":"Menzies SA, Hoff JT, Betz AL: Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery. 1992, 31: 100-106.","journal-title":"Neurosurgery"},{"key":"220_CR6","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1161\/01.STR.31.10.2325","volume":"31","author":"N Vila","year":"2000","unstructured":"Vila N, Castillo J, D\u00e1valos A, Chamorro A: Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke. 2000, 31: 2325-2329.","journal-title":"Stroke"},{"key":"220_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000074791","volume":"17","author":"J Castillo","year":"2004","unstructured":"Castillo J, Rodriguez I: Biochemical changes and inflammatory response as markers for brain ischaemia: molecular markers of diagnostic utility and prognosis in human clinical practice. Cerebrovasc Dis. 2004, 17: 7-18.","journal-title":"Cerebrovasc Dis"},{"issue":"6","key":"220_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1600-0404.2005.00416.x","volume":"111","author":"U Waje-Andreassen","year":"2005","unstructured":"Waje-Andreassen U, Krakenes J, Ulvestad E, Thomassen L, Myhr KM, Aarseth J, Vedeler CA: IL-6: an early marker for outcome in acute ischemic stroke. Acta Neurol Scand. 2005, 111 (6): 360-365.","journal-title":"Acta Neurol Scand"},{"issue":"Suppl 3","key":"220_CR9","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1212\/WNL.51.3_Suppl_3.S62","volume":"51","author":"TJ DeGraba","year":"1998","unstructured":"DeGraba TJ: The role of inflammation after acute stroke: utility of pursuing antiadhesion molecule therapy. Neurology. 1998, 51 (Suppl 3): S62-S68.","journal-title":"Neurology"},{"issue":"3","key":"220_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/WCO.0b013e3282ffafbf","volume":"21","author":"M Rodr\u00edguez-Y\u00e1\u00f1ez","year":"2008","unstructured":"Rodr\u00edguez-Y\u00e1\u00f1ez M, Castillo J: Role of inflammatory markers in brain ischemia. Curr Opin Neurol. 2008, 21 (3): 353-357.","journal-title":"Curr Opin Neurol"},{"issue":"11","key":"220_CR11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/BF03401714","volume":"3","author":"GI Botchkina","year":"1997","unstructured":"Botchkina GI, Meistrell ME, Botchkina I, Tracey KJ: Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med. 1997, 3 (11): 765-781.","journal-title":"Mol Med"},{"key":"220_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0140-6736(96)04453-4","volume":"349","author":"J Castillo","year":"1997","unstructured":"Castillo J, D\u00e1valos A, Noya M: Progression of ischaemic stroke and excitotoxic amino acids. Lancet. 1997, 349: 79-83.","journal-title":"Lancet"},{"key":"220_CR13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1161\/01.STR.27.6.1060","volume":"27","author":"J Castillo","year":"1996","unstructured":"Castillo J, D\u00e1valos A, Naveiro J, Noya M: Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke. Stroke. 1996, 27: 1060-1065.","journal-title":"Stroke"},{"key":"220_CR14","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1212\/01.wnl.0000326064.42186.7e","volume":"71","author":"M Castellanos","year":"2008","unstructured":"Castellanos M, Sobrino T, Pedraza S, Moldes O, Pumar JM, Silva Y, Serena J, Garc\u00eda-Gil M, Castillo J, D\u00e1valos A: High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke. Neurology. 2008, 71: 1862-1868.","journal-title":"Neurology"},{"key":"220_CR15","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/jcbfm.1992.66","volume":"12","author":"K Overgaard","year":"1992","unstructured":"Overgaard K, Sereghy T, Boysen G, Pedersen H, Hoyer S, Diemer NH: A rat model of reproducible cerebral infarction using thrombotic blood clot emboli. J Cereb Blood Flow Metab. 1992, 12: 484-490.","journal-title":"J Cereb Blood Flow Metab"},{"key":"220_CR16","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1161\/01.STR.17.4.738","volume":"17","author":"ST Chen","year":"1986","unstructured":"Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD: A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke. 1986, 17: 738-743.","journal-title":"Stroke"},{"key":"220_CR17","first-page":"H589","volume":"256","author":"TH Liu","year":"1989","unstructured":"Liu TH, Beckman JS, Freeman BA, Hogan EL, Hsu CY: Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol. 1989, 256: H589-H593.","journal-title":"Am J Physiol"},{"issue":"5","key":"220_CR18","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1161\/STROKEAHA.107.181486","volume":"38","author":"HP Adams Jr","year":"2007","unstructured":"Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A: Guidelines for the early management of adults with ischemic stroke. Stroke. 2007, 38 (5): 1655-1711.","journal-title":"Stroke"},{"issue":"9","key":"220_CR19","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1161\/01.STR.21.9.1280","volume":"21","author":"S Weingarten","year":"1990","unstructured":"Weingarten S, Bolus R, Riedinger MS, Maldonado L, Stein S, Ellrodt AG: The principle of parsimony: Glasgow Coma Scale score predicts mortality as well as the APACHE II score for stroke patients. Stroke. 1990, 21 (9): 1280-1282.","journal-title":"Stroke"},{"key":"220_CR20","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1161\/01.STR.30.8.1538","volume":"30","author":"G Sulter","year":"1999","unstructured":"Sulter G, Steen C, De Keyser J: Use of the Barthel Index and modified Rankin Scale in acute stroke trials. Stroke. 1999, 30: 1538-1541.","journal-title":"Stroke"},{"key":"220_CR21","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/320769a0","volume":"320","author":"SA Cohen","year":"1986","unstructured":"Cohen SA, Bidlingmeyer BA, Tarvin TL: PITC derivatives in amino acid analysis. Natures. 1986, 320: 769-770.","journal-title":"Natures"},{"key":"220_CR22","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1136\/gut.32.12.1478","volume":"32","author":"A Hernanz","year":"1991","unstructured":"Hernanz A, Polanco I: Plasma precursor amino acids of central nervous system monoamines in children with coeliac disease. Gut. 1991, 32: 1478-1481.","journal-title":"Gut"},{"key":"220_CR23","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jns.2006.03.022","volume":"247","author":"M Alonso de Leci\u00f1ana","year":"2006","unstructured":"Alonso de Leci\u00f1ana M, Gutierrez M, Roda JM, Carceller F, D\u00edez-Tejedor E: Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke. J Neurol Sci. 2006, 247: 121-129.","journal-title":"J Neurol Sci"},{"key":"220_CR24","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1161\/01.STR.26.10.1888","volume":"26","author":"JM Roda","year":"1995","unstructured":"Roda JM, Carceller F, Diez Tejedor E, Avenda\u00f1o C: Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia. Stroke. 1995, 26: 1888-1889.","journal-title":"Stroke"},{"key":"220_CR25","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1161\/01.STR.28.10.2060","volume":"28","author":"DC Rogers","year":"1997","unstructured":"Rogers DC, Campbell CA, Stretton JL, Mackay KB: Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke. 1997, 28: 2060-2066.","journal-title":"Stroke"},{"key":"220_CR26","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuroscience.2010.11.054","volume":"175","author":"M Guti\u00e9rrez-Fern\u00e1ndez","year":"2011","unstructured":"Guti\u00e9rrez-Fern\u00e1ndez M, Rodr\u00edguez-Frutos B, Alvarez-Grech J, Vallejo-Cremades MT, Exp\u00f3sito-Alcaide M, Merino J, Roda JM, D\u00edez-Tejeder E: Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats. Neuroscience. 2011, 175: 394-405.","journal-title":"Neuroscience"},{"key":"220_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0006-8993(94)01407-9","volume":"673","author":"C Avenda\u00f1o","year":"1995","unstructured":"Avenda\u00f1o C, Roda JM, Carceller F, D\u00edez-Tejedor E: Morphometric study of focal cerebral ischemia in rats: a stereological evaluation. Brain Res. 1995, 673: 83-92.","journal-title":"Brain Res"},{"key":"220_CR28","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/hs0402.105339","volume":"33","author":"M Castellanos","year":"2002","unstructured":"Castellanos M, Castillo J, Garc\u00eda MM, Leira R, Serena J, Chamorro A, D\u00e1valos A: Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target. Stroke. 2002, 33: 982-987.","journal-title":"Stroke"},{"key":"220_CR29","first-page":"393","volume":"47","author":"IM Cojocaru","year":"2009","unstructured":"Cojocaru IM, Cojocaru M, T\u0103n\u0103sescu R, Iliescu I, Dumitrescu L, Silosi I: Expression of IL-6 activity in patients with acute ischemic stroke. Rom J Intern Med. 2009, 47: 393-396.","journal-title":"Rom J Intern Med"},{"key":"220_CR30","first-page":"55","volume":"25","author":"B Dunjic-Kostic","year":"2013","unstructured":"Dunjic-Kostic B, Jasovic-Gasic M, Ivkovic M, Radonjic NV, Pantovic M, Damjanovic A, Poznanovic ST, Jovanovic A, Nikolic T, Petronijevic ND: Serum levels of interleukin-6 and tumor necrosis factor-alpha in exacerbation and remission phase of schizophrenia. Psychiatr Danub. 2013, 25: 55-61.","journal-title":"Psychiatr Danub"},{"key":"220_CR31","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/sj.jcbfm.9600039","volume":"25","author":"A Aliprandi","year":"2005","unstructured":"Aliprandi A, Longoni M, Stanzani L, Tremolizzo L, Vaccaro M, Begni B, Galimberti G, Garofolo R, Ferrarese C: Increased plasma glutamate in stroke patients might be linked to altered platelet release and uptake. J Cereb Blood Flow Metab. 2005, 25: 523-529.","journal-title":"J Cereb Blood Flow Metab"},{"key":"220_CR32","doi-asserted-by":"crossref","unstructured":"Alexander GM, Reichenberger E, Peterlin BL, Perreault MJ, Grothusen JR, Schwartzman RJ: Plasma amino acids changes in complex regional pain s\u00edndrome.Pain Res Treat 2013, 2013:742407.,","DOI":"10.1155\/2013\/742407"},{"key":"220_CR33","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0022-510X(94)90289-5","volume":"122","author":"K Fassbender","year":"1994","unstructured":"Fassbender K, Rossol S, Kammer T, Daffertshofer M, Wirth S, Dollman M, Hennerici M: Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci. 1994, 122: 135-139.","journal-title":"J Neurol Sci"},{"key":"220_CR34","doi-asserted-by":"crossref","unstructured":"Smith CJ, Emsley HC, Gavin CM, Georgiou RF, Vail A, Barberan EM, del Zoppo GJ, Hallenbeck JM, Rothwell NJ, Hopkins SJ, Tyrrell PJ: Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long term outcome.BMC Neurol 2004, 4:2.,","DOI":"10.1186\/1471-2377-4-5"},{"issue":"4","key":"220_CR35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1042\/CS20110340","volume":"122","author":"M Mihara","year":"2012","unstructured":"Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M: IL-6\/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond). 2012, 122 (4): 143-159.","journal-title":"Clin Sci (Lond)"},{"key":"220_CR36","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1046\/j.1365-2796.1997.00209.x","volume":"242","author":"F Carlstedt","year":"1997","unstructured":"Carlstedt F, Lind L, Lindahl B: Proinflammatory cytokines, measured in a mixed population on arrival in the emergency department, are related to mortality and severity of disease. J Intern Med. 1997, 242: 361-365.","journal-title":"J Intern Med"},{"key":"220_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(95)00414-9","volume":"71","author":"M Buttini","year":"1996","unstructured":"Buttini M, Appel K, Sauter A, Gebicke-Haerter PJ, Boddeke HWGM: Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat. Neuroscience. 1996, 71: 1-16.","journal-title":"Neuroscience"},{"key":"220_CR38","doi-asserted-by":"crossref","unstructured":"Maddahi A, Kruse LS, Chen QW, Edvinsson L: The role of tumor necrosis factor-\u03b1 and TNF-\u03b1 receptors in cerebral arteries following cerebral ischemia in rat.J Neuroinflammatin 2011, 8:107.,","DOI":"10.1186\/1742-2094-8-107"},{"issue":"1","key":"220_CR39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0305-4179(96)00071-X","volume":"23","author":"FL Yeh","year":"1997","unstructured":"Yeh FL, Wl L, Shen HD, Fang RH: Changes in serum tumour necrosis factor-alpha in burned patients. Burns. 1997, 23 (1): 6-10.","journal-title":"Burns"},{"key":"220_CR40","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1161\/01.STR.32.5.1154","volume":"32","author":"J Serena","year":"2001","unstructured":"Serena J, Leira R, Castillo J, Pumar JM, Castellanos M, D\u00e1valos A: Neurological deterioration in acute lacunar infarctions: The role of excitatory and inhibitory neurotransmitters. Stroke. 2001, 32: 1154-1161.","journal-title":"Stroke"},{"issue":"3","key":"220_CR41","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1602\/neurorx.2.3.396","volume":"2","author":"ST Carmichael","year":"2005","unstructured":"Carmichael ST: Rodent models of focal stroke: size, mechanism, and purpose. NeuroRx. 2005, 2 (3): 396-409.","journal-title":"NeuroRx"},{"issue":"4","key":"220_CR42","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1161\/01.STR.28.4.708","volume":"28","author":"A Davalos","year":"1997","unstructured":"Davalos A, Castillo J, Serena J, Noya M: Duration of glutamate release after acute ischemic stroke. Stroke. 1997, 28 (4): 708-710.","journal-title":"Stroke"},{"issue":"4","key":"220_CR43","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3171\/2009.3.JNS0990","volume":"111","author":"F Agnesi","year":"2009","unstructured":"Agnesi F, Tye SJ, Bledsoe JM, Griessenauer CJ, Kimble CJ, Sieck GC, Bennet KE, Garris PA, Blaha CD, Lee KH: Wireless instantaneous neurotransmitter concentration system-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring. J Neurosurg. 2009, 111 (4): 701-711.","journal-title":"J Neurosurg"},{"key":"220_CR44","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/0006-8993(95)01102-1","volume":"704","author":"N Singewald","year":"1995","unstructured":"Singewald N, Zou GY, Schneider C: Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress. Brain Res. 1995, 704: 42-50.","journal-title":"Brain Res"},{"key":"220_CR45","unstructured":"Fuentes B, D\u00edez Tejedor E, Garc\u00e9s MC, Hernanz A, G\u00f3mez-Cerezo J: The real value of serum glutamate levels in acute ischemic stroke. A case-control study.Cerebrovasc Dis 2002, 13:4. Abstract.,"},{"key":"220_CR46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00234-006-0183-z","volume":"49","author":"J Pan","year":"2007","unstructured":"Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J: Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007, 49: 93-102.","journal-title":"Neuroradiology"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0220-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-014-0220-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0220-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0220-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:15:07Z","timestamp":1630545307000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-014-0220-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,3]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["220"],"URL":"https:\/\/doi.org\/10.1186\/s12967-014-0220-3","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,3]]},"assertion":[{"value":"8 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"220"}}