{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:39:18Z","timestamp":1789886358953,"version":"4.0.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,9,21]],"date-time":"2014-09-21T00:00:00Z","timestamp":1411257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12967-014-0266-2","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T19:40:00Z","timestamp":1411242000000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages"],"prefix":"10.1186","volume":"12","author":[{"given":"Jiatian","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozhi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,21]]},"reference":[{"key":"266_CR1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.thromres.2013.04.017","volume":"131","author":"N Joghetaei","year":"2013","unstructured":"Joghetaei N, Stein A, Byrne RA, Schulz C, King L, May AE, Schmidt R: The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?. Thromb Res. 2013, 131: 474-480. 10.1016\/j.thromres.2013.04.017.","journal-title":"Thromb Res"},{"key":"266_CR2","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.2174\/0929867321666131227163352","volume":"21","author":"X Zhu","year":"2014","unstructured":"Zhu X, Song Z, Zhang S, Nanda A, Li G: CD147: a novel modulator of inflammatory and immune disorders. Curr Med Chem. 2014, 21: 2138-2145. 10.2174\/0929867321666131227163352.","journal-title":"Curr Med Chem"},{"key":"266_CR3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4110\/in.2009.9.3.90","volume":"9","author":"JY Kim","year":"2009","unstructured":"Kim JY, Kim WJ, Kim H, Suk K, Lee WH: The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis. IImmune Netw. 2009, 9: 90-97. 10.4110\/in.2009.9.3.90.","journal-title":"IImmune Netw"},{"key":"266_CR4","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/jre.12019","volume":"48","author":"D Yang","year":"2013","unstructured":"Yang D, Wang J, Ni J, Shang S, Liu L, Xiang J, Li C: Temporal expression of metalloproteinase-8 and \u221213 and their relationships with extracellular matrix metalloproteinase inducer in the development of ligature-induced periodontitis in rats. J Periodontal Res. 2013, 48: 411-419. 10.1111\/jre.12019.","journal-title":"J Periodontal Res"},{"key":"266_CR5","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.2353\/ajpath.2009.080845","volume":"175","author":"TR Lizarbe","year":"2009","unstructured":"Lizarbe TR, Tarin C, Gomez M, Lavin B, Aracil E, Orte LM, Zaragoza C: Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN. Am J Pathol. 2009, 175: 1421-1430. 10.2353\/ajpath.2009.080845.","journal-title":"Am J Pathol"},{"key":"266_CR6","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.105.568162","volume":"113","author":"R Schmidt","year":"2006","unstructured":"Schmidt R, Bultmann A, Ungerer M, Joghetaei N, Bulbul O, Thieme S, Chavakis T, Toole BP, Gawaz M, Schomig A, May AE: Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Circulation. 2006, 113: 834-841. 10.1161\/CIRCULATIONAHA.105.568162.","journal-title":"Circulation"},{"key":"266_CR7","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1158\/0008-5472.CAN-04-3605","volume":"65","author":"Y Tang","year":"2005","unstructured":"Tang Y, Nakada MT, Kesavan P, McCabe F, Millar H, Rafferty P, Bugelski P, Yan L: Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res. 2005, 65: 3193-3199.","journal-title":"Cancer Res"},{"key":"266_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.atherosclerosis.2004.11.021","volume":"180","author":"YW Yoon","year":"2005","unstructured":"Yoon YW, Kwon HM, Hwang KC, Choi EY, Hong BK, Kim D, Kim HS, Cho SH, Song KS, Sangiorgi G: Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque. Atherosclerosis. 2005, 180: 37-44. 10.1016\/j.atherosclerosis.2004.11.021.","journal-title":"Atherosclerosis"},{"key":"266_CR9","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/10409238.2013.770819","volume":"48","author":"J Vandooren","year":"2013","unstructured":"Vandooren J, Van den Steen PE, Opdenakker G: Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit Rev Biochem Mol Biol. 2013, 48: 222-272. 10.3109\/10409238.2013.770819.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"266_CR10","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1161\/01.ATV.0000021411.53577.1C","volume":"22","author":"TC Major","year":"2002","unstructured":"Major TC, Liang L, Lu X, Rosebury W, Bocan TM: Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced upon monocyte differentiation and is expressed in human atheroma. Arterioscler Thromb Vasc Biol. 2002, 22: 1200-1207. 10.1161\/01.ATV.0000021411.53577.1C.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"266_CR11","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1161\/01.ATV.0000142806.59283.11","volume":"24","author":"C Haug","year":"2004","unstructured":"Haug C, Lenz C, Diaz F, Bachem MG: Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004, 24: 1823-1829. 10.1161\/01.ATV.0000142806.59283.11.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"266_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s11883-004-0099-1","volume":"6","author":"N Watanabe","year":"2004","unstructured":"Watanabe N, Ikeda U: Matrix metalloproteinases and atherosclerosis. Curr Atheroscler Rep. 2004, 6: 112-120. 10.1007\/s11883-004-0099-1.","journal-title":"Curr Atheroscler Rep"},{"key":"266_CR13","first-page":"1565","volume":"92","author":"PK Shah","year":"1995","unstructured":"Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V: Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995, 92: 1565-1569.","journal-title":"Circulation"},{"key":"266_CR14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1067\/mhj.2001.112238","volume":"141","author":"Y Inokubo","year":"2001","unstructured":"Inokubo Y, Hanada H, Ishizaka H, Fukushi T, Kamada T, Okumura K: Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome. Am Heart J. 2001, 141: 211-217. 10.1067\/mhj.2001.112238.","journal-title":"Am Heart J"},{"key":"266_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1172\/JCI25074","volume":"116","author":"PJ Gough","year":"2006","unstructured":"Gough PJ, Gomez IG, Wille PT, Raines EW: Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest. 2006, 116: 59-69. 10.1172\/JCI25074.","journal-title":"J Clin Invest"},{"key":"266_CR16","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1161\/01.CIR.0000121728.14930.DE","volume":"109","author":"A Luttun","year":"2004","unstructured":"Luttun A, Lutgens E, Manderveld A, Maris K, Collen D, Carmeliet P, Moons L: Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth. Circulation. 2004, 109: 1408-1414. 10.1161\/01.CIR.0000121728.14930.DE.","journal-title":"Circulation"},{"key":"266_CR17","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1161\/hq1201.098945","volume":"21","author":"WH Lee","year":"2001","unstructured":"Lee WH, Kim SH, Lee Y, Lee BB, Kwon B, Song H, Kwon BS, Park JE: Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler Thromb Vasc Biol. 2001, 21: 2004-2010. 10.1161\/hq1201.098945.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"266_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1161\/ATVBAHA.108.169623","volume":"29","author":"C Tarin","year":"2009","unstructured":"Tarin C, Gomez M, Calvo E, Lopez JA, Zaragoza C: Endothelial nitric oxide deficiency reduces MMP-13-mediated cleavage of ICAM-1 in vascular endothelium: a role in atherosclerosis. Arterioscler Thromb Vasc Biol. 2009, 29: 27-32. 10.1161\/ATVBAHA.108.169623.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"266_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1749-6632.1999.tb07683.x","volume":"878","author":"MF Prescott","year":"1999","unstructured":"Prescott MF, Sawyer WK, Von Linden-Reed J, Jeune M, Chou M, Caplan SL, Jeng AY: Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury. Ann N Y Acad Sci. 1999, 878: 179-190. 10.1111\/j.1749-6632.1999.tb07683.x.","journal-title":"Ann N Y Acad Sci"},{"key":"266_CR20","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1517\/14728222.2012.710603","volume":"16","author":"D Kumar","year":"2012","unstructured":"Kumar D, Kumar M, Saravanan C, Singh SK: Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets. 2012, 16: 959-972. 10.1517\/14728222.2012.710603.","journal-title":"Expert Opin Ther Targets"},{"key":"266_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.fct.2013.04.008","volume":"58","author":"KJ Min","year":"2013","unstructured":"Min KJ, Um HJ, Cho KH, Kwon TK: Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation. Food Chem Toxicol. 2013, 58: 77-85. 10.1016\/j.fct.2013.04.008.","journal-title":"Food Chem Toxicol"},{"key":"266_CR22","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/mnfr.201100818","volume":"56","author":"D Coban","year":"2012","unstructured":"Coban D, Milenkovic D, Chanet A, Khallou-Laschet J, Sabbe L, Palagani A, Vanden Berghe W, Mazur A, Morand C: Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Mol Nutr Food Res. 2012, 56: 1270-1281. 10.1002\/mnfr.201100818.","journal-title":"Mol Nutr Food Res"},{"key":"266_CR23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.numecd.2009.03.001","volume":"20","author":"YM Yu","year":"2010","unstructured":"Yu YM, Lin HC: Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression. Nutr Metab Cardiovasc Dis. 2010, 20: 125-132. 10.1016\/j.numecd.2009.03.001.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"266_CR24","first-page":"627","volume":"56","author":"R Olszanecki","year":"2005","unstructured":"Olszanecki R, Jawien J, Gajda M, Mateuszuk L, Gebska A, Korabiowska M, Chlopicki S, Korbut R: Effect of curcumin on atherosclerosis in apoE\/LDLR-double knockout mice. J Physiol Pharmacol. 2005, 56: 627-635.","journal-title":"J Physiol Pharmacol"},{"key":"266_CR25","first-page":"1530","volume":"42","author":"S Tsuchiya","year":"1982","unstructured":"Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, Tada K: Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res. 1982, 42: 1530-1536.","journal-title":"Cancer Res"},{"key":"266_CR26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.yjmcc.2012.04.003","volume":"53","author":"S Meng","year":"2012","unstructured":"Meng S, Cao JT, Zhang B, Zhou Q, Shen CX, Wang CQ: Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1. J Mol Cell Cardiol. 2012, 53: 64-72. 10.1016\/j.yjmcc.2012.04.003.","journal-title":"J Mol Cell Cardiol"},{"key":"266_CR27","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1172\/JCI117619","volume":"94","author":"ZS Galis","year":"1994","unstructured":"Galis ZS, Sukhova GK, Lark MW, Libby P: Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994, 94: 2493-2503. 10.1172\/JCI117619.","journal-title":"J Clin Invest"},{"key":"266_CR28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ijcard.2009.06.023","volume":"146","author":"Z Huang","year":"2011","unstructured":"Huang Z, Wang L, Meng S, Wang Y, Chen T, Wang C: Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. Int J Cardiol. 2011, 146: 153-158. 10.1016\/j.ijcard.2009.06.023.","journal-title":"Int J Cardiol"},{"key":"266_CR29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.bbrc.2008.07.058","volume":"374","author":"Z Huang","year":"2008","unstructured":"Huang Z, Wang C, Wei L, Wang J, Fan Y, Wang L, Wang Y, Chen T: Resveratrol inhibits EMMPRIN expression via P38 and ERK1\/2 pathways in PMA-induced THP-1 cells. Biochem Biophys Res Commun. 2008, 374: 517-521. 10.1016\/j.bbrc.2008.07.058.","journal-title":"Biochem Biophys Res Commun"},{"key":"266_CR30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ijcard.2006.05.023","volume":"117","author":"J Zhang","year":"2007","unstructured":"Zhang J, Ge H, Wang C, Guo TB, He Q, Shao Q, Fan Y: Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells. Int J Cardiol. 2007, 117: 373-380. 10.1016\/j.ijcard.2006.05.023.","journal-title":"Int J Cardiol"},{"key":"266_CR31","doi-asserted-by":"publisher","first-page":"7398","DOI":"10.1038\/sj.onc.1204899","volume":"20","author":"A Besson","year":"2001","unstructured":"Besson A, Davy A, Robbins SM, Yong VW: Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells. Oncogene. 2001, 20: 7398-7407. 10.1038\/sj.onc.1204899.","journal-title":"Oncogene"},{"key":"266_CR32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0304-3835(01)00505-5","volume":"171","author":"MS Kim","year":"2001","unstructured":"Kim MS, Lim WK, Cha JG, An NH, Yoo SJ, Park JH, Kim HM, Lee YM: The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells. Cancer Lett. 2001, 171: 79-85. 10.1016\/S0304-3835(01)00505-5.","journal-title":"Cancer Lett"},{"key":"266_CR33","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1161\/ATVBAHA.108.173898","volume":"28","author":"AC Newby","year":"2008","unstructured":"Newby AC: Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol. 2008, 28: 2108-2114. 10.1161\/ATVBAHA.108.173898.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"266_CR34","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.ijcard.2012.10.040","volume":"168","author":"G Cimmino","year":"2013","unstructured":"Cimmino G, Ragni M, Cirillo P, Petrillo G, Loffredo F, Chiariello M, Gresele P, Falcinelli E, Golino P: C-reactive protein induces expression of matrix metalloproteinase-9: a possible link between inflammation and plaque rupture. Int J Cardiol. 2013, 168: 981-986. 10.1016\/j.ijcard.2012.10.040.","journal-title":"Int J Cardiol"},{"key":"266_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-065X.2012.01157.x","volume":"249","author":"J Blagih","year":"2012","unstructured":"Blagih J, Krawczyk CM, Jones RG: LKB1 and AMPK: central regulators of lymphocyte metabolism and function. Immunol Rev. 2012, 249: 59-71. 10.1111\/j.1600-065X.2012.01157.x.","journal-title":"Immunol Rev"},{"key":"266_CR36","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2337\/db09-1732","volume":"59","author":"MD Fullerton","year":"2010","unstructured":"Fullerton MD, Steinberg GR: SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes. 2010, 59: 551-553. 10.2337\/db09-1732.","journal-title":"Diabetes"},{"key":"266_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.arr.2013.12.002","volume":"13","author":"H Chen","year":"2014","unstructured":"Chen H, Liu X, Chen H, Cao J, Zhang L, Hu X, Wang J: Role of SIRT1 and AMPK in mesenchymal stem cells differentiation. Ageing Res Rev. 2014, 13: 55-64. 10.1016\/j.arr.2013.12.002.","journal-title":"Ageing Res Rev"},{"key":"266_CR38","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ejphar.2011.08.040","volume":"670","author":"SY Chuang","year":"2011","unstructured":"Chuang SY, Yang SH, Chen TY, Pang JH: Cilostazol inhibits matrix invasion and modulates the gene expressions of MMP-9 and TIMP-1 in PMA-differentiated THP-1 cells. Eur J Pharmacol. 2011, 670: 419-426. 10.1016\/j.ejphar.2011.08.040.","journal-title":"Eur J Pharmacol"},{"key":"266_CR39","doi-asserted-by":"publisher","first-page":"e40999","DOI":"10.1371\/journal.pone.0040999","volume":"7","author":"MY Chang","year":"2012","unstructured":"Chang MY, Huang DY, Ho FM, Huang KC, Lin WW: PKC-dependent human monocyte adhesion requires AMPK and Syk activation. PLoS One. 2012, 7: e40999-10.1371\/journal.pone.0040999.","journal-title":"PLoS One"},{"key":"266_CR40","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1159\/000354516","volume":"32","author":"Y Pu","year":"2013","unstructured":"Pu Y, Zhang H, Wang P, Zhao Y, Li Q, Wei X, Cui Y, Sun J, Shang Q, Liu D, Zhu Z: Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK\/uncoupling protein 2 pathway. Cell Physiol Biochem. 2013, 32: 1167-1177. 10.1159\/000354516.","journal-title":"Cell Physiol Biochem"},{"key":"266_CR41","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1254\/jphs.13085FP","volume":"123","author":"K Xiao","year":"2013","unstructured":"Xiao K, Jiang J, Guan C, Dong C, Wang G, Bai L, Sun J, Hu C, Bai C: Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells. J Pharmacol Sci. 2013, 123: 102-109. 10.1254\/jphs.13085FP.","journal-title":"J Pharmacol Sci"},{"key":"266_CR42","doi-asserted-by":"publisher","first-page":"e23554","DOI":"10.1371\/journal.pone.0023554","volume":"6","author":"Z Zhu","year":"2011","unstructured":"Zhu Z, Fu C, Li X, Song Y, Li C, Zou M, Guan Y, Zhu Y: Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation. PLoS One. 2011, 6: e23554-10.1371\/journal.pone.0023554.","journal-title":"PLoS One"},{"key":"266_CR43","first-page":"753","volume":"28","author":"Y Kimdo","year":"2011","unstructured":"Kimdo Y, Park KH, Jung MS, Huang B, Yuan HD, Quan HY, Chung SH: Ginsenoside Rh2(S) induces differentiation and mineralization of MC3T3-E1 cells through activation of the PKD\/AMPK signaling pathways. Int J Mol Med. 2011, 28: 753-759.","journal-title":"Int J Mol Med"},{"key":"266_CR44","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.taap.2009.10.007","volume":"242","author":"SJ Lee","year":"2010","unstructured":"Lee SJ, Kim CE, Yun MR, Seo KW, Park HM, Yun JW, Shin HK, Bae SS, Kim CD: 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. Toxicol Appl Pharmacol. 2010, 242: 191-198. 10.1016\/j.taap.2009.10.007.","journal-title":"Toxicol Appl Pharmacol"},{"key":"266_CR45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1016-8478(23)17569-8","volume":"25","author":"D Park","year":"2008","unstructured":"Park D, Shim E, Kim Y, Kim YM, Lee H, Choe J, Kang D, Lee YS, Jeoung D: C-FLIP promotes the motility of cancer cells by activating FAK and ERK, and increasing MMP-9 expression. Mol Cells. 2008, 25: 184-195.","journal-title":"Mol Cells"},{"key":"266_CR46","doi-asserted-by":"publisher","first-page":"34833","DOI":"10.1074\/jbc.M605483200","volume":"281","author":"HJ Byun","year":"2006","unstructured":"Byun HJ, Hong IK, Kim E, Jin YJ, Jeoung DI, Hahn JH, Kim YM, Park SH, Lee H: A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation signaling pathways. J Biol Chem. 2006, 281: 34833-34847. 10.1074\/jbc.M605483200.","journal-title":"J Biol Chem"},{"key":"266_CR47","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1158\/1541-7786.MCR-10-0386","volume":"9","author":"T Yu","year":"2011","unstructured":"Yu T, Wu Y, Helman JI, Wen Y, Wang C, Li L: CXCR4 promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway. Mol Cancer Res. 2011, 9: 161-172. 10.1158\/1541-7786.MCR-10-0386.","journal-title":"Mol Cancer Res"},{"key":"266_CR48","first-page":"1135","volume":"58","author":"C Simon","year":"1998","unstructured":"Simon C, Goepfert H, Boyd D: Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. Cancer Res. 1998, 58: 1135-1139.","journal-title":"Cancer Res"},{"key":"266_CR49","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3171\/jns.2002.97.1.0112","volume":"97","author":"MJ Park","year":"2002","unstructured":"Park MJ, Park IC, Hur JH, Kim MS, Lee HC, Woo SH, Lee KH, Rhee CH, Hong SI, Lee SH: Modulation of phorbol ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase. J Neurosurg. 2002, 97: 112-118. 10.3171\/jns.2002.97.1.0112.","journal-title":"J Neurosurg"},{"key":"266_CR50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/carcin\/bgm261","volume":"29","author":"CJ Weng","year":"2008","unstructured":"Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC: Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK\/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1. Carcinogenesis. 2008, 29: 147-156. 10.1093\/carcin\/bgm261.","journal-title":"Carcinogenesis"},{"key":"266_CR51","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/carcin\/bgn284","volume":"30","author":"TW Tan","year":"2009","unstructured":"Tan TW, Yang WH, Lin YT, Hsu SF, Li TM, Kao ST, Chen WC, Fong YC, Tang CH: Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. Carcinogenesis. 2009, 30: 258-268. 10.1093\/carcin\/bgn284.","journal-title":"Carcinogenesis"},{"key":"266_CR52","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1093\/nar\/29.21.4361","volume":"29","author":"JA Mengshol","year":"2001","unstructured":"Mengshol JA, Vincenti MP, Brinckerhoff CE: IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. Nucleic Acids Res. 2001, 29: 4361-4372. 10.1093\/nar\/29.21.4361.","journal-title":"Nucleic Acids Res"},{"key":"266_CR53","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S0014-5793(98)01474-4","volume":"441","author":"M Lim","year":"1998","unstructured":"Lim M, Martinez T, Jablons D, Cameron R, Guo H, Toole B, Li JD, Basbaum C: Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38. FEBS Lett. 1998, 441: 88-92. 10.1016\/S0014-5793(98)01474-4.","journal-title":"FEBS Lett"},{"key":"266_CR54","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2121-6-25","volume":"6","author":"J Zhou","year":"2005","unstructured":"Zhou J, Zhu P, Jiang JL, Zhang Q, Wu ZB, Yao XY, Tang H, Lu N, Yang Y, Chen ZN: Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1. BMC Cell Biol. 2005, 6: 25-10.1186\/1471-2121-6-25.","journal-title":"BMC Cell Biol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0266-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-014-0266-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0266-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0266-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T19:33:21Z","timestamp":1717356801000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-014-0266-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,21]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["266"],"URL":"https:\/\/doi.org\/10.1186\/s12967-014-0266-2","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,21]]},"assertion":[{"value":"24 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"266"}}