{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:51:44Z","timestamp":1772913104101,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12967-014-0282-2","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T02:03:59Z","timestamp":1412129039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous\/cancerous lesions: a comparison of E2\/E6E7 ratio-based vs. multiple E1-L1\/E6E7 ratio-based detection techniques"],"prefix":"10.1186","volume":"12","author":[{"given":"Rong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-feng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-jing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,2]]},"reference":[{"key":"282_CR1","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","volume":"370","author":"M Schiffman","year":"2007","unstructured":"Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S: Human papillomavirus and cervical cancer. Lancet. 2007, 370: 890-907. 10.1016\/S0140-6736(07)61416-0.","journal-title":"Lancet"},{"key":"282_CR2","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.2741\/1971","volume":"11","author":"ZM Zheng","year":"2006","unstructured":"Zheng ZM, Baker CC: Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci. 2006, 11: 2286-2302. 10.2741\/1971.","journal-title":"Front Biosci"},{"issue":"Suppl 7","key":"282_CR3","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1002\/cncr.23704","volume":"113","author":"DR Lowy","year":"2008","unstructured":"Lowy DR, Solomon D, Hildesheim A, Schiller JT, Schiffman M: Human papillomavirus infection and the primary and secondary prevention of cervical cancer. Cancer. 2008, 113 (Suppl 7): 1980-1993. 10.1002\/cncr.23704.","journal-title":"Cancer"},{"key":"282_CR4","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1158\/0008-5472.CAN-04-0009","volume":"64","author":"N Wentzensen","year":"2004","unstructured":"Wentzensen N, Vinokurova S, Von Knebel Doeberitz M: Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res. 2004, 64: 3878-3884. 10.1158\/0008-5472.CAN-04-0009.","journal-title":"Cancer Res"},{"key":"282_CR5","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ygyno.2007.05.004","volume":"106","author":"M Cricca","year":"2007","unstructured":"Cricca M, Morselli-Labate AM, Venturoli S, Ambretti S, Gentilomi GA, Gallinella G, Costa S, Musiani M, Zerbini M: Viral DNA load, physical status and E2\/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesions. Gynecol Oncol. 2007, 106: 549-557. 10.1016\/j.ygyno.2007.05.004.","journal-title":"Gynecol Oncol"},{"key":"282_CR6","doi-asserted-by":"publisher","first-page":"e66693","DOI":"10.1371\/journal.pone.0066693","volume":"8","author":"B Xu","year":"2013","unstructured":"Xu B, Chotewutmontri S, Wolf S, Klos U, Schmitz M, D\u00fcrst M, Schwarz E: Multiplex identification of human papillomavirus 16 DNA integration sites in cervical carcinomas. PLoS One. 2013, 8: e66693-10.1371\/journal.pone.0066693.","journal-title":"PLoS One"},{"key":"282_CR7","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1002\/ijc.22959","volume":"121","author":"J Briolat","year":"2007","unstructured":"Briolat J, Dalstein V, Saunier M, Joseph K, Caudroy S, Pr\u00e9tet JL, Birembaut P, Clavel C: HPV prevalence, viral load and physical state of HPV-16 in cervical smears of patients with different grades of CIN. Int J Cancer. 2007, 121: 2198-2204. 10.1002\/ijc.22959.","journal-title":"Int J Cancer"},{"key":"282_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/path.2192","volume":"212","author":"M Pett","year":"2007","unstructured":"Pett M, Coleman N: Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?. J Pathol. 2007, 212: 356-367. 10.1002\/path.2192.","journal-title":"J Pathol"},{"key":"282_CR9","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1038\/sj.onc.1206629","volume":"22","author":"C Ziegert","year":"2003","unstructured":"Ziegert C, Wentzensen N, Vinokurova S, Kisseljov F, Einenkel J, Hoeckel M, Von Knebel Doeberitz M: A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques. Oncogene. 2003, 22: 3977-3984. 10.1038\/sj.onc.1206629.","journal-title":"Oncogene"},{"key":"282_CR10","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1158\/1078-0432.CCR-03-0565","volume":"10","author":"P Melsheimer","year":"2004","unstructured":"Melsheimer P, Vinokurova S, Wentzensen N, Bastert G, Von Knebel Doeberitz M: DNA aneuploidy and integration of human papillomavirus type 16 e6\/e7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri. Clin Cancer Res. 2004, 10: 3059-3063. 10.1158\/1078-0432.CCR-03-0565.","journal-title":"Clin Cancer Res"},{"key":"282_CR11","doi-asserted-by":"publisher","first-page":"8249","DOI":"10.1158\/0008-5472.CAN-08-1741","volume":"68","author":"KL Dall","year":"2008","unstructured":"Dall KL, Scarpini CG, Roberts I, Winder DM, Stanley MA, Muralidhar B, Herdman MT, Pett MR, Coleman N: Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions. Cancer Res. 2008, 68: 8249-8259. 10.1158\/0008-5472.CAN-08-1741.","journal-title":"Cancer Res"},{"key":"282_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1144>3.0.CO;2-L","volume":"92","author":"F Luft","year":"2001","unstructured":"Luft F, Klaes R, Nees M, D\u00fcrst M, Heilmann V, Melsheimer P, Von Knebel Doeberitz M: Detection of integrated papillomavirus sequences by ligation-mediated PCR (DIPS-PCR) and molecular characterization in cervical cancer cells. Int J Cancer. 2001, 92: 9-17. 10.1002\/1097-0215(200102)9999:9999<::AID-IJC1144>3.0.CO;2-L.","journal-title":"Int J Cancer"},{"key":"282_CR13","first-page":"6132","volume":"59","author":"R Klaes","year":"1999","unstructured":"Klaes R, Woerner SM, Ridder R, Wentzensen N, Duerst M, Schneider A, Lotz B, Melsheimer P, Von Knebel Doeberitz M: Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res. 1999, 59: 6132-6136.","journal-title":"Cancer Res"},{"key":"282_CR14","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1128\/JCM.44.5.1755-1762.2006","volume":"44","author":"H Arias-Pulido","year":"2006","unstructured":"Arias-Pulido H, Peyton CL, Joste NE, Vargas H, Wheeler CM: Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J Clin Microbiol. 2006, 44: 1755-1762. 10.1128\/JCM.44.5.1755-1762.2006.","journal-title":"J Clin Microbiol"},{"key":"282_CR15","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1128\/JCM.40.3.886-891.2002","volume":"40","author":"P Peitsaro","year":"2002","unstructured":"Peitsaro P, Johansson B, Syrj\u00e4nen S: Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J Clin Microbiol. 2002, 40: 886-891. 10.1128\/JCM.40.3.886-891.2002.","journal-title":"J Clin Microbiol"},{"key":"282_CR16","first-page":"1992","volume":"68","author":"BS Apgar","year":"2001","unstructured":"Apgar BS, Zoschnick L, Wright TC: The 2001 Bethesda System terminology. Am Fam Physician. 2001, 68: 1992-1998.","journal-title":"Am Fam Physician"},{"key":"282_CR17","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1056\/NEJMoa021641","volume":"348","author":"N Mu\u00f1oz","year":"2003","unstructured":"Mu\u00f1oz N, Bosch FX, De Sanjos\u00e9 S, Herrero R, Castellsagu\u00e9 X, Shah KV, Snijders PJ, Meijer CJ: Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003, 348: 518-527. 10.1056\/NEJMoa021641.","journal-title":"N Engl J Med"},{"key":"282_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1479-828X.2010.01251.x","volume":"51","author":"D Williamson","year":"2011","unstructured":"Williamson D, Nagappan R, Sirikonda R, Rahnama F, Thomas S, Lovell-Smith M, Croxson M: Distribution of HPV genotypes in women with cervical cancer in Auckland, New Zealand; a review of 50 specimens between 2000-2006. Aust N Z J Obstet Gynaecol. 2011, 51: 67-70. 10.1111\/j.1479-828X.2010.01251.x.","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"282_CR19","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/oxfordjournals.jncimonographs.a003487","volume":"31","author":"T Iftner","year":"2003","unstructured":"Iftner T, Villa LL: Chapter 12: Human papillomavirus technologies. J Natl Cancer Inst Monogr. 2003, 31: 80-88. 10.1093\/oxfordjournals.jncimonographs.a003487.","journal-title":"J Natl Cancer Inst Monogr"},{"key":"282_CR20","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1128\/JCM.02098-06","volume":"45","author":"V Fontaine","year":"2007","unstructured":"Fontaine V, Mascaux C, Weyn C, Bernis A, Celio N, Lef\u00e8vre P, Kaufman L, Garbar C: Evaluation of combined general primer-mediated PCR sequencing and type-specific PCR strategies for determination of human papillomavirus genotypes in cervical cell specimens. J Clin Microbiol. 2007, 45: 928-934. 10.1128\/JCM.02098-06.","journal-title":"J Clin Microbiol"},{"key":"282_CR21","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1128\/JCM.37.11.3545-3555.1999","volume":"37","author":"CA Harwood","year":"1999","unstructured":"Harwood CA, Spink PJ, Surentheran T, Leigh IM, De Villiers EM, McGregor JM, Proby CM, Breuer J: Degenerate and nested PCR: a highly sensitive and specific method for detection of human papillomavirus infection in cutaneous warts. J Clin Microbiol. 1999, 37: 3545-3555.","journal-title":"J Clin Microbiol"},{"key":"282_CR22","doi-asserted-by":"publisher","first-page":"e127","DOI":"10.1093\/nar\/gkm671","volume":"35","author":"H Gudnason","year":"2007","unstructured":"Gudnason H, Dufva M, Bang DD, Wolff A: Comparison of multiple DNA dyes for real-time PCR: effects of dye concentration and sequence composition on DNA amplification and melting temperature. Nucleic Acids Res. 2007, 35: e127-10.1093\/nar\/gkm671.","journal-title":"Nucleic Acids Res"},{"key":"282_CR23","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1582-4934.2007.00073.x","volume":"11","author":"CE Depuydt","year":"2007","unstructured":"Depuydt CE, Boulet GA, Horvath CA, Benoy IH, Vereecken AJ, Bogers JJ: Comparison of MY09\/11 consensus PCR and type-specific PCRs in the detection of oncogenic HPV types. J Cell Mol Med. 2007, 11: 881-891. 10.1111\/j.1582-4934.2007.00073.x.","journal-title":"J Cell Mol Med"},{"key":"282_CR24","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1128\/JCM.01785-07","volume":"46","author":"JL Cheung","year":"2008","unstructured":"Cheung JL, Cheung TH, Tang JW, Chan PK: Increase of integration events and infection loads of human papillomavirus type 52 with lesion severity from low-grade cervical lesion to invasive cancer. J Clin Microbiol. 2008, 46: 1356-1362. 10.1128\/JCM.01785-07.","journal-title":"J Clin Microbiol"},{"key":"282_CR25","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1086\/520884","volume":"196","author":"PK Chan","year":"2007","unstructured":"Chan PK, Cheung JL, Cheung TH, Lo KW, Yim SF, Siu SS, Tang JW: Profile of viral load, integration, and E2 gene disruption of HPV58 in normal cervix and cervical neoplasia. J Infect Dis. 2007, 196: 868-875. 10.1086\/520884.","journal-title":"J Infect Dis"},{"key":"282_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1158\/0008-5472.CAN-07-2754","volume":"68","author":"S Vinokurova","year":"2008","unstructured":"Vinokurova S, Wentzensen N, Kraus I, Klaes R, Driesch C, Melsheimer P, Kisseljov F, D\u00fcrst M, Schneider A, Von Knebel Doeberitz M: Type-dependent integration frequency of human papillomavirus genomes in cervical lesions. Cancer Res. 2008, 68: 307-313. 10.1158\/0008-5472.CAN-07-2754.","journal-title":"Cancer Res"},{"key":"282_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1158\/1055-9965.EPI-06-0649","volume":"16","author":"SM Kulmala","year":"2007","unstructured":"Kulmala SM, Shabalova IP, Petrovitchev N, Syrj\u00e4nen KJ, Gyllensten UB, Johansson BC, Syrj\u00e4nen SM: Type-specific persistence of high-risk human papillomavirus infections in the New Independent States of the former Soviet Union Cohort Study. Cancer Epidemiol Biomarkers Prev. 2007, 16: 17-22. 10.1158\/1055-9965.EPI-06-0649.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"282_CR28","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1002\/ijc.23006","volume":"121","author":"S Khouadri","year":"2007","unstructured":"Khouadri S, Villa LL, Gagnon S, Koushik A, Richardson H, Matlashewski G, Roger M, Ferenczy AS, Franco EL, Coutl\u00e9e F: Viral load of episomal and integrated forms of human papillomavirus type 33 in high-grade squamous intraepithelial lesions of the uterine cervix. Int J Cancer. 2007, 121: 2674-2681. 10.1002\/ijc.23006.","journal-title":"Int J Cancer"},{"key":"282_CR29","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.7314\/APJCP.2013.14.6.3837","volume":"14","author":"L Wang","year":"2013","unstructured":"Wang L, Dai SZ, Chu HJ, Cui HF, Xu XY: Integration sites and genotype distributions of human papillomavirus in cervical intraepithelial neoplasia. Asian Pac J Cancer Prev. 2013, 14: 3837-3841. 10.7314\/APJCP.2013.14.6.3837.","journal-title":"Asian Pac J Cancer Prev"},{"key":"282_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jcv.2006.09.008","volume":"38","author":"L De Marco","year":"2007","unstructured":"De Marco L, Gillio-Tos A, Bonello L, Ghisetti V, Ronco G, Merletti F: Detection of human papillomavirus type 16 integration in pre-neoplastic cervical lesions and confirmation by DIPS-PCR and sequencing. J Clin Virol. 2007, 38: 7-13. 10.1016\/j.jcv.2006.09.008.","journal-title":"J Clin Virol"},{"key":"282_CR31","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.clinbiochem.2007.12.014","volume":"41","author":"MP Ruutu","year":"2008","unstructured":"Ruutu MP, Kulmala SM, Peitsaro P, Syrj\u00e4nen SM: The performance of the HPV16 real-time PCR integration assay. Clin Biochem. 2008, 41: 423-428. 10.1016\/j.clinbiochem.2007.12.014.","journal-title":"Clin Biochem"},{"key":"282_CR32","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1093\/infdis\/jir049","volume":"203","author":"LF Xi","year":"2011","unstructured":"Xi LF, Hughes JP, Castle PE, Edelstein ZR, Wang C, Galloway DA, Koutsky LA, Kiviat NB, Schiffman M: Viral load in the natural history of human papillomavirus type 16 infection: a nested case-control study. J Infect Dis. 2011, 203: 1425-1433. 10.1093\/infdis\/jir049.","journal-title":"J Infect Dis"},{"key":"282_CR33","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1093\/jnci\/94.2.102","volume":"94","author":"ME Sherman","year":"2002","unstructured":"Sherman ME, Schiffman M, Cox JT: Effects of age and human papilloma viral load on colposcopy triage: data from the randomized atypical squamous cells of undetermined significance\/low-grade squamous intraepithelial lesion triage study (ALTS). J Natl Cancer Inst. 2002, 94: 102-107. 10.1093\/jnci\/94.2.102.","journal-title":"J Natl Cancer Inst"},{"key":"282_CR34","first-page":"1038","volume":"12","author":"ME Sherman","year":"2003","unstructured":"Sherman ME, Wang SS, Wheeler CM, Rich L, Gravitt PE, Tarone R, Schiffman M: Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions. Cancer Epidemiol Biomarkers Prev. 2003, 12: 1038-1044.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"282_CR35","doi-asserted-by":"publisher","first-page":"12450","DOI":"10.1128\/JVI.77.23.12450-12459.2003","volume":"77","author":"K Kim","year":"2003","unstructured":"Kim K, Garner-Hamrick PA, Fisher C, Lee D, Lambert PF: Methylation patterns of papillomavirusDNA, its influence on E2 function, and implications in viral infection. J Virol. 2003, 77: 12450-12459. 10.1128\/JVI.77.23.12450-12459.2003.","journal-title":"J Virol"},{"key":"282_CR36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1346-8138.2000.tb02126.x","volume":"27","author":"T Ishiji","year":"2000","unstructured":"Ishiji T: Molecular mechanism of carcinogenesis by human papillomavirus-16. J Dermatol. 2000, 27: 73-86.","journal-title":"J Dermatol"},{"key":"282_CR37","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.7314\/APJCP.2012.13.4.1651","volume":"13","author":"H Chen","year":"2012","unstructured":"Chen H, Shu HM, Chang ZL, Wang ZF, Yao HH, Zhu HM, Lu TM, Ma QY, Yang BL: Efficacy of Pap test in combination with ThinPrep cytological test in screening for cervical cancer. Asian Pac J Cancer Prev. 2012, 13: 1651-1655. 10.7314\/APJCP.2012.13.4.1651.","journal-title":"Asian Pac J Cancer Prev"},{"key":"282_CR38","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/jnci\/djn065","volume":"100","author":"G Ronco","year":"2008","unstructured":"Ronco G, Giorgi-Rossi P, Carozzi F, Confortini M, Dalla Palma P, Del Mistro A, Gillio-Tos A, Minucci D, Naldoni C, Rizzolo R, Schincaglia P, Volante R, Zappa M, Zorzi M, Cuzick J, Segnan N: Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test. J Natl Cancer Inst. 2008, 100: 492-501. 10.1093\/jnci\/djn065.","journal-title":"J Natl Cancer Inst"},{"key":"282_CR39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0029-7844(98)00245-2","volume":"92","author":"J Melnikow","year":"1998","unstructured":"Melnikow J, Nuovo J, Willan AR, Chan BK, Howell LP: Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998, 92: 727-735. 10.1016\/S0029-7844(98)00245-2.","journal-title":"Obstet Gynecol"},{"key":"282_CR40","first-page":"609","volume":"61","author":"K Nasiell","year":"1983","unstructured":"Nasiell K, Nasiell M, Va\u0107lavinkov\u00e1 V: Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol. 1983, 61: 609-614.","journal-title":"Obstet Gynecol"},{"key":"282_CR41","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/sj.bjc.6601415","volume":"90","author":"C Scheungraber","year":"2004","unstructured":"Scheungraber C, Kleekamp N, Schneider A: Management of low-grade squamous intraepithelial lesions of the uterine cervix. Br J Cancer. 2004, 90: 975-978. 10.1038\/sj.bjc.6601415.","journal-title":"Br J Cancer"},{"key":"282_CR42","first-page":"194","volume":"92","author":"CF Fluhmann","year":"1960","unstructured":"Fluhmann CF, Lyons HM: Carcinoma in situ of the uterine cervix-diagnosis by biopsy. Calif Med. 1960, 92: 194-197.","journal-title":"Calif Med"},{"key":"282_CR43","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1590\/S1516-31802009000500004","volume":"127","author":"FR Veiga","year":"2009","unstructured":"Veiga FR, Russomano FB, Camargo MJ, Monteiro AC, Trist\u00e3o A, Silva GV: Prevalence of high-grade squamous intraepithelial lesions and cervical cancer among patients with unsatisfactory colposcopic examination, without visible lesion. Sao Paulo Med J. 2009, 127: 266-269.","journal-title":"Sao Paulo Med J"},{"key":"282_CR44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00128360-200501000-00006","volume":"9","author":"LS Massad","year":"2005","unstructured":"Massad LS, Tate N, Cejtin E, Collins YC: Quantifying the risk of cervical intraepithelial neoplasia in women with unsatisfactory colposcopy results. J Low Genit Tract Dis. 2005, 9: 23-28. 10.1097\/00128360-200501000-00006.","journal-title":"J Low Genit Tract Dis"},{"key":"282_CR45","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1128\/JCM.00746-12","volume":"50","author":"MT Pyne","year":"2012","unstructured":"Pyne MT, Vest L, Clement J, Lee J, Rosvall JR, Luk K, Rossi M, Cobb B, Hillyard DR: Comparison of three Roche hepatitis B virus viral load assay formats. J Clin Microbiol. 2012, 50: 2337-2342. 10.1128\/JCM.00746-12.","journal-title":"J Clin Microbiol"},{"key":"282_CR46","doi-asserted-by":"publisher","first-page":"155","DOI":"10.5230\/jgc.2010.10.4.155","volume":"10","author":"S Park","year":"2010","unstructured":"Park S, Woo Y, Kim H, Lee YC, Choi S, Hyung WJ, Noh SH: In vitro adenosine triphosphate based chemotherapy response assay in gastric cancer. J Gastric Cancer. 2010, 10: 155-161. 10.5230\/jgc.2010.10.4.155.","journal-title":"J Gastric Cancer"},{"key":"282_CR47","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/1479-5876-11-197","volume":"11","author":"D Rustichelli","year":"2013","unstructured":"Rustichelli D, Castiglia S, Gunetti M, Mareschi K, Signorino E, Muraro M, Castello L, Sanavio F, Leone M, Ferrero I, Fagioli F: Validation of analytical methods in compliance with good manufacturing practice: a practical approach. J Transl Med. 2013, 11: 197-10.1186\/1479-5876-11-197.","journal-title":"J Transl Med"},{"key":"282_CR48","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1101\/gr.1.1.46","volume":"1","author":"CE Greer","year":"1991","unstructured":"Greer CE, Lund JK, Manos MM: PCR amplification from paraffin-embedded tissues: recommendations on fixatives for long-term storage and prospective studies. PCR Methods Appl. 1991, 1: 46-50. 10.1101\/gr.1.1.46.","journal-title":"PCR Methods Appl"},{"key":"282_CR49","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1073\/pnas.91.6.2216","volume":"91","author":"WM Barnes","year":"1994","unstructured":"Barnes WM: PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc Natl Acad Sci U S A. 1994, 91: 2216-2220. 10.1073\/pnas.91.6.2216.","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0282-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-014-0282-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0282-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-014-0282-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T05:49:50Z","timestamp":1630561790000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-014-0282-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,2]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["282"],"URL":"https:\/\/doi.org\/10.1186\/s12967-014-0282-2","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,2]]},"assertion":[{"value":"31 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"282"}}