{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:41:20Z","timestamp":1789900880010,"version":"4.0.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T00:00:00Z","timestamp":1430524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12967-015-0473-5","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T04:05:04Z","timestamp":1430453104000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma"],"prefix":"10.1186","volume":"13","author":[{"given":"Carmela","family":"Rozera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo Antonini","family":"Cappellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Santodonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Castiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Urbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iole","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Aric\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Casorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sestili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Montefiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Monque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Carlei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Moschella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Buccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Belli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Proietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Belardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imerio","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,2]]},"reference":[{"key":"473_CR1","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","volume":"27","author":"CM Balch","year":"2009","unstructured":"Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27:6199\u2013206.","journal-title":"J Clin Oncol"},{"key":"473_CR2","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.ejca.2004.04.030","volume":"40","author":"AMM Eggermont","year":"2004","unstructured":"Eggermont AMM, Kirkwood JM. Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years? Eur J Cancer. 2004;40:1825\u201336.","journal-title":"Eur J Cancer"},{"key":"473_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1634\/theoncologist.2010-0190","volume":"16","author":"C Garbe","year":"2011","unstructured":"Garbe C, Eigentler TK, Keilholz U, Hauschild A, Kirkwood JM. Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist. 2011;16:5\u201324.","journal-title":"Oncologist"},{"issue":"Suppl 7","key":"473_CR4","doi-asserted-by":"crossref","first-page":"vii339","DOI":"10.1093\/annonc\/mdq364","volume":"21","author":"AMM Eggermont","year":"2010","unstructured":"Eggermont AMM. Advances in systemic treatment of melanoma. Ann Oncol. 2010;21 Suppl 7:vii339\u201344.","journal-title":"Ann Oncol"},{"key":"473_CR5","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1016\/S1470-2045(12)70539-9","volume":"14","author":"S Jang","year":"2013","unstructured":"Jang S, Atkins MB. Which drug, and when, for patients with BRAF-mutant melanoma? Lancet Oncol. 2013;14:e60\u20139.","journal-title":"Lancet Oncol"},{"key":"473_CR6","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1056\/NEJMoa1003466","volume":"363","author":"FS Hodi","year":"2010","unstructured":"Hodi FS, O\u2019Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with Ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711\u201323.","journal-title":"N Engl J Med"},{"key":"473_CR7","doi-asserted-by":"crossref","unstructured":"Schadendorf D, Hodi FS, Robert C, Weber JS, Margolin K, Hamid O, et al. Pooled analysis of long-term survival data from phase II and phase III trials of Ipilimumab in unresectable or metastatic melanoma. J Clin Oncol. 2015. [Epub ahead of print].","DOI":"10.1200\/JCO.2014.56.2736"},{"key":"473_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/nyas.12180","volume":"1291","author":"JD Wolchok","year":"2013","unstructured":"Wolchok JD, Hodi FS, Weber JS, Allison JP, Urba WJ, Robert C, et al. Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma. Ann N Y Acad Sci. 2013;1291:1\u201313.","journal-title":"Ann N Y Acad Sci"},{"key":"473_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.immuni.2013.07.004","volume":"39","author":"K Palucka","year":"2013","unstructured":"Palucka K, Banchereau J. Dendritic-cell-based therapeutic cancer vaccines. Immunity. 2013;39:38\u201348.","journal-title":"Immunity"},{"key":"473_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00262-008-0568-4","volume":"58","author":"L Engell-Noerregaard","year":"2009","unstructured":"Engell-Noerregaard L. Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine. Cancer Immunol. 2009;58:1\u201314.","journal-title":"Cancer Immunol"},{"key":"473_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fimmu.2015.00091","volume":"6","author":"GA Pizzurro","year":"2015","unstructured":"Pizzurro GA, Barrio MM. Dendritic cell-based vaccine efficacy: aiming for hot spots. Front Immunol. 2015;6:91. eCollection 2015.","journal-title":"Front Immunol"},{"key":"473_CR12","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1084\/jem.191.10.1777","volume":"191","author":"SM Santini","year":"2000","unstructured":"Santini SM, Lapenta C, Logozzi M, Parlato S, Spada M, Di Pucchio T, et al. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med. 2000;191:1777\u201388.","journal-title":"J Exp Med"},{"key":"473_CR13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jlb.64.3.358","volume":"64","author":"RL Paquette","year":"1998","unstructured":"Paquette RL, Hsu NC, Kiertscher SM, Park AN, Tran L, Roth MD, et al. Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells. J Leukoc Biol. 1998;64:358\u201367.","journal-title":"J Leukoc Biol"},{"key":"473_CR14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/978-3-540-71029-5_14","volume":"188","author":"SM Santini","year":"2009","unstructured":"Santini SM, Lapenta C, Santodonato L, D\u2019Agostino G, Belardelli F, Ferrantini M. IFN-alpha in the generation of dendritic cells for cancer immunotherapy. Handb Exp Pharmacol. 2009;188:295\u2013317.","journal-title":"Handb Exp Pharmacol"},{"key":"473_CR15","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1365-2133.2008.08508.x","volume":"158","author":"A Farkas","year":"2008","unstructured":"Farkas A, Tonel G, Nestle FO. Interferon-alpha and viral triggers promote functional maturation of human monocyte-derived dendritic cells. Br J Dermatol. 2008;158:921\u20139.","journal-title":"Br J Dermatol"},{"key":"473_CR16","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.4049\/jimmunol.180.3.1462","volume":"180","author":"C Papewalis","year":"2008","unstructured":"Papewalis C, Jacobs B, Wuttke M, Ullrich E, Baehring T, Fenk R, et al. IFN-alpha skews monocytes into CD56\u2009+\u2009\u2212expressing dendritic cells with potent functional activities in vitro and in vivo. J Immunol. 2008;180:1462\u201370.","journal-title":"J Immunol"},{"key":"473_CR17","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1182\/blood-2009-07-234468","volume":"115","author":"S Parlato","year":"2010","unstructured":"Parlato S, Romagnoli G, Spadaro F, Canini I, Sirabella P, Borghi P, et al. LOX-1 as a natural IFN-alpha-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells. Blood. 2010;115:1554\u201363.","journal-title":"Blood"},{"key":"473_CR18","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.4049\/jimmunol.170.10.5195","volume":"170","author":"L Santodonato","year":"2003","unstructured":"Santodonato L, D\u2019Agostino G, Nisini R, Mariotti S, Monque DM, Spada M, et al. Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response. J Immunol. 2003;170:5195\u2013202.","journal-title":"J Immunol"},{"key":"473_CR19","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.4049\/jimmunol.172.9.5363","volume":"172","author":"D Tosi","year":"2004","unstructured":"Tosi D, Valenti R, Cova A, Sovena G, Huber V, Pilla L, et al. Role of cross-talk between IFN-alpha-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T cell responses against human tumor antigens. J Immunol. 2004;172:5363\u201370.","journal-title":"J Immunol"},{"key":"473_CR20","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1002\/eji.200535579","volume":"36","author":"C Lapenta","year":"2006","unstructured":"Lapenta C, Santini SM, Spada M, Donati S, Urbani F, Accapezzato D, et al. IFN-alpha-conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens. Eur J Immunol. 2006;36:2046\u201360.","journal-title":"Eur J Immunol"},{"key":"473_CR21","doi-asserted-by":"publisher","first-page":"e17364","DOI":"10.1371\/journal.pone.0017364","volume":"6","author":"SM Santini","year":"2011","unstructured":"Santini SM, Lapenta C, Donati S, Spadaro F, Belardelli F, Ferrantini M. Interferon-\u03b1-conditioned human monocytes combine a Th-1-orienting attitude with the induction of autologous Th-17 responses: role of IL-23 and IL-12. PLoS One. 2011;6:e17364.","journal-title":"PLoS One"},{"key":"473_CR22","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/CJI.0b013e318174a52a","volume":"31","author":"L Bracci","year":"2008","unstructured":"Bracci L, Schumacher R, Provenzano M, Adamina M, Rosenthal R, Groeper C, et al. Efficient stimulation of T cell responses by human IFN-alpha-induced dendritic cells does not require Toll-like receptor triggering. J Immunother. 2008;31:466\u201374.","journal-title":"J Immunother"},{"key":"473_CR23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1365-2133.2011.10301.x","volume":"165","author":"A Farkas","year":"2011","unstructured":"Farkas A, Kem\u00e9ny L. Interferon-\u03b1 in the generation of monocyte-derived dendritic cells: recent advances and implications for dermatology. Br J Dermatol. 2011;165:247\u201354.","journal-title":"Br J Dermatol"},{"key":"473_CR24","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1586\/14760584.2013.836905","volume":"12","author":"L Bracci","year":"2013","unstructured":"Bracci L, Capone I, Moschella F, Proietti E, Belardelli F. Exploiting dendritic cells in the development of cancer vaccines. Expert Rev Vaccines. 2013;12:1195\u2013210.","journal-title":"Expert Rev Vaccines"},{"key":"473_CR25","first-page":"228","volume":"61","author":"KA Candido","year":"2001","unstructured":"Candido KA, Shimizu K, McLaughlin JC, Kunkel R, Fuller JA, Redman BG, et al. Local administration of dendritic cells inhibits established breast tumor growth: implications for apoptosis-inducing agents. Cancer Res. 2001;61:228\u201336.","journal-title":"Cancer Res"},{"key":"473_CR26","doi-asserted-by":"publisher","first-page":"5958","DOI":"10.1158\/0008-5472.CAN-05-0406","volume":"65","author":"W Song","year":"2005","unstructured":"Song W, Levy R. Therapeutic vaccination against murine lymphoma by intratumoral injection of naive dendritic cells. Cancer Res. 2005;65:5958\u201364.","journal-title":"Cancer Res"},{"key":"473_CR27","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1002\/1097-0142(20001215)89:12<2646::AID-CNCR18>3.0.CO;2-A","volume":"89","author":"PL Triozzi","year":"2000","unstructured":"Triozzi PL, Khurram R, Aldrich WA, Walker MJ, Kim JA, Jaynes S. Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer. Cancer. 2000;89:2646\u201354.","journal-title":"Cancer"},{"key":"473_CR28","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1200\/JCO.2005.00.463","volume":"23","author":"G Mazzolini","year":"2005","unstructured":"Mazzolini G, Alfaro C, Sangro B, Feijo\u00f3 E, Ruiz J, Benito A, et al. Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. J Clin Oncol. 2005;23:999\u20131010.","journal-title":"J Clin Oncol"},{"key":"473_CR29","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nature10673","volume":"480","author":"I Mellman","year":"2011","unstructured":"Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011;480:480\u20139.","journal-title":"Nature"},{"key":"473_CR30","first-page":"7530","volume":"61","author":"Y Tong","year":"2001","unstructured":"Tong Y, Song W, Crystal RG. Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors. Cancer Res. 2001;61:7530\u20135.","journal-title":"Cancer Res"},{"key":"473_CR31","first-page":"285","volume":"9","author":"B Yu","year":"2003","unstructured":"Yu B, Kusmartsev S, Cheng F, Paolini M, Nefedova Y, Sotomayor E, et al. Effective combination of chemotherapy and dendritic cell administration for the treatment of advanced-stage experimental breast cancer. Clin Cancer Res. 2003;9:285\u201394.","journal-title":"Clin Cancer Res"},{"key":"473_CR32","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/ijc.10597","volume":"101","author":"F Tanaka","year":"2002","unstructured":"Tanaka F, Yamaguchi H, Ohta M, Mashino K, Sonoda H, Sadanaga N, et al. Intratumoral injection of dendritic cells after treatment of anticancer drugs induces tumor-specific antitumor effect in vivo. Int J Cancer. 2002;101:265\u20139.","journal-title":"Int J Cancer"},{"key":"473_CR33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1749-6632.2009.04934.x","volume":"1174","author":"DL Mann","year":"2009","unstructured":"Mann DL, Celluzzi CM, Hankey KG, Harris KM, Watanabe R, Hasumi K. Combining conventional therapies with intratumoral injection of autologous dendritic cells and activated T cells to treat patients with advanced cancers. Ann N Y Acad Sci. 2009;1174:41\u201350.","journal-title":"Ann N Y Acad Sci"},{"key":"473_CR34","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/CJI.0b013e3182619cb4","volume":"35","author":"S Fujiwara","year":"2012","unstructured":"Fujiwara S, Wada H, Miyata H, Kawada J, Kawabata R, Nishikawa H, et al. Clinical trial of the intratumoral administration of labeled DC combined with systemic chemotherapy for esophageal cancer. J Immunother. 2012;35:513\u201321.","journal-title":"J Immunother"},{"key":"473_CR35","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/1097-0215(20011215)94:6<825::AID-IJC1545>3.0.CO;2-5","volume":"94","author":"EY Nikitina","year":"2001","unstructured":"Nikitina EY, Gabrilovich DI. Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: approach to treatment of advanced stage cancer. Int J Cancer. 2001;94:825\u201333.","journal-title":"Int J Cancer"},{"key":"473_CR36","first-page":"8466","volume":"63","author":"S Teitz-Tennenbaum","year":"2003","unstructured":"Teitz-Tennenbaum S, Li Q, Rynkiewicz S, Ito F, Davis MA, McGinn CJ, et al. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 2003;63:8466\u201375.","journal-title":"Cancer Res"},{"key":"473_CR37","first-page":"509","volume":"31","author":"Y Akutsu","year":"2007","unstructured":"Akutsu Y, Matsubara H, Urashima T, Komatsu A, Sakata H, Nishimori T, et al. Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94\/gp96 against squamous cell carcinoma in mice. Int J Oncol. 2007;31:509\u201315.","journal-title":"Int J Oncol"},{"key":"473_CR38","doi-asserted-by":"publisher","first-page":"e26381","DOI":"10.4161\/onci.26381","volume":"2","author":"K Hasumi","year":"2013","unstructured":"Hasumi K, Aoki Y, Wantanabe R, Mann DL. Clinical response of advanced cancer patients to cellular immunotherapy and intensity-modulated radiation therapy. Oncoimmunology. 2013;2:e26381.","journal-title":"Oncoimmunology"},{"key":"473_CR39","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.ijrobp.2010.12.068","volume":"82","author":"SE Finkelstein","year":"2012","unstructured":"Finkelstein SE, Iclozan C, Bui MM, Cotter MJ, Ramakrishnan R, Ahmed J, et al. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Int J Radiat Oncol Biol Phys. 2012;82:924\u201332.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"473_CR40","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1158\/1078-0432.CCR-08-2810","volume":"15","author":"B Altvater","year":"2009","unstructured":"Altvater B, Landmeier S, Pscherer S. 2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells. Clin Cancer. 2009;15:4857\u201366.","journal-title":"Clin Cancer"},{"key":"473_CR41","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.immuni.2013.06.014","volume":"39","author":"L Zitvogel","year":"2013","unstructured":"Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39:74\u201388.","journal-title":"Immunity"},{"key":"473_CR42","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00262-012-1388-0","volume":"62","author":"G Chen","year":"2013","unstructured":"Chen G, Emens LA. Chemoimmunotherapy: reengineering tumor immunity. Cancer Immunol Immunother. 2013;62:203\u201316.","journal-title":"Cancer Immunol Immunother"},{"key":"473_CR43","first-page":"608","volume":"84","author":"B Sori\u0107","year":"1989","unstructured":"Sori\u0107 B. Statistical \u201cdiscoveries\u201d and effect-size estimation. J Am Stat Assoc. 1989;84:608\u201310.","journal-title":"J Am Stat Assoc"},{"key":"473_CR44","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki R a. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44\u201357.","journal-title":"Nat Protoc"},{"key":"473_CR45","doi-asserted-by":"publisher","first-page":"726239","DOI":"10.1155\/2013\/726239","volume":"2013","author":"I Macchia","year":"2013","unstructured":"Macchia I, Urbani F, Proietti E. Immune monitoring in cancer vaccine clinical trials: critical issues of functional flow cytometry-based assays. Biomed Res Int. 2013;2013:726239.","journal-title":"Biomed Res Int"},{"key":"473_CR46","volume-title":"AJCC cancer staging manual","year":"2010","unstructured":"Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors. AJCC cancer staging manual. 7th ed. New York, NY: Springer; 2010.","edition":"7"},{"key":"473_CR47","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1002\/ijc.20036","volume":"109","author":"K-W Kim","year":"2004","unstructured":"Kim K-W, Kim S-H, Shin J-G, Kim G-S, Son Y-O, Park S-W, et al. Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity. Int J Cancer. 2004;109:685\u201390.","journal-title":"Int J Cancer"},{"key":"473_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.imlet.2006.03.007","volume":"106","author":"T-H Lee","year":"2006","unstructured":"Lee T-H, Cho Y-H, Lee JD, Yang WI, Shin JL, Lee M-G. Enhanced antitumor effect of dendritic cell based immunotherapy after intratumoral injection of radionuclide Ho-166 against B16 melanoma. Immunol Lett. 2006;106:19\u201326.","journal-title":"Immunol Lett"},{"key":"473_CR49","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/ijc.21061","volume":"116","author":"K Tanaka","year":"2005","unstructured":"Tanaka K, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K, et al. Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int J Cancer. 2005;116:624\u201333.","journal-title":"Int J Cancer"},{"key":"473_CR50","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/01.cji.0000154248.74383.5e","volume":"28","author":"K-H Chi","year":"2005","unstructured":"Chi K-H, Liu S-J, Li C-P, Kuo H-P, Wang Y-S, Chao Y, et al. Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother. 2005;28:129\u201335.","journal-title":"J Immunother"},{"key":"473_CR51","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1182\/blood-2014-07-592162","volume":"125","author":"A Kolstad","year":"2015","unstructured":"Kolstad A, Kumari S, Walczak M, Madsbu U, Hagtvedt T, Bogsrud TV, et al. Sequential intranodal immunotherapy induces anti-tumor immunity and correlated regression of disseminated follicular lymphoma. Blood. 2015;125:82\u20139.","journal-title":"Blood"},{"key":"473_CR52","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1084\/jem.20050463","volume":"202","author":"F Ghiringhelli","year":"2005","unstructured":"Ghiringhelli F, Puig PE, Roux S, Parcellier A, Schmitt E, Solary E, et al. Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4\u2009+\u2009CD25+ regulatory T cell proliferation. J Exp Med. 2005;202:919\u201329.","journal-title":"J Exp Med"},{"key":"473_CR53","doi-asserted-by":"publisher","first-page":"e27944","DOI":"10.1371\/journal.pone.0027944","volume":"6","author":"AJ Michielsen","year":"2011","unstructured":"Michielsen AJ, Hogan AE, Marry J, Tosetto M, Cox F, Hyland JM, et al. Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer. PLoS One. 2011;6:e27944.","journal-title":"PLoS One"},{"key":"473_CR54","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00262-011-1138-8","volume":"61","author":"GV Shurin","year":"2012","unstructured":"Shurin GV, Ouellette CE, Shurin MR. Regulatory dendritic cells in the tumor immunoenvironment. Cancer Immunol Immunother. 2012;61:223\u201330.","journal-title":"Cancer Immunol Immunother"},{"key":"473_CR55","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/jid.2012.273","volume":"133","author":"A Hervieu","year":"2013","unstructured":"Hervieu A, R\u00e9b\u00e9 C, V\u00e9gran F, Chalmin F, Bruchard M, Vabres P, et al. Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth. J Invest Dermatol. 2013;133:499\u2013508.","journal-title":"J Invest Dermatol"},{"key":"473_CR56","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/annonc\/mdp325","volume":"21","author":"P Quaglino","year":"2010","unstructured":"Quaglino P, Marenco F, Osella-Abate S, Cappello N, Ortoncelli M, Salomone B, et al. Vitiligo is an independent favourable prognostic factor in stage III and IV metastatic melanoma patients: results from a single-institution hospital-based observational cohort study. Ann Oncol. 2010;21:409\u201314.","journal-title":"Ann Oncol"},{"key":"473_CR57","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0190-9622(83)70182-9","volume":"9","author":"JJ Nordlund","year":"1983","unstructured":"Nordlund JJ, Kirkwood JM, Forget BM, Milton G, Albert DM, Lerner AB. Vitiligo in patients with metastatic melanoma: a good prognostic sign. J Am Acad Dermatol. 1983;9:689\u201396.","journal-title":"J Am Acad Dermatol"},{"key":"473_CR58","doi-asserted-by":"crossref","first-page":"684","DOI":"10.18632\/oncotarget.323","volume":"2","author":"KT Byrne","year":"2011","unstructured":"Byrne KT, Turk MJ. New perspectives on the role of Vitiligo in immune responses to melanoma ABSTRACT. Oncotarget. 2011;2:684\u201394.","journal-title":"Oncotarget"},{"key":"473_CR59","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1046\/j.1523-1747.2001.01363.x","volume":"116","author":"KS Lang","year":"2001","unstructured":"Lang KS, Caroli CC, Muhm A, Wernet D, Moris A, Schittek B, et al. HLA-A2 restricted, melanocyte-specific CD8(+) T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against MelanA\/MART1. J Invest Dermatol. 2001;116:891\u20137.","journal-title":"J Invest Dermatol"},{"key":"473_CR60","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1200\/JCO.2012.41.6750","volume":"30","author":"JS Weber","year":"2012","unstructured":"Weber JS, K\u00e4hler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 2012;30:2691\u20137.","journal-title":"J Clin Oncol"},{"key":"473_CR61","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrclinonc.2013.153","volume":"10","author":"HL Kaufman","year":"2013","unstructured":"Kaufman HL, Kirkwood JM, Hodi FS, Agarwala S, Amatruda T, Bines SD, et al. The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. Nat Rev Clin Oncol. 2013;10:588\u201398.","journal-title":"Nat Rev Clin Oncol"},{"key":"473_CR62","doi-asserted-by":"publisher","first-page":"7412","DOI":"10.1158\/1078-0432.CCR-09-1624","volume":"15","author":"JD Wolchok","year":"2009","unstructured":"Wolchok JD, Hoos A, O\u2019Day S, Weber JS, Hamid O, Lebb\u00e9 C, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15:7412\u201320.","journal-title":"Clin Cancer Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0473-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-015-0473-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0473-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0473-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T12:13:13Z","timestamp":1630584793000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-015-0473-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,2]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["473"],"URL":"https:\/\/doi.org\/10.1186\/s12967-015-0473-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,2]]},"assertion":[{"value":"18 November 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"139"}}