{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T15:14:43Z","timestamp":1771168483140,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12967-015-0498-9","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T15:39:50Z","timestamp":1432049990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years"],"prefix":"10.1186","volume":"13","author":[{"given":"Anna","family":"Paaso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna-Mari","family":"Koskimaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marij JP","family":"Welters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seija","family":"Gr\u00e9nman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoerd H","family":"van der Burg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"498_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.virol.2010.02.002","volume":"401","author":"HU Bernard","year":"2010","unstructured":"Bernard HU, Burk RD, Chen Z, van Doorslaer K, Zur Hausen H, de Villiers EM. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology. 2010;401:70\u20139.","journal-title":"Virology"},{"key":"498_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/sj.bjc.6601024","volume":"89","author":"GM Clifford","year":"2003","unstructured":"Clifford GM, Smith JS, Aguado T, Franceschi S. Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. Br J Cancer. 2003;89:101\u20135.","journal-title":"Br J Cancer"},{"issue":"Suppl 1","key":"498_CR3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1601-0825.2011.01792.x","volume":"17","author":"S Syrj\u00e4nen","year":"2011","unstructured":"Syrj\u00e4nen S, Lodi G, von B\u00fcltzingsl\u00f6wen I, Aliko A, Arduino P, Campisi G, et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011;17 Suppl 1:58\u201372.","journal-title":"Oral Dis"},{"key":"498_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042171","volume":"7","author":"J Rautava","year":"2012","unstructured":"Rautava J, Willberg J, Louvanto K, Wideman L, Syrj\u00e4nen K, Gr\u00e9nman S, et al. Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study. PLoS One. 2012;7, e42171.","journal-title":"PLoS One"},{"key":"498_CR5","doi-asserted-by":"publisher","first-page":"e53413","DOI":"10.1371\/journal.pone.0053413","volume":"8","author":"K Louvanto","year":"2013","unstructured":"Louvanto K, Rautava J, Willberg J, Wideman L, Syrj\u00e4nen K, Gr\u00e9nman S, et al. Genotype-specific incidence and clearance of human papillomavirus in oral mucosa of women: a six-year follow-up study. PLoS One. 2013;8:e53413.","journal-title":"PLoS One"},{"key":"498_CR6","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/modpathol.2010.109","volume":"23","author":"IT \u00d8vestad","year":"2010","unstructured":"\u00d8vestad IT, Gudlaugsson E, Skaland I, Malpica A, Kruse AJ, Janssen EA, et al. Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression. Mod Pathol. 2010;23:1231\u201340.","journal-title":"Mod Pathol"},{"key":"498_CR7","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ijc.25361","volume":"128","author":"M Heusinkveld","year":"2011","unstructured":"Heusinkveld M, Welters MJ, van Poelgeest MI, van der Hulst JM, Melief CJ, Fleuren GJ, et al. The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors. Int J Cancer. 2011;128:379\u201389.","journal-title":"Int J Cancer"},{"key":"498_CR8","doi-asserted-by":"publisher","first-page":"11895","DOI":"10.1073\/pnas.1006500107","volume":"107","author":"MJ Welters","year":"2010","unstructured":"Welters MJ, Kenter GG, de Vos van Steenwijk PJ, L\u00f6wik MJ, der Meer DM B-v, Essahsah F, et al. Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses. Proc Natl Acad Sci U S A. 2010;107:11895\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"498_CR9","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1056\/NEJMoa0810097","volume":"361","author":"GG Kenter","year":"2009","unstructured":"Kenter GG, Welters MJ, Valentijn AR, Lowik MJ, der Meer DM B-v, Vloon AP, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med. 2009;361:1838\u201347.","journal-title":"N Engl J Med"},{"key":"498_CR10","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1158\/0008-5472.CAN-04-0831","volume":"64","author":"A de Jong","year":"2004","unstructured":"de Jong A, van Poelgeest MI, van der Hulst JM, Drijfhout JW, Fleuren GJ, Melief CJ, et al. Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6. Cancer Res. 2004;64:5449\u201355.","journal-title":"Cancer Res"},{"key":"498_CR11","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1119>3.0.CO;2-C","volume":"91","author":"SH van der Burg","year":"2001","unstructured":"van der Burg SH, Ressing ME, Kwappenberg KM, de Jong A, Straathof K, de Jong J, et al. Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes. Int J Cancer. 2001;91:612\u20138.","journal-title":"Int J Cancer"},{"key":"498_CR12","first-page":"636","volume":"63","author":"MJ Welters","year":"2003","unstructured":"Welters MJ, de Jong A, van den Eeden SJ, van der Hulst JM, Kwappenberg KM, Hassane S, et al. Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter. Cancer Res. 2003;63:636\u201341.","journal-title":"Cancer Res"},{"key":"498_CR13","first-page":"472","volume":"62","author":"A de Jong","year":"2002","unstructured":"de Jong A, van der Burg SH, Kwappenberg KM, van der Hulst JM, Franken KL, Geluk A, et al. Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects. Cancer Res. 2002;62:472\u20139.","journal-title":"Cancer Res"},{"key":"498_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/ijc.24804","volume":"126","author":"YL Woo","year":"2010","unstructured":"Woo YL, van den Hende M, Sterling JC, Coleman N, Crawford RA, Kwappenberg KM, et al. A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses. Int J Cancer. 2010;126:133\u201341.","journal-title":"Int J Cancer"},{"key":"498_CR15","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1099\/vir.0.82678-0","volume":"88","author":"S Dillon","year":"2007","unstructured":"Dillon S, Sasagawa T, Crawford A, Prestidge J, Inder MK, Jerram J, et al. Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. J Gen Virol. 2007;88:803\u201313.","journal-title":"J Gen Virol"},{"key":"498_CR16","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/path.2192","volume":"212","author":"M Pett","year":"2007","unstructured":"Pett M, Coleman N. Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J Pathol. 2007;212:356\u201367.","journal-title":"J Pathol"},{"key":"498_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036651","volume":"7","author":"S Jacobelli","year":"2012","unstructured":"Jacobelli S, Sanaa F, Moyal-Barracco M, Pelisse M, Berville S, Villefroy P, et al. Anti-HPV16 E2 protein T-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partners. PLoS One. 2012;7, e36651.","journal-title":"PLoS One"},{"key":"498_CR18","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000214438","volume":"30","author":"VH Berm\u00fadez-Morales","year":"2009","unstructured":"Berm\u00fadez-Morales VH, Peralta-Zaragoza O, Guzm\u00e1n-Olea E, Garc\u00eda-Carranc\u00e1 A, Bahena-Rom\u00e1n M, Alcocer-Gonz\u00e1lez JM, et al. HPV 16 E2 protein induces apoptosis in human and murine HPV 16 transformed epithelial cells and has antitumoral effects in vivo. Tumour Biol. 2009;30:61\u201372.","journal-title":"Tumour Biol"},{"key":"498_CR19","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.bbrc.2014.03.042","volume":"446","author":"N Sunthamala","year":"2014","unstructured":"Sunthamala N, Pientong C, Ohno T, Zhang C, Bhingare A, Kondo Y, et al. HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status. Biochem Biophys Res Commun. 2014;446:977\u201382.","journal-title":"Biochem Biophys Res Commun"},{"key":"498_CR20","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1128\/JCM.43.1.376-381.2005","volume":"43","author":"MA Rintala","year":"2005","unstructured":"Rintala MA, Gr\u00e9nman SE, Puranen MH, Isolauri E, Ekblad U, Kero PO, et al. Transmission of high-risk human papillomavirus (HPV) between parents and infant: a prospective study of HPV in families in Finland. J Clin Microbiol. 2005;43:376\u201381.","journal-title":"J Clin Microbiol"},{"key":"498_CR21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jcv.2005.05.012","volume":"35","author":"M Rintala","year":"2006","unstructured":"Rintala M, Gr\u00e9nman S, Puranen M, Syrj\u00e4nen S. Natural history of oral papillomavirus infections in spouses: a prospective Finnish HPV Family Study. J Clin Virol. 2006;35:89\u201394.","journal-title":"J Clin Virol"},{"key":"498_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3109\/00365548.2011.619999","volume":"44","author":"MA Rintala","year":"2012","unstructured":"Rintala MA, Louvanto K, Rantanen V, Gr\u00e9nman SE, Syrj\u00e4nen KJ, Syrj\u00e4nen SM. High-risk human papillomavirus associated with incident cervical intraepithelial neoplasia developing in mothers in the Finnish Family HPV Study cohort. Scand J Infect Dis. 2012;44:115\u201325.","journal-title":"Scand J Infect Dis"},{"key":"498_CR23","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1128\/JCM.00783-10","volume":"48","author":"K Louvanto","year":"2010","unstructured":"Louvanto K, Syrj\u00e4nen KJ, Rintala MA, Gr\u00e9nman SE, Syrj\u00e4nen SM. Genotype-specific clearance of genital human papillomavirus (HPV) infections among mothers in the Finnish family HPV study. J Clin Microbiol. 2010;48:2665\u201371.","journal-title":"J Clin Microbiol"},{"key":"498_CR24","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1086\/653826","volume":"202","author":"K Louvanto","year":"2010","unstructured":"Louvanto K, Rintala MA, Syrj\u00e4nen KJ, Gr\u00e9nman SE, Syrj\u00e4nen SM. Genotype-specific persistence of genital human papillomavirus (HPV) infections in women followed for 6\u00a0years in the Finnish Family HPV Study. J Infect Dis. 2010;202:436\u201344.","journal-title":"J Infect Dis"},{"key":"498_CR25","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1600-0463.2010.02620.x","volume":"118","author":"S Syrj\u00e4nen","year":"2010","unstructured":"Syrj\u00e4nen S. Current concepts on human papillomavirus infections in children. APMIS. 2010;118:494\u2013509.","journal-title":"APMIS"},{"key":"498_CR26","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215.","journal-title":"Nucleic Acids Res"},{"key":"498_CR27","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1099\/vir.0.032011-0","volume":"92","author":"AE Paaso","year":"2011","unstructured":"Paaso AE, Louvanto K, Syrj\u00e4nen KJ, Waterboer T, Gr\u00e9nman SE, Pawlita M, et al. Lack of type-specific concordance between human papillomavirus (HPV) serology and HPV DNA detection in the uterine cervix and oral mucosa. J Gen Virol. 2011;92:2034\u201346.","journal-title":"J Gen Virol"},{"key":"498_CR28","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1099\/vir.0.007823-0","volume":"90","author":"S Syrj\u00e4nen","year":"2009","unstructured":"Syrj\u00e4nen S, Waterboer T, Sarkola M, Michael K, Rintala M, Syrj\u00e4nen K, et al. Dynamics of human papillomavirus serology in women followed up for 36\u00a0months after pregnancy. J Gen Virol. 2009;90:1515\u201326.","journal-title":"J Gen Virol"},{"key":"498_CR29","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1373\/clinchem.2005.052381","volume":"51","author":"T Waterboer","year":"2005","unstructured":"Waterboer T, Sehr P, Michael KM, Franceschi S, Nieland JD, Joos TO, et al. Multiplex human papillomavirus serology based on in situ-purified glutathione s-transferase fusion proteins. Clin Chem. 2005;51:1845\u201353.","journal-title":"Clin Chem"},{"key":"498_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1479-5876-12-44","volume":"12","author":"HM Koskimaa","year":"2014","unstructured":"Koskimaa HM, Paaso AE, Welters MJ, Gr\u00e9nman SE, Syrj\u00e4nen KJ, van der Burg SH, et al. Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort. J Transl Med. 2014;12:44.","journal-title":"J Transl Med"},{"key":"498_CR31","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1158\/1078-0432.CCR-07-1880","volume":"14","author":"MJ Welters","year":"2008","unstructured":"Welters MJ, Kenter GG, Piersma SJ, Vloon AP, L\u00f6wik MJ, der Meer DM B-v, et al. Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine. Clin Cancer Res. 2008;14:178\u201387.","journal-title":"Clin Cancer Res"},{"key":"498_CR32","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1111\/1469-0691.12700","volume":"20","author":"K Louvanto","year":"2014","unstructured":"Louvanto K, Rautava J, Syrj\u00e4nen K, Gr\u00e9nman S, Syrj\u00e4nen S. The clearance of oral high-risk hpv infection is impaired by long-term persistence of cervical hpv infection. Clin Microbiol Infect. 2014;20:1167\u201372.","journal-title":"Clin Microbiol Infect"},{"key":"498_CR33","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s00262-010-0903-4","volume":"59","author":"TY Lee","year":"2010","unstructured":"Lee TY, Kim YH, Lee KS, Kim JK, Lee IH, Yang JM, et al. Human papillomavirus type 16 E6-specific antitumor immunity is induced by oral administration of HPV16 E6-expressing Lactobacillus casei in C57BL\/6 mice. Cancer Immunol Immunother. 2010;59:1727\u201337.","journal-title":"Cancer Immunol Immunother"},{"key":"498_CR34","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/ijc.24497","volume":"125","author":"E Derhovanessian","year":"2009","unstructured":"Derhovanessian E, Adams V, H\u00e4hnel K, Groeger A, Pandha H, Ward S, et al. Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int J Cancer. 2009;125:1372\u20139.","journal-title":"Int J Cancer"},{"key":"498_CR35","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cca.2011.01.015","volume":"412","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Ma D, Tian Y, Wang X, Qiao Y, Cui B. The imbalance of Th17\/Treg in patients with uterine cervical cancer. Clin Chim Acta. 2011;412:894\u2013900.","journal-title":"Clin Chim Acta"},{"key":"498_CR36","first-page":"466","volume":"34","author":"JM Souza","year":"2013","unstructured":"Souza JM, Matias BF, Rodrigues CM, Murta EF, Michelin MA. IL-17 and IL-22 serum cytokine levels in patients with squamous intraepithelial lesion and invasive cervical carcinoma. Eur J Gynaecol Oncol. 2013;34:466\u20138.","journal-title":"Eur J Gynaecol Oncol"},{"key":"498_CR37","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.4049\/jimmunol.1400216","volume":"193","author":"C Gosmann","year":"2014","unstructured":"Gosmann C, Mattarollo SR, Bridge JA, Frazer IH, Blumenthal A. IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. J Immunol. 2014;193:2248\u201357.","journal-title":"J Immunol"},{"key":"498_CR38","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1158\/1055-9965.EPI-12-0663","volume":"21","author":"KE Jensen","year":"2012","unstructured":"Jensen KE, Schmiedel S, Frederiksen K, Norrild B, Iftner T, Kj\u00e6r SK. Risk for cervical intraepithelial neoplasia grade 3 or worse in relation to smoking among women with persistent human papillomavirus infection. Cancer Epidemiol Biomarkers Prev. 2012;21:1949\u201355.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"498_CR39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1590\/S1516-31802000000400006","volume":"118","author":"EF Murta","year":"2000","unstructured":"Murta EF, Souza MA, Ara\u00fajo J\u00fanior E, Adad SJ. Incidence of Gardnerella vaginalis, Candida sp and human papilloma virus in cytological smears. Sao Paulo Med J. 2000;118:105\u20138.","journal-title":"Sao Paulo Med J"},{"key":"498_CR40","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1189\/jlb.0503226","volume":"75","author":"G Romagnoli","year":"2004","unstructured":"Romagnoli G, Nisini R, Chiani P, Mariotti S, Teloni R, Cassone A, et al. The interaction of human dendritic cells with yeast and germ-tube forms of Candida albicans leads to efficient fungal processing, dendritic cell maturation, and acquisition of a Th1 response-promoting function. J Leukoc Biol. 2004;75:117\u201326.","journal-title":"J Leukoc Biol"},{"key":"498_CR41","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/ijc.21459","volume":"118","author":"MJ Welters","year":"2006","unstructured":"Welters MJ, van der Logt P, van den Eeden SJ, Kwappenberg KM, Drijfhout JW, Fleuren GJ, et al. Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease. Int J Cancer. 2006;118:950\u20136.","journal-title":"Int J Cancer"},{"key":"498_CR42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/oxfordjournals.aje.a116494","volume":"136","author":"PK Mills","year":"1992","unstructured":"Mills PK, Beeson WL, Fraser GE, Phillips RL. Allergy and cancer: organ site-specific results from the Adventist Health Study. Am J Epidemiol. 1992;136:287\u201395.","journal-title":"Am J Epidemiol"},{"key":"498_CR43","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/sj.bjc.6600585","volume":"87","author":"SM Montgomery","year":"2002","unstructured":"Montgomery SM, Ehlin AG, Spar\u00e9n P, Bj\u00f6rkst\u00e9n B, Ekbom A. Childhood indicators of susceptibility to subsequent cervical cancer. Br J Cancer. 2002;87:989\u201393.","journal-title":"Br J Cancer"},{"key":"498_CR44","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s10654-007-9180-8","volume":"22","author":"K Syrj\u00e4nen","year":"2007","unstructured":"Syrj\u00e4nen K, Shabalova I, Petrovichev N, Kozachenko V, Zakharova T, Pajanidi J, et al. Smoking is an independent risk factor for oncogenic human papillomavirus (HPV) infections but not for high-grade CIN. Eur J Epidemiol. 2007;22:723\u201335.","journal-title":"Eur J Epidemiol"},{"key":"498_CR45","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/00016340902846072","volume":"88","author":"R Guarisi","year":"2009","unstructured":"Guarisi R, Sarian LO, Hammes LS, Longatto-Filho A, Derchain SF, Roteli-Martins C, et al. Smoking worsens the prognosis of mild abnormalities in cervical cytology. Acta Obstet Gynecol Scand. 2009;88:514\u201320.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"498_CR46","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1158\/1055-9965.EPI-04-0918","volume":"14","author":"K McIntyre-Seltman","year":"2005","unstructured":"McIntyre-Seltman K, Castle PE, Guido R, Schiffman M, Wheeler CM, Group A. Smoking is a risk factor for cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology. Cancer Epidemiol Biomarkers Prev. 2005;14:1165\u201370.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"498_CR47","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1023\/B:CACO.0000003811.98261.3e","volume":"14","author":"M Plummer","year":"2003","unstructured":"Plummer M, Herrero R, Franceschi S, Meijer CJ, Snijders P, Bosch FX, et al. Group IM-cCCS: Smoking and cervical cancer: pooled analysis of the IARC multi-centric case\u2013control study. Cancer Causes Control. 2003;14:805\u201314.","journal-title":"Cancer Causes Control"},{"key":"498_CR48","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/ijc.28666","volume":"135","author":"E Roura","year":"2014","unstructured":"Roura E, Castellsagu\u00e9 X, Pawlita M, Travier N, Waterboer T, Margall N, et al. Smoking as a major risk factor for cervical cancer and pre-cancer: Results from the EPIC cohort. Int J Cancer. 2014;135:453\u201366.","journal-title":"Int J Cancer"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0498-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-015-0498-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0498-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0498-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T13:51:41Z","timestamp":1630590701000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-015-0498-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,20]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["498"],"URL":"https:\/\/doi.org\/10.1186\/s12967-015-0498-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,20]]},"assertion":[{"value":"2 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"163"}}