{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:04:43Z","timestamp":1790928283228,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12967-015-0583-0","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T15:54:51Z","timestamp":1436802891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function"],"prefix":"10.1186","volume":"13","author":[{"given":"Mohamed A","family":"Ghonim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusma","family":"Pyakurel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome V","family":"Ibba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A","family":"Al-Khami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamada F","family":"Rady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H","family":"El-Bahrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Lammi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moselhy S","family":"Mansy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Al-Ghareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjit S","family":"Naura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Hamid","family":"Boulares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"583_CR1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11882-014-0465-1","volume":"14","author":"Y Yoo","year":"2014","unstructured":"Yoo Y, Perzanowski MS (2014) Allergic sensitization and the environment: latest update. Curr Allergy Asthma Rep 14:465","journal-title":"Curr Allergy Asthma Rep"},{"issue":"3","key":"583_CR2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4187\/respcare.03200","volume":"60","author":"CB Barnes","year":"2015","unstructured":"Barnes CB, Ulrik CS (2015) Asthma and adherence to inhaled corticosteroids: current status and future perspectives. Respir Care 60(3):455\u2013468","journal-title":"Respir Care"},{"key":"583_CR3","doi-asserted-by":"crossref","first-page":"32899","DOI":"10.1074\/jbc.R110.206466","volume":"286","author":"PJ Barnes","year":"2011","unstructured":"Barnes PJ (2011) Biochemical basis of asthma therapy. J Biol Chem 286:32899\u201332905","journal-title":"J Biol Chem"},{"key":"583_CR4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1165\/rcmb.2001-0015OC","volume":"28","author":"AH Boulares","year":"2003","unstructured":"Boulares AH, Zoltoski AJ, Sherif ZA, Jolly P, Massaro D, Smulson ME (2003) Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. Am J Respir Cell Mol Biol 28:322\u2013329","journal-title":"Am J Respir Cell Mol Biol"},{"key":"583_CR5","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.4049\/jimmunol.177.9.6489","volume":"177","author":"M Oumouna","year":"2006","unstructured":"Oumouna M, Datta R, Oumouna-Benachour K, Suzuki Y, Hans C, Matthews K et al (2006) Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5. J Immunol 177:6489\u20136496","journal-title":"J Immunol"},{"key":"583_CR6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1365-2222.2008.02943.x","volume":"38","author":"AS Naura","year":"2008","unstructured":"Naura AS, Hans CP, Zerfaoui M, You D, Cormier SA, Oumouna M et al (2008) Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. Clin Exp Allergy 38:839\u2013846","journal-title":"Clin Exp Allergy"},{"key":"583_CR7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1183\/09031936.00089008","volume":"33","author":"AS Naura","year":"2009","unstructured":"Naura AS, Datta R, Hans CP, Zerfaoui M, Rezk BM, Errami Y et al (2009) Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. Eur Respir J 33:252\u2013262","journal-title":"Eur Respir J"},{"key":"583_CR8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1398-9995.2011.02549.x","volume":"66","author":"R Datta","year":"2011","unstructured":"Datta R, Naura AS, Zerfaoui M, Errami Y, Oumouna M, Kim H et al (2011) PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. Allergy 66:853\u2013861","journal-title":"Allergy"},{"key":"583_CR9","first-page":"BR77","volume":"10","author":"L Virag","year":"2004","unstructured":"Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L et al (2004) Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med Sci Monit 10:BR77\u2013BR83","journal-title":"Med Sci Monit"},{"key":"583_CR10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1124\/jpet.104.072546","volume":"311","author":"Y Suzuki","year":"2004","unstructured":"Suzuki Y, Masini E, Mazzocca C, Cuzzocrea S, Ciampa A, Suzuki H et al (2004) Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. J Pharmacol Exp Ther 311:1241\u20131248","journal-title":"J Pharmacol Exp Ther"},{"key":"583_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.phrs.2005.02.012","volume":"52","author":"L Virag","year":"2005","unstructured":"Virag L (2005) Poly(ADP-ribosyl)ation in asthma and other lung diseases. Pharmacol Res 52:83\u201392","journal-title":"Pharmacol Res"},{"key":"583_CR12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/02770900902777791","volume":"46","author":"G Tezcan","year":"2009","unstructured":"Tezcan G, Gurel CB, Tutluoglu B, Onaran I, Kanigur-Sultuybek G (2009) The Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population. J Asthma 46:371\u2013374","journal-title":"J Asthma"},{"key":"583_CR13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/jcmm.12197","volume":"18","author":"L Lucarini","year":"2014","unstructured":"Lucarini L, Pini A, Gerace E, Pellicciari R, Masini E, Moroni F (2014) Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling. J Cell Mol Med 18:468\u2013479","journal-title":"J Cell Mol Med"},{"key":"583_CR14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0065-2571(99)00024-2","volume":"40","author":"ME Smulson","year":"2000","unstructured":"Smulson ME, Simbulan-Rosenthal CM, Boulares AH, Yakovlev A, Stoica B, Iyer S et al (2000) Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1. Adv Enzyme Regul 40:183\u2013215","journal-title":"Adv Enzyme Regul"},{"key":"583_CR15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cellsig.2007.10.007","volume":"20","author":"M Zerfaoui","year":"2008","unstructured":"Zerfaoui M, Suzuki Y, Naura AS, Hans CP, Nichols C, Boulares AH (2008) Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction. Cell Signal 20:186\u2013194","journal-title":"Cell Signal"},{"key":"583_CR16","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1189\/jlb.0309183","volume":"86","author":"M Zerfaoui","year":"2009","unstructured":"Zerfaoui M, Naura AS, Errami Y, Hans CP, Rezk BM, Park J et al (2009) Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy Antigen Receptor for Chemokines. J Leukoc Biol 86:1385\u20131392","journal-title":"J Leukoc Biol"},{"key":"583_CR17","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.4049\/jimmunol.1000646","volume":"185","author":"M Zerfaoui","year":"2010","unstructured":"Zerfaoui M, Errami Y, Naura AS, Suzuki Y, Kim H, Ju J et al (2010) Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol 185:1894\u20131902","journal-title":"J Immunol"},{"key":"583_CR18","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.mam.2013.01.006","volume":"34","author":"NJ Curtin","year":"2013","unstructured":"Curtin NJ, Szabo C (2013) Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Mol Aspects Med 34:1217\u20131256","journal-title":"Mol Aspects Med"},{"key":"583_CR19","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1158\/1535-7163.MCT-13-0906-T","volume":"13","author":"P Jelinic","year":"2014","unstructured":"Jelinic P, Levine DA (2014) New insights into PARP inhibitors\u2019 effect on cell cycle and homology-directed DNA damage repair. Mol Cancer Ther 13:1645\u20131654","journal-title":"Mol Cancer Ther"},{"key":"583_CR20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/bcr2877","volume":"13","author":"R Plummer","year":"2011","unstructured":"Plummer R (2011) Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? Breast Cancer Res 13:218","journal-title":"Breast Cancer Res"},{"key":"583_CR21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0900212","volume":"361","author":"PC Fong","year":"2009","unstructured":"Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M et al (2009) Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361:123\u2013134","journal-title":"N Engl J Med"},{"key":"583_CR22","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.4049\/jimmunol.0904214","volume":"185","author":"AS Naura","year":"2010","unstructured":"Naura AS, Zerfaoui M, Kim H, Abd Elmageed ZY, Rodriguez PC, Hans CP et al (2010) Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. J Immunol 185:3076\u20133085","journal-title":"J Immunol"},{"key":"583_CR23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jaci.2014.09.005","volume":"135","author":"MA Ghonim","year":"2015","unstructured":"Ghonim MA, Pyakurel K, Ju J, Rodriguez PC, Lammi MR, Davis C et al (2015) DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4 T-cell function without causing severe combined immunodeficiency. J Allergy Clin Immunol 135:425\u2013440","journal-title":"J Allergy Clin Immunol"},{"key":"583_CR24","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1074\/jbc.M112.419580","volume":"288","author":"AS Naura","year":"2013","unstructured":"Naura AS, Kim H, Ju J, Rodriguez PC, Jordan J, Catling AD et al (2013) Minocycline blocks asthma-associated inflammation in part by interfering with the T Cell receptor-NF-kB-GATA-3-IL-4 axis without a prominent effect on PARP. J Biol Chem 288:1458\u20131468","journal-title":"J Biol Chem"},{"key":"583_CR25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"583_CR26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11010-014-2271-4","volume":"400","author":"K Kapoor","year":"2015","unstructured":"Kapoor K, Singla E, Sahu B, Naura AS (2015) PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice. Mol Cell Biochem 400:153\u2013162","journal-title":"Mol Cell Biochem"},{"key":"583_CR27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jaut.2012.02.001","volume":"38","author":"R Sharma","year":"2012","unstructured":"Sharma R, Sung SS, Gaskin F, Fu SM, Ju ST (2012) A novel function of IL-2: chemokine\/chemoattractant\/retention receptor genes induction in Th subsets for skin and lung inflammation. J Autoimmun 38:322\u2013331","journal-title":"J Autoimmun"},{"key":"583_CR28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","volume":"89","author":"W Zheng","year":"1997","unstructured":"Zheng W, Flavell RA (1997) The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89:587\u2013596","journal-title":"Cell"},{"key":"583_CR29","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.4049\/jimmunol.0901568","volume":"184","author":"F Nasta","year":"2010","unstructured":"Nasta F, Laudisi F, Sambucci M, Rosado MM, Pioli C (2010) Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency. J Immunol 184:3470\u20133477","journal-title":"J Immunol"},{"key":"583_CR30","doi-asserted-by":"crossref","first-page":"e71590","DOI":"10.1371\/journal.pone.0071590","volume":"8","author":"P Zhang","year":"2013","unstructured":"Zhang P, Maruyama T, Konkel JE, Abbatiello B, Zamarron B, Wang ZQ et al (2013) PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3. PLoS One 8:e71590","journal-title":"PLoS One"},{"key":"583_CR31","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S1470-2045(11)70214-5","volume":"12","author":"KA Gelmon","year":"2011","unstructured":"Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, Tonkin K et al (2011) Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 12:852\u2013861","journal-title":"Lancet Oncol"},{"key":"583_CR32","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa1105535","volume":"366","author":"J Ledermann","year":"2012","unstructured":"Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G et al (2012) Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med 366:1382\u20131392","journal-title":"N Engl J Med"},{"key":"583_CR33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S1470-2045(14)70228-1","volume":"15","author":"J Ledermann","year":"2014","unstructured":"Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G et al (2014) Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol 15:852\u2013861","journal-title":"Lancet Oncol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-015-0583-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T15:34:18Z","timestamp":1498232058000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.translational-medicine.com\/content\/13\/1\/225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["583"],"URL":"https:\/\/doi.org\/10.1186\/s12967-015-0583-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]},"article-number":"225"}}