{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:07:19Z","timestamp":1793902039742,"version":"4.8.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570127"],"award-info":[{"award-number":["81570127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370638"],"award-info":[{"award-number":["81370638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530046"],"award-info":[{"award-number":["81530046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Science and Technology Project of Guangdong Province of China","award":["2016B030230003"],"award-info":[{"award-number":["2016B030230003"]}]},{"name":"the Foundation for Innovative Research Groups of the National Natural Science Foundation of China","award":["81621001"],"award-info":[{"award-number":["81621001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12967-017-1159-y","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T12:04:27Z","timestamp":1489493067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1186","volume":"15","author":[{"given":"Yuan","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie-Na","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"1159_CR1","first-page":"935","volume":"91","author":"A Larocca","year":"2006","unstructured":"Larocca A, Piaggio G, Podesta M, Pitto A, Bruno B, Di Grazia C, Gualandi F, Occhini D, Raiola AM, Dominietto A, et al. Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation. Haematologica. 2006;91:935\u201340.","journal-title":"Haematologica"},{"key":"1159_CR2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/leu.2015.75","volume":"29","author":"RF Olsson","year":"2015","unstructured":"Olsson RF, Logan BR, Chaudhury S, Zhu X, Akpek G, Bolwell BJ, Bredeson CN, Dvorak CC, Gupta V, Ho VT, et al. Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies. Leukemia. 2015;29:1754\u201362.","journal-title":"Leukemia"},{"key":"1159_CR3","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1182\/blood-2011-07-338822","volume":"118","author":"Y Reisner","year":"2011","unstructured":"Reisner Y, Hagin D, Martelli MF. Haploidentical hematopoietic transplantation: current status and future perspectives. Blood. 2011;118:6006\u201317.","journal-title":"Blood"},{"key":"1159_CR4","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2015-07-533588","volume":"126","author":"LM Calvi","year":"2015","unstructured":"Calvi LM, Link DC. The hematopoietic stem cell niche in homeostasis and disease. Blood. 2015;126:2443\u201351.","journal-title":"Blood"},{"key":"1159_CR5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","volume":"505","author":"SJ Morrison","year":"2014","unstructured":"Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature. 2014;505:327\u201334.","journal-title":"Nature"},{"key":"1159_CR6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nature04957","volume":"441","author":"DT Scadden","year":"2006","unstructured":"Scadden DT. The stem-cell niche as an entity of action. Nature. 2006;441:1075\u20139.","journal-title":"Nature"},{"key":"1159_CR7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","volume":"425","author":"LM Calvi","year":"2003","unstructured":"Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425:841\u20136.","journal-title":"Nature"},{"key":"1159_CR8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","volume":"481","author":"L Ding","year":"2012","unstructured":"Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481:457\u201362.","journal-title":"Nature"},{"key":"1159_CR9","doi-asserted-by":"crossref","first-page":"30892","DOI":"10.18632\/oncotarget.8810","volume":"7","author":"Y Kong","year":"2016","unstructured":"Kong Y, Song Y, Hu Y, Shi MM, Wang YT, Wang Y, Zhang XH, Xu LP, Liu KY, Deng HK, Huang XJ. Increased reactive oxygen species and exhaustion of quiescent CD34-positive bone marrow cells may contribute to poor graft function after allotransplants. Oncotarget. 2016;7:30892\u2013906.","journal-title":"Oncotarget"},{"key":"1159_CR10","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.bbmt.2013.07.014","volume":"19","author":"Y Kong","year":"2013","unstructured":"Kong Y, Chang YJ, Wang YZ, Chen YH, Han W, Wang Y, Sun YQ, Yan CH, Wang FR, Liu YR, et al. Association of an impaired bone marrow microenvironment with secondary poor graft function after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:1465\u201373.","journal-title":"Biol Blood Marrow Transplant"},{"key":"1159_CR11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/bmt.2015.229","volume":"51","author":"Y Kong","year":"2016","unstructured":"Kong Y, Wang YT, Hu Y, Han W, Chang YJ, Zhang XH, Jiang ZF, Huang XJ. The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function. Bone Marrow Transplant. 2016;51:249\u201355.","journal-title":"Bone Marrow Transplant"},{"key":"1159_CR12","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1182\/blood-2016-03-702803","volume":"128","author":"MM Shi","year":"2016","unstructured":"Shi MM, Kong Y, Song Y, Sun YQ, Wang Y, Zhang XH, Xu LP, Liu KY, Huang XJ. Atorvastatin enhances endothelial cell function in posttransplant poor graft function. Blood. 2016;128:2988\u201399.","journal-title":"Blood"},{"key":"1159_CR13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nri3132","volume":"12","author":"FE Mercier","year":"2011","unstructured":"Mercier FE, Ragu C, Scadden DT. The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol. 2011;12:49\u201360.","journal-title":"Nat Rev Immunol"},{"key":"1159_CR14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/cdd.2014.89","volume":"22","author":"C Riether","year":"2015","unstructured":"Riether C, Schurch CM, Ochsenbein AF. Regulation of hematopoietic and leukemic stem cells by the immune system. Cell Death Differ. 2015;22:187\u201398.","journal-title":"Cell Death Differ"},{"key":"1159_CR15","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1182\/blood-2009-11-253559","volume":"115","author":"Y Shono","year":"2010","unstructured":"Shono Y, Ueha S, Wang Y, Abe J, Kurachi M, Matsuno Y, Sugiyama T, Nagasawa T, Imamura M, Matsushima K. Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation. Blood. 2010;115:5401\u201311.","journal-title":"Blood"},{"key":"1159_CR16","doi-asserted-by":"crossref","first-page":"e104607","DOI":"10.1371\/journal.pone.0104607","volume":"9","author":"Y Yao","year":"2014","unstructured":"Yao Y, Song X, Cheng H, Tang G, Hu X, Zhou H, Wang J. Dysfunction of bone marrow vascular niche in acute graft-versus-host disease after MHC-haploidentical bone marrow transplantation. PLoS ONE. 2014;9:e104607.","journal-title":"PLoS ONE"},{"key":"1159_CR17","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.bbmt.2016.04.016","volume":"22","author":"YT Wang","year":"2016","unstructured":"Wang YT, Kong Y, Song Y, Han W, Zhang YY, Zhang XH, Chang YJ, Jiang ZF, Huang XJ. Increased type 1 immune response in the bone marrow immune microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2016;22:1376\u201382.","journal-title":"Biol Blood Marrow Transplant"},{"key":"1159_CR18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/imr.12036","volume":"252","author":"LA Zuniga","year":"2013","unstructured":"Zuniga LA, Jain R, Haines C, Cua DJ. Th17 cell development: from the cradle to the grave. Immunol Rev. 2013;252:78\u201388.","journal-title":"Immunol Rev"},{"key":"1159_CR19","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","volume":"13","author":"H Kebir","year":"2007","unstructured":"Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med. 2007;13:1173\u20135.","journal-title":"Nat Med"},{"key":"1159_CR20","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.autrev.2014.08.019","volume":"13","author":"RP Singh","year":"2014","unstructured":"Singh RP, Hasan S, Sharma S, Nagra S, Yamaguchi DT, Wong DT, Hahn BH, Hossain A. Th17 cells in inflammation and autoimmunity. Autoimmun Rev. 2014;13:1174\u201381.","journal-title":"Autoimmun Rev"},{"key":"1159_CR21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","volume":"22","author":"JD Fontenot","year":"2005","unstructured":"Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005;22:329\u201341.","journal-title":"Immunity"},{"key":"1159_CR22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature14452","volume":"523","author":"N Gagliani","year":"2015","unstructured":"Gagliani N, Vesely MCA, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limon P, Paiva RS, Ching T, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 2015;523:221\u20135.","journal-title":"Nature"},{"key":"1159_CR23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/08916934.2013.879862","volume":"47","author":"M Klatka","year":"2014","unstructured":"Klatka M, Grywalska E, Partyka M, Charytanowicz M, Kiszczak-Bochynska E, Rolinski J. Th17 and Treg cells in adolescents with Graves\u2019 disease. impact of treatment with methimazole on these cell subsets. Autoimmunity. 2014;47:201\u201311.","journal-title":"Autoimmunity"},{"key":"1159_CR24","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood-2009-12-255810","volume":"116","author":"P Ratajczak","year":"2010","unstructured":"Ratajczak P, Janin A, de Latour RP, Leboeuf C, Desveaux A, Keyvanfar K, Robin M, Clave E, Douay C, Quinquenel A, et al. Th17\/Treg ratio in human graft-versus-host disease. Blood. 2010;116:1165\u201371.","journal-title":"Blood"},{"key":"1159_CR25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00277-016-2641-y","volume":"95","author":"Y Song","year":"2016","unstructured":"Song Y, Wang YT, Huang XJ, Kong Y. Abnormalities of the bone marrow immune microenvironment in patients with immune thrombocytopenia. Ann Hematol. 2016;95:959\u201365.","journal-title":"Ann Hematol"},{"key":"1159_CR26","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/eji.201040793","volume":"41","author":"XY Zhao","year":"2011","unstructured":"Zhao XY, Xu LL, Lu SY, Huang XJ. IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation. Eur J Immunol. 2011;41:514\u201326.","journal-title":"Eur J Immunol"},{"key":"1159_CR27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10160","volume":"474","author":"J Fujisaki","year":"2011","unstructured":"Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Celso CL, Tsuyuzaki H, et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature. 2011;474:216\u20139.","journal-title":"Nature"},{"key":"1159_CR28","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/oxfordjournals.aje.a116398","volume":"135","author":"S Wacholder","year":"1992","unstructured":"Wacholder S, Silverman DT, McLaughlin JK, Mandel JS. Selection of controls in case\u2013control studies. III. Design options. Am J Epidemiol. 1992;135:1042\u201350.","journal-title":"Am J Epidemiol"},{"key":"1159_CR29","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1200\/JCO.2015.63.8817","volume":"34","author":"YJ Chang","year":"2016","unstructured":"Chang YJ, Xu LP, Wang Y, Zhang XH, Chen H, Chen YH, Wang FR, Han W, Sun YQ, Yan CH, et al. Controlled, randomized, open-label trial of risk-stratified corticosteroid prevention of acute graft-versus-host disease after haploidentical transplantation. J Clin Oncol. 2016;34:1855\u201363.","journal-title":"J Clin Oncol"},{"key":"1159_CR30","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.1182\/blood-2011-11-389809","volume":"119","author":"XJ Huang","year":"2012","unstructured":"Huang XJ, Zhu HH, Chang YJ, Xu LP, Liu DH, Zhang XH, Jiang B, Jiang Q, Jiang H, Chen YH, et al. The superiority of haploidentical related stem cell transplantation over chemotherapy alone as postremission treatment for patients with intermediate- or high-risk acute myeloid leukemia in first complete remission. Blood. 2012;119:5584\u201390.","journal-title":"Blood"},{"key":"1159_CR31","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1182\/blood-2014-03-563130","volume":"124","author":"Y Wang","year":"2014","unstructured":"Wang Y, Chang YJ, Xu LP, Liu KY, Liu DH, Zhang XH, Chen H, Han W, Chen YH, Wang FR, et al. Who is the best donor for a related HLA haplotype-mismatched transplant? Blood. 2014;124:843\u201350.","journal-title":"Blood"},{"key":"1159_CR32","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1182\/blood-2014-03-563403","volume":"124","author":"Y Wang","year":"2014","unstructured":"Wang Y, Wu DP, Liu QF, Qin YZ, Wang JB, Xu LP, Liu YR, Zhu HH, Chen J, Dai M, Huang XJ. In adults with t(8;21)AML, posttransplant RUNX1\/RUNX1T1-based MRD monitoring, rather than c-KIT mutations, allows further risk stratification. Blood. 2014;124:1880\u20136.","journal-title":"Blood"},{"key":"1159_CR33","first-page":"407","volume":"24","author":"LP Xu","year":"2003","unstructured":"Xu LP, Huang XJ, Guo NL, Ren HY, Zhang YC, Lu DP. Detection of cytomegalovirus infection by polymerase chain reaction in hematopoietic stem cell transplantation recipients. Zhonghua Xue Ye Xue Za Zhi. 2003;24:407\u20139.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"1159_CR34","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bbmt.2014.04.015","volume":"20","author":"Y Kong","year":"2014","unstructured":"Kong Y, Hu Y, Zhang XH, Wang YZ, Mo XD, Zhang YY, Wang Y, Han W, Xu LP, Chang YJ, Huang XJ. Association between an impaired bone marrow vascular microenvironment and prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20:1190\u20137.","journal-title":"Biol Blood Marrow Transplant"},{"key":"1159_CR35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nri3158","volume":"12","author":"HT Maecker","year":"2012","unstructured":"Maecker HT, McCoy JP, Nussenblatt R. Standardizing immunophenotyping for the human immunology project. Nat Rev Immunol. 2012;12:191\u2013200.","journal-title":"Nat Rev Immunol"},{"key":"1159_CR36","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1182\/blood-2013-02-482539","volume":"122","author":"S Dong","year":"2013","unstructured":"Dong S, Maiella S, Xhaard A, Pang Y, Wenandy L, Larghero J, Becavin C, Benecke A, Bianchi E, Socie G, Rogge L. Multiparameter single-cell profiling of human CD4+ FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease. Blood. 2013;122:1802\u201312.","journal-title":"Blood"},{"key":"1159_CR37","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","volume":"30","author":"M Miyara","year":"2009","unstructured":"Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, Parizot C, Taflin C, Heike T, Valeyre D, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity. 2009;30:899\u2013911.","journal-title":"Immunity"},{"key":"1159_CR38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2141.2003.04729.x","volume":"124","author":"NC Giannakoulas","year":"2004","unstructured":"Giannakoulas NC, Karakantza M, Theodorou GL, Pagoni M, Galanopoulos A, Kakagianni T, Kouraklis-Symeonidis A, Matsouka P, Maniatis A, Zoumbos NC. Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anaemia patients. Br J Haematol. 2004;124:97\u2013105.","journal-title":"Br J Haematol"},{"key":"1159_CR39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1182\/blood-2002-01-0035","volume":"100","author":"E Sloand","year":"2002","unstructured":"Sloand E, Kim S, Maciejewski JP, Tisdale J, Follmann D, Young NS. Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood. 2002;100:1185\u201391.","journal-title":"Blood"},{"key":"1159_CR40","first-page":"914","volume":"90","author":"T Wang","year":"2005","unstructured":"Wang T, Zhao H, Ren H, Guo J, Xu M, Yang R, Han ZC. Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica. 2005;90:914\u201323.","journal-title":"Haematologica"},{"key":"1159_CR41","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1182\/blood-2010-01-266098","volume":"116","author":"RP Latour de","year":"2010","unstructured":"de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, et al. Th17 immune responses contribute to the pathophysiology of aplastic anemia. Blood. 2010;116:4175\u201384.","journal-title":"Blood"},{"key":"1159_CR42","first-page":"273","volume":"14","author":"B Tao","year":"2015","unstructured":"Tao B, Ruan G, Wang D, Li Y, Wang Z, Yin G. Imbalance of peripheral Th17 and regulatory T Cells in children with allergic Rhinitis AND bronchial asthma. Iran J Allergy Asthma Immunol. 2015;14:273\u20139.","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"1159_CR43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12906-015-0572-0","volume":"15","author":"Q Zheng","year":"2015","unstructured":"Zheng Q, Yang T, Fang L, Liu L, Liu H, Zhao H, Zhao Y, Guo H, Fan Y, Wang L. Effects of Bu Shen Yi Sui Capsule on Th17\/Treg cytokines in C57BL\/6 mice with experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2015;15:60.","journal-title":"BMC Complement Altern Med"},{"key":"1159_CR44","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/eji.201545788","volume":"46","author":"R Wang","year":"2016","unstructured":"Wang R, Solt LA. Metabolism of murine TH 17 cells: impact on cell fate and function. Eur J Immunol. 2016;46:807\u201316.","journal-title":"Eur J Immunol"},{"key":"1159_CR45","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1182\/blood-2011-11-390708","volume":"120","author":"J Shi","year":"2012","unstructured":"Shi J, Ge M, Lu S, Li X, Shao Y, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia. Blood. 2012;120:1624\u201332.","journal-title":"Blood"},{"key":"1159_CR46","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1182\/blood-2007-01-066258","volume":"110","author":"EE Solomou","year":"2007","unstructured":"Solomou EE, Rezvani K, Mielke S, Malide D, Keyvanfar K, Visconte V, Kajigaya S, Barrett AJ, Young NS. Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood. 2007;110:1603\u20136.","journal-title":"Blood"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-017-1159-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T21:03:44Z","timestamp":1601759024000},"score":1,"resource":{"primary":{"URL":"http:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-017-1159-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1159"],"URL":"https:\/\/doi.org\/10.1186\/s12967-017-1159-y","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"article-number":"57"}}